Fatemeh Ghiasi - Academia.edu (original) (raw)

Papers by Fatemeh Ghiasi

Journal of Intellectual Disability - Diagnosis and Treatment

Patients admitted to Critical Care Units (CCU) face multiple stressors, and these stressors cause... more Patients admitted to Critical Care Units (CCU) face multiple stressors, and these stressors cause anxiety in patients. Anxiety increases heart function in heart patients. High levels of anxiety in cardiac patients increase in association with hospital complications. The purpose of this study was to determine the effect of Cognitive-Behavioral Therapy (CBT) on reducing the anxiety of patients in CCU during their hospitalization. The study design was quasi-experimental (pre-test and post-test). This study was performed on patients in CCU of Shahid Mostafa Khomeini hospital in 2019; for this purpose, 30 patients in CCU were randomly divided into intervention (n=15) and control (n=15) groups. Before the intervention, the demographic variables questionnaire and DASS-21 anxiety questionnaire were completed by both groups. Then, the intervention group received CBT for eight sessions according to the average number of hospital days (eight days) by the therapist (researcher). The control gro...

Iranian rehabilitation journal, Dec 1, 2021

To compare the efficacy of balance exercises in the aquatic and Non-aquatic environments compared... more To compare the efficacy of balance exercises in the aquatic and Non-aquatic environments compared with control in patients with grade 2 or 3 knee Osteoarthritis (OA). Methods: For this single-blind, randomized control trial study, 43 women with mild to moderate knee OA were recruited through a simple non-probability sampling method. They were randomly assigned to the aquatic balance exercise group (n=15), Non-aquatic balance exercise group (n=15), and a control group (n=13). The intervention programs comprised aquatic and Non-aquatic balance training. Fall risk, the primary outcome, was measured by the Biodex balance system before and after the intervention. One-way ANOVA and paired sample t-test were used for analyzing data. Results: After 4 weeks training, the Mean±SD fall risk score significantly decreased from 3.49±1.14 to 2.59±1.22 (P<0.001) in the aquatic balance training group, from 3.21±0.62 to 2.19±0.62 (P<0.001) in the Non-aquatic balance training group, and from 3.77±1.13 to 3.17±1.22 (P<0.001) in the control group. Regarding between-group comparisons, we found significant differences between the Non-aquatic balance training group and the control group (P=0.03). Discussion: Despite the environment, the balance exercise program significantly improved fall risk scores among patients with grade 2 or 3 knee osteoarthritis.

Nanoencapsulation Technologies for the Food and Nutraceutical Industries, 2017

Biopolymers, including proteins and polysaccharides, have enormous potential applications in nano... more Biopolymers, including proteins and polysaccharides, have enormous potential applications in nanoencapsulation technology. The synergistic effect of different biopolymers makes biopolymer complexes excellent candidates for delivery, targeting, and controlled release purposes in food, nutraceutical, and pharmaceutical industries. The objectives of this chapter are to cover the fundamentals of delivery systems generated by mixed biopolymers. Therefore, an overview of the biopolymer complexation will be presented in the first part of the chapter. Further, the application of different mixed biopolymer systems to fabricate advanced carrier systems, with the aim of protecting nutraceuticals and enabling subsequent fortification of food products, will be overviewed. Finally, advantages and disadvantages associated with complexed biopolymer–based delivery systems and active research areas in this field will be highlighted.

Physicochemical and Enzymatic Modification of Gums, 2021

Food Chemistry, 2022

In this study, the effect of sol-gel transition of oil phase (O) and inner aqueous phase (W1) on ... more In this study, the effect of sol-gel transition of oil phase (O) and inner aqueous phase (W1) on the physical and chemical stability of a model PUFA rich-W1/O/W2 double emulsion (DE) was investigated. Thermal-driven gelation of O and W1 was performed using monoglyceride and κ-carrageenan, respectively. To accelerate lipid oxidation, ferrous sulfate was encapsulated in W1. Using this approach, O gelation reduced the volume-weighted size (d4,3) of DEs droplets and provided good physical stability. However, non-gelled DEs and those containing gelled W1 exhibited extensive flocculation and coalescence. Moreover, oleogelation resulted in a predominant elastic behavior with weak frequency dependence of viscoelastic properties. Oxidation was significantly reduced by W1 gelation; however, the O gelation led to a higheroxidation rate. Oxidation kinetic parameters induced by a hydrophilic (gallic acid) and a lipophilic (α-tocopherol) antioxidant showed that DEs containing gelled O droplets presented high physical and oxidative stability when α-tocopherol was present.

International Journal of Pharmaceutics, 2021

This work aimed to develop a novel nanoencapsulation system for food colloidal formulations using... more This work aimed to develop a novel nanoencapsulation system for food colloidal formulations using gelled lipid nanoparticles (GLNs) to improve the functionality, stability, and bioactivity of cuminaldehyde as a highly volatile and poor hydrophilic food additive. Cuminaldehyde-loaded GLNs with diameters of 117-138 nm were fabricated through a hot emulsification process with monoglyceride (10 and 15 g/100 g lipid phase) as a lipid gelator at two concentrations of cuminaldehyde (500 and 1000 mg/L). All samples remained stable towards macroscopic phase separation and creaming during 28 days of storage at 4 °C, which could be related to the rigid structure of dispersed particles in the gelled state and retarding droplet movement. Moreover, all samples were stable to creaming after subjecting to the environmental changes including temperature (30, 60, and 90 °C for 30 min), ionic strength (100, 200, and 300 mM NaCl), and pH (3, 5, and 7). Measurement of apparent viscosity showed non-Newtonian shear thinning nature in all samples, which was more pronounced at higher concentrations of the gelator. Interestingly, higher cytotoxic effects of cuminaldehyde against human lung and colorectal cancer cells were observed after encapsulation within GLNs. However, weak toxicity was also found against normal peripheral blood mononuclearcells.On the other hand, the antioxidant activity and lipid oxidation stability were improved by increasing cuminaldehyde concentration, while it was reduced at higher monoglyceride concentration. All samples exhibited stronger antibacterial activity against Bacillus cereus than Eschershia coli. These findings suggest the significant potential benefits of GLNs as novel nanocarriers to enrich various food and beverage formulations with essential oils, flavors, and aromas.

Colloids and Surfaces B: Biointerfaces, 2021

In this study, electrospinning of hordein and glutelin extracted from barley was carried out. Dif... more In this study, electrospinning of hordein and glutelin extracted from barley was carried out. Different ratios of the glutelin-hordein blends (25:75, 30:70, 35:65) were tested and the operation parameters including voltage, ejection flow rate and needle-to-collector distance were optimized. According to the scanning electron microscope images, the glutelin-hordein 25:75 blend generated at the voltage of 15 kV, the needle-to-collector distance of 150 mm and the ejection rate of 1 mL/h was selected for the fabrication of uniform nanofibers. The apparent viscosity at the ejection point was decreased with increasing the glutelin concentration from 25 to 35 %. Moreover, the Oliveria decumbens essential oil (ODEO) with different loading concentrations (2-4 % (v/v)) was incorporated into the protein blend. Fourier-transform infrared spectra demonstrated the occurrence of the interactions of proteins the ODEO. The encapsulation efficiency of ODEO in the nanofibers was 79.30 %. The presence of ODEO led to inhibition the growth of Staphylococcus aureus, Escherichia coli and Bacillus cereus in a synthetic medium. The optimal nanofibers showed high antioxidnat activity. The results herein showed the possibility of the production of electrospun nanofibers using barley proteins with promising (bio)functionalities for the active food packaging applications.

LWT, 2022

Abstract Composite films of Persian gum (PG) and gelatin (G) were prepared by complex coacervatio... more Abstract Composite films of Persian gum (PG) and gelatin (G) were prepared by complex coacervation approach at different mixing ratios (100:0, 75:25 and 50:50, respectively) and critical pH levels corresponding to the electrostatic interactions. First, PG, G, and their mixture solutions were characterized in terms of turbidity as a function of pH. The maximum interaction of biopolymers was observed at pH 4.18 and the corresponding composite film revealed a compact and homogeneous structure as a result of strong electrostatic interactions and hydrogen bondings within the film network, whereas PG films had rough and slightly irregular surfaces as observed in SEM micrographs. Moreover, composite films showed reduced water solubility and elongation at break and enhanced water vapor barrier properties and tensile strength. G concentration positively affected the lightness of films, while the reverse trend was observed for opacity. In the DSC thermograms of composite films, there was only one glass transition temperature which decreased gradually with an increase in the G content, indicating appropriate miscibility between biopolymers in the film matrix. In general, the most desirable composite regarding physical and mechanical characteristics was produced from the interaction of PG and G at a mass ratio of 50:50 and pH 4.18.

International Journal of Biological Macromolecules, 2020

In this study, the effects of various fatty (including caprylic, lauric, and palmitic) acids on p... more In this study, the effects of various fatty (including caprylic, lauric, and palmitic) acids on physicochemical, mechanical, and barrier properties of basil seed gum (BSG)-based edible films were investigated. The introduction of fatty acids (FAs) into the BSG-based matrix was confirmed by FT-IR. Increasing the FA chain length resulted in an increase in the thickness and opacity of FA-modified BSG films, while water solubility decreased. The water vapor permeability (WVP) of FA-modified films was significantly (P < 0.05) lower than that of control film. The mechanical properties and color attributes of edible films were improved after incorporating caprylic and lauric acids. SEM micrographs revealed a more homogenous microstructure with a higher surface density in the films incorporated with caprylic acid, while a higher roughness and insoluble particles were observed in those incorporated with lauric, and palmitic acids. Our findings showed that lauric acid is a good candidate for improving the barrier and textural characteristics of BSG-based edible films.

Journal of Agricultural and Food Chemistry, 2021

The inherent thermodynamic instability of liposomes during production and storage has limited the... more The inherent thermodynamic instability of liposomes during production and storage has limited their widespread applications. Therefore, a novel structure of food-grade nanoliposomes stabilized by a 3D organogel network within the bilayer shell was developed through the extrusion process and successfully applied to encapsulate vitamin D 3. A huge flocculation and a significant reduction of zeta potential (−17 mV) were observed in control nanoliposomes (without the organogel shell) after 2 months of storage at 4°C, while the sample with a gelled bilayer showed excellent stability with a particle diameter of 105 nm and a high negative zeta potential (−63.4 mV), even after 3 months. The development of spherical vesicles was confirmed by TEM. Interestingly, the gelled bilayer shell led to improved stability against osmotically active divalent salt ions. Electron paramagnetic resonance confirmed the higher rigidity of the shell bilayer upon gelation. The novel liposome offered a dramatic increase in encapsulation efficiency and loading of vitamin D 3 compared to those of control.

LWT, 2021

Abstract Solvent free ohmic-assisted esterification (OAE) was investigated as a promising tool fo... more Abstract Solvent free ohmic-assisted esterification (OAE) was investigated as a promising tool for ethyl butyrate (pineapple flavor) synthesis. To this end, Amberlyst 15 dry was used as an ion exchange catalyst to promote the esterification reaction between ethanol and butyric acid. Solubility, electrical conductivity, and heating rate of the reaction mixture as affected by different salt types and concentrations were studied. Then, the OAE operation parameters (i.e., electrical field, catalyst concentration, and mole ratio of ethanol:butyric acid) were optimized. The highest ethyl butyrate yield (63%) was achieved after 90 min in presence of 1% LiCl, 2% Amberlyst 15 dry using field strength of 25 V/cm and an ethanol:butyric acid mole ratio of 1:1. Optimum conditions of OAE were also compared with microwave- and magnetic stirrer-assisted esterification methods. OAE provided the highest yield (61.20%) at a shorter time with the lowest specific energy consumption (0.04 kWh/g ethyl butyrate) and specific CO2 emission (0.03 kg CO2/g ethyl butyrate). The micrographs of scanning electron microscopy showed less structural damages in the catalyst structure using OAE compared to other esterification methods. Therefore, OAE can be proposed as a cost-effective and environmentally friendly technology for the synthesis of flavor esters in the food industry.

Industrial Crops and Products, 2020

This work aimed to study the effect of structured oil nanoparticles (SONs) for improving the hydr... more This work aimed to study the effect of structured oil nanoparticles (SONs) for improving the hydrophobicity of polysaccharide-based edible films as a novel modification approach. SONs were fabricated from sunflower oil (SFO) using ethyl cellulose or monoglyceride as gelator. Farsi gum (FG) was selected as a model polysaccharide to develop edible films. The physicochemical, mechanical, thermal, and morphological properties of FG-based films incorporated with different concentrations (0%, 0.5 %, and 1% (w/w)) of SONs were compared with those of SFO-free (control) and SFO-incorporated FG films. Irrespective of the physical nature of added oil, the water vapor permeability, solubility, swelling ability, and surface hydrophilicity of FG films incorporated with SONs or SFO were significantly decreased. The SFO was more effective than the SONs in improving some hydrophobic properties; however, the flocculation of SFO droplets decreased the water vapor barrier properties. Incorporating SONs resulted in a compact and more uniform surface morphology, while a higher roughness and surface irregularity were observed after modification with SFO. The modified films prepared by incorporating SONs showed appropriate tensile strength and higher flexibility than control film, while those incorporated with liquid SFO droplets were too sticky and stretchy to be subjected to the tensile forces. The thermal stability of modified films was enhanced after incorporating SONs. The results indicated that the key properties of FG films were better improved by incorporating SONs than liquid oil droplets. Therefore, the SONs can be considered as an appropriate candidate for developing novel edible food packaging materials with high moisture barrier characteristics.

Journal of Pharmaceutical Research International, 2018

Indian Journal of Forensic Medicine & Toxicology, 2019

Introduction: The ethical climate ruled in the operating room is one of the important factors aff... more Introduction: The ethical climate ruled in the operating room is one of the important factors affecting the educational quality and clinical skills of anesthesia and operating room students. Given the difference of ethical space in different wards of hospital and the importance of governing space in operating room of Ilam University of Medical Sciences teaching hospitals, the purpose of this research was to determine the viewpoints of anesthesiology and operating room students about operating room space in the second semester of 2018-19. Method: In this descriptive cross-sectional study, all anesthesia and operating room students who were studying in the second semester of 2018-19were enrolled (n = 95). In addition to individual-social form, Olson Hospital Ethical Climate Survey (HECS) was used for data collection. Data were analyzed using descriptive statistics (frequency, percentage, etc.) and inferential statistics (Chi-square test) in SPSS 18. Results: Among anesthesia and operating room students, anesthesia students had a better view of the ethical climate in the operating room than the operating room students. The most negative viewpoint of the students in both groups was the hospital scope. Conclusion: Considering the difference between the viewpoints of the students of both groups regarding the ethical atmosphere in the operating room, it seems necessary to consider the causes and to improve the ethical climate for the students in the operating room. © 2019, Indian Journal of Forensic Medicine and Toxicology. All rights reserved

Nutrition and Cancer, 2019

In the etiology of breast malignancy, dietary habits and lifestyle-related risk factors in the co... more In the etiology of breast malignancy, dietary habits and lifestyle-related risk factors in the coherence of cancer prevention guidelines, e.g., WCRF/AICR is well documented. In addition, the consumption of staple food products rich in carbohydrate as major calorie resources such as potato, bread, and ready-to-eat cereals are partly object to having roles in breast tumorigenesis. In this review, the possible associations of preservatives and nutritive risk factors of staple foods in dietary patterns with breast cancer development based on the experimental and observational cohort-based studies were discussed. In this regard, the influence kinetics of insulin, insulin-like growth factor-1, and insulin-activated AMPK/Akt pathway on sorts of starch and protein is a concerning biologic concept in promoting the risk of tumorigenesis. Hence, Akt-dependent controlled proliferation, induced apoptosis, and controlled oxidative stress in specific condition could be concentrated as the preventive strategies. Although preservatives such as sorbate, benzoate, and nitrate are considered Generally Recognized as Safe, there are some issues concerning the safety of their applications, including the possibility of allergies and immunosuppressive effects from benzoate, the formation of carcinogenic nitrosamines from nitrites, and interaction sorbate with nitrite in the stomach which consequently can be resulted in the production of a series of genotoxic compounds.

Journal of Colloid and Interface Science, 2019

The main objective of this work was to develop an aqueous dispersion of gelled-oil nanoparticles ... more The main objective of this work was to develop an aqueous dispersion of gelled-oil nanoparticles as a novel carrier for cuminaldehyde. A hot emulsification process followed by cooling to room temperature was used to prepare gelled-oil nanoparticles in the presence of monoglyceride as organogelator. The effects of monoglyceride (10% and 15 % w/w of the total lipid phase) and cuminaldehyde (0, 500 and 1000 mg/L) concentrations on different characteristics (e.g. droplet size, zeta potential, physical stability, rheology, encapsulation efficiency, release behavior and morphology) of the colloidal dispersions were studied during 28-d storage. The average droplet size of freshly prepared samples was within the range of 117-138 nm with a relatively narrow distribution. Large negative ζ-potential values (-38 to-55 mV) were a proof for the kinetic stability of the colloidal dispersions. Samples which were prepared with 10% monoglyceride showed a higher physical stability over a period of 90 d. Non-Newtonian (shear-thinning) and solid-like viscoelastic properties were observed due to particle-particle interactions. The results of the temperature ramp test confirmed that the droplets were in the gelled state. An increase in the organogelator concentration decreased the interfacial tension and contact angle. Transmission electron microscopy micrographs confirmed the formation of spherical nanoparticles. The encapsulation efficiency of cuminaldehyde in gelled-oil nanoparticles was 73%-87%. In-vitro release profiles exhibited that the release of cuminaldehyde from gelled-oil nanoparticles in the simulated gastric fluid was lower than its release in the simulated intestinal fluid. Moreover, the release was increased by decreasing the concentration of organogelator. The obtained colloidal dispersions have the potential to be utilized as effective encapsulation systems for poorly watersoluble nutraceuticals.

Journal of Shahrekord University of Medical Sciences, Mar 15, 2007

The Journal of Rehabilitation Research and Development, 2007

A single-blind, randomized controlled trial was conducted to evaluate vacuum-compression therapy ... more A single-blind, randomized controlled trial was conducted to evaluate vacuum-compression therapy (VCT) for the healing of diabetic foot ulcers. Eighteen diabetic patients with foot ulcers were recruited through simple nonprobability sampling. Subjects were randomly assigned to either an experimental or a control group. Before and after intervention, the foot ulcer surface area was estimated stereologically, based on Cavalieri's principle. The experimental group was treated with VCT in addition to conventional therapy for 10 sessions. The control group received only conventional therapy, including debridement, blood glucose control agents, systemic antibiotics, wound cleaning with normal saline, offloading (pressure relief), and daily wound dressings. The mean foot ulcer surface area decreased from 46.88 +/-9.28 mm 2 to 35.09 +/-4.09 mm 2 in the experimental group (p = 0.006) and from 46.62 +/-10.03 mm 2 to 42.89 +/-8.1 mm 2 in the control group (p = 0.01). After treatment, the experimental group significantly improved in measures of foot ulcer surface area compared with the control group (p = 0.024). VCT enhances diabetic foot ulcer healing when combined with appropriate wound care.