Gehan T . El-Bassyouni - Academia.edu (original) (raw)
Papers by Gehan T . El-Bassyouni
Ceramics International, 2025
Foamed ceramic based on stoichiometric anorthite (CaAl2Si2O8) composition was prepared from solid... more Foamed ceramic based on stoichiometric anorthite (CaAl2Si2O8) composition was prepared from solid wastes and local raw materials (aluminum slag, silica fume, and limestone). Sintering of the green sample between 1000 and 1300 ◦C gave dicalcium silicate, wollastonite, hedenpergite, pseudowollastonite, and anorthite. The samples sintered at high temperatures, i.e., 1250 and 1300 ◦C, show swelling that is concomitant with low density. The microstructure displays that the pore spaces increase in size with increasing temperature and that the submicrometric and nanometric particles are disseminated in a glassy matrix, especially at 1300 ◦C. The bulk and specific density values vary in the range of 1.471–0.958 g/cc and 2.996–2.759 g/cm3, respectively. The thermal conductivity (0.6525 ≤ κ ≤ 1.7668 W/(K.m)) is directly proportional to the bulk (apparent) density values (ρb, R2 = 0.966), which are in the range of 1.471–0.958 g/cm3, and inversely proportional to the porosity values (∅He, R2 = 0.954), which vary between 50.91 % and 81.56 %. Thermal conductivity is also directly proportional to the thermal diffusivity (0.3552 ≤ α ≤ 0.5255 mm2/s, R2 = 0.933) and heat capacitance (823.2 ≤ Cp ≤ 1122.3 J/(K.kg), R2 = 0.939). This lightweight prepared ceramic material can be used as a heat insulator up to 1000 ◦C.
Ceramics International 51 (2025) 401–410, 2025
Devitrified silica minerals glass was obtained from stoichiometric tanohataite (LiMn2Si3O8F) mine... more Devitrified silica minerals glass was obtained from stoichiometric tanohataite (LiMn2Si3O8F) mineral prepared by melt quench route. Low-quartz and cristobalite (~19.5 %) were developed in glass during melt cooling and casting the glass melt. However, a scanning electron microscope (SEM) for the devitrified glass showed nanoscale particles scattered in a few crystallized spots. When it was tested as an anode for lithium-ion batteries, a relatively high initial capacity of ca.785 mAh g 1 was obtained at 50 mA g 1 as an initial discharge capacity. Very good stability with excellent capacity retention (sometimes it exceeds 100 %) was observed based on the 2nd discharge capacity until the 500th cycle with about 100 % coulombic efficiency. The sample showed good rate capability as it still delivers a capacity of 26 mAh g 1 after increasing the current density 40 times of magnitude. Also, it is a flexible material as after this considerable load, it can restore 185 mAh g 1 after returning to the initial low current (50 mA g 1). The electrochemical performance was supported by electrochemical impedance (EIS) measurement, which showed a decrease in EIS and an increase in lithium diffusion upon extended cycling. This unique electrochemical performance for this multicomponent non-crystalline glass was formerly supported by XPS characterization, which emphasized the presence of Mn4+ in the synthesized sample.
This study investigated the synthesis and characterization of CeO 2 /SnO 2 composite powders and ... more This study investigated the synthesis and characterization of CeO 2 /SnO 2 composite powders and films by varying CeO 2 concentration ranging from 2 to 10 mol%. The sol-gel process was utilized to create composites. X-ray diffraction demonstrated that the resulting CeO 2 /SnO 2 powders were polycrystalline, whereas the composite films had amorphous structures. The morphology of the produced samples was studied with SEM and TEM. Also the specific surface area was measured using the Brunauer-Emmett-Teller (BET) technique and the optical characteristics were assessed using a UV-Vis spectrophotometer. The absorption coefficients, energy gaps, and refractive indices of the composite films were determined. Direct and indirect energy gaps were from 3.71 to 3.27 eV and 2.70 to 2.26 eV, respectively. The refractive index increases from 1.61 to 1.7 as the CeO 2 concentration increases. The variation in the energy band gap and refractive index values indicate that CeO 2 /SnO 2 nanocomposite films are a viable composite film for optoelectronic devices. The investigated films have electrical conductivity values ranging from 10 − 2 to 10 − 8 Ω − 1 cm − 1. The gas sensing test was studied using different gases as liquid petroleum gas (LPG), carbon monoxide (CO), and Hydrogen sulfide (H 2 S). CeO 2 /SnO 2 films demonstrated the highest sensitivity for hydrogen sulfide (H 2 S), with a sensitivity of 0.988 % and a response time of 40 s.
Nano-composite films of cobalt (II⋅III) oxide/tin (IV) oxide (Co 3 O 4 /SnO 2) to be applicable f... more Nano-composite films of cobalt (II⋅III) oxide/tin (IV) oxide (Co 3 O 4 /SnO 2) to be applicable for optoelectronic applications were prepared via sol gel method with variable concentrations of the Co 3 O 4 in the range of 0-45 mol %. Structural analysis using x-ray diffraction (XRD)of the composite powder Co 3 O 4 /SnO 2 revealed that a polycrystalline structure was formed, whereas the composite films showed an amorphous behavior. Transmission electron microscope (TEM) was performed to investigate the polycrystalline structure of the prepared films. The results obtained from optical measurements indicated that the absorption edge was shifted towards longer wavelengths upon increasing the Co 3 O 4 content from 0 to 35 mol %. Further increase of Co 3 O 4 , revealed that the cut off transmission spectra were shifted to higher energies. The refractive index of prepared films increases from 1.61to1.892 along with increasing the Co 3 O 4 mole %. The Co 3 O 4 /SnO 2 content ratio can control the optical properties and energy band gap of the mixture consequently, the present study is an innovative, promising, and appreciating the Co 3 O 4 /SnO 2 based composite for optical applications.
Biocatalysis and Agricultural Biotechnology, Aug 31, 2023
The objective of this study was to explore the potential of ZnO-nanoparticles (NPs) and Cu-doped ... more The objective of this study was to explore the potential of ZnO-nanoparticles (NPs) and Cu-doped ZnO-nanoparticles (NPs) as insecticides for controlling the population of Spodoptera littoralis, a major pest in Egyptian fields. The researchers employed various characterization techniques like zeta potential, XRD, Fourier-transform infrared spectroscopy (FTIR) spectroscopy, scanning electron microscopy, and transmission electron microscopy to analyze and identify the nanomaterials used. The study investigated the effects of different concentrations of nanomaterials, ranging from 1 % to 5 %. The results revealed that the presence of Cu-doped ZnO-NPs led to a significant reduction in the pest population compared to the control group. Notably, the highest concentration of 5 % Cu-doped ZnO-NPs exhibited a toxic effect on Spodoptera littoralis, resulting in a remarkable 95 % reduction in their population after 16 days of treatment. Additionally, the findings demonstrate that Cu-doped ZnO-NPs have effective insecticidal properties and are costeffective, making them a viable option for local application in pest control. Finally, the research highlights the potential of Cu-doped ZnO-NPs as an environmentally safe and efficient insecticide against Spodoptera littoralis in Egyptian fields. The study emphasizes the utility of nanomaterials in pest management, which could significantly reduce the reliance on conventional insecticides, mitigating potential environmental and health risks.
Journal of Applied Pharmaceutical Science, 2018
The objective of the present study was the extraction of chitosan from the seashell exoskeleton, ... more The objective of the present study was the extraction of chitosan from the seashell exoskeleton, then it was modified by the exposure to different time intervals of ultraviolet/ozone (UV/ozone). Also, the study focused on the differentiation between the properties of native chitosan and their UV/ozone forms. The molecular weight and degree of deacetylation of the extracted chitosan were determined. UV/ozone modified chitosan was analyzed using FTIR. The result proved that the irradiation of the prepared samples resulted in slight shifts in the absorbance bands position, also the occurrence of UV-induced photooxidation in the range of OH vibration. Molecular modeling at B3LYP/6-31g(d, p) and PM6 levels indicated that radiation was supposed to affect the H-bonding of the NH 2 group through weak interaction with the six-respective hydrogen bonding in the three NH 2 groups. UV/ozone chitosan acquired improvement in the antimicrobial activity by an increment of the exposure time against different pathogen with variable degrees. Antioxidant activity was determined using different methods and the results confirmed the role of UV/ozone in improving this property. The fibrinolytic activity reported that chitosan treated with UV/ozone for 3 and 4 h showed great activity. On the other hand, the anticoagulant activity was non-significant.
Scientific Reports, Jan 17, 2024
Helicobacter pylori (H. pylori) is a universal health intimidation as mentioned by the World Heal... more Helicobacter pylori (H. pylori) is a universal health intimidation as mentioned by the World Health Organization. The primary causal agent linked to a number of illnesses, including inflammation and the development of stomach ulcers, is Helicobacter pylori. Since, H. pylori develops antibiotic resistance quickly, current H. pylori treatment approaches are becoming less effective. Our research aims to highlight novel formulation antibiotics using CuO-NPs as catalysts and studied their activity as anti-helicobacter pylori supported by computational studies (POM analysis and molecular docking) software. They were designed for anti-Helicobacter Pylori action. All compounds revealed a bactericidal effect better than the reference McFarland standards. Gram-negative, spiral-shaped, microaerophilic Helicobacter pylori (H. pylori) bacterium. H. pylori infection affects over 50% of people worldwide, with infection rates being greater in underdeveloped nations. The pathophysiology of chronic gastritis, peptic stomach ulcers, gastric mucosa-related lymphomas, and even gastric cancer are all linked to H. pylori infection. H. pylori was classified by the World Health Organization as a Group I human carcinogen in 1994. H. pylori infection causes more than 85% of cases of stomach cancer. There is general agreement that eliminating H. pylori can lower the prevalence of stomach cancer 1. In 1980, the H. pylori genome was fully sequenced after it was obtained from a gastritis patient. With 1, 667, 867 base pairs on its circular chromosome, it is projected to have 1590 coding sequences. The findings imply that the fundamental processes of cell division, secretion, and replication are comparable to those of E. Coli and H. influenza. However, the number of genes found in isolates, or the size of its core genome, varies based on the number of strains examined and where in the world they are from. Furthermore, the capacity of H. pylori species to generate an active vacuolating cytotoxin (VacA) and a cytotoxin-associated protein (CagA) has been linked to their virulence, according to genome analysis. VacA is known to damage epithelial cells, disrupts tight junctions, and causes apoptosis, while CagA may cause inflammation and is a potentially carcinogen agent 2. In fact, because H. pylori strains differ from one another, the particular strain that affects a person might determine their prognosis. Conversely, during the past several decades, there has been a significant shift in the clinical features and epidemiology of H. pylori infections, particularly in poorer nations. In the context of the worldwide growth in antibiotic use in the general population, there is presently a visible failure, mostly owing to H. pylori resistance to various antibiotics, despite the use of therapeutic regimens and international standards created by microbiology specialists 3. Our research aims to highlight novel formulation designs and chemicals to battle the rising rates of antibiotic-resistant H. pylori strains, as well as the associated risk factors and global prevalence. To achieve our goal, cyclization of azo compounds to create new families of triazine and diazine derivatives, exhibiting various pharmaceutical activities. Triazine derivatives revealed many activities as antimicrobial 4 , anti-inflammatory 5 , anti-cancer 6 , anti-depressant 7 , anti-bacterial 8 , anti-fungal 9 , antioxidant 10 , antimalarial 11 , antiproliferative 12 , and analgesic activities 13. Moreover, diazine derivatives disclosed a wide-ranging of applications 14. More than half of all the chemicals used in the majority of chemical reactions are produced by catalysis 15. Numerous industrialized operations, such as oil refining, organic synthesis, and pollution management, now depend
Ceramics International, 2024
Devitrified silica minerals glass was obtained from stoichiometric tanohataite (LiMn2Si3O8F) mine... more Devitrified silica minerals glass was obtained from stoichiometric tanohataite (LiMn2Si3O8F) mineral prepared by melt quench route. Low-quartz and cristobalite (~19.5 %) were developed in glass during melt cooling and casting the glass melt. However, a scanning electron microscope (SEM) for the devitrified glass showed nanoscale
particles scattered in a few crystallized spots. When it was tested as an anode for lithium-ion batteries, a relatively high initial capacity of ca.785 mAh g 1 was obtained at 50 mA g 1 as an initial discharge capacity. Very good stability with excellent capacity retention (sometimes it exceeds 100 %) was observed based on the 2nd discharge capacity until the 500th cycle with about 100 % coulombic efficiency. The sample showed good rate capability as it still delivers a capacity of 26 mAh g 1 after increasing the current density 40 times of magnitude. Also, it is a flexible material as after this considerable load, it can restore 185 mAh g 1 after returning to the initial low current (50 mA g 1). The electrochemical performance was supported by electrochemical impedance (EIS) measurement, which showed a decrease in EIS and an increase in lithium diffusion upon extended cycling. This unique electrochemical performance for this multicomponent non-crystalline glass was formerly supported by XPS characterization, which emphasized the presence of Mn4+ in the synthesized sample.
Optical Materials , 2024
This study investigated the synthesis and characterization of CeO 2 /SnO 2 composite powders and ... more This study investigated the synthesis and characterization of CeO 2 /SnO 2 composite powders and films by varying CeO 2 concentration ranging from 2 to 10 mol%. The sol-gel process was utilized to create composites. X-ray diffraction demonstrated that the resulting CeO 2 /SnO 2 powders were polycrystalline, whereas the composite films had amorphous structures. The morphology of the produced samples was studied with SEM and TEM. Also the specific surface area was measured using the Brunauer-Emmett-Teller (BET) technique and the optical characteristics were assessed using a UV-Vis spectrophotometer. The absorption coefficients, energy gaps, and refractive indices of the composite films were determined. Direct and indirect energy gaps were from 3.71 to 3.27 eV and 2.70 to 2.26 eV, respectively. The refractive index increases from 1.61 to 1.7 as the CeO 2 concentration increases. The variation in the energy band gap and refractive index values indicate that CeO 2 /SnO 2 nanocomposite films are a viable composite film for optoelectronic devices. The investigated films have electrical conductivity values ranging from 10 − 2 to 10 − 8 Ω − 1 cm − 1. The gas sensing test was studied using different gases as liquid petroleum gas (LPG), carbon monoxide (CO), and Hydrogen sulfide (H 2 S). CeO 2 /SnO 2 films demonstrated the highest sensitivity for hydrogen sulfide (H 2 S), with a sensitivity of 0.988 % and a response time of 40 s.
Scientific reports, Apr 19, 2024
Copper-doped ZnO nanoparticles with the formula Zn 1−x(Cu) O, where x = 0.0, 0.03, 0.05, and 0.07... more Copper-doped ZnO nanoparticles with the formula Zn 1−x(Cu) O, where x = 0.0, 0.03, 0.05, and 0.07 were produced using the co-precipitation process. Physical, chemical, and structural properties were properly examined. Powdered X-ray diffraction (P-XRD) patterns revealed the formation of hexagonal wurtzite crystal structure in all samples, through atomic substitutional incorporation in the Cu-doped ZnO lattice. The presence of Cu ions and their dissolution in the host ZnO crystal structure was supported by FT-IR spectra. HR-TEM images were used to assess the average size, morphology, and shape regularity of the synthesized samples. The form and homogeneity of the ZnO changed when Cu ions were substituted, as evidenced by FE-SEM/EDX analysis. The presence of copper signals in the Cu-doped samples indicates that the doping was successful. The decrease in zeta potential with an increased copper doping percentage designates that the nanoparticles (NPs) are more stable, which could be attributed to an increase in the ionic strength of the aqueous solution. The synthesized NPs were evaluated for their substantial in vitro antioxidant properties. In addition, the antimicrobial efficacy of the materials was tested against pathogenic microorganisms. Regarding the anti-diabetic activity, the 7Cu ZnO sample showed the highest inhibitory effect on the α-amylase enzyme. No variations were observed in the activities of the acetylcholinesterase enzyme (AChE) and proteinase enzymes with ZnO and samples doped with different concentrations of Cu. Therefore, further studies are recommended to reveal the in-vitro anti-diabetic activity of the studied doped samples. Finally, molecular docking provided valuable insights into the potential binding interactions of Cu-doped ZnO with α-amylase, FabH of E. coli, and Penicillin-binding proteins of S. aureus. These outcomes suggest that the prepared materials may have an inhibitory effect on enzymes and hold promise in the battle against microbial infections and diabetes.
Surfaces and interfaces, May 1, 2024
Recently, the development of particles fortified polymer composites has grown significantlydue to... more Recently, the development of particles fortified polymer composites has grown significantlydue to their intelligent uses in many fields.Cobalt nanoparticles' impact on the dielectric, optical, and magnetic properties of cobalt/polystyrene (Co/PS) nanocomposite films has been investigated. Co-NPs were preparedusing the reduction method and loadedintothepolystyrenematrixwith different concentrations(2, 5, 8, and 10 wt.%),forming nanocompositefilms. X-ray diffraction XRD was used to describe the structure of the produced films. The results showed a hexagonal (hcp) structure with ε phase of the Co-NPs in the PS matrix. The topography of the crosssection of nanocomposite films was scanned through a field emission electron microscope (FE-SEM). The high-resolution transmission electron microscope (HR-TEM) was used to examine the morphology of the produced Co-NPs. Zetasizer considered the charge and particle size distribution of the prepared Co-NPs powder. At room temperature, dielectric spectroscopy looked at the dielectric characteristics over a frequency range from 10 − 1-10 7 Hz. The UV analyzed the optical properties of nanocomposite films-VIS technique. The optical bandgap of the nanocomposite films is a direct allowed transition and decreases from 4.51 to 3.69e, which increases the absorption coefficient. A vibrating sample magnetometer (VSM) was used to measure the magnetic hysteresis loops of the produced films at room temperature. The ferromagnetic behavior of all samples was evident, and there was an apparent magnetic hysteresis. All samples exhibited high coercivity, where the exchange bias decreased from 28.02 Oe to 1.42 Oe with increasing Co wt% in PS. The present work found that the Co/PS nanocomposite films loaded with various concentrations of Co-NPs and tuned properties may be suitable for use in electrical energy storage, photonic devices, and some magnetic applications, such as spintronic devices.
Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology, Nov 30, 2023
Objective: Evaluation of the osteoconductive p otential of the nanocomposite tricalcium phosphate... more Objective: Evaluation of the osteoconductive p otential of the nanocomposite tricalcium phosphate/hydroxyapatite (TCP/HA) bi-doped with zirconium (Zr) and silver (Ag) ions versus TCP/HA & 4AgTCP/HA in induced defects.
Methods: Fifteen dogs were divided into four groups in 12 weeks duration before euthanasia: 1-control, 2- TCP/HA, 3- TCP/HA doped with Ag and 4-TCP/HA bi-doped with Ag & Zr groups. Four surgically created defects were randomly allocated in each animal on the left and right mandibular sides, three defects were grafted with
mentioned alloplasts and one empty control. Clinical, radiographic, and histological evaluations were performed for the newly formed bone.
Results: Clinical results revealed no infection or inflammatory conditions. All graft groups revealed a significant increase (P<0.05) in mature bone mean density versus controls. TCP/HA bidoped with Ag and Zr group elucidated a highly significant increase (P <0.01) in mature bone density compared to other groups while the TCP/HA
was statistically insignificant (P > 0.05) compared to the Ag-doped TCP/HA. The bactericidal action of both Zr and Ag nanoparticles was evident by antibacterial testing.
Conclusion: Bi-doping of TCP/HA with Ag and Zr has a synergistic osteoconductive effect to enhance bone formation as an excellent modality for defective bone reconstruction. Histomorphometric investigation clarified that Ag and Zr doped TCP/HA stimulated osteogenesis and bone remodeling as compared to un-doped TCP/HA. Therefore, this nanocomposite has promising clinical significance in grafting maxillofacial bone defects for optimal healing compared to un-doped TCP/HA. Moreover, Zr and Ag nanoparticles are effective bactericidal materials with optimal biological safety on the animals.
Ceramics international, Feb 1, 2024
The main objective of this study is to fabricate composite materials having excellent thermal, me... more The main objective of this study is to fabricate composite materials having excellent thermal, mechanical and electrical properties for thermal and electronic applications. In this work, strontium feldspar-containing composites (Sr-feldspar/cordierite and Sr-feldspar/Sr-osumilite) were prepared by solid-state sintering of SrOcontaining cordierite (MgSrAl 4 Si 5 O 18)/borosilicate glass powder mixtures. The phase composition, physical properties and microstructure of sintered composites were investigated by X-ray diffraction technique, water displacement method and scanning electron microscope, respectively. Moreover, the thermal expansion coefficient, hardness, and electrical properties were also measured. The results of X-ray patterns revealed the crystallization of Sr-feldspar and cordierite in the composites that contain up to 20% borosilicate glass. On the other hand, the composites that include more than 20% glass, displayed the crystallization of Sr-feldspar and Srosumilite with little amount of cristobalite. The bulk density values of sintered composites were decreased from 2.41 to 1.84 g/cm 3 with increasing the amount of added glass. The microhardness values were increased from 519 to 710 kg/mm 2 with increasing the glass content. Low thermal expansion coefficient (2.65 × 10 − 6 , 2.22 × 10 − 6 , 3.45 × 10 − 6 and 4.26 × 10 − 6 K-1 for C0, CG91, CG73, CG55, respectively) and low dialectic constant (7-8.5) were obtained for the prepared composites.
Ceramics International, Dec 31, 2023
The novel nanocomposites of ZnO-containing CaSiO 3 /NiO 2 were prepared through the wet precipita... more The novel nanocomposites of ZnO-containing CaSiO 3 /NiO 2 were prepared through the wet precipitation method. The XRD of samples sintered at 1100 • C/2 h presented variable phases, mainly hardystonite (Ca 2 ZnSi 2 O 7) with two secondary phases of willemite (Zn 2 SiO 4) and tridymite (SiO 2). Similarly, small diffraction peaks of peroxide nickel oxide (NiO 2) arose in samples containing significant concentrations of it. All composites were crystallized in the nano-range, and their particle sizes (Ps) range from 60 to 70 nm. According to the morphological investigation, the percentage of NiO 2 increased grain size. The optical result assured that the willemite phase has an optical band gap of 5.35-5.58 eV and a minor transition at ~3.4 eV. While NiO 2 had a small transition found at 1.7 ± 0.05 eV. The lattice vibrations of Ca-O, the stretching of the CO group in CaCO 3 , and the Si-O symmetric stretching were affected by the NiO 2 concentration, as evident from the Raman spectra. Nevertheless, the FTIR result revealed that the increasing NiO 2 concentration did not affect the stretching and bending vibrations of the composites. The values of moment/g increased with NiO 2 , and two magnetic contributions were revealed. The concentration of NiO 2 in the composite was shown to be connected to the composite's ability to suppress the various microbiological strains tested. There is no detectable inhibitory impact when the sample's NiO 2 content is less than 3%. This research topic provides an opportunity to look into novel materials with possible antimicrobial uses for infection prevention in biological fields, such as bone repair.
Journal of materials science. Materials in electronics, 2024
Bioactive Carbohydrates and Dietary Fibers, 2024
The current study was directed to explore new natural products that alleviate inflammation with t... more The current study was directed to explore new natural products that alleviate inflammation with the least harming effects on the gastric mucosa. This study examined the anti-ulcerative properties of micro and nanocrystalline cellulose (MCC, NCC) palm frond and their chemically modified samples (sulfated (SMCC and SNCC), methylated (MMCC and MNCC) and phosphorylated (PMCC and PNCC)). The lowest prebiotic index (I) was recorded in case of the MMCC and MNCC extract with L. Reuteri (I = 1) while the higher prebiotic index was recorded in case of the PMCC against L. casei (I = 3.7). All treated groups showed significant improvements in the ulcer scores (P < 0.05) compared to the control (indomethacin) group. However, MMCC showed marked effects similar to ranitidine. A significant decrease was found in pro-inflammatory cytokines (IL-6 and TNF-α) and proapoptotic gene (Bax) in all treated groups compared to the ulcer-induced group. In conclusion, the histopathological evaluation of MNCC, PNCC and SNCC had superior ameliorating effect on gastric ulcer induced in rats when compared to Omeprazole 20 mg/kg and other treated groups (MMCC, PMCC, SMCC).
Scientific reports, 2024
Most of the conditions involving cartilaginous tissues are irreversible and involve degenerative ... more Most of the conditions involving cartilaginous tissues are irreversible and involve degenerative processes. The aim of the present study was to fabricate a biocompatible fibrous and film scaffolds using electrospinning and casting techniques to induce chondrogenic differentiation for possible application in cartilaginous tissue regeneration. Polycaprolactone (PCL) electrospun nanofibrous scaffolds and PCL film were fabricated and incorporated with multi-walled carbon nanotubes (MWCNTs). Thereafter, coating of chondroitin sulfate (CS) on the fibrous and film structures was applied to promote chondrogenic differentiation of human dental pulp stem cells (hDPSCs). First, the morphology, hydrophilicity and mechanical properties of the scaffolds were characterized by scanning electron microscopy (SEM), spectroscopic characterization, water contact angle measurements and tensile strength testing. Subsequently, the effects of the fabricated scaffolds on stimulating the proliferation of human dental pulp stem cells (hDPSCs) and inducing their chondrogenic differentiation were evaluated via electron microscopy, flow cytometry and RT-PCR. The results of the study demonstrated that the different forms of the fabricated PCL-MWCNTs scaffolds analyzed demonstrated biocompatibility. The nanofilm structures demonstrated a higher rate of cellular proliferation, while the nanofibrous architecture of the scaffolds supported the cellular attachment and differentiation capacity of hDPSCs and was further enhanced with CS addition. In conclusion, the results of the present investigation highlighted the significance of this combination of parameters on the viability, proliferation and chondrogenic differentiation capacity of hDPSCs seeded on PCL-MWCNT scaffolds. This approach may be applied when designing PCL-based scaffolds for future cellbased therapeutic approaches developed for chondrogenic diseases.
Scientific reports, 2024
Alzheimer disease (AD) is the cause of dementia and accounts for 60-80% cases. Tumor Necrosis Fac... more Alzheimer disease (AD) is the cause of dementia and accounts for 60-80% cases. Tumor Necrosis Factor-alpha (TNF-α) is a multifunctional cytokine that provides resistance to infections, inflammation, and cancer. It developed as a prospective therapeutic target against multiple autoimmune and inflammatory disorders. Cholinergic insufficiency is linked to Alzheimer's disease, and several cholinesterase inhibitors have been created to treat it, including naturally produced inhibitors, synthetic analogs, and hybrids. In the current study, we tried to prepared compounds may also support the discovery and development of novel therapeutic and preventative drugs for Alzheimer's using manganese tetroxide nanoparticles (Mn 3 O 4-NPs) as a catalyst to generate compounds with excellent reaction conditions. The Biginelli synthesis yields 4-(4-cyanophenyl)-6-oxo-2-thioxohexahydropyrimidine-5-carbonitrile when the 4-cyanobenzaldehyde, ethyl cyanoacetate, and thiourea were coupled with Mn 3 O 4-NPs to produce compound 1. This multi-component method is non-toxic, safe, and environmentally friendly. The new approach reduced the amount of chemicals used and preserved time. Compound 1 underwent reactions with methyl iodide, acrylonitrile, chloroacetone, ethyl chloroacetate, and chloroacetic acid/benzaldehyde, each of the synthetized compounds was docked with TNF-α converting enzyme. These compounds may also support the discovery and development of novel therapeutic and preventative drugs for Alzheimer's disease. The majority of the produced compounds demonstrated pharmacokinetic features, making them potentially attractive therapeutic candidates for Alzheimer's disease treatment.
Ceramics International, 2024
This work investigates the bioactivity of pure Wollastonite and gold-doped Wollastonite nanohybri... more This work investigates the bioactivity of pure Wollastonite and gold-doped Wollastonite nanohybrids synthesized via a wet chemical technique. Doping with gold nanoparticles at different ratios for Wollastonite, where a dramatic decrease in the respective average particle sizes at the lowest doping ratio of 1.25 wt./v%, then the particle size raised gradually with an increase in the content of gold nanoparticles. In addition, a significant increase in the calculated surface area and the cumulative pore volume upon incorporating gold nanoparticles with the lowest doping ratio of 1.25 wt./v% is associated with a slight decrease in the average pore size. Then, a
gradual decrease in the calculated surface area and cumulative pore volume with the increase of doping ratio with gold nanoparticles is associated with an increase in average pore size. The results revealed that after two days of incubation for treated MG-63 cells, the W/Au 5 wt./v% showed the significantly highest alkaline phosphatase (ALP) activity among all other concentrations and the control cells. The ALP activity exceeded four mU/mL. After four days of incubation, the ALP activity in all doping ratios was significantly higher than the control cells, with no significant difference among other groups, but lower than ALP levels after two days of incubation. Also, pure Wollastonite and gold-doped Wollastonite nanohybrids, especially the lowest doping ratio of 1.25 wt./v%, have remarkable efficacy in combating E. coli (Gram-negative), S. aureus (Gram-positive) andbCandida albicans. In vitro studies showed that pure Wollastonite and gold-doped Wollastonite nanohybrids had minimal cytotoxic effects on osteosarcoma MG-63 cells, while they showed remarkable cell proliferation even at low concentrations. Based on the in-vitro ALP, bioactivity and biocompatibility results, the content of ALP can directly reflect the activity or function of osteoblasts and is positively correlated with the mineralization ability of cells, which shows that pure and gold-doped Wollastonite nanohybrids were suitable candidates for bone regeneration/healing applications.
Journal of Applied Pharmaceutical Science, 2016
In the present work, variation in the group coordination of chitosan due to the exposure to UV/oz... more In the present work, variation in the group coordination of chitosan due to the exposure to UV/ozone was considered by the FTIR reflectance. Pronounced variations in the intensities of reflectance bands and shifts in their positions were detected. This could be attributed to the change in the molecular configuration of chitosan. On the other hand, the well diffusion method was used to investigate the anti-bactericidal activities against two common bacterial strains [Bacillus subtitles (B. subtilis) and Escherichia coli (E. coli)] by detecting the mean inhibition zone diameters (IZD) against the microorganisms. The achieved data revealed that the chitosan exposed to UV/ozone confirmed a high potential of antibacterial activity.
Ceramics International, 2025
Foamed ceramic based on stoichiometric anorthite (CaAl2Si2O8) composition was prepared from solid... more Foamed ceramic based on stoichiometric anorthite (CaAl2Si2O8) composition was prepared from solid wastes and local raw materials (aluminum slag, silica fume, and limestone). Sintering of the green sample between 1000 and 1300 ◦C gave dicalcium silicate, wollastonite, hedenpergite, pseudowollastonite, and anorthite. The samples sintered at high temperatures, i.e., 1250 and 1300 ◦C, show swelling that is concomitant with low density. The microstructure displays that the pore spaces increase in size with increasing temperature and that the submicrometric and nanometric particles are disseminated in a glassy matrix, especially at 1300 ◦C. The bulk and specific density values vary in the range of 1.471–0.958 g/cc and 2.996–2.759 g/cm3, respectively. The thermal conductivity (0.6525 ≤ κ ≤ 1.7668 W/(K.m)) is directly proportional to the bulk (apparent) density values (ρb, R2 = 0.966), which are in the range of 1.471–0.958 g/cm3, and inversely proportional to the porosity values (∅He, R2 = 0.954), which vary between 50.91 % and 81.56 %. Thermal conductivity is also directly proportional to the thermal diffusivity (0.3552 ≤ α ≤ 0.5255 mm2/s, R2 = 0.933) and heat capacitance (823.2 ≤ Cp ≤ 1122.3 J/(K.kg), R2 = 0.939). This lightweight prepared ceramic material can be used as a heat insulator up to 1000 ◦C.
Ceramics International 51 (2025) 401–410, 2025
Devitrified silica minerals glass was obtained from stoichiometric tanohataite (LiMn2Si3O8F) mine... more Devitrified silica minerals glass was obtained from stoichiometric tanohataite (LiMn2Si3O8F) mineral prepared by melt quench route. Low-quartz and cristobalite (~19.5 %) were developed in glass during melt cooling and casting the glass melt. However, a scanning electron microscope (SEM) for the devitrified glass showed nanoscale particles scattered in a few crystallized spots. When it was tested as an anode for lithium-ion batteries, a relatively high initial capacity of ca.785 mAh g 1 was obtained at 50 mA g 1 as an initial discharge capacity. Very good stability with excellent capacity retention (sometimes it exceeds 100 %) was observed based on the 2nd discharge capacity until the 500th cycle with about 100 % coulombic efficiency. The sample showed good rate capability as it still delivers a capacity of 26 mAh g 1 after increasing the current density 40 times of magnitude. Also, it is a flexible material as after this considerable load, it can restore 185 mAh g 1 after returning to the initial low current (50 mA g 1). The electrochemical performance was supported by electrochemical impedance (EIS) measurement, which showed a decrease in EIS and an increase in lithium diffusion upon extended cycling. This unique electrochemical performance for this multicomponent non-crystalline glass was formerly supported by XPS characterization, which emphasized the presence of Mn4+ in the synthesized sample.
This study investigated the synthesis and characterization of CeO 2 /SnO 2 composite powders and ... more This study investigated the synthesis and characterization of CeO 2 /SnO 2 composite powders and films by varying CeO 2 concentration ranging from 2 to 10 mol%. The sol-gel process was utilized to create composites. X-ray diffraction demonstrated that the resulting CeO 2 /SnO 2 powders were polycrystalline, whereas the composite films had amorphous structures. The morphology of the produced samples was studied with SEM and TEM. Also the specific surface area was measured using the Brunauer-Emmett-Teller (BET) technique and the optical characteristics were assessed using a UV-Vis spectrophotometer. The absorption coefficients, energy gaps, and refractive indices of the composite films were determined. Direct and indirect energy gaps were from 3.71 to 3.27 eV and 2.70 to 2.26 eV, respectively. The refractive index increases from 1.61 to 1.7 as the CeO 2 concentration increases. The variation in the energy band gap and refractive index values indicate that CeO 2 /SnO 2 nanocomposite films are a viable composite film for optoelectronic devices. The investigated films have electrical conductivity values ranging from 10 − 2 to 10 − 8 Ω − 1 cm − 1. The gas sensing test was studied using different gases as liquid petroleum gas (LPG), carbon monoxide (CO), and Hydrogen sulfide (H 2 S). CeO 2 /SnO 2 films demonstrated the highest sensitivity for hydrogen sulfide (H 2 S), with a sensitivity of 0.988 % and a response time of 40 s.
Nano-composite films of cobalt (II⋅III) oxide/tin (IV) oxide (Co 3 O 4 /SnO 2) to be applicable f... more Nano-composite films of cobalt (II⋅III) oxide/tin (IV) oxide (Co 3 O 4 /SnO 2) to be applicable for optoelectronic applications were prepared via sol gel method with variable concentrations of the Co 3 O 4 in the range of 0-45 mol %. Structural analysis using x-ray diffraction (XRD)of the composite powder Co 3 O 4 /SnO 2 revealed that a polycrystalline structure was formed, whereas the composite films showed an amorphous behavior. Transmission electron microscope (TEM) was performed to investigate the polycrystalline structure of the prepared films. The results obtained from optical measurements indicated that the absorption edge was shifted towards longer wavelengths upon increasing the Co 3 O 4 content from 0 to 35 mol %. Further increase of Co 3 O 4 , revealed that the cut off transmission spectra were shifted to higher energies. The refractive index of prepared films increases from 1.61to1.892 along with increasing the Co 3 O 4 mole %. The Co 3 O 4 /SnO 2 content ratio can control the optical properties and energy band gap of the mixture consequently, the present study is an innovative, promising, and appreciating the Co 3 O 4 /SnO 2 based composite for optical applications.
Biocatalysis and Agricultural Biotechnology, Aug 31, 2023
The objective of this study was to explore the potential of ZnO-nanoparticles (NPs) and Cu-doped ... more The objective of this study was to explore the potential of ZnO-nanoparticles (NPs) and Cu-doped ZnO-nanoparticles (NPs) as insecticides for controlling the population of Spodoptera littoralis, a major pest in Egyptian fields. The researchers employed various characterization techniques like zeta potential, XRD, Fourier-transform infrared spectroscopy (FTIR) spectroscopy, scanning electron microscopy, and transmission electron microscopy to analyze and identify the nanomaterials used. The study investigated the effects of different concentrations of nanomaterials, ranging from 1 % to 5 %. The results revealed that the presence of Cu-doped ZnO-NPs led to a significant reduction in the pest population compared to the control group. Notably, the highest concentration of 5 % Cu-doped ZnO-NPs exhibited a toxic effect on Spodoptera littoralis, resulting in a remarkable 95 % reduction in their population after 16 days of treatment. Additionally, the findings demonstrate that Cu-doped ZnO-NPs have effective insecticidal properties and are costeffective, making them a viable option for local application in pest control. Finally, the research highlights the potential of Cu-doped ZnO-NPs as an environmentally safe and efficient insecticide against Spodoptera littoralis in Egyptian fields. The study emphasizes the utility of nanomaterials in pest management, which could significantly reduce the reliance on conventional insecticides, mitigating potential environmental and health risks.
Journal of Applied Pharmaceutical Science, 2018
The objective of the present study was the extraction of chitosan from the seashell exoskeleton, ... more The objective of the present study was the extraction of chitosan from the seashell exoskeleton, then it was modified by the exposure to different time intervals of ultraviolet/ozone (UV/ozone). Also, the study focused on the differentiation between the properties of native chitosan and their UV/ozone forms. The molecular weight and degree of deacetylation of the extracted chitosan were determined. UV/ozone modified chitosan was analyzed using FTIR. The result proved that the irradiation of the prepared samples resulted in slight shifts in the absorbance bands position, also the occurrence of UV-induced photooxidation in the range of OH vibration. Molecular modeling at B3LYP/6-31g(d, p) and PM6 levels indicated that radiation was supposed to affect the H-bonding of the NH 2 group through weak interaction with the six-respective hydrogen bonding in the three NH 2 groups. UV/ozone chitosan acquired improvement in the antimicrobial activity by an increment of the exposure time against different pathogen with variable degrees. Antioxidant activity was determined using different methods and the results confirmed the role of UV/ozone in improving this property. The fibrinolytic activity reported that chitosan treated with UV/ozone for 3 and 4 h showed great activity. On the other hand, the anticoagulant activity was non-significant.
Scientific Reports, Jan 17, 2024
Helicobacter pylori (H. pylori) is a universal health intimidation as mentioned by the World Heal... more Helicobacter pylori (H. pylori) is a universal health intimidation as mentioned by the World Health Organization. The primary causal agent linked to a number of illnesses, including inflammation and the development of stomach ulcers, is Helicobacter pylori. Since, H. pylori develops antibiotic resistance quickly, current H. pylori treatment approaches are becoming less effective. Our research aims to highlight novel formulation antibiotics using CuO-NPs as catalysts and studied their activity as anti-helicobacter pylori supported by computational studies (POM analysis and molecular docking) software. They were designed for anti-Helicobacter Pylori action. All compounds revealed a bactericidal effect better than the reference McFarland standards. Gram-negative, spiral-shaped, microaerophilic Helicobacter pylori (H. pylori) bacterium. H. pylori infection affects over 50% of people worldwide, with infection rates being greater in underdeveloped nations. The pathophysiology of chronic gastritis, peptic stomach ulcers, gastric mucosa-related lymphomas, and even gastric cancer are all linked to H. pylori infection. H. pylori was classified by the World Health Organization as a Group I human carcinogen in 1994. H. pylori infection causes more than 85% of cases of stomach cancer. There is general agreement that eliminating H. pylori can lower the prevalence of stomach cancer 1. In 1980, the H. pylori genome was fully sequenced after it was obtained from a gastritis patient. With 1, 667, 867 base pairs on its circular chromosome, it is projected to have 1590 coding sequences. The findings imply that the fundamental processes of cell division, secretion, and replication are comparable to those of E. Coli and H. influenza. However, the number of genes found in isolates, or the size of its core genome, varies based on the number of strains examined and where in the world they are from. Furthermore, the capacity of H. pylori species to generate an active vacuolating cytotoxin (VacA) and a cytotoxin-associated protein (CagA) has been linked to their virulence, according to genome analysis. VacA is known to damage epithelial cells, disrupts tight junctions, and causes apoptosis, while CagA may cause inflammation and is a potentially carcinogen agent 2. In fact, because H. pylori strains differ from one another, the particular strain that affects a person might determine their prognosis. Conversely, during the past several decades, there has been a significant shift in the clinical features and epidemiology of H. pylori infections, particularly in poorer nations. In the context of the worldwide growth in antibiotic use in the general population, there is presently a visible failure, mostly owing to H. pylori resistance to various antibiotics, despite the use of therapeutic regimens and international standards created by microbiology specialists 3. Our research aims to highlight novel formulation designs and chemicals to battle the rising rates of antibiotic-resistant H. pylori strains, as well as the associated risk factors and global prevalence. To achieve our goal, cyclization of azo compounds to create new families of triazine and diazine derivatives, exhibiting various pharmaceutical activities. Triazine derivatives revealed many activities as antimicrobial 4 , anti-inflammatory 5 , anti-cancer 6 , anti-depressant 7 , anti-bacterial 8 , anti-fungal 9 , antioxidant 10 , antimalarial 11 , antiproliferative 12 , and analgesic activities 13. Moreover, diazine derivatives disclosed a wide-ranging of applications 14. More than half of all the chemicals used in the majority of chemical reactions are produced by catalysis 15. Numerous industrialized operations, such as oil refining, organic synthesis, and pollution management, now depend
Ceramics International, 2024
Devitrified silica minerals glass was obtained from stoichiometric tanohataite (LiMn2Si3O8F) mine... more Devitrified silica minerals glass was obtained from stoichiometric tanohataite (LiMn2Si3O8F) mineral prepared by melt quench route. Low-quartz and cristobalite (~19.5 %) were developed in glass during melt cooling and casting the glass melt. However, a scanning electron microscope (SEM) for the devitrified glass showed nanoscale
particles scattered in a few crystallized spots. When it was tested as an anode for lithium-ion batteries, a relatively high initial capacity of ca.785 mAh g 1 was obtained at 50 mA g 1 as an initial discharge capacity. Very good stability with excellent capacity retention (sometimes it exceeds 100 %) was observed based on the 2nd discharge capacity until the 500th cycle with about 100 % coulombic efficiency. The sample showed good rate capability as it still delivers a capacity of 26 mAh g 1 after increasing the current density 40 times of magnitude. Also, it is a flexible material as after this considerable load, it can restore 185 mAh g 1 after returning to the initial low current (50 mA g 1). The electrochemical performance was supported by electrochemical impedance (EIS) measurement, which showed a decrease in EIS and an increase in lithium diffusion upon extended cycling. This unique electrochemical performance for this multicomponent non-crystalline glass was formerly supported by XPS characterization, which emphasized the presence of Mn4+ in the synthesized sample.
Optical Materials , 2024
This study investigated the synthesis and characterization of CeO 2 /SnO 2 composite powders and ... more This study investigated the synthesis and characterization of CeO 2 /SnO 2 composite powders and films by varying CeO 2 concentration ranging from 2 to 10 mol%. The sol-gel process was utilized to create composites. X-ray diffraction demonstrated that the resulting CeO 2 /SnO 2 powders were polycrystalline, whereas the composite films had amorphous structures. The morphology of the produced samples was studied with SEM and TEM. Also the specific surface area was measured using the Brunauer-Emmett-Teller (BET) technique and the optical characteristics were assessed using a UV-Vis spectrophotometer. The absorption coefficients, energy gaps, and refractive indices of the composite films were determined. Direct and indirect energy gaps were from 3.71 to 3.27 eV and 2.70 to 2.26 eV, respectively. The refractive index increases from 1.61 to 1.7 as the CeO 2 concentration increases. The variation in the energy band gap and refractive index values indicate that CeO 2 /SnO 2 nanocomposite films are a viable composite film for optoelectronic devices. The investigated films have electrical conductivity values ranging from 10 − 2 to 10 − 8 Ω − 1 cm − 1. The gas sensing test was studied using different gases as liquid petroleum gas (LPG), carbon monoxide (CO), and Hydrogen sulfide (H 2 S). CeO 2 /SnO 2 films demonstrated the highest sensitivity for hydrogen sulfide (H 2 S), with a sensitivity of 0.988 % and a response time of 40 s.
Scientific reports, Apr 19, 2024
Copper-doped ZnO nanoparticles with the formula Zn 1−x(Cu) O, where x = 0.0, 0.03, 0.05, and 0.07... more Copper-doped ZnO nanoparticles with the formula Zn 1−x(Cu) O, where x = 0.0, 0.03, 0.05, and 0.07 were produced using the co-precipitation process. Physical, chemical, and structural properties were properly examined. Powdered X-ray diffraction (P-XRD) patterns revealed the formation of hexagonal wurtzite crystal structure in all samples, through atomic substitutional incorporation in the Cu-doped ZnO lattice. The presence of Cu ions and their dissolution in the host ZnO crystal structure was supported by FT-IR spectra. HR-TEM images were used to assess the average size, morphology, and shape regularity of the synthesized samples. The form and homogeneity of the ZnO changed when Cu ions were substituted, as evidenced by FE-SEM/EDX analysis. The presence of copper signals in the Cu-doped samples indicates that the doping was successful. The decrease in zeta potential with an increased copper doping percentage designates that the nanoparticles (NPs) are more stable, which could be attributed to an increase in the ionic strength of the aqueous solution. The synthesized NPs were evaluated for their substantial in vitro antioxidant properties. In addition, the antimicrobial efficacy of the materials was tested against pathogenic microorganisms. Regarding the anti-diabetic activity, the 7Cu ZnO sample showed the highest inhibitory effect on the α-amylase enzyme. No variations were observed in the activities of the acetylcholinesterase enzyme (AChE) and proteinase enzymes with ZnO and samples doped with different concentrations of Cu. Therefore, further studies are recommended to reveal the in-vitro anti-diabetic activity of the studied doped samples. Finally, molecular docking provided valuable insights into the potential binding interactions of Cu-doped ZnO with α-amylase, FabH of E. coli, and Penicillin-binding proteins of S. aureus. These outcomes suggest that the prepared materials may have an inhibitory effect on enzymes and hold promise in the battle against microbial infections and diabetes.
Surfaces and interfaces, May 1, 2024
Recently, the development of particles fortified polymer composites has grown significantlydue to... more Recently, the development of particles fortified polymer composites has grown significantlydue to their intelligent uses in many fields.Cobalt nanoparticles' impact on the dielectric, optical, and magnetic properties of cobalt/polystyrene (Co/PS) nanocomposite films has been investigated. Co-NPs were preparedusing the reduction method and loadedintothepolystyrenematrixwith different concentrations(2, 5, 8, and 10 wt.%),forming nanocompositefilms. X-ray diffraction XRD was used to describe the structure of the produced films. The results showed a hexagonal (hcp) structure with ε phase of the Co-NPs in the PS matrix. The topography of the crosssection of nanocomposite films was scanned through a field emission electron microscope (FE-SEM). The high-resolution transmission electron microscope (HR-TEM) was used to examine the morphology of the produced Co-NPs. Zetasizer considered the charge and particle size distribution of the prepared Co-NPs powder. At room temperature, dielectric spectroscopy looked at the dielectric characteristics over a frequency range from 10 − 1-10 7 Hz. The UV analyzed the optical properties of nanocomposite films-VIS technique. The optical bandgap of the nanocomposite films is a direct allowed transition and decreases from 4.51 to 3.69e, which increases the absorption coefficient. A vibrating sample magnetometer (VSM) was used to measure the magnetic hysteresis loops of the produced films at room temperature. The ferromagnetic behavior of all samples was evident, and there was an apparent magnetic hysteresis. All samples exhibited high coercivity, where the exchange bias decreased from 28.02 Oe to 1.42 Oe with increasing Co wt% in PS. The present work found that the Co/PS nanocomposite films loaded with various concentrations of Co-NPs and tuned properties may be suitable for use in electrical energy storage, photonic devices, and some magnetic applications, such as spintronic devices.
Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology, Nov 30, 2023
Objective: Evaluation of the osteoconductive p otential of the nanocomposite tricalcium phosphate... more Objective: Evaluation of the osteoconductive p otential of the nanocomposite tricalcium phosphate/hydroxyapatite (TCP/HA) bi-doped with zirconium (Zr) and silver (Ag) ions versus TCP/HA & 4AgTCP/HA in induced defects.
Methods: Fifteen dogs were divided into four groups in 12 weeks duration before euthanasia: 1-control, 2- TCP/HA, 3- TCP/HA doped with Ag and 4-TCP/HA bi-doped with Ag & Zr groups. Four surgically created defects were randomly allocated in each animal on the left and right mandibular sides, three defects were grafted with
mentioned alloplasts and one empty control. Clinical, radiographic, and histological evaluations were performed for the newly formed bone.
Results: Clinical results revealed no infection or inflammatory conditions. All graft groups revealed a significant increase (P<0.05) in mature bone mean density versus controls. TCP/HA bidoped with Ag and Zr group elucidated a highly significant increase (P <0.01) in mature bone density compared to other groups while the TCP/HA
was statistically insignificant (P > 0.05) compared to the Ag-doped TCP/HA. The bactericidal action of both Zr and Ag nanoparticles was evident by antibacterial testing.
Conclusion: Bi-doping of TCP/HA with Ag and Zr has a synergistic osteoconductive effect to enhance bone formation as an excellent modality for defective bone reconstruction. Histomorphometric investigation clarified that Ag and Zr doped TCP/HA stimulated osteogenesis and bone remodeling as compared to un-doped TCP/HA. Therefore, this nanocomposite has promising clinical significance in grafting maxillofacial bone defects for optimal healing compared to un-doped TCP/HA. Moreover, Zr and Ag nanoparticles are effective bactericidal materials with optimal biological safety on the animals.
Ceramics international, Feb 1, 2024
The main objective of this study is to fabricate composite materials having excellent thermal, me... more The main objective of this study is to fabricate composite materials having excellent thermal, mechanical and electrical properties for thermal and electronic applications. In this work, strontium feldspar-containing composites (Sr-feldspar/cordierite and Sr-feldspar/Sr-osumilite) were prepared by solid-state sintering of SrOcontaining cordierite (MgSrAl 4 Si 5 O 18)/borosilicate glass powder mixtures. The phase composition, physical properties and microstructure of sintered composites were investigated by X-ray diffraction technique, water displacement method and scanning electron microscope, respectively. Moreover, the thermal expansion coefficient, hardness, and electrical properties were also measured. The results of X-ray patterns revealed the crystallization of Sr-feldspar and cordierite in the composites that contain up to 20% borosilicate glass. On the other hand, the composites that include more than 20% glass, displayed the crystallization of Sr-feldspar and Srosumilite with little amount of cristobalite. The bulk density values of sintered composites were decreased from 2.41 to 1.84 g/cm 3 with increasing the amount of added glass. The microhardness values were increased from 519 to 710 kg/mm 2 with increasing the glass content. Low thermal expansion coefficient (2.65 × 10 − 6 , 2.22 × 10 − 6 , 3.45 × 10 − 6 and 4.26 × 10 − 6 K-1 for C0, CG91, CG73, CG55, respectively) and low dialectic constant (7-8.5) were obtained for the prepared composites.
Ceramics International, Dec 31, 2023
The novel nanocomposites of ZnO-containing CaSiO 3 /NiO 2 were prepared through the wet precipita... more The novel nanocomposites of ZnO-containing CaSiO 3 /NiO 2 were prepared through the wet precipitation method. The XRD of samples sintered at 1100 • C/2 h presented variable phases, mainly hardystonite (Ca 2 ZnSi 2 O 7) with two secondary phases of willemite (Zn 2 SiO 4) and tridymite (SiO 2). Similarly, small diffraction peaks of peroxide nickel oxide (NiO 2) arose in samples containing significant concentrations of it. All composites were crystallized in the nano-range, and their particle sizes (Ps) range from 60 to 70 nm. According to the morphological investigation, the percentage of NiO 2 increased grain size. The optical result assured that the willemite phase has an optical band gap of 5.35-5.58 eV and a minor transition at ~3.4 eV. While NiO 2 had a small transition found at 1.7 ± 0.05 eV. The lattice vibrations of Ca-O, the stretching of the CO group in CaCO 3 , and the Si-O symmetric stretching were affected by the NiO 2 concentration, as evident from the Raman spectra. Nevertheless, the FTIR result revealed that the increasing NiO 2 concentration did not affect the stretching and bending vibrations of the composites. The values of moment/g increased with NiO 2 , and two magnetic contributions were revealed. The concentration of NiO 2 in the composite was shown to be connected to the composite's ability to suppress the various microbiological strains tested. There is no detectable inhibitory impact when the sample's NiO 2 content is less than 3%. This research topic provides an opportunity to look into novel materials with possible antimicrobial uses for infection prevention in biological fields, such as bone repair.
Journal of materials science. Materials in electronics, 2024
Bioactive Carbohydrates and Dietary Fibers, 2024
The current study was directed to explore new natural products that alleviate inflammation with t... more The current study was directed to explore new natural products that alleviate inflammation with the least harming effects on the gastric mucosa. This study examined the anti-ulcerative properties of micro and nanocrystalline cellulose (MCC, NCC) palm frond and their chemically modified samples (sulfated (SMCC and SNCC), methylated (MMCC and MNCC) and phosphorylated (PMCC and PNCC)). The lowest prebiotic index (I) was recorded in case of the MMCC and MNCC extract with L. Reuteri (I = 1) while the higher prebiotic index was recorded in case of the PMCC against L. casei (I = 3.7). All treated groups showed significant improvements in the ulcer scores (P < 0.05) compared to the control (indomethacin) group. However, MMCC showed marked effects similar to ranitidine. A significant decrease was found in pro-inflammatory cytokines (IL-6 and TNF-α) and proapoptotic gene (Bax) in all treated groups compared to the ulcer-induced group. In conclusion, the histopathological evaluation of MNCC, PNCC and SNCC had superior ameliorating effect on gastric ulcer induced in rats when compared to Omeprazole 20 mg/kg and other treated groups (MMCC, PMCC, SMCC).
Scientific reports, 2024
Most of the conditions involving cartilaginous tissues are irreversible and involve degenerative ... more Most of the conditions involving cartilaginous tissues are irreversible and involve degenerative processes. The aim of the present study was to fabricate a biocompatible fibrous and film scaffolds using electrospinning and casting techniques to induce chondrogenic differentiation for possible application in cartilaginous tissue regeneration. Polycaprolactone (PCL) electrospun nanofibrous scaffolds and PCL film were fabricated and incorporated with multi-walled carbon nanotubes (MWCNTs). Thereafter, coating of chondroitin sulfate (CS) on the fibrous and film structures was applied to promote chondrogenic differentiation of human dental pulp stem cells (hDPSCs). First, the morphology, hydrophilicity and mechanical properties of the scaffolds were characterized by scanning electron microscopy (SEM), spectroscopic characterization, water contact angle measurements and tensile strength testing. Subsequently, the effects of the fabricated scaffolds on stimulating the proliferation of human dental pulp stem cells (hDPSCs) and inducing their chondrogenic differentiation were evaluated via electron microscopy, flow cytometry and RT-PCR. The results of the study demonstrated that the different forms of the fabricated PCL-MWCNTs scaffolds analyzed demonstrated biocompatibility. The nanofilm structures demonstrated a higher rate of cellular proliferation, while the nanofibrous architecture of the scaffolds supported the cellular attachment and differentiation capacity of hDPSCs and was further enhanced with CS addition. In conclusion, the results of the present investigation highlighted the significance of this combination of parameters on the viability, proliferation and chondrogenic differentiation capacity of hDPSCs seeded on PCL-MWCNT scaffolds. This approach may be applied when designing PCL-based scaffolds for future cellbased therapeutic approaches developed for chondrogenic diseases.
Scientific reports, 2024
Alzheimer disease (AD) is the cause of dementia and accounts for 60-80% cases. Tumor Necrosis Fac... more Alzheimer disease (AD) is the cause of dementia and accounts for 60-80% cases. Tumor Necrosis Factor-alpha (TNF-α) is a multifunctional cytokine that provides resistance to infections, inflammation, and cancer. It developed as a prospective therapeutic target against multiple autoimmune and inflammatory disorders. Cholinergic insufficiency is linked to Alzheimer's disease, and several cholinesterase inhibitors have been created to treat it, including naturally produced inhibitors, synthetic analogs, and hybrids. In the current study, we tried to prepared compounds may also support the discovery and development of novel therapeutic and preventative drugs for Alzheimer's using manganese tetroxide nanoparticles (Mn 3 O 4-NPs) as a catalyst to generate compounds with excellent reaction conditions. The Biginelli synthesis yields 4-(4-cyanophenyl)-6-oxo-2-thioxohexahydropyrimidine-5-carbonitrile when the 4-cyanobenzaldehyde, ethyl cyanoacetate, and thiourea were coupled with Mn 3 O 4-NPs to produce compound 1. This multi-component method is non-toxic, safe, and environmentally friendly. The new approach reduced the amount of chemicals used and preserved time. Compound 1 underwent reactions with methyl iodide, acrylonitrile, chloroacetone, ethyl chloroacetate, and chloroacetic acid/benzaldehyde, each of the synthetized compounds was docked with TNF-α converting enzyme. These compounds may also support the discovery and development of novel therapeutic and preventative drugs for Alzheimer's disease. The majority of the produced compounds demonstrated pharmacokinetic features, making them potentially attractive therapeutic candidates for Alzheimer's disease treatment.
Ceramics International, 2024
This work investigates the bioactivity of pure Wollastonite and gold-doped Wollastonite nanohybri... more This work investigates the bioactivity of pure Wollastonite and gold-doped Wollastonite nanohybrids synthesized via a wet chemical technique. Doping with gold nanoparticles at different ratios for Wollastonite, where a dramatic decrease in the respective average particle sizes at the lowest doping ratio of 1.25 wt./v%, then the particle size raised gradually with an increase in the content of gold nanoparticles. In addition, a significant increase in the calculated surface area and the cumulative pore volume upon incorporating gold nanoparticles with the lowest doping ratio of 1.25 wt./v% is associated with a slight decrease in the average pore size. Then, a
gradual decrease in the calculated surface area and cumulative pore volume with the increase of doping ratio with gold nanoparticles is associated with an increase in average pore size. The results revealed that after two days of incubation for treated MG-63 cells, the W/Au 5 wt./v% showed the significantly highest alkaline phosphatase (ALP) activity among all other concentrations and the control cells. The ALP activity exceeded four mU/mL. After four days of incubation, the ALP activity in all doping ratios was significantly higher than the control cells, with no significant difference among other groups, but lower than ALP levels after two days of incubation. Also, pure Wollastonite and gold-doped Wollastonite nanohybrids, especially the lowest doping ratio of 1.25 wt./v%, have remarkable efficacy in combating E. coli (Gram-negative), S. aureus (Gram-positive) andbCandida albicans. In vitro studies showed that pure Wollastonite and gold-doped Wollastonite nanohybrids had minimal cytotoxic effects on osteosarcoma MG-63 cells, while they showed remarkable cell proliferation even at low concentrations. Based on the in-vitro ALP, bioactivity and biocompatibility results, the content of ALP can directly reflect the activity or function of osteoblasts and is positively correlated with the mineralization ability of cells, which shows that pure and gold-doped Wollastonite nanohybrids were suitable candidates for bone regeneration/healing applications.
Journal of Applied Pharmaceutical Science, 2016
In the present work, variation in the group coordination of chitosan due to the exposure to UV/oz... more In the present work, variation in the group coordination of chitosan due to the exposure to UV/ozone was considered by the FTIR reflectance. Pronounced variations in the intensities of reflectance bands and shifts in their positions were detected. This could be attributed to the change in the molecular configuration of chitosan. On the other hand, the well diffusion method was used to investigate the anti-bactericidal activities against two common bacterial strains [Bacillus subtitles (B. subtilis) and Escherichia coli (E. coli)] by detecting the mean inhibition zone diameters (IZD) against the microorganisms. The achieved data revealed that the chitosan exposed to UV/ozone confirmed a high potential of antibacterial activity.
Carbon Nanotubes (CNTs) Synthesis and Their Application, 2018
Advanced 3D-Printed Systems and Nanosystems for Drug Delivery and Tissue Engineering A volume in Woodhead Publishing Series in Biomaterials Book , 2020
Mechanical properties of three-dimensional (3D) scaffolds are critical for their biomedical appli... more Mechanical properties of three-dimensional (3D) scaffolds are critical for their biomedical applications. Several methods have been utilized to augment the mechanical properties of the 3D-printed scaffolds. The current chapter focuses on potential techniques that are applicable for the augmentation of mechanical properties of 3D-printed scaffolds. Particularly, the utilization of inorganic materials to reinforce 3D-printed scaffolds as reported in the current literature is highlighted. The overall aim is to provide a relatively exhaustive account of the various inorganic materials applied for 3D printing innovation. Different sources were reviewed in this chapter involving 3D structures for industrial applications and 3D-printed scaffolds for biomedical applications. Various inorganic materials were reported, including metal composites, metal oxides, and ceramic materials. Therefore, in this chapter, the most relevant materials that have been reported for mechanical augmentation of 3D-printed scaffolds are reviewed.
E-Book, ISBN-13: 978-620-2-31270-7, ISBN-10: 620231270X, 2018
ISBN-13: 9783330652835, ISBN-10: 3330652837, Central account ID: 200333325. Scholars’ Press 14/12... more ISBN-13: 9783330652835, ISBN-10: 3330652837, Central account ID: 200333325. Scholars’ Press 14/12/2017