Geraint Parry - Academia.edu (original) (raw)

Papers by Geraint Parry

Proceedings of the National Academy of Sciences of the United States of America, Jan 26, 2002

Exposure of blood to tissue factor (TF) activates the extrinsic (TF:FVIIa) and intrinsic (FVIIIa:... more Exposure of blood to tissue factor (TF) activates the extrinsic (TF:FVIIa) and intrinsic (FVIIIa:FIXa) pathways of coagulation. In this study, we found that mice expressing low levels of human TF ( approximately 1% of wild-type levels) in an mTF(-/-) background had significantly shorter lifespans than wild-type mice, in part, because of spontaneous fatal hemorrhages. All low-TF mice exhibited a selective heart defect that consisted of hemosiderin deposition and fibrosis. Direct intracardiac measurement demonstrated a 30% reduction (P < 0.001) in left ventricular function in 8-month-old low-TF mice compared with age-matched wild-type mice. Mice expressing low levels of murine FVII ( approximately 1% of wild-type levels) exhibited a similar pattern of hemosiderin deposition and fibrosis in their hearts. In contrast, FIX(-/-) mice, a model of hemophilia B, had normal hearts. Cardiac fibrosis in low-TF and low-FVII mice appears to be caused by hemorrhage from cardiac vessels due to i...

Political Participation and Democracy in Britain, 1992

Local Politics and Participation in Britain and France, 1990

THE PLANT CELL ONLINE, 2004

THE PLANT CELL ONLINE, 2006

Nucleocytoplasmic transport of macromolecules is regulated by a large multisubunit complex called... more Nucleocytoplasmic transport of macromolecules is regulated by a large multisubunit complex called the nuclear pore complex (NPC). Although this complex is well characterized in animals and fungi, there is relatively little information on the NPC in plants.

Seminars in Cell & Developmental Biology, 2004

The expression of the ubiquitin related protein Nedd8/RUB is essential for growth in most organis... more The expression of the ubiquitin related protein Nedd8/RUB is essential for growth in most organisms. Nedd8/RUB has been shown to modify the cullin subunit of culling-based ubiquitin protein ligases (E3). Neddylation acts to regulate the function of these E3s and organisms with lesions in the neddylation process exhibit severe growth defects. In this review we describe the proteins that participate in neddylation and discuss a model for Nedd8/RUB regulation of ubiquitin ligase function.

Paedagogica Historica, 1998

Thomas Hobbes (1588‐1679), the greatest English political philosopher, famously argued that the s... more Thomas Hobbes (1588‐1679), the greatest English political philosopher, famously argued that the solution to civil disorders lay in a sovereign authority backed with force. But force was insufficient unless people were also educated to obedience. The key was the re‐education of teachers, including ministers of religion and lawyers, who would then instruct the masses. Hobbes attributed disorder, particularly in the

Government and Opposition, 1994

A particularly strange version of the democratic spring occurred in Cuba. After the revolution of... more A particularly strange version of the democratic spring occurred in Cuba. After the revolution of 1933, and a few years of instability, Fulgencio B a t h had come to power quite democratically in 1940, with the support of the Communists, whom he repaid with a couple of ministries. Democratic spring uvunf la Icttn? In a sense, yes, and a lasting one too, because by 1944 free elections were lost by Batista's prottg6, inaugurating a period in power of the democratic but quite corrupt Partido Revolucionario Auttntico of Ram611 Grau San Martln (1944-48). Grau antagonized the Communists and eroded their basu of support among the trade unionists, repressing some strikes and other activities, but not enough, again, to proclaim the beginning of winter. Winter had to wait to the end of the next Revolucionario Auttntico presidency, in 1952, when Batista, now no longer a democrat with leftist leanings, staged a coup d'ttat and became dictator until 1958.

Government and Opposition, 1993

Government and Opposition, 1984

HISTORICALLY SPEAKING, THE THEME OF POLITICAL PARTICIpation and the set of issues connected with ... more HISTORICALLY SPEAKING, THE THEME OF POLITICAL PARTICIpation and the set of issues connected with it are as old as politics itself, because they touch on some of the most central and perennial questions of political lifewho decides, where are the boundaries of community and citizenship to be drawn, who benefits, how will decisions be made? However, beyond this, participation has from time to time become a particularly central and salient issue in British politics. In the seventeenth century the issues revolved around the 'claims of the gentry and merchant classes to play a larger part in the making of government policy'.' In the nineteenth and early twentieth centuries, the issue moved on to representation of the nonropertied classesthe town worker, the rural worker and Etterly universal suffrage.' In recent times, political participation has again been relatively high on the agenda of British politics, this time focusing not so much on the quantity or legal extent of electoral participation, but on broader, more informal and qualitative aspects. Within the electoral sphere, for example, there has been renewed pressure (since its last major appearance early this By present-day standards for the funding of social scientific research in Britain this characterization would seem justified.