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Papers by Gianluigi Cetto

Research paper thumbnail of Prognosis in breast cancer: significance of estrogen receptors by immunohistochemistry

Research paper thumbnail of Invasive breast cancer: Ki-67 evaluation in 3909 early breast cancer patients

Journal of Clinical Oncology, Jun 1, 2005

678 Background: The rate of cell proliferation correlates with the response of breast cancer to c... more 678 Background: The rate of cell proliferation correlates with the response of breast cancer to chemotherapy and disease outcome. The Ki-67 protein is a useful histopathological marker for assessing the growth fraction of tumour cells during all of the active phases of the cell cycle. The measurement of Ki-67 levels by means of immunohistochemistry (MIB-1 antibody) is the most widely used method of evaluating cell proliferation and the biological aggressiveness of a tumour. High Ki-67 levels usually correlates with a poor prognosis in breast cancer. The aim of this study was to verify the relationshoip between Ki-67 levels and tumour characteristics. Patients and Methods: We analysed 3909 women who underwent surgery for an invasive breast tumour between 1992 and 2003, and correlated Ki-67 expression (low:0–15%; medium:16–25%; high:26–100%) with the clinical (menopausal status, disease presentation and age), biological (ER and PgR expression, c-erbB2 overexpression, and p53, p21 and bcl-2 expression) and p...

Research paper thumbnail of Caratterizzazione di una nuova linea cellulare di melanoma umano

Research paper thumbnail of Significato prognostico dei recettori (R) per estrogeni (RE) e progesterone (RP) nel cr mammario: correlazione con alcuni parametri clinici

Research paper thumbnail of Monoterapia empirica con ceftazidime nelle infezioni di pazienti neutropenici affetti da emopatie maligne

Research paper thumbnail of Adjuvant chemotherapy with high dose epirubicin and cyclophosphamide (ec) vs cyclophosphamide, methotrexate, fluorouracil (CMF) in high risk premenopausal breast cancer patients (PTS). A prospective randomized trial. E

Research paper thumbnail of Efficacia antiemetica dell'ondansetron (GR 38032): continuità dell'attività terapeutica

Research paper thumbnail of Assessment of Liver and Spleen Involvement in Hodgkin's Disease

Tumori Journal, 1984

Prognosis and proper treatment in Hodgkin's disease (HD) are strictly related to staging accu... more Prognosis and proper treatment in Hodgkin's disease (HD) are strictly related to staging accuracy: liver and spleen involvement is of particular importance in this regard. We have evaluated, in 113 consecutive patients, the accuracy of clinical parameters to detect histologically documented HD involvement by comparing hepatosplenomegaly, liver function tests, liver and spleen scan, inspection of liver and spleen surface at laparoscopy with histologic findings. Our data suggest that of all the parameters studied, laparoscopy has the highest sensitivity and specificity values (about 100 %). Laparoscopy may precede laparotomy as a staging procedure in HD and may give, in patients not submitted to laparotomy whatever the reasons, very reliable information.

Research paper thumbnail of Ifosfamide Encephalopathy: A Case Report

Tumori Journal, 2005

The aim of this short communication is to discuss the mechanism, modality and treatment of ifosfa... more The aim of this short communication is to discuss the mechanism, modality and treatment of ifosfamide encephalopathy. We present the case of a 52-year-old woman treated with this alkylating agent who developed severe neurotoxicity. It was resolved with administration of Methylene blue, abundant intravenous hydration and interruption of ifosfamide.

Research paper thumbnail of Prognostic significance of tumour size in T1 breast cancer patients with no axillary lymph node involvement: Analysis of 1857 patients

Journal of Clinical Oncology, 2005

771 Background: Tumour size and node involvement are the most important prognostic factors in bre... more 771 Background: Tumour size and node involvement are the most important prognostic factors in breast cancer (BC). Node-negative (N-) and T1 BCs usually have a better prognosis, but some of these patients experience a recurrence and die of systemic disease. Materials and Methods: We studied 1857 patients with invasive N- and T1 BCs to evaluate the importance of the tumour diameter and correlated it with pathological, biological and clinical parameters in order to define a subgroup of patients at higher risk of recurrence. T1a, T1b and T1c tumours were correlated with grading (G1, G2, G3), vascular invasion (VI) (positive vs negative), ER and PgR (positive vs negative), Ki-67 proliferative index (low 0–10%; intermediate 11–25%; high 26–100%), mammary family history (MF) (positive vs negative) and type of diagnosis (asymptomatic vs symptomatic). The data were analysed using the chi-squared test. Results: The larger lesions were associated with poor prognostic factors such as G3 (76.1% in T1c vs 18.1% in T1b ...

Research paper thumbnail of Invasive breast cancer: Ki-67 evaluation in 3909 early breast cancer patients

Journal of Clinical Oncology, 2005

678 Background: The rate of cell proliferation correlates with the response of breast cancer to c... more 678 Background: The rate of cell proliferation correlates with the response of breast cancer to chemotherapy and disease outcome. The Ki-67 protein is a useful histopathological marker for assessing the growth fraction of tumour cells during all of the active phases of the cell cycle. The measurement of Ki-67 levels by means of immunohistochemistry (MIB-1 antibody) is the most widely used method of evaluating cell proliferation and the biological aggressiveness of a tumour. High Ki-67 levels usually correlates with a poor prognosis in breast cancer. The aim of this study was to verify the relationshoip between Ki-67 levels and tumour characteristics. Patients and Methods: We analysed 3909 women who underwent surgery for an invasive breast tumour between 1992 and 2003, and correlated Ki-67 expression (low:0–15%; medium:16–25%; high:26–100%) with the clinical (menopausal status, disease presentation and age), biological (ER and PgR expression, c-erbB2 overexpression, and p53, p21 and bcl-2 expression) and p...

Research paper thumbnail of Hormone Refractory Metastatic Prostate Cancer: Does Psa Halving Time During Docetaxel Treatment Have a Prognostic Role?

European Urology Supplements, 2008

Research paper thumbnail of Menopausal status and breast cancer (BC) characteristics: analysis of 3143 consecutive patients

European Journal of Cancer Supplements, 2004

Research paper thumbnail of Fasting bilirubinaemia in haemolytic and Gilbert's patients

Research paper thumbnail of 690 Prognostic significance of estrogen receptors in 405 primary breast cancers (B.C.): A comparison of immunohistochemical (ICA) and biochemical (DCC) methods

European Journal of Cancer, 1995

Research paper thumbnail of Comparison of clinical, biological and pathological characteristics in symptomatic vs asymptomatic breast cancers (BC): study of 1969 patients (pts)

European Journal of Cancer, 1999

Research paper thumbnail of Comparison of two different methods for determination of ER, IN·648 breast cancer (B.C.) patients

European Journal of Cancer, 1993

Research paper thumbnail of A new method for the determination of sodium and potassium in human red blood cells, using indocyanine green as a marker for trapped plasma

Clinica Chimica Acta, 1974

... The standard RBC solutions (c,d) are slight modifications of those used by Funder and Wieth [... more ... The standard RBC solutions (c,d) are slight modifications of those used by Funder and Wieth [15], in order to avoid the photometric interference be-tween the cations. ... This study was supported by Consiglio Nazionale dell Ricerche, Rome, Italy. References 1 M. Maizels, Quart. ...

Research paper thumbnail of Estrogen receptors in 699 primary breast cancers: A comparison of immunohistochemical and biochemical methods

Breast Cancer Research and Treatment, 1995

Research paper thumbnail of Recommendations of the European Association for Palliative Care (EAPC) For the Development of Undergraduate Curricula in Palliative Medicine At European Medical Schools

Research paper thumbnail of Prognosis in breast cancer: significance of estrogen receptors by immunohistochemistry

Research paper thumbnail of Invasive breast cancer: Ki-67 evaluation in 3909 early breast cancer patients

Journal of Clinical Oncology, Jun 1, 2005

678 Background: The rate of cell proliferation correlates with the response of breast cancer to c... more 678 Background: The rate of cell proliferation correlates with the response of breast cancer to chemotherapy and disease outcome. The Ki-67 protein is a useful histopathological marker for assessing the growth fraction of tumour cells during all of the active phases of the cell cycle. The measurement of Ki-67 levels by means of immunohistochemistry (MIB-1 antibody) is the most widely used method of evaluating cell proliferation and the biological aggressiveness of a tumour. High Ki-67 levels usually correlates with a poor prognosis in breast cancer. The aim of this study was to verify the relationshoip between Ki-67 levels and tumour characteristics. Patients and Methods: We analysed 3909 women who underwent surgery for an invasive breast tumour between 1992 and 2003, and correlated Ki-67 expression (low:0–15%; medium:16–25%; high:26–100%) with the clinical (menopausal status, disease presentation and age), biological (ER and PgR expression, c-erbB2 overexpression, and p53, p21 and bcl-2 expression) and p...

Research paper thumbnail of Caratterizzazione di una nuova linea cellulare di melanoma umano

Research paper thumbnail of Significato prognostico dei recettori (R) per estrogeni (RE) e progesterone (RP) nel cr mammario: correlazione con alcuni parametri clinici

Research paper thumbnail of Monoterapia empirica con ceftazidime nelle infezioni di pazienti neutropenici affetti da emopatie maligne

Research paper thumbnail of Adjuvant chemotherapy with high dose epirubicin and cyclophosphamide (ec) vs cyclophosphamide, methotrexate, fluorouracil (CMF) in high risk premenopausal breast cancer patients (PTS). A prospective randomized trial. E

Research paper thumbnail of Efficacia antiemetica dell'ondansetron (GR 38032): continuità dell'attività terapeutica

Research paper thumbnail of Assessment of Liver and Spleen Involvement in Hodgkin's Disease

Tumori Journal, 1984

Prognosis and proper treatment in Hodgkin's disease (HD) are strictly related to staging accu... more Prognosis and proper treatment in Hodgkin's disease (HD) are strictly related to staging accuracy: liver and spleen involvement is of particular importance in this regard. We have evaluated, in 113 consecutive patients, the accuracy of clinical parameters to detect histologically documented HD involvement by comparing hepatosplenomegaly, liver function tests, liver and spleen scan, inspection of liver and spleen surface at laparoscopy with histologic findings. Our data suggest that of all the parameters studied, laparoscopy has the highest sensitivity and specificity values (about 100 %). Laparoscopy may precede laparotomy as a staging procedure in HD and may give, in patients not submitted to laparotomy whatever the reasons, very reliable information.

Research paper thumbnail of Ifosfamide Encephalopathy: A Case Report

Tumori Journal, 2005

The aim of this short communication is to discuss the mechanism, modality and treatment of ifosfa... more The aim of this short communication is to discuss the mechanism, modality and treatment of ifosfamide encephalopathy. We present the case of a 52-year-old woman treated with this alkylating agent who developed severe neurotoxicity. It was resolved with administration of Methylene blue, abundant intravenous hydration and interruption of ifosfamide.

Research paper thumbnail of Prognostic significance of tumour size in T1 breast cancer patients with no axillary lymph node involvement: Analysis of 1857 patients

Journal of Clinical Oncology, 2005

771 Background: Tumour size and node involvement are the most important prognostic factors in bre... more 771 Background: Tumour size and node involvement are the most important prognostic factors in breast cancer (BC). Node-negative (N-) and T1 BCs usually have a better prognosis, but some of these patients experience a recurrence and die of systemic disease. Materials and Methods: We studied 1857 patients with invasive N- and T1 BCs to evaluate the importance of the tumour diameter and correlated it with pathological, biological and clinical parameters in order to define a subgroup of patients at higher risk of recurrence. T1a, T1b and T1c tumours were correlated with grading (G1, G2, G3), vascular invasion (VI) (positive vs negative), ER and PgR (positive vs negative), Ki-67 proliferative index (low 0–10%; intermediate 11–25%; high 26–100%), mammary family history (MF) (positive vs negative) and type of diagnosis (asymptomatic vs symptomatic). The data were analysed using the chi-squared test. Results: The larger lesions were associated with poor prognostic factors such as G3 (76.1% in T1c vs 18.1% in T1b ...

Research paper thumbnail of Invasive breast cancer: Ki-67 evaluation in 3909 early breast cancer patients

Journal of Clinical Oncology, 2005

678 Background: The rate of cell proliferation correlates with the response of breast cancer to c... more 678 Background: The rate of cell proliferation correlates with the response of breast cancer to chemotherapy and disease outcome. The Ki-67 protein is a useful histopathological marker for assessing the growth fraction of tumour cells during all of the active phases of the cell cycle. The measurement of Ki-67 levels by means of immunohistochemistry (MIB-1 antibody) is the most widely used method of evaluating cell proliferation and the biological aggressiveness of a tumour. High Ki-67 levels usually correlates with a poor prognosis in breast cancer. The aim of this study was to verify the relationshoip between Ki-67 levels and tumour characteristics. Patients and Methods: We analysed 3909 women who underwent surgery for an invasive breast tumour between 1992 and 2003, and correlated Ki-67 expression (low:0–15%; medium:16–25%; high:26–100%) with the clinical (menopausal status, disease presentation and age), biological (ER and PgR expression, c-erbB2 overexpression, and p53, p21 and bcl-2 expression) and p...

Research paper thumbnail of Hormone Refractory Metastatic Prostate Cancer: Does Psa Halving Time During Docetaxel Treatment Have a Prognostic Role?

European Urology Supplements, 2008

Research paper thumbnail of Menopausal status and breast cancer (BC) characteristics: analysis of 3143 consecutive patients

European Journal of Cancer Supplements, 2004

Research paper thumbnail of Fasting bilirubinaemia in haemolytic and Gilbert's patients

Research paper thumbnail of 690 Prognostic significance of estrogen receptors in 405 primary breast cancers (B.C.): A comparison of immunohistochemical (ICA) and biochemical (DCC) methods

European Journal of Cancer, 1995

Research paper thumbnail of Comparison of clinical, biological and pathological characteristics in symptomatic vs asymptomatic breast cancers (BC): study of 1969 patients (pts)

European Journal of Cancer, 1999

Research paper thumbnail of Comparison of two different methods for determination of ER, IN·648 breast cancer (B.C.) patients

European Journal of Cancer, 1993

Research paper thumbnail of A new method for the determination of sodium and potassium in human red blood cells, using indocyanine green as a marker for trapped plasma

Clinica Chimica Acta, 1974

... The standard RBC solutions (c,d) are slight modifications of those used by Funder and Wieth [... more ... The standard RBC solutions (c,d) are slight modifications of those used by Funder and Wieth [15], in order to avoid the photometric interference be-tween the cations. ... This study was supported by Consiglio Nazionale dell Ricerche, Rome, Italy. References 1 M. Maizels, Quart. ...

Research paper thumbnail of Estrogen receptors in 699 primary breast cancers: A comparison of immunohistochemical and biochemical methods

Breast Cancer Research and Treatment, 1995

Research paper thumbnail of Recommendations of the European Association for Palliative Care (EAPC) For the Development of Undergraduate Curricula in Palliative Medicine At European Medical Schools