Mostafa Ghasemi - Academia.edu (original) (raw)

Papers by Mostafa Ghasemi

Public Health, 1997

Background: Iran like other middle east countries has a large number of major thalassaemics. Due ... more Background: Iran like other middle east countries has a large number of major thalassaemics. Due to religious restrictions on abortion, the routine prevention of the birth of thalassaemic children by this means is not possible. The aim of this study is to describe an alternative means to prevent the birth of thalassaemic children. people preparing for marriage were screened for the thalassaemia trait, using CBC and HbA2 level measurement. High risk couples were referred for further consultation regarding the disease and the means of its prevention. The proposed actions of the couples regarding thalassaemia prevention were evaluated immediately after consultation and then re-evaluated three months later. Result: After the project had been running for three years the average of high risk couple initially deciding not to marry was 90% and no new cases of thalassemia were detected in the children of the screened population. Conclusion: Where both members of the couple were trait-positive their preferred choice was not to marry, rather than to marry and use other or no methods of preventing a thalassemia affected child being born to them. Cultural and religious ideas can affect such decisions and in some Islamic countries the establishment and use of a genetic counselling centre can help prevent most of new thalassaemia cases.

Analytica Chimica Acta, 2007

This work reports the preparation of molecularly imprinted polymer (MIP) particles for selective ... more This work reports the preparation of molecularly imprinted polymer (MIP) particles for selective extraction and determination of selenium ions from aqueous media. Polymerization was achieved in a glass tube containing SeO 2 , o-phenylenediamine, 2-vinylpyridine (VP), ethyleneglycoldimethacrylate (EDMA), 2,2 -azobisisobutyronitrile (AIBN). The polymer block obtained was ground and sieved (55-75 m) and the Se-o-phenylenediamine complex was removed from polymer particles by leaching with 2 M of HCl, which leaves a cavity in the polymer particles. The polymer particles both prior to and after leaching have been characterized by IR and thermogravimetric (TG) studies. The effect of different parameters, such as pH, extraction time, type and least amount of eluent for elution of complex from polymer were evaluated. Extraction efficiencies >99% were obtained by elution of the polymers with 15 mL of methanol-acetonitrile mixture (1:2, v/v). The limit of detection of the proposed method followed by hydride generation atomic absorption spectroscopy (HG-AAS) was found to be 3.3 g L −1 and a dynamic linear range (DLR) of 10-200 g L −1 was obtained. The relative standard deviations (R.S.D.s) at 30.0 g L −1 of Se were below than 8.1%. The influence of various cationic interferences on percent recovery of complex was studied. The method was applied to the recovery and determination of selenium in different real samples.

Journal of Plant Protection Research, 2008

... Elham Ghasemie1, Mostafa Niknejad Kazempour1*, Ferydon Padasht2 ... For isolation of bacte-ri... more ... Elham Ghasemie1, Mostafa Niknejad Kazempour1*, Ferydon Padasht2 ... For isolation of bacte-ria, infected tissue of leaves, stems and roots were crushed in pepton water then 100 µl of homogenate were cultured on nutrient agar (NA) and yeast dextrose carbonate (YDC ...

Chemical & Pharmaceutical Bulletin, 2010

Pyridine-functionalized MCM-41 catalyzed reactions between tetracyanoethylene and various activat... more Pyridine-functionalized MCM-41 catalyzed reactions between tetracyanoethylene and various activated CH-acid compounds are described. These reactions afford the corresponding pyran annulated heterocyclic ring systems in high yields at room temperature within a few minutes. The work-up procedure is very simple and the products do not require further purification. The catalyst can be recycled and reused for several times without observable loss of performance.

Journal of Refractive Surgery, 2010

to compare treatments with wavefront-optimized and topography-guided ablations. this prospective,... more to compare treatments with wavefront-optimized and topography-guided ablations. this prospective, randomized, contralateral study comprised 40 eyes (20 patients) with low to moderate myopia with or without astigmatism that underwent topography-guided photorefractive keratectomy (PRK) (ALLEGRO Topolyzer, Alcon Laboratories Inc) in one eye and wavefront-optimized PRK (ALLEGRETTO WAVE software version 2.020 default treatment, Alcon Laboratories Inc) in the fellow eye. Visual acuity, refractive error, contrast sensitivity, and Orbscan (Bausch &amp;amp;amp;amp;amp;amp; Lomb) 3- and 5-mm corneal irregularities were measured preoperatively and 3 and 6 months postoperatively. The results were compared between the two eyes. in both groups, preoperative corrected distance visual acuity (CDVA) (0.03±0.09 logMAR for topography-guided and 0.01 ± 0.06 logMAR for wavefront-optimized [P=.1]), 3-month postoperative uncorrected distance visual acuity (UDVA) (-0.0 1± 0.03 logMAR for topography-guided and -0.01 ± 0.03 logMAR for wavefront-optimized [P=.4]), and 6-month postoperative UDVA (0.01 ± 0.03 logMAR for topography-guided and 0.0 ± 0.01 logMAR for wavefront-optimized [P=.3]) were the same. All wavefront-optimized and 18 (90%) topography-guided eyes had UDVA of 20/20 or better. No significant differences were noted between groups in pre- and postoperative spherical and cylindrical refractive errors or corneal irregularity and contrast sensitivity measurements. Six months postoperatively, contrast sensitivity values at 3, 6, 12, and 18 cycles/degree were 5.7 ± 0.7, 6.0 ± 1.5, 6.1 ± 1.3, and 5.5 ± 1.5, respectively, in the topography-guided group, and 6.2 ± 0.6, 6.4 ±1.2, 6.4 ± 1.1, and 5.8 ± 1.3, respectively, in the wavefront-optimized group (P=.3, P=.5, P=.4, and P=.6, respectively). using the WaveLight excimer laser platform for PRK, CDVA and contrast sensitivity outcomes were statistically similar between the wavefront-optimized and topography-guided ablations in eyes with low to moderate myopia with and without astigmatism.

The objective of this paper is to numerically investigate the cooling performance of electronic d... more The objective of this paper is to numerically investigate the cooling performance of electronic devices with an emphasis on the effects of the arrangement and number of electronic components. The analysis uses a two dimensional rectangular enclosure under combined natural and forced convection flow conditions and considers a range of Rayleigh numbers. Heat sources in the enclosure generate the natural convection flow and an externally sourced air stream through the enclosure generates the forced convection flow. The results show that increasing the Rayleigh number significantly improves the enclosure heat transfer process. At low Rayleigh numbers, placing more heat sources within the enclosure reduces the heat transfer rate from the sources and consequently increases their overall maximum temperature. The arrangement and number of heat sources have a considerable contribution to the cooling performance. However, increasing the Rayleigh number reduces this contribution.

Toxin Reviews, 2009

Sulfur mustard (SM) has widely been used against the military and civilians during the Iraq-Iran ... more Sulfur mustard (SM) has widely been used against the military and civilians during the Iraq-Iran war (1980)(1981)(1982)(1983)(1984)(1985)(1986)(1987)(1988). It mostly affects the respiratory system. A large historical cohort study was designed to evaluate the pulmonary status of non-military victims in Sardasht, Iran, in comparison with a matched control group 20 years after a single massive exposure. The exposed group was divided into two subgroups of hospitalized and non-hospitalized based on the severity of the injuries indicated by hospitalization a few days following exposure. All participants' respiratory symptoms and signs were evaluated by internists. Dyspnea (n = 261; P = 93.2%) was the most common symptom. Chronic cough, cough severity, sputum, hemoptysis, dyspnea, pattern of dyspnea, severity of dyspnea (P <0.001 for all), and chest pain (P = 0.003) were statistically significantly different between the two groups. Wheezing was the most common pulmonary finding (11.4%). There was also a statistically significant difference in the auscultation of wheezing (P = 0.045) and rhonchi (P = 0.018) between the hospitalized and control groups. Considering objective findings, pulmonary involvement was observed in 24.3% (n = 68, P = 0.007).

British Journal of Ophthalmology, 2006

Optic nerve aplasia is a rare developmental anomaly characterised by the congenital absence of th... more Optic nerve aplasia is a rare developmental anomaly characterised by the congenital absence of the optic nerve, central retinal vessels and retinal ganglion cells that is seen most often in a unilaterally malformed eye. 1 2 Unilateral optic nerve aplasia is generally associated with otherwise normal brain development while bilateral optic nerve aplasia is usually accompanied by severe and widespread congenital central nervous system (CNS) malformations. 1 2 We report here a unique presentation of a unilateral microphthalmos ...

Background: We conducted this study to report the demographics and clinical profile of patients w... more Background: We conducted this study to report the demographics and clinical profile of patients with nonarteritic anterior ischemic optic neuropathy referred to a referral neuroophthalmology center in Iran.

British Journal of Ophthalmology, 2009

To compare retrobulbar haemodynamics and ipsilateral carotid wall thickness of patients with unil... more To compare retrobulbar haemodynamics and ipsilateral carotid wall thickness of patients with unilateral non-arteritic anterior ischaemic optic neuropathy (NAION) with their contralateral side. Seventeen patients with unilateral NAION participated in this study. By means of Colour Doppler imaging, the blood-flow velocities of the ophthalmic artery were measured. Intima-media thickness (IMT) of common carotid and internal carotid arteries were measured using B-mode ultrasonography. Measurements of the affected side were compared with the non-involved side. Flow velocities in the ophthalmic arteries on the side of the eyes with NAION were significantly decreased compared with those on the side of the unaffected eyes (p<0.001). In addition, in all patients, both common and internal carotid artery IMT were significantly greater on the side of the NAION compared with the contralateral side (p<0.001). NAION may be associated with decreased retrobulbar flow velocities and increased carotid wall thickness.

Ophthalmic Plastic and Reconstructive Surgery, 2007

A 24-year-old woman developed subarachnoid hemorrhage and left frontal lobe ischemia following un... more A 24-year-old woman developed subarachnoid hemorrhage and left frontal lobe ischemia following uneventful right transconjunctival orbital decompression for thyroid-related immune orbitopathy. CT, MRI, CT angiography, and carotid angiography confirmed subarachnoid hemorrhage and brain ischemia on the left side without any cerebral vascular abnormalities on either side. All tests were unremarkable. She fully recovered at last follow-up, 4 months after surgery. We did not find any reason for the subarachnoid hemorrhage and left frontal lobe ischemia. This complication should be considered after orbital surgery for patients with thyroid-related immune orbitopathy.

Food Chemistry, 2008

Essential oil of Salvia mirzayanii cultivated in Iran was obtained by hydrodistillation and super... more Essential oil of Salvia mirzayanii cultivated in Iran was obtained by hydrodistillation and supercritical (carbon dioxide) extraction methods. The oil was analysed by capillary gas chromatography using flame ionization and mass spectrometric detections. The compounds were identified according to their retention indices and mass spectra (EI, 70 eV). The effects of different parameters such as pressure, temperature, modifier volume and extraction times (dynamic and static) on the supercritical fluid extraction (SFE) of S. mirzayanii oil were investigated. The results showed that, under a pressure of 35.5 MPa, temperature of 35°C, 6% methanol, dynamic extraction time of 50 min and static extraction time of 30 min, extraction was more selective for the linalyl acetate. Thirty four compounds were identified in the hydrodistilled oil. The major components of S. mirzayanii were linalyl acetate (7.6%), 1,8-cineole (8.0%), linalool (9.0%) and 8-acetoxy linalool (11.0%). However, by using supercritical carbon dioxide in optimum conditions, only three components contain more than 63% of the oil. The yield of the obtained oil based on hydrodistillation was 2.20% (v/w). Extraction yield based on the SFE varied in the range of 1.50-9.67% (w/w) under different conditions. The results revealed that, in Iranian S. mirzayanii oil, linalyl acetate is a major component.

$Research paper thumbnail of Generation of nondiffracting X waves using annular-array transducers$

Journal of The Acoustical Society of America, 1992

British Journal of Ophthalmology, 2010

To evaluate the effect of intravitreal injection of erythropoietin for the treatment of non-arter... more To evaluate the effect of intravitreal injection of erythropoietin for the treatment of non-arteritic anterior ischaemic optic neuropathy (NAION). In this prospective interventional case series, 31 eyes of 31 patients with NAION were included. Patients received intravitreal injection of 2000 unit (0.2 cm³) of erythropoietin within 1 month of the onset of the disease. Visual acuity and visual field were recorded before injections and 1 week, 1 month, 3 months and 6 months after the injections. The mean duration of symptoms before injections was 11.2 ± 5.5 days. Six months after injections, visual acuity improved in 27 eyes (87%), and 17 eyes (54.8%) had ≥ 3 lines of visual improvement. The mean preinjection visual acuity was 1.01 ± 0.88 logMAR and 0.58 ± 0.58 logMAR (p&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt;0.001) at last follow-up. Visual acuity improvement occurred in 61.2% of patients within the first month. It followed a biphasic pattern in which there was continuous improvement up to 3 months and then started to deteriorate, although it remained significantly better than baseline until the last follow-up. No patient lost any lines of visual acuity compared with the baseline values. The mean of mean deviations of visual field was -19.6 ± 5.7 dB at baseline and -18.6 ± 6.3 dB (p = 0.6) at last follow-up. Intravitreal injection of erythropoietin may be safe and effective in the treatment of NAION. The effect may last for a few months and then decline.

Cutaneous and Ocular Toxicology, 2009

2009)'Long-term ocular consequences of sulfur mustard in seriously eye-injured war veterans',Cuta... more 2009)'Long-term ocular consequences of sulfur mustard in seriously eye-injured war veterans',Cutaneous and Ocular Toxicology,28:2,71 -77

Ophthalmology, 2007

To study the results of vitrectomy and release of epipapillary vitreous adhesions for the treatme... more To study the results of vitrectomy and release of epipapillary vitreous adhesions for the treatment of nonarteritic anterior ischemic optic neuropathy (NAION) associated with partial posterior vitreous detachment (PVD).

Journal of Molecular Diagnostics, 2006

This is the first comprehensive profile of cystic fibrosis transmembrane conductance regulator (C... more This is the first comprehensive profile of cystic fibrosis transmembrane conductance regulator (CFTR) mutations and their corresponding haplotypes in the Iranian population. All of the 27 CFTR exons of 60 unrelated Iranian CF patients were sequenced to identify diseasecausing mutations. Eleven core haplotypes of CFTR were identified by genotyping six high-frequency simple nucleotide polymorphisms. The carrier frequency of 2.5 in 100 (1 in 40) was estimated from the frequency of heterozygous patients and suggests that contrary to popular belief, cystic fibrosis may be a common, underdiagnosed disease in Iran. A heterogeneous mutation spectrum was observed at the CFTR locus in 60 cystic fibrosis (CF) patients from Iran. Twenty putative disease-causing mutations were identified on 64 (53%) of the 120 chromosomes. The five most common Iranian mutations together represented 37% of the expected mutated alleles. The most frequent mutation, ⌬F508 (p.F508del), represented only 16% of the expected mutated alleles. The next most frequent mutations were c.1677del2 (p.515fs) at 7.5%, c.4041C>G (p.N1303K) at 5.6%, c.2183AA>G (p.684fs) at 5%, and c.3661A>T (p.K1177X) at 2.5%. Three of the five most frequent Iranian mutations are not included in a commonly used panel of CF mutations, underscoring the importance of identifying geographic-specific mutations in this population.

Applied Radiation and Isotopes, 2011

Radiotherapy remains a major modality of cancer therapy. Thanks to high flux and high brilliance ... more Radiotherapy remains a major modality of cancer therapy. Thanks to high flux and high brilliance of synchrotron-generated X-ray, laboratory research with planar microscopically thin X-ray beam promise exciting new opportunities for treatment of cancer. High tolerance of normal tissues at doses up to several hundred Gy in a single dose fraction and preferential damage of tumors at very high doses have been uniquely observed in animal models exposed to microbeams. The fact that beams as thick as 0.68 mm could retain a part of these effects, opens the possibility that the required beam can be produced by high power X-ray tubes besides a dedicated synchrotron. Fortunately, dose distribution due to kilovolt X-rays could be enhanced by the introduction of high-Z contrast agents to tissue-like media. In this work, dose deposition in a phantom-partially loaded with Au and I as contrast agents-irradiated by multi-sliced kV X-ray beam was experimentally investigated in the peak and valley regions both on the surface and in the depth of phantom. The results of experimental dosimetry using Gaf-chromic films were compared with corresponding Monte-Carlo simulation. Relative reduction in the deposited dose in the peak regions downstream the area containing contrast agents in comparison with the adjacent areas was experimentally observed.

Proteins nanoparticles are one of the new methods for food delivery systems. The protein nanopart... more Proteins nanoparticles are one of the new methods for food delivery systems. The protein nanoparticles which represent promising carriers for delivery are fabricated based on different methods. Synthetic protein nanostructure acts as surrogate mimics such as viruses and plasmid for food and drug delivery system. The benefits of protein nanoparticles include non-toxicity, stability for long duration, nonantigenicity and biodegradability. The purpose of this paper was to explain different ways of fabrication of nanoparticles in the unique range which is suitable for the food and drug delivery system