Gianluca Orgeas - Academia.edu (original) (raw)

Papers by Gianluca Orgeas

Minerva stomatologica, 1999

The complexity and importance of the biological structures that form the so-called pulpal dentina... more The complexity and importance of the biological structures that form the so-called pulpal dentinal complex call for considerable accuracy during restorative procedures. In practice this means accurate techniques and appropriate dental materials, able to combine protective and restorative qualities, and above all, offering biocompatibility. In order to analyze this property, a number of international studies suggest the use of sequential tests divided into three different levels: initial tests, secondary tests and usage tests in the form of in vivo and in vitro tests to observe and simulate the biological reactions to dental materials used in particular tissues. The authors publish a review of the literature regarding the biocompatibility of intermediate materials regarded as useful aids in restorative dental practice; these include paints, liners and cavity bases made from Ca(OH)2, ZOE cements, zinc phosphate, polycarboxylic compounds, glass ionomers, bonding agents and mordents. Th...

BMC Oral Health, 2008

Background: In daily clinical practice of a dental department it's common to find gingival overgr... more Background: In daily clinical practice of a dental department it's common to find gingival overgrowth (GO) in periodontal patients under treatment with Cyclosporine A (CsA). The pathogenesis of GO and the mechanism of action of Azithromycin (AZM) are unclear. A systematic review was conducted in order to evaluate the efficacy of Azithromycin in patients with gingival overgrowth induced by assumption of Cyclosporine A. Methods: A bibliographic search was performed using the online databases MEDLINE, EMBASE and Cochrane Central of Register Controlled Trials (CENTRAL) in the time period between 1966 and September 2008. Results: The literature search retrieved 24 articles; only 5 were Randomised Controlled Trials (RCTs), published in English, fulfilled the inclusion criteria. A great heterogeneity between proposed treatments and outcomes was found, and this did not allow to conduct a quantitative meta-analysis. The systematic review revealed that a 5-day course of Azithromycin with Scaling and Root Planing reduces the degree of gingival overgrowth, while a 7-day course of metronidazole is only effective on concomitant bacterial over-infection. Conclusion: Few RCTs on the efficacy of systemic antibiotic therapy in case of GO were found in the literature review. A systemic antibiotic therapy without plaque and calculus removal is not able to reduce gingival overgrowth. The great heterogeneity of diagnostic data and outcomes is due to the lack of precise diagnostic methods and protocols about GO. Future studies need to improve both diagnostic methods and tools and adequate classification aimed to determine a correct prognosis and an appropriate therapy for gingival overgrowth.

Dental Cadmos, Apr 1, 2022

Methods: 42 chronic periodontitis patients, each contributing a 2-, 3- or 2-3-wall intrabony defe... more Methods: 42 chronic periodontitis patients, each contributing a 2-, 3- or 2-3-wall intrabony defect, were treated. Sites were randomly assigned into one of two groups: control (OFD alone) or test (OFD+IMP). Papilla preservation flaps were raised and defects were thoroughly debrided. In the control group, complete primary closure of flaps was ensured following debridement. In the test group, IMP was performed before flap closure, using a round bur to penetrate the cortical defect wall. Clinical and radiographic parameters were assessed at baseline and 12 months post-treatment. Results: At baseline, there were no statistically significant differences between groups. At 12 months, both groups experienced significant improvements, in terms of probing depth reduction, clinical attachment level (CAL) gain, and bone level (clinical and radiographic). The test group experienced significantly greater clinical bone gain (3.07±1.74 mm) and prevalence of CAL gain ≥2 mm (93% of sites), compared ...

Journal of clinical periodontology, Jan 15, 2015

to analyze alveolar ridge volume changes after immediate implant placement, with or without a reg... more to analyze alveolar ridge volume changes after immediate implant placement, with or without a regenerative technique. Studies investigating the effect of immediate implant placement on ridge dimensional changes were identified through an electronic search conducted using MEDLINE (PubMed) and EMBASE. Weighted mean changes (WMC) between baseline and follow-up time were calculated and subgroup analysis was performed according to study design, evaluation method and regenerative strategies. After immediate implant placement alone WMC of RCTs showed a loss in width and height of 1.1 mm. After flapless immediate implant placement with immediate provisionalization and a graft WMC showed a loss in width and heigth of 1.02 mm and 0.79 mm, while after flapped immediate implant placement and a graft WMC showed a gain of 1.79 mm. After immediate implant placement plus a a non resorbable membrane WMC showed a loss in height of 0.07 mm. After immediate implant placement plus a resorbable membrane ...

Minerva stomatologica

The complexity and importance of the biological structures that form the so-called pulpal dentina... more The complexity and importance of the biological structures that form the so-called pulpal dentinal complex call for considerable accuracy during restorative procedures. In practice this means accurate techniques and appropriate dental materials, able to combine protective and restorative qualities, and above all, offering biocompatibility. In order to analyze this property, a number of international studies suggest the use of sequential tests divided into three different levels: initial tests, secondary tests and usage tests in the form of in vivo and in vitro tests to observe and simulate the biological reactions to dental materials used in particular tissues. The authors publish a review of the literature regarding the biocompatibility of intermediate materials regarded as useful aids in restorative dental practice; these include paints, liners and cavity bases made from Ca(OH)2, ZOE cements, zinc phosphate, polycarboxylic compounds, glass ionomers, bonding agents and mordents. Th...

The Journal of oral implantology, 2013

In this report, a case is presented in which a patient received eight implants 10 months after to... more In this report, a case is presented in which a patient received eight implants 10 months after tooth extraction and socket preservation. The implants were placed in both arches (maxilla = 4, mandible = 4) and immediately loaded using fixed partial restorations; they remained functional over 5 years. No changes in bleeding on probing or plaque index were observed; however, a 1.5-mm probing attachment level loss was observed during the first 3 years (mean: 0.25 mm/year) with no subsequent changes.

Modern dentistry is focused on patient needs, with the current trend shifting from merely restori... more Modern dentistry is focused on patient needs, with the current trend shifting from merely restoring the loss of function to pursuing the esthetic satisfaction of patients and professional operators, as well as achieving optimal and stable results. Ideal smile esthetics depend on the balance between white and pink components, and therefore papilla reconstruction is one of the most challenging goals in periodontal plastic surgery and restorative procedures. The present case report proposes a surgical technique for the combined treatment of RT2 and RT3 recession defects and interdental papilla loss by means of a modified coronally advanced flap with an interdental subepithelial connective tissue graft.

Journal of Esthetic and Restorative Dentistry

Statement of the Problem: Gingival recession (GR) is a highly prevalent dental problem that may b... more Statement of the Problem: Gingival recession (GR) is a highly prevalent dental problem that may be associated with dentin hypersensitivity and aesthetic complaint. Furthermore, GR is often complicated by dental cervical wear of substance, such as erosion, abrasion, or abfraction lesions, as well as initial or more extensive carious involvement of the cervical area, which worsen the symptoms and make the treatment of this periodontal condition more challenging. The Purpose of the Study: To provide an overview of surgical treatment options presented in the literature for sites affected by GR with carious cervical lesions (CCLs) or non-carious cervical lesions (NCCLs). Methods: The Medline database was searched for items dealing with GR and its treatment options, especially on GR associated with CCLs or NCCLs. Results: Several periodontal surgical techniques have shown good potential for treating GR over the years. Specifically, considering GR associated with CCL or NCCL, an assessment...

Objective: Alveolar ridge preservation techniques (ARPs) are raising a growing interest among cli... more Objective: Alveolar ridge preservation techniques (ARPs) are raising a growing interest among clinicians, but their efficacy and effectiveness are still unclear. The aim of this paper is to systematically review clinical and histomorphometrical data from literature that provide information regarding the effect of alveolar ridge preservation procedures on healing after tooth extraction in humans. Method: The MEDLINE-PubMed and the Cochrane CENTRAL databases were searched regarding clinical and histological studies about alveolar ridge preservation techniques on humans. A quality assessment of included studies was performed. Mean values and standard deviation were extracted with regard to dimensional changes in both bone width and height, and histomorphometrical data such as percentage of bone, connective tissue and residual graft material. Different meta-analysis were conducted between different groups of alveolar ridge preservation procedures. Result: A relevant heterogeneity betwee...

The International Journal of Oral & Maxillofacial Implants, 2013

Purpose: To evaluate, through a systematic review of the literature, the efficacy of different su... more Purpose: To evaluate, through a systematic review of the literature, the efficacy of different surgical techniques in maintaining residual bone in the alveolar process following tooth extractions. Materials and Methods: MEDLINE/PubMed was searched through January 2010 and papers were selected according to the CONSORT statement and an independent three-stage screening process. The selected outcome variables were clinical width and height changes of the socket, and means and standard deviations were calculated from the included studies. For those studies that were randomized controlled trials, six meta-analyses were performed by dividing studies into three groups with regard to the use of barriers and grafting (barriers alone, graft alone, or both). Results: Thirteen papers met the eligibility criteria and were included in the analyses. Statistically significant ridge preservation was found for studies that used barriers alone; the pooled weighted mean was 0.909 mm (95% confidence interval, 0.497554 to 1.320732 mm) for bone height, while the mean for bone width was 2.966 mm (95% confidence interval, 2.334770 to 3.598300 mm). Conclusions: Socket preservation procedures are effective in limiting horizontal and vertical ridge alterations in postextraction sites. The meta-analysis indicates that the use of barrier membranes alone might improve normal wound healing in extraction sites.

Journal of Periodontology, 2014

procedures. However, the actual benefits of adding IMP to such a procedure remain undocumented. T... more procedures. However, the actual benefits of adding IMP to such a procedure remain undocumented. The purpose of this randomized controlled trial was to investigate the contribution of IMP to the outcomes of open flap debridement (OFD) treatment of intrabony defects.

Clinical Oral Implants Research, 2013

Aim: The aim of this article was to systematically review histological and histomorphometrical da... more Aim: The aim of this article was to systematically review histological and histomorphometrical data from literature that provide information regarding the effect of alveolar ridge preservation procedures on healing after tooth extraction in humans.

Journal of Esthetic and Restorative Dentistry, 2013

BMC Oral Health, 2008

In daily clinical practice of a dental department it's common to find gingival overgrowth (GO) in... more In daily clinical practice of a dental department it's common to find gingival overgrowth (GO) in periodontal patients under treatment with Cyclosporine A (CsA). The pathogenesis of GO and the mechanism of action of Azithromycin (AZM) are unclear. A systematic review was conducted in order to evaluate the efficacy of Azithromycin in patients with gingival overgrowth induced by assumption of Cyclosporine A.

Minerva stomatologica, 1999

The complexity and importance of the biological structures that form the so-called pulpal dentina... more The complexity and importance of the biological structures that form the so-called pulpal dentinal complex call for considerable accuracy during restorative procedures. In practice this means accurate techniques and appropriate dental materials, able to combine protective and restorative qualities, and above all, offering biocompatibility. In order to analyze this property, a number of international studies suggest the use of sequential tests divided into three different levels: initial tests, secondary tests and usage tests in the form of in vivo and in vitro tests to observe and simulate the biological reactions to dental materials used in particular tissues. The authors publish a review of the literature regarding the biocompatibility of intermediate materials regarded as useful aids in restorative dental practice; these include paints, liners and cavity bases made from Ca(OH)2, ZOE cements, zinc phosphate, polycarboxylic compounds, glass ionomers, bonding agents and mordents. Th...

BMC Oral Health, 2008

Background: In daily clinical practice of a dental department it's common to find gingival overgr... more Background: In daily clinical practice of a dental department it's common to find gingival overgrowth (GO) in periodontal patients under treatment with Cyclosporine A (CsA). The pathogenesis of GO and the mechanism of action of Azithromycin (AZM) are unclear. A systematic review was conducted in order to evaluate the efficacy of Azithromycin in patients with gingival overgrowth induced by assumption of Cyclosporine A. Methods: A bibliographic search was performed using the online databases MEDLINE, EMBASE and Cochrane Central of Register Controlled Trials (CENTRAL) in the time period between 1966 and September 2008. Results: The literature search retrieved 24 articles; only 5 were Randomised Controlled Trials (RCTs), published in English, fulfilled the inclusion criteria. A great heterogeneity between proposed treatments and outcomes was found, and this did not allow to conduct a quantitative meta-analysis. The systematic review revealed that a 5-day course of Azithromycin with Scaling and Root Planing reduces the degree of gingival overgrowth, while a 7-day course of metronidazole is only effective on concomitant bacterial over-infection. Conclusion: Few RCTs on the efficacy of systemic antibiotic therapy in case of GO were found in the literature review. A systemic antibiotic therapy without plaque and calculus removal is not able to reduce gingival overgrowth. The great heterogeneity of diagnostic data and outcomes is due to the lack of precise diagnostic methods and protocols about GO. Future studies need to improve both diagnostic methods and tools and adequate classification aimed to determine a correct prognosis and an appropriate therapy for gingival overgrowth.

Dental Cadmos, Apr 1, 2022

Methods: 42 chronic periodontitis patients, each contributing a 2-, 3- or 2-3-wall intrabony defe... more Methods: 42 chronic periodontitis patients, each contributing a 2-, 3- or 2-3-wall intrabony defect, were treated. Sites were randomly assigned into one of two groups: control (OFD alone) or test (OFD+IMP). Papilla preservation flaps were raised and defects were thoroughly debrided. In the control group, complete primary closure of flaps was ensured following debridement. In the test group, IMP was performed before flap closure, using a round bur to penetrate the cortical defect wall. Clinical and radiographic parameters were assessed at baseline and 12 months post-treatment. Results: At baseline, there were no statistically significant differences between groups. At 12 months, both groups experienced significant improvements, in terms of probing depth reduction, clinical attachment level (CAL) gain, and bone level (clinical and radiographic). The test group experienced significantly greater clinical bone gain (3.07±1.74 mm) and prevalence of CAL gain ≥2 mm (93% of sites), compared ...

Journal of clinical periodontology, Jan 15, 2015

to analyze alveolar ridge volume changes after immediate implant placement, with or without a reg... more to analyze alveolar ridge volume changes after immediate implant placement, with or without a regenerative technique. Studies investigating the effect of immediate implant placement on ridge dimensional changes were identified through an electronic search conducted using MEDLINE (PubMed) and EMBASE. Weighted mean changes (WMC) between baseline and follow-up time were calculated and subgroup analysis was performed according to study design, evaluation method and regenerative strategies. After immediate implant placement alone WMC of RCTs showed a loss in width and height of 1.1 mm. After flapless immediate implant placement with immediate provisionalization and a graft WMC showed a loss in width and heigth of 1.02 mm and 0.79 mm, while after flapped immediate implant placement and a graft WMC showed a gain of 1.79 mm. After immediate implant placement plus a a non resorbable membrane WMC showed a loss in height of 0.07 mm. After immediate implant placement plus a resorbable membrane ...

Minerva stomatologica

The complexity and importance of the biological structures that form the so-called pulpal dentina... more The complexity and importance of the biological structures that form the so-called pulpal dentinal complex call for considerable accuracy during restorative procedures. In practice this means accurate techniques and appropriate dental materials, able to combine protective and restorative qualities, and above all, offering biocompatibility. In order to analyze this property, a number of international studies suggest the use of sequential tests divided into three different levels: initial tests, secondary tests and usage tests in the form of in vivo and in vitro tests to observe and simulate the biological reactions to dental materials used in particular tissues. The authors publish a review of the literature regarding the biocompatibility of intermediate materials regarded as useful aids in restorative dental practice; these include paints, liners and cavity bases made from Ca(OH)2, ZOE cements, zinc phosphate, polycarboxylic compounds, glass ionomers, bonding agents and mordents. Th...

The Journal of oral implantology, 2013

In this report, a case is presented in which a patient received eight implants 10 months after to... more In this report, a case is presented in which a patient received eight implants 10 months after tooth extraction and socket preservation. The implants were placed in both arches (maxilla = 4, mandible = 4) and immediately loaded using fixed partial restorations; they remained functional over 5 years. No changes in bleeding on probing or plaque index were observed; however, a 1.5-mm probing attachment level loss was observed during the first 3 years (mean: 0.25 mm/year) with no subsequent changes.

Modern dentistry is focused on patient needs, with the current trend shifting from merely restori... more Modern dentistry is focused on patient needs, with the current trend shifting from merely restoring the loss of function to pursuing the esthetic satisfaction of patients and professional operators, as well as achieving optimal and stable results. Ideal smile esthetics depend on the balance between white and pink components, and therefore papilla reconstruction is one of the most challenging goals in periodontal plastic surgery and restorative procedures. The present case report proposes a surgical technique for the combined treatment of RT2 and RT3 recession defects and interdental papilla loss by means of a modified coronally advanced flap with an interdental subepithelial connective tissue graft.

Journal of Esthetic and Restorative Dentistry

Statement of the Problem: Gingival recession (GR) is a highly prevalent dental problem that may b... more Statement of the Problem: Gingival recession (GR) is a highly prevalent dental problem that may be associated with dentin hypersensitivity and aesthetic complaint. Furthermore, GR is often complicated by dental cervical wear of substance, such as erosion, abrasion, or abfraction lesions, as well as initial or more extensive carious involvement of the cervical area, which worsen the symptoms and make the treatment of this periodontal condition more challenging. The Purpose of the Study: To provide an overview of surgical treatment options presented in the literature for sites affected by GR with carious cervical lesions (CCLs) or non-carious cervical lesions (NCCLs). Methods: The Medline database was searched for items dealing with GR and its treatment options, especially on GR associated with CCLs or NCCLs. Results: Several periodontal surgical techniques have shown good potential for treating GR over the years. Specifically, considering GR associated with CCL or NCCL, an assessment...

Objective: Alveolar ridge preservation techniques (ARPs) are raising a growing interest among cli... more Objective: Alveolar ridge preservation techniques (ARPs) are raising a growing interest among clinicians, but their efficacy and effectiveness are still unclear. The aim of this paper is to systematically review clinical and histomorphometrical data from literature that provide information regarding the effect of alveolar ridge preservation procedures on healing after tooth extraction in humans. Method: The MEDLINE-PubMed and the Cochrane CENTRAL databases were searched regarding clinical and histological studies about alveolar ridge preservation techniques on humans. A quality assessment of included studies was performed. Mean values and standard deviation were extracted with regard to dimensional changes in both bone width and height, and histomorphometrical data such as percentage of bone, connective tissue and residual graft material. Different meta-analysis were conducted between different groups of alveolar ridge preservation procedures. Result: A relevant heterogeneity betwee...

The International Journal of Oral & Maxillofacial Implants, 2013

Purpose: To evaluate, through a systematic review of the literature, the efficacy of different su... more Purpose: To evaluate, through a systematic review of the literature, the efficacy of different surgical techniques in maintaining residual bone in the alveolar process following tooth extractions. Materials and Methods: MEDLINE/PubMed was searched through January 2010 and papers were selected according to the CONSORT statement and an independent three-stage screening process. The selected outcome variables were clinical width and height changes of the socket, and means and standard deviations were calculated from the included studies. For those studies that were randomized controlled trials, six meta-analyses were performed by dividing studies into three groups with regard to the use of barriers and grafting (barriers alone, graft alone, or both). Results: Thirteen papers met the eligibility criteria and were included in the analyses. Statistically significant ridge preservation was found for studies that used barriers alone; the pooled weighted mean was 0.909 mm (95% confidence interval, 0.497554 to 1.320732 mm) for bone height, while the mean for bone width was 2.966 mm (95% confidence interval, 2.334770 to 3.598300 mm). Conclusions: Socket preservation procedures are effective in limiting horizontal and vertical ridge alterations in postextraction sites. The meta-analysis indicates that the use of barrier membranes alone might improve normal wound healing in extraction sites.

Journal of Periodontology, 2014

procedures. However, the actual benefits of adding IMP to such a procedure remain undocumented. T... more procedures. However, the actual benefits of adding IMP to such a procedure remain undocumented. The purpose of this randomized controlled trial was to investigate the contribution of IMP to the outcomes of open flap debridement (OFD) treatment of intrabony defects.

Clinical Oral Implants Research, 2013

Aim: The aim of this article was to systematically review histological and histomorphometrical da... more Aim: The aim of this article was to systematically review histological and histomorphometrical data from literature that provide information regarding the effect of alveolar ridge preservation procedures on healing after tooth extraction in humans.

Journal of Esthetic and Restorative Dentistry, 2013

BMC Oral Health, 2008

In daily clinical practice of a dental department it's common to find gingival overgrowth (GO) in... more In daily clinical practice of a dental department it's common to find gingival overgrowth (GO) in periodontal patients under treatment with Cyclosporine A (CsA). The pathogenesis of GO and the mechanism of action of Azithromycin (AZM) are unclear. A systematic review was conducted in order to evaluate the efficacy of Azithromycin in patients with gingival overgrowth induced by assumption of Cyclosporine A.