Germaine Cornélissen - Academia.edu (original) (raw)

Papers by Germaine Cornélissen

For a reliable diagnosis of hypertension, around-the-clock monitoring for 7 days or longer has be... more For a reliable diagnosis of hypertension, around-the-clock monitoring for 7 days or longer has been advocated. As part of a larger study in India, 32 subjects had their blood pressure and heart rate measured manually every 3 h for 7 days. As expected, spectral peaks corresponded to circadian variation. The about half-weekly component was statistically significant. Separate analyses of the data collected during consecutive days indicated that large day-today changes may, in part, have been accounted for by adaptation to the measurements. The results corroborate the view that, if reliable values are to be obtained, serial measurements for at least 7 days are needed K e y w o r d s Circasemiseptan rhythm, Blood pressure, Heart rate

Biomedicine & Pharmacotherapy, Oct 1, 2005

Several opinion leaders have monitored their blood pressure systematically a sufficient number of... more Several opinion leaders have monitored their blood pressure systematically a sufficient number of times a day for chronomic (time structural) analyses, from the time of encountering chronobiology until their death; they set an example for others who also may not wish to base treatment on single spotchecks in a health care office. Such self-measurements, while extremely helpful, were not readily feasible without a noteworthy interruption of activities during waking as well as of sleep. New, relatively unobtrusive instrumentation now makes monitoring possible and cost-effective and will save lives. Illustrative results and problems encountered in an as-one-goes self-survey by GSK, a physician-scientist, are presented herein. Both MESOR-hypertension and CHAT (circadian hyperamplitude-tension) can be intermittent conditions even under treatment, and treatment is best adjusted based on monitoring, rather than "flying blind".

Biomedicine & Pharmacotherapy, Oct 1, 2005

An impeccable time series, published in 1930, consisting of hourly observations on colony advance... more An impeccable time series, published in 1930, consisting of hourly observations on colony advance in a fluid culture of E. coli, was analyzed by a periodogram and power spectrum in 1961. While the original senior author had emphasized specifically periodicity with no estimate of period length, he welcomed further analyses. After consulting his technician, he knew of no environmental periodicity related to human schedules other than an hourly photography. A periodogram analysis in 1961 showed a 20.75-h period. It was emphasized that "… the circadian period disclosed is not of exactly 24-h length." Confirmations notwithstanding, a committee ruled out microbial circadian rhythms based on grounds that could have led to a different conclusion, namely first, the inability of some committee members to see (presumably by eyeballing) the rhythms in their own data, and second, what hardly follows, that there were "too many analyses" in the published papers. Our point in dealing with microbes and humans is that analyses are indispensable for quantification and for discovering a biologically novel spectrum of cyclicities, matching physical ones. The scope of circadian organization estimated in 1961 has become broader, including about 7-day, about half-yearly, about-yearly and ex-yearly and decadal periodisms, among others. Microbial circadians have become a field of their own with eyeballing, yet time-microscopy can quantify characteristics with their uncertainties and can assess broad chronomes (time structures) with features beyond circadians. As yet only suggestive differences between eukaryotes and prokaryotes further broaden the perspective and may lead to life's sites of origin and to new temporal aspects of life' s development as a chronomic tree by eventual rhythm dating in ontogeny and phylogeny.

Scientific Reports, Jul 5, 2023

This study was designed to examine the feasibility of analyzing heart rate variability (HRV) data... more This study was designed to examine the feasibility of analyzing heart rate variability (HRV) data from repeat-flier astronauts at matching days on two separate missions to assess any effect of repeated missions on brain plasticity and psychological resilience, as conjectured by Demertzi. As an example, on the second mission of a healthy astronaut studied about 20 days after launch, sleep duration lengthened, sleep quality improved, and spectral power (ms 2) co-varying with activity of the salience network (SN) increased at night. HF-component (0.15-0.50 Hz) increased by 61.55%, and HF-band (0.30-0.40 Hz) by 92.60%. Spectral power of HRV indices during daytime, which correlate negatively with psychological resilience, decreased, HF-component by 22.18% and HF-band by 37.26%. LF-component and LF-band, reflecting activity of the default mode network, did not change significantly. During the second mission, 24-h acrophases of HRV endpoints did not change but the 12-h acrophase of TF-HRV did (P < 0.0001), perhaps consolidating the circadian system to help adapt to space by taking advantage of brain plasticity at night and psychological resilience during daytime. While this N-of-1 study prevents drawing definitive conclusions, the methodology used herein to monitor markers of brain plasticity could pave the way for further studies that could add to the present results. Herein, we illustrate our method for investigating brain plasticity of an astronaut by assessing how sleep performance and heart rate variability (HRV), gauging activity of intrinsic networks of the brain, particularly the default mode network (DMN) and salience network (SN), changed from first-time to second-time long-duration spaceflight 4 years later. Magnetic resonance imaging (MRI) studies showed narrowing of the central sulcus, upward shift of the brain, and narrowing of cerebrospinal fluid spaces at the vertex in most astronauts examined 1-9. Impaired cerebrovascular circulation in microgravity may induce cortical reorganization. Understanding the effects of spaceflight on the human central nervous system is pivotal for the development of adequate countermeasures. Maximizing crew performance and health is crucial for the success and safety of future prolonged space missions, including missions to the moon or Mars 10-12. The central nervous system seems capable of adaptation to microgravity by the process of neuroplasticity, as previously shown in animals 13. Yet, little is known about the effects of microgravity and gravity transitions on the human brain 14. After exposure to microgravity, significant differences in resting-state functional connectivity between motor cortex and cerebellum, and changes within the DMN have been reported 2,14. Changes in brain function could account for the fact that second-time flyers are less prone to some microgravity-related problems than first-time flyers, given the process of neural adaptation, as conjectured by some 14-16. It is thus important to learn how long physiological adaptation processes last. Research investigating space travelers at different intervals post-flight could answer this question.

International Journal of Clinical Practice, Feb 1, 2023

Aim. Specify the risk rate of incorrect patient classifcation based on the night-today ratio spec... more Aim. Specify the risk rate of incorrect patient classifcation based on the night-today ratio specifcation from singular 24-h ABPM in comparison to the results of 7-day ABPM monitoring Materials and Methods. 1197 24 h cycles were enrolled in 171 subjects in the study and divided into 4 groups: group 1 (40 healthy men and women without exercise), group 2 (40 healthy exercise-training men and women), group 3 (40 patients with ischemic coronary artery disease without exercise), and group 4 (51 patients with ischemic coronary artery disease following cardiovascular rehabilitation). Te subject of the evaluation was the percentage rate of incorrect subject classifcation (dipper, nondipper, extreme dipper, and riser) based on the mean blood pressure values for 7 days and from seven independent 24-hour cycles (the mean value mode). Results. In the case of the individuals included in the monitored groups, the mean night-today ratio-based (mode for the 7 days versus the individual days of 24-hour monitoring) classifcation accordance ranged between 59% and 62%. Only in singular cases did the accordance reach 0% or 100%. Te accordance size was not dependent on the health or cardiovascular disease (p < 0.594; 56% vs. 54%) or physical activity (p < 0.833; 55% vs. 54%) of the monitored individuals. Conclusion. Te specifcation of the night-today ratio of each individual for each day of the 7-day ABPM monitoring would be the most convenient option. In many patients, diagnosing could thus be based on the most frequently occurring values (mode specifcation). Te study protocol was registered with ClinicalTrials.gov (NCT05264090)

Sun and Geosphere, Dec 1, 2009

Melatonin, produced mainly in the pineal and the gut, is often thought of as the "dark hormone" a... more Melatonin, produced mainly in the pineal and the gut, is often thought of as the "dark hormone" as its concentration in the circulation is high during darkness and low during light in diurnally-and nocturnally-active mammals in health. About-daily and about-yearly periodicities can thus be anticipated to characterize melatonin, matching the two major photic environmental cycles. Non-photic solar influences have also been observed, melatonin being depressed in association with magnetic storms. While less stable than the daily and yearly changes, non-photic solar dynamics also undergo various periodicities. Among them is an about 0.42-year (about 5-month or 154-day) cycle, reported by several physicists in relation to Zürich relative sunspot numbers and to solar flares. This putative signature of solar activity was found in the incidence pattern of sudden cardiac death in Minnesota, USA, among other geographic locations. A cycle with a period of about 0.42 year is here reported in data on circulating melatonin of 172 patients studied between Oct 1992 and Dec 1995 in Florence, Italy. Melatonin may mediate some of the Sun's effects upon the biosphere in certain frequency-windows such as a cis-half-year of about 5 months.

In order to examine differences among individuals and among variables related to the rate of shif... more In order to examine differences among individuals and among variables related to the rate of shift of the circadian system, nine male students were studied for 72 h under controlled physical environmental conditions. During this 3-day test, they were subjected to a 12-hour shift in the times of sleep and meals. Differences in the rate of shift from day 1 to day 3 were observed for blood pressure and urinary cortisol, norepinephrine and dopamine, but not for other urinary variables or for heart rate, temperature and body weight. Inter-individual differences in the rate and/or direction of adjustment were seen primarily for blood pressure and heart rate. The experimental design used in this study may detect differences in the suitability of a subject for shift-work. K e y w o r d s Circadian rhythm, Blood pressure, Sleep changes, Meal intake changes

In order to analyse the dynamics of blood pressure measured in periods shorter than a week, we ev... more In order to analyse the dynamics of blood pressure measured in periods shorter than a week, we evaluated the results of measurements in a 68-year-old man with benign prostatic hypertrophy and hypertension. During the period of investigation between September and November 1999, he changed his drinking habits and the time of Hytrin intake. In three 7-day periods, he monitored his blood pressure and heart rate around the clock. The results showed that alcohol consumption was related to an increase in circadian-hyper-amplitude-tension regardless of medication. K e y w o r d s Blood pressure variability, Circadian rhythm, Circaseptan rhythm

Biomedicine & Pharmacotherapy, Oct 1, 2005

Several cohort studies have examined the association of carotid intima-media thickness (IMT) with... more Several cohort studies have examined the association of carotid intima-media thickness (IMT) with the risk of stroke or myocardial infarction in apparently healthy persons. We investigated the predictive value of IMT of cardiovascular mortality in elderly community-dwelling people, beyond the prediction provided by age and MMSE. assessed by means of a multivariate Cox model. Carotid IMT and plaque were evaluated bilaterally with ultrasonography in 298 people older than 75 years (120 men and 178 women, average age: 79.6 years). The LILAC study started on July 25, 2000. Consultations were repeated every year. The follow-up ended on November 30, 2004. During the mean follow-up span of 1152 days, 30 subjects (21 men and nine women) died. Nine deaths were attributable to cardiovascular causes Imyocardial infarction: two men and three women; stroke: two men and two women). The age-and MMSE-adjusted relative risk (RR) and 95% confidence interval (95% CI) of developing all-cause mortality was assessed. A 0.3 mm increase in left IMT was associated with a RR of predicted 1.647 (1.075-2.524), and a similar increase in right IMT with a RR of 3.327 (1.429-7.746). For cardiovascular mortality, the corresponding RR values were 2.351

Scientific Reports, Jul 13, 2022

The intrinsic cardiovascular regulatory system (β, 0.00013-0.02 Hz) did not adapt to microgravity... more The intrinsic cardiovascular regulatory system (β, 0.00013-0.02 Hz) did not adapt to microgravity after a 6-month spaceflight. The infraslow oscillation (ISO, 0.01-0.10 Hz) coordinating brain dynamics via thalamic astrocytes plays a key role in the adaptation to novel environments. We investigate the adaptive process of a healthy astronaut during a 12-month-long spaceflight by analyzing heart rate variability (HRV) in the LF (0.01-0.05 Hz) and MF1 (0.05-0.10 Hz) bands for two consecutive days on four occasions: before launch, at 1-month (ISS01) and 11-month (ISS02) in space, and after return to Earth. Alteration of β during ISS01 improved during ISS02 (P = 0.0167). During ISS01, LF and MF1 bands, reflecting default mode network (DMN) activity, started to increase at night (by 43.1% and 32.0%, respectively), when suprachiasmatic astrocytes are most active, followed by a 25.9% increase in MF1-band throughout the entire day during ISS02, larger at night (47.4%) than during daytime. Magnetic declination correlated positively with β during ISS01 (r = 0.6706, P < 0.0001) and ISS02 (r = 0.3958, P = 0.0095). Magnetic fluctuations may affect suprachiasmatic astrocytes, and the DMN involving ISOs and thalamic astrocytes may then be activated, first at night, then during the entire day, a mechanism that could perhaps promote an anti-aging effect noted in other investigations. Exposure to microgravity in space heavily influences human physiology, resulting in cardiovascular dysfunction, immune suppression and impaired secretion of hormones and neurotransmitters. Microgravity-induced blood volume redistribution is the initial trigger to cardiovascular dysfunction, involving diverse processes and complex mechanisms 1-3. As we reported previously 4,5 , the "intrinsic" cardiovascular regulatory system (β) 6,7 did not adapt to space microgravity even during a 6-month spaceflight. Astronauts living on the International Space Station (ISS) also experience other unique stressors, including cosmic radiation, noise, social isolation, and confinement, factors that can impact human aging. It was once widely accepted that the space environment accelerates the aging process 8,9. Unexpectedly, however, recent research suggested that genes involved in Caenorhabditis elegans lifespan extension were up-regulated after spaceflight 10 and that spaceflight could extend lifespan in Drosophila 11. With the increasing duration of current and planned spaceflight missions, studying the effect of the space environment on lifespan has increased in interest and medical importance. Studies are needed to determine whether long-duration spaceflight affects human well-being and aging. Several recent investigations suggest that long-duration space travel may be associated with anti-aging effects. In the National Aeronautics and Space Administration (NASA) Twin Study, the identical twin astronaut monitored before, during, and after a 1-year mission onboard the ISS had lengthened telomeres upon return to Earth as compared to his twin brother who served as a genetically matched ground control 12,13. Because telomere length is considered a marker of cellular aging, aging being usually associated with decreased telomere length 14,15 , the NASA twin study suggests a possible anti-aging effect of long-duration space travel. Another study of blood DNA

Research Square (Research Square), Oct 6, 2022

Heart rate variability (HRV) re ects brain's 'vertical integration' in association with functions... more Heart rate variability (HRV) re ects brain's 'vertical integration' in association with functions of the default mode network (DMN) and salience network (SN). We investigate the role of 12-h components in HRV endpoints in facilitating adaptation to the space environment. Ambulatory 24-h electrocardiograms were obtained from 20 healthy astronauts (47.2 ± 5.9 years) before launch, twice in space (ISS01 on days 21.7 ± 2.9 and ISS02 on days 159.2 ± 46.1), and after return to Earth. Astronauts were classi ed depending on whether the 12-h amplitude of the TF-component of HRV during ISS01 versus pre-ight increased (Group I, N = 11) or not (Group II, N = 9). In Group I, the circadian acrophases of TF-and ULF-components were delayed during ISS01 versus pre-launch, whereas in Group II, the circadian acrophase of the MF1-band advanced. Lower HRV spectral power indicated psychological resilience during both ISS01 and ISS02 in association with the brain's DMN and SN. Since adverse consequences of circadian desynchrony may be more pronounced due to phase advances than to phase delays, the differential behavior of the 12-h component between Groups I and II suggests its amenability to manipulation in interventions aimed at improving space adaptation. Experimental protocol Ambulatory around-the-clock 24-h electrocardiographic (ECG) records were obtained by using a twochannel Holter recorder (FM-180; Fukuda Denshi, Tokyo, Japan or H12+; Mortara, NY, USA). Measurements were made four times: once before launch (Pre-ight), twice on the ISS (ISS01 and ISS02), and once after return to Earth (Post-ight). The control session was conducted on days 175.6 ± 116.7 (50 to 469) before launch in all but three astronauts who had technical problems with their before-ight record, in which case a replacement control record was obtained 116, 242 or 469 days after return to Earth. The two sessions in space were performed on days 21.7 ± 2.9 (18 to 30, ISS01) and 159.2 ± 46.1 (122 to 326, ISS02) after launch, the latter corresponding to 18.1 ± 3.4 days (11 to 21) before return to Earth. The last measurement session was performed on days 82.9 ± 35.4 (17 to 156 days) after return to Earth (After ight). Universal Time Coordinated (UTC) is used aboard the ISS. The windows are covered during night hours to give the impression of darkness because the station experiences 16 sunrises and sunsets per day. Astronauts follow a strict 24-h routine, waking up at 06:00 and retiring for sleep at 21:30. At the time of data collection, arti cial lighting from both incandescent and uorescent light sources was used on the ISS; maximal light intensity was 700 lx [15, 16, 17, 18, 19]. Analysis of HRV Data collection and measurement procedures were conducted as previously reported [13, 14, 15, 16, 17, 18, 19]. Brie y, for HRV measurements, the RR intervals between normal QRS waveforms were extracted as normal-to-normal (NN) intervals, which were A/D converted (125-Hz) with 8-ms time resolution. The authors rst con rmed that all artifacts were actually removed and that the data excluded supraventricular or ventricular arrhythmia. Time-domain measures (CVNN, r-MSSD and pNN50), Lorenz plot (Length, Width and Length/Width ratio), and conventional frequency-domain measures (TF-, ULF-, VLF-, LF-and HF-HRV and LF/HF ratio) [38] were determined, as was β, re ecting the intrinsic cardiovascular regulatory system, using the Maximum Entropy Method (MEM) software (MemCalc/CHIRAM, Suwa Trust GMS, Tokyo, Japan) [39]. Time series of NN intervals covering 5-min intervals were analyzed by the MEM to compute the spectral power in different frequency regions. HRV measures re ecting dynamics of brain functional connectivity [16, 40, 41, 42, 43, 44, 45] were also assessed, as de ned in Table 1. Frequency regions examined were 0.01-0.05 Hz (LF-band), 0.05-0.10 Hz (MF1-band), 0.10-0.15 Hz (MF2-band), and 0.15-0.20 Hz (HF01-band), according to Baria et al. [46]; 0.20-0.30 Hz (HF02-band), 0.30-0.40 Hz (HF03-band), and 0.40-0.50 Hz (HF04-band), according to Chen and Glover [47]. Changes in MF2-and HF01-, HF02-, HF03-, and HF04-bands show dynamic interactions among the DMN and SN, i.e., the alerted DMN involved in the adaptation to a novel environment [16, 46, 47]. Low-frequency uctuations (LFFs) (0.01-0.10 Hz) during daytime were measured as HRV indices re ecting psychological resilience (subjective well-being and/or life-satisfaction) related to brain's DMN

Biomedicine & Pharmacotherapy, Oct 1, 2005

The predictive value of blood pressure (BP), heart rate (HR), and catecholamines in terms of any ... more The predictive value of blood pressure (BP), heart rate (HR), and catecholamines in terms of any subsequent development of cardiovascular disease was investigated. Systolic (S) and diastolic (D) BP, HR, epinephrine (E) and norepinephrine (NE) were measured three times a year in 1980, 1984, and 1989 on 20 clinically healthy subjects, 18 patients with 'essential hypertension', and 22 patients with angina pectoris. Of the 22 patients in the latter group, 15 died during a 2-year follow-up (1990-1991). Each individual data series was analyzed by single cosinor to assess the circannual variation. Results were summarized by population-mean cosinor for each group. Parameter tests were used to compare the circannual rhythm characteristics among the different patient groups. A circannual rhythm was invariably demonstrated on a group basis (P < 0.05). Differences in MESOR and/or circannual amplitude were found among the different groups. In particular, patients with angina pectoris who will die within the 2-year follow-up differ in terms of their E and NE from all other patient groups, a difference already detected at the beginning of the study, more than 10 years before they die. A similar separation is not achieved in terms of BP or HR.

Biomedicine & Pharmacotherapy, Oct 1, 2005

We investigated the predictive value of arterial stiffness to assess cardiovascular risk in elder... more We investigated the predictive value of arterial stiffness to assess cardiovascular risk in elderly community-dwelling people by means of a multivariate Cox model. In 298 people older than 75 years (120 men and 178 women, average age: 79.6 years), brachial-ankle pulse wave velocity (baPWV) was measured between the right arm and ankle in a supine position. The LILAC study started on July 25, 2000, consultation was repeated yearly, and the last follow-up ended on November 30, 2004. During this follow-up span of 1227 days, there were nine cardiovascular deaths, the cause of death being myocardial infarction for two men and three women or stroke for two men and two women. In Cox proportional hazard models, baPWV as well as age, Mini-Mental State Examination (MMSE), Hasegawa Dementia Scale Revised (HDSR) and the low-frequency/high-frequency (LF/HF) ratio showed a statistically significant association with the occurrence of cardiovascular death. A twopoint increase in MMSE and HDSR score significantly protected against cardiovascular death, the relative risk (RR) being 0.776 (P = 0.0369) and 0.753 (P = 0.0029), respectively. The LF/HF ratio also was significant (P = 0.025), but the other indices of HRV were not. After adjustment for age

Электронный научно-образовательный вестник «Здоровье и образование в XXI веке», 2007

Background. Observations made by physicians, by engineers in the radio industry and by scientists... more Background. Observations made by physicians, by engineers in the radio industry and by scientists in communications (1-5) support the thesis of Chizhevsky's book on life as an echo of the sun (6; cf. 7), among others (8-20). Reports contesting their observations (21, 22) are readily explained by omnipresent temporal and geographic differences (23, 24). The literature as a whole constitutes a largely and often descriptive rather than analytical and inferential framework for associations of the cosmos, including the interplanetary magnetic field (IMF), with human affairs. Myocardial infarctions, among other illnesses of individuals and societal diseases such as crime (15), war (16) and terrorism (17) as well as proselytism (18) are all involved. These phenomena require rational countermeasures. The problems are theoretically and practically far-reaching and are a matter of transdisciplinary science, rather than of politics. Materials and Methods. Data on violence from 1998-2007 from Princeton (http://www.princeton.edu/~pear/publications.html) were analyzed by linear-nonlinear least squares spectra (25-27), as the entire available series in Figure 1 top and after excluding data on the left side of a gap seen in this figure, to check on the extent to which the large missing data set may have contributed artifacts (cf. 23). Results. Table 1 summarizes the results obtained on the original data by the fit of a 1.3-year cosine curve with a oneparameter approach (25), since the more rigorous nonlinear and consecutive approaches did not resolve a transyear. While one-parameter results in themselves are usually regarded by us as insufficient evidence, they agreed with the outcome of analyses made on a larger data base by Grigoriev and Vladimirskii (17), who kindly allowed us insight into their original scholarship. Analyses are tabulated on the Figure 1 top data as a whole as well as on the shorter series, after omitting the limited data from the time before the gap, to check on gap-associated artifacts. The results were nearly the same, suggesting that the gap did not play a critical role. The results are also similar whether or not a linear or quadratic trend is added to the model. Against the background of Grigoriev's data, the results confirm the likely presence of a transyear in a separate different data set as well as the absence of a calendar-yearly spectral component in terrorism. Discussion. Figure 1 bottom shows no peak at the trial period of a calendar year in the incidence pattern of violence, only a peak at ~1.3 years, a transyear, in keeping with results on the incidence patterns of sudden cardiac death in Minnesota (23) and Tokyo (28), but not overall worldwide, and in keeping with the occurrence of both a transyear and a calendar-yearly component in sudden cardiac death in Arkansas and the Czech Republic (23). A near-transyear and a fartransyear are found with a calendar-yearly component and a prominent cis-year in the incidence of suicides in Minnesota (29). The amplitude of the transyear is numerically greater than the amplitude of an also-present calendar-yearly component. It seems pertinent that some of the non-photic transdisciplinary, probably magnetic associations may be mediated according to Freund by a coupling between the ionosphere and solid earth, with vortices in the former resulting in telluric currents in the latter, generating a horizontal torque (30) to which human physiology may be responsive. We are probably dealing with selected frequency windows for which there may be special resonating mechanisms as postulated for frequencies much higher than those considered herein earlier by others (31, 32). These windows, encountered in terrorism (17) are found coincident with "entangled" events (33) influenced by the IMF (34). These may lead to mechanisms as a basis for rational countermeasures to violence, notwithstanding the fact that, contrary to Einstein, God does throw dice (33). As to the next steps, the availability of satellites to probe the interplanetary magnetic field has allowed the use of a subtractive approach in the longitudinal study of one individual's physiology (23) and of another's psychology as well (35). The same approach by subtraction and addition has also proved useful in studying cosmic associations with the weekly component of human heart rate (36). Whenever nature happens to permit it, the approach by remove-and-replace is best applied to time series on social ills as well and to their association with the solar wind (37), the existence of which was already reportedly suspected by Kepler, who noted that comets' tails point away from the sun. They may point to a sooner or later manipulable undesirable aspect of ecosystems such as ours that happen to be in the atmosphere of the sun (38). Just as we heat and cool against the sun's photic and thermic effects, we face the task of resolving "entangled" consequences of unseen magnetics that call for an international effort. The IMF may influence not only myocardial infarction (9, 24, 39, 40) but may have interdigitated information with both collective emotions and changes in the output entropy of random event generators (34). These may eventually differ with geographic location, since the earth is a round (not flat), rotating (not fixed) and heterogeneous magnet itself, residing in the atmosphere of an even stronger, also variable magnet the sun, and hence longitudinal and latitudinal differences have long been anticipated (41) and are indeed found (23). The sun and the cosmos may have many modes (42); we respond preferentially to some of them at certain frequencies in specific variables at a given time (23). Elucidating the complex mechanisms involved is a challenge for our civilization's survival, although "He who controls magnetism might not end up controlling the world, but will have a better handle on technologies so important in our information age" (43). Электронный научно-образовательный вестник "Здоровье и образование в XXI веке" №1, 2007 г. (Т. 9) Материалы VIII Международного конгресса «Здоровье и образование в XXI веке: Концепции болезней цивилизации» Стр.

Biomedicine & Pharmacotherapy, Oct 1, 2005

Daily data on solar magnetism, available from May 1975 to April 2002, were analyzed by linearnonl... more Daily data on solar magnetism, available from May 1975 to April 2002, were analyzed by linearnonlinear rhythmometry, with particular focus on the near-transyear, slightly longer than the calendar year. The time structure of solar magnetism is compared to that of solar activity, gauged by Wolf numbers. An about 27-day component corresponding to the solar rotation period, is common to both variables but differs in harmonic content. About 10-year component characterizes solar activity but not solar magnetism. A near-transyear with a period of about 1.05 years is detected in solar magnetism. In solar activity, a near-transyear is also found but its period of about 1.10 years is longer than that characterizing solar magnetism, and it may be paired with an about 0.9-year component to correspond to an about 10-year modulation in amplitude or phase of an about-yearly component.

Yearly mortality data on stroke in the Czech Republic, recorded from 1950 to 1999, were analysed.... more Yearly mortality data on stroke in the Czech Republic, recorded from 1950 to 1999, were analysed. About 50-and 21-year cycles were suggested, regardless of whether all data were considered or whether they were analysed for men and women separately. After detrending, a selfstarting cumulative sum (CUSUM) control chart showed an increase in stroke deaths that took place around 1997. These results are in keeping with similar findings in four other geographic locations. They warrant a renewed effort toward stroke prevention. Ambulatory monitoring of blood pressure and heart rate in the general population is a useful tool to detect and correct certain abnormalities of the circadian pattern of these variables which have been associated with large increases in stroke risk, even in conventionally normotensive subjects.

The paper deals with the investigation of disturbance of 24-hour blood pressure cycle under the i... more The paper deals with the investigation of disturbance of 24-hour blood pressure cycle under the influence of illumination during the night.

Izvestiya, Atmospheric and Oceanic Physics, 2010

Cycles of about 35 years found in the climate by Brückner and Egeson were aligned with periodic c... more Cycles of about 35 years found in the climate by Brückner and Egeson were aligned with periodic changes in the length of the solar cycle by the Lockyers. The solar-cycle length and climate were subsequently revisited without reference to any cyclicity or those who discovered it. The descriptive statistics of Bruckner and Lockyer were repeatedly questioned and, with notable exceptions,

Journal of Anti-Aging Medicine, 2000

Circadian rhythms in circulating, urinary, salivary, pineal, pituitary and hypothalamic melatonin... more Circadian rhythms in circulating, urinary, salivary, pineal, pituitary and hypothalamic melatonin have been mapped. About weekly (circaseptan) rhythms, mapped previously in several other species, are demonstrated herein for human saliva, in individuals of widely ...

Journal of Medical Engineering & Technology, 1997

Page 1. Journal of Medical Engineering &amp; Technology, Volume 21, Number 3-4, (May-Augu... more Page 1. Journal of Medical Engineering &amp; Technology, Volume 21, Number 3-4, (May-August 1997), pages 111-120 Individual assessment of antihypertensive response by self-starting cumulative sums G. Cornelissent, F. Halbergt&quot;, D. Hawkinst, K. OtsukaS and W. Henke? ...

Biomedicine & Pharmacotherapy, Oct 1, 2005

Scientific Reports, Jul 5, 2023

International Journal of Clinical Practice, Feb 1, 2023

Sun and Geosphere, Dec 1, 2009

Biomedicine & Pharmacotherapy, Oct 1, 2005

Scientific Reports, Jul 13, 2022

Research Square (Research Square), Oct 6, 2022

Biomedicine & Pharmacotherapy, Oct 1, 2005

Электронный научно-образовательный вестник «Здоровье и образование в XXI веке», 2007

Biomedicine & Pharmacotherapy, Oct 1, 2005

Izvestiya, Atmospheric and Oceanic Physics, 2010

Journal of Anti-Aging Medicine, 2000

Journal of Medical Engineering & Technology, 1997