Geetanjali S. Masamaddi - Academia.edu (original) (raw)
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Papers by Geetanjali S. Masamaddi
International Journal of Research in Medical Sciences, Jan 25, 2023
Journal of Evidence Based Medicine and Healthcare, Jan 19, 2017
BACKGROUND Effective pain control is essential for optimum care of patients in the postoperative ... more BACKGROUND Effective pain control is essential for optimum care of patients in the postoperative period. Epidural and intrathecal administration of drugs have been used increasingly for relief of postoperative pain. Tramadol is a centrally acting analgesic that has minimal respiratory depressant effects compared to other opioids like morphine. This study was conducted to evaluate safety and efficacy of the intrathecal tramadol and to determine the postoperative analgesia.
In today's' vitality power industries Boost converters highly required to convert the normal powe... more In today's' vitality power industries Boost converters highly required to convert the normal power into improvised power. Normally vitality converters struggled with voltage pressure over the power electronics switching nature and undulation. The renewable energy of a kind that vitality Photovoltaic (PV)-cell sources, windmill and battery are the sources for the converters; in this Photovoltaic play a vital role and mostly used medium to provide converters for further processing. The vitality PV is basically acted along with solar power efficiency, which is improvised ZeroVoltage Switching [ZVS] converters. The Zero-Voltage Switching [ZVS] converters transforms the low-power DC energy to high-power or vitality DC-energy, which reduces the voltage pressure over the power electronics switching units and undulation is improving execution of the electrical system vitality efficiently and simplifying the circuit nature.
Indian Journal of Clinical Anaesthesia, 2020
Introduction and Objectives: Laryngoscopy and tracheal intubation are noxious stimuli that produc... more Introduction and Objectives: Laryngoscopy and tracheal intubation are noxious stimuli that produce marked sympathetic responses manifesting as tachycardia and hypertension, which can be deleterious in susceptible-patients if they precipitate myocardial ischaemia, infarction, arrhythmias etc. Since β-blockers counteract these sympathetic activation, this clinical study was designed to evaluate and compare a short-acting β-blocker, Esmolol as IV bolus to a placebo in attenuating sympathetic responses at laryngoscopy and intubation in healthy adults. Materials and Methods: This was a randomized prospective controlled study consisting of 60 patients who were allocated into group A (Esmolol) and Group B (Placebo). Patients were premedicated with glycopyrolate 0.2 mg IV 90 minutes before surgery. Esmolol was given as 100 mg IV bolus immediately before induction with Thiopentone 5 mg/kg and Suxamethonium 1.5 mg/kg. The study period extended up to 5 minutes after intubation. Pre-induction readings of Heart rate, Systolic blood pressure, Diastolic blood pressure, mean arterial pressure and Rate pressure product were compared to those at 1 st , 3 rd and 5 th minutes after intubation. Changes in ECG and any other adverse effects were looked for. Results: The mean values of Heart rate, Systolic blood pressure, Diastolic blood pressure, Mean arterial pressure and Rate pressure product for esmolol group at pre-induction, at 1 st , 3 rd and 5 th minute were noted to be as follows: (Figures in parenthesis for placebo).
Indian Journal of Anaesthesia and Analgesia, 2017
BACKGROUND Relieving pain is one of the fundamental responsibilities of medical practitioners and... more BACKGROUND Relieving pain is one of the fundamental responsibilities of medical practitioners and is frequently a primary goal of patients seeking care. Many published reviews have outlined this problem, some showing that up to 70% of patients receive ineffective, inadequate or delayed pain relief. The pain that accompanies surgical procedures remains prevalent and is an aspect of the perioperative experience that generates the greatest concern for patients about to undergo surgery. There is also a growing concern that acute painful experiences can also lead to long-term painful consequences, even when tissue healing appears to be complete. The objective of our study is to assess intramuscular Parecoxib with regard to its efficacy in pain relief, duration of action, need for supplements, safety and adverse effects. MATERIALS AND METHODS This study comprised of 100 postoperative patients of both sexes between age group of 18-70 years who were scheduled for various elective surgical procedures and all those who satisfied inclusion and exclusion criteria. All patients were visited preoperatively, a written informed consent was taken and premedicated with diazepam 0.2 mg/kg body weight at night. Parecoxib sodium 40 mg IM was given in the recovery room, when patient complained of pain and injection time was noted. The time of onset of action of Parecoxib, duration of analgesia, quality of analgesia were recorded by VAS. Heart rate and blood pressure were recorded at intervals. Supplementary doses of Parecoxib necessary was administered and the time noted. Any adverse effects were noted. The observations were recorded, tabulated and subjected to statistical analysis.
IP Innovative Publication Pvt. Ltd., 2018
Introduction and Objectives: Laryngoscopy and tracheal intubation are noxious stimuli that produc... more Introduction and Objectives: Laryngoscopy and tracheal intubation are noxious stimuli that produce marked sympathetic responses manifesting as tachycardia and hypertension, which can be deleterious in susceptible-patients if they precipitate myocardial ischaemia, infarction, arrhythmias etc. Since β-blockers counteract these sympathetic activation, this clinical study was designed to evaluate and compare a short-acting β-blocker, Esmolol as IV bolus to a placebo in attenuating sympathetic responses at laryngoscopy and intubation in healthy adults.
Materials and Methods: This was a randomized prospective controlled study consisting of 60 patients who were allocated into group A (Esmolol) and Group B (Placebo). Patients were premedicated with glycopyrolate 0.2 mg IV 90 minutes before surgery.
Esmolol was given as 100 mg IV bolus immediately before induction with Thiopentone 5 mg/kg and Suxamethonium 1.5 mg/kg. The study period extended up to 5 minutes after intubation. Pre-induction readings of Heart rate, Systolic blood pressure, Diastolic blood pressure, mean arterial pressure and Rate pressure product were compared to those at 1st, 3rd and 5th minutes after intubation. Changes in ECG and any other adverse effects were looked for.
Results: The mean values of Heart rate, Systolic blood pressure, Diastolic blood pressure, Mean arterial pressure and Rate pressure product for esmolol group at pre-induction, at 1st, 3rd and 5th minute were noted to be as follows: (Figures in parenthesis for placebo).
Heart rate (b/min) was 87.93 (86.03), 87.37 (102.03), 88.40 (100.77), 88.13 (98.63); Systolic blood pressure (mmHg) was 130.93 (128.33), 128.80 (145.73), 122.80 (136.13), 121.80 (130.80); Diastolic blood pressure (mmHg) 81.40 (79.87), 79.00 (97.87), 78.07 (87.80), 78.67 (85.13); Mean arterial pressure (mmHg) was 97.35 (94.91), 94.03 (114.42), 93.01 (103.84), 92.68 (100.57) and Rate pressure product was 11323.60 (11042.50), 10831.6 (14971.4), 10826.8 (13817.9), 10779.9 (12896.6) respectively. There were neither significant adverse effects nor ECG changes.
Interpretation and Conclusion: Esmolol 100 mg IV bolus effectively attenuates sympathetic responses at laryngoscopy and tracheal intubation without any adverse effects.
Keywords: Diastolic blood pressure, Esmolol, Heart rate, Laryngoscopy and Tracheal Intubation (LTI), Mean arterial pressure, Rate pressure product, Systolic blood pressure.
International Journal of Research in Medical Sciences, Jan 25, 2023
Journal of Evidence Based Medicine and Healthcare, Jan 19, 2017
BACKGROUND Effective pain control is essential for optimum care of patients in the postoperative ... more BACKGROUND Effective pain control is essential for optimum care of patients in the postoperative period. Epidural and intrathecal administration of drugs have been used increasingly for relief of postoperative pain. Tramadol is a centrally acting analgesic that has minimal respiratory depressant effects compared to other opioids like morphine. This study was conducted to evaluate safety and efficacy of the intrathecal tramadol and to determine the postoperative analgesia.
In today's' vitality power industries Boost converters highly required to convert the normal powe... more In today's' vitality power industries Boost converters highly required to convert the normal power into improvised power. Normally vitality converters struggled with voltage pressure over the power electronics switching nature and undulation. The renewable energy of a kind that vitality Photovoltaic (PV)-cell sources, windmill and battery are the sources for the converters; in this Photovoltaic play a vital role and mostly used medium to provide converters for further processing. The vitality PV is basically acted along with solar power efficiency, which is improvised ZeroVoltage Switching [ZVS] converters. The Zero-Voltage Switching [ZVS] converters transforms the low-power DC energy to high-power or vitality DC-energy, which reduces the voltage pressure over the power electronics switching units and undulation is improving execution of the electrical system vitality efficiently and simplifying the circuit nature.
Indian Journal of Clinical Anaesthesia, 2020
Introduction and Objectives: Laryngoscopy and tracheal intubation are noxious stimuli that produc... more Introduction and Objectives: Laryngoscopy and tracheal intubation are noxious stimuli that produce marked sympathetic responses manifesting as tachycardia and hypertension, which can be deleterious in susceptible-patients if they precipitate myocardial ischaemia, infarction, arrhythmias etc. Since β-blockers counteract these sympathetic activation, this clinical study was designed to evaluate and compare a short-acting β-blocker, Esmolol as IV bolus to a placebo in attenuating sympathetic responses at laryngoscopy and intubation in healthy adults. Materials and Methods: This was a randomized prospective controlled study consisting of 60 patients who were allocated into group A (Esmolol) and Group B (Placebo). Patients were premedicated with glycopyrolate 0.2 mg IV 90 minutes before surgery. Esmolol was given as 100 mg IV bolus immediately before induction with Thiopentone 5 mg/kg and Suxamethonium 1.5 mg/kg. The study period extended up to 5 minutes after intubation. Pre-induction readings of Heart rate, Systolic blood pressure, Diastolic blood pressure, mean arterial pressure and Rate pressure product were compared to those at 1 st , 3 rd and 5 th minutes after intubation. Changes in ECG and any other adverse effects were looked for. Results: The mean values of Heart rate, Systolic blood pressure, Diastolic blood pressure, Mean arterial pressure and Rate pressure product for esmolol group at pre-induction, at 1 st , 3 rd and 5 th minute were noted to be as follows: (Figures in parenthesis for placebo).
Indian Journal of Anaesthesia and Analgesia, 2017
BACKGROUND Relieving pain is one of the fundamental responsibilities of medical practitioners and... more BACKGROUND Relieving pain is one of the fundamental responsibilities of medical practitioners and is frequently a primary goal of patients seeking care. Many published reviews have outlined this problem, some showing that up to 70% of patients receive ineffective, inadequate or delayed pain relief. The pain that accompanies surgical procedures remains prevalent and is an aspect of the perioperative experience that generates the greatest concern for patients about to undergo surgery. There is also a growing concern that acute painful experiences can also lead to long-term painful consequences, even when tissue healing appears to be complete. The objective of our study is to assess intramuscular Parecoxib with regard to its efficacy in pain relief, duration of action, need for supplements, safety and adverse effects. MATERIALS AND METHODS This study comprised of 100 postoperative patients of both sexes between age group of 18-70 years who were scheduled for various elective surgical procedures and all those who satisfied inclusion and exclusion criteria. All patients were visited preoperatively, a written informed consent was taken and premedicated with diazepam 0.2 mg/kg body weight at night. Parecoxib sodium 40 mg IM was given in the recovery room, when patient complained of pain and injection time was noted. The time of onset of action of Parecoxib, duration of analgesia, quality of analgesia were recorded by VAS. Heart rate and blood pressure were recorded at intervals. Supplementary doses of Parecoxib necessary was administered and the time noted. Any adverse effects were noted. The observations were recorded, tabulated and subjected to statistical analysis.
IP Innovative Publication Pvt. Ltd., 2018
Introduction and Objectives: Laryngoscopy and tracheal intubation are noxious stimuli that produc... more Introduction and Objectives: Laryngoscopy and tracheal intubation are noxious stimuli that produce marked sympathetic responses manifesting as tachycardia and hypertension, which can be deleterious in susceptible-patients if they precipitate myocardial ischaemia, infarction, arrhythmias etc. Since β-blockers counteract these sympathetic activation, this clinical study was designed to evaluate and compare a short-acting β-blocker, Esmolol as IV bolus to a placebo in attenuating sympathetic responses at laryngoscopy and intubation in healthy adults.
Materials and Methods: This was a randomized prospective controlled study consisting of 60 patients who were allocated into group A (Esmolol) and Group B (Placebo). Patients were premedicated with glycopyrolate 0.2 mg IV 90 minutes before surgery.
Esmolol was given as 100 mg IV bolus immediately before induction with Thiopentone 5 mg/kg and Suxamethonium 1.5 mg/kg. The study period extended up to 5 minutes after intubation. Pre-induction readings of Heart rate, Systolic blood pressure, Diastolic blood pressure, mean arterial pressure and Rate pressure product were compared to those at 1st, 3rd and 5th minutes after intubation. Changes in ECG and any other adverse effects were looked for.
Results: The mean values of Heart rate, Systolic blood pressure, Diastolic blood pressure, Mean arterial pressure and Rate pressure product for esmolol group at pre-induction, at 1st, 3rd and 5th minute were noted to be as follows: (Figures in parenthesis for placebo).
Heart rate (b/min) was 87.93 (86.03), 87.37 (102.03), 88.40 (100.77), 88.13 (98.63); Systolic blood pressure (mmHg) was 130.93 (128.33), 128.80 (145.73), 122.80 (136.13), 121.80 (130.80); Diastolic blood pressure (mmHg) 81.40 (79.87), 79.00 (97.87), 78.07 (87.80), 78.67 (85.13); Mean arterial pressure (mmHg) was 97.35 (94.91), 94.03 (114.42), 93.01 (103.84), 92.68 (100.57) and Rate pressure product was 11323.60 (11042.50), 10831.6 (14971.4), 10826.8 (13817.9), 10779.9 (12896.6) respectively. There were neither significant adverse effects nor ECG changes.
Interpretation and Conclusion: Esmolol 100 mg IV bolus effectively attenuates sympathetic responses at laryngoscopy and tracheal intubation without any adverse effects.
Keywords: Diastolic blood pressure, Esmolol, Heart rate, Laryngoscopy and Tracheal Intubation (LTI), Mean arterial pressure, Rate pressure product, Systolic blood pressure.