Gianpaolo Grisolia - Academia.edu (original) (raw)

Papers by Gianpaolo Grisolia

Prenatal Diagnosis, 2015

The aim of this research was to determine the prevalence and sonographic appearance of the hippoc... more The aim of this research was to determine the prevalence and sonographic appearance of the hippocampal commissure in fetuses with isolated complete agenesis of the corpus callosum by three-dimensional neurosonography in the multiplanar mode. Methods This was a multicenter observational study. Stored volume datasets of fetuses with isolated complete agenesis of the corpus were retrospectively retrieved for analysis in three tertiary centers. The presence or absence of the hippocampal commissure was independently evaluated in the coronal and midsagittal planes by two operators. Postnatal follow-up was obtained in all cases. Results From November 2007 to February 2013, 41 cases between 19 and 30 weeks of gestation were retrieved for analysis. The hippocampal commissure was visible in the coronal and sagittal planes in 27/41 (65.8%), absent or not clearly recognizable in the remaining 14 cases. The qualitative analysis of the two operators was concordant in 100% of cases. Conclusions In more than half of fetuses with complete callosal agenesis, the hippocampal commissure may be visualized at prenatal ultrasound. This is a residual interhemispheric connection, which in normal cases is hidden by the corpus callosum itself. Further research is needed to establish if this has an impact on postnatal outcome.

Ultrasound in Obstetrics & Gynecology, 2018

Short oral presentation abstracts Results: The median gestational age at MRI was 30 (18-41) weeks... more Short oral presentation abstracts Results: The median gestational age at MRI was 30 (18-41) weeks, birth weight of 3285 (1700-3750) grams, with a time of outcome of 6 (1.3-10) years. 69.2% of the masses were located on the left side, and were predominantly cystic (69.2%). In this series, there were no signs of polydramnious or fetal hydropsis. Associated malformations were found in 23% of the fetuses, being the cardiac malformation the more prevalent. Preterm delivery occurred in 23% of the pregnancies, as consequence of obstetrical complications as preeclampsia (7.6%), placenta previa (7.6%) and preterm rupture of membranes (7.6%). 15.4% of the fetuses had involution of the SRM during the pregnancy, one fetus had surgical treatment with a different diagnosis of the ultrasound and MRI. Of the 69.2% of the cases, the spontaneous resolution occurred in 30.7% during the first year of life and in 38.4% the masses presented without modifications or signs of regression since the neonatal period. Conclusions: Prenatal suprarenal masses are related with preterm labour and congenital heart defects. The spontaneous regression and the absence of modifications in the masses were a common long-term outcome of SRM. OP18. 02 Sonographic features of fetal hepatic hemangioma before and after birth

American Journal of Neuroradiology, 2015

BACKGROUND AND PURPOSE: Agenesis of the corpus callosum, even when isolated, may be characterized... more BACKGROUND AND PURPOSE: Agenesis of the corpus callosum, even when isolated, may be characterized by anatomic variability. The aim of this study was to describe the types of other forebrain commissures in a large cohort of randomly enrolled fetuses with apparently isolated agenesis of the corpus callosum at prenatal MR imaging. MATERIALS AND METHODS: All fetuses with apparent isolated agenesis of the corpus callosum undergoing prenatal MR imaging from 2004 to 2014, were evaluated for the presence of the anterior or a vestigial hippocampal commissure assessed in consensus by 2 pediatric neuroradiologists. RESULTS: Overall, 62 cases of agenesis of the corpus callosum were retrieved from our data base. In 3/62 fetuses (4.8%), no forebrain commissure was visible at prenatal MR imaging, 23/62 fetuses (37.1%) presented with only the anterior commissure, and 20/62 fetuses (32.3%) showed both the anterior commissure and a residual vestigial hippocampal commissure, whereas in the remaining 16/62 fetuses (25.8%), a hybrid structure merging a residual vestigial hippocampal commissure and a rudiment of the corpus callosum body was detectable. Postnatal MR imaging, when available, confirmed prenatal forebrain commissure findings. CONCLUSIONS: Most fetuses with apparent isolated agenesis of the corpus callosum showed at least 1 forebrain commissure at prenatal MR imaging, and approximately half of fetuses also had a second commissure: a vestigial hippocampal commissure or a hybrid made of a hippocampal commissure and a rudimentary corpus callosum body. Whether such variability is the result of different genotypes and whether it may have any impact on the long-term neurodevelopmental outcome remains to be assessed. ABBREVIATIONS: AC ϭ anterior commissure; ACC ϭ agenesis of the corpus callosum; CC ϭ corpus callosum; GA ϭ gestational age; HC ϭ hippocampal commissure; HS ϭ hybrid structure

The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians, Jan 26, 2016

To evaluate prenatal predictors of postnatal survival in fetuses with agenesis of ductus venosus ... more To evaluate prenatal predictors of postnatal survival in fetuses with agenesis of ductus venosus (ADV). This retrospective study reviewed our experience and the literature between 1991 and 2015. Prenatal findings were evaluated and perinatal morbidity and mortality was documented. A total of 259 cases were included in the present analysis from our centers and 49 published studies (15 patients from our retrospective cohort review and 244 from literature review). The intrahepatic and extrahepatic shunts were present in 32.0% (73/226) and 67.7% (153/226), respectively. Cardiomegaly (n=64/259, 24.7%), hydrops (n=31/259, 12.0%) and amniotic fluid abnormalities (n=22/259, 8.5%) were among the most frequent initial ultrasound findings. 147 fetuses (56.8%) had ADV without structural anomalies while 112 (43.2%) had associated anomalies (cardiac anomalies (n=66), extra-cardiac anomalies (n=19), and both cardiac and extra-cardiac anomalies (n=27). The mean gestational age at ultrasound diagnos...

Real-time four-dimensional (4D) echocardiography is the examination of the fetal heart in the thr... more Real-time four-dimensional (4D) echocardiography is the examination of the fetal heart in the three spatial dimensions plus motion.The matrix probe’s technology allows direct volume scanning by electronically interrogation of a region of interest and acquisition of a pyramidal volume of ultrasonographic data. This technology has the potential to minimize motion artifacts associated with 3D/4D ultrasonography with a satisfactory spatial resolution.The system allows beam steering and focusing in the 3D volume dataset, making it possible to simultaneously examine two different planes of section of the same structure, in real-time, without resolution loss (Live xPlane imaging). The system achieves a pyramidal volume of data, creating a new real-time 3D moving imaging mode called Live 3D Volume Imaging, without the use of software-reconstructed section planes. Combination with Doppler techniques creates a new imaging option: Full Volume 3D imaging. The technique of Thick Slice Live Volum...

Viruses, 2021

The treatment of COVID-19 is particularly critical in pregnant women, considering the potential t... more The treatment of COVID-19 is particularly critical in pregnant women, considering the potential teratogenic effects of antiviral agents and the immune-depression related with pregnancy. The aim of this review is to systematically examine the current evidence on the clinical use of convalescent plasma during pregnancy. The electronic databases Medline PubMed Advanced Search Builder, Scopus, Web Of Science and Google Scholar were searched (until 1 January 2021). Inclusion criteria were pregnant women with COVID-19 (or SARS-CoV-2 infection), in whom convalescent plasma (or hyperimmune plasma) was used as treatment. We searched clinical trial registries (censored 5 January 2021) for eligible studies under way. After elimination of duplications, the initial search yielded 79 potentially relevant records, of which 67 were subsequently excluded. The 12 remaining records were case reports involving 12 pregnancies. Six of the mothers were reported to be well, two were reported to have preecl...

BJOG: An International Journal of Obstetrics & Gynaecology

To evaluate the usefulness of a Doppler technology highly sensitive for low‐velocity flow in the ... more To evaluate the usefulness of a Doppler technology highly sensitive for low‐velocity flow in the antenatal imaging of the torcular herophili (TH) in the second trimester of pregnancy.

Fetal and Pediatric Pathology

Ultrasound in Obstetrics & Gynecology

Taiwanese journal of obstetrics & gynecology, 2016

Skeletal dysplasia with bowing long bones is a rare group of multiple characterized congenital an... more Skeletal dysplasia with bowing long bones is a rare group of multiple characterized congenital anomalies. We introduce a simple, practical diagnostic flowchart that may be helpful in identifying the appropriate pathway of obstetrical management. Herein, we describe four fetal cases of bent bony dysplasia that focus on ultrasound findings, phenotype, molecular tests, distinctive X-ray features, and chondral growth plate histology. The first case was a typical campomelic dysplasia resulting from a de novo mutation in the SOX9 gene. The second fetus was affected by osteogenesis imperfecta Type II carrying a mutation in the COLA1 gene. The third case was a rare presentation of campomelic dysplasia, Cumming type, in which SOX9 examination was normal. Subsequently, a femoral hypoplasia unusual facies syndrome is also discussed. Targeted molecular tests and genetic counseling are required for supplementing ultrasound imaging in order to diagnose the correct skeletal disorders.

World Journal of Radiology, 2016

To show imaging results from application of four-dimensional (4D) ultrasound lightening technique... more To show imaging results from application of four-dimensional (4D) ultrasound lightening technique (HDlive™) in clinical obstetrics practice. Normal and abnormal fetuses at second and third trimester of pregnancy undergoing routine scan with 4D HDlive™ (5DUS) in the rendering mode are described. Realistic features of fetal structures were provided by 5DUS in the rendering mode. Normal anatomy as well as pathology like cleft lip, hypoplastic face, micrognathia, low-set ears, corpus callosum, arthrogryposis, aortic arch, left congenital diaphragmatic hernia are highlighted in this study. Anatomical details of the fetuses were provided by 5DUS with higher quality imaging modality compared to those obtained using conventional 2D/3D ultrasound. Realistic views of fetal anatomy details were displayed by means of 5DUS in the rendering mode, with high image quality obtained either in low-risk or in high-risk obstetrics population. Corpus callosum, esophagus, and aortic arch were obtained in normal fetuses. Cleft lip, cleft lip and palate, micrognathia, hypoplastic face, low-set ears, arthrogryposis, left congenital diaphragmatic hernia, exomphalos, and clitoris hypertrophy were clearly rendered by 5DUS application. The use of 5DUS in the rendering mode, when clinical available, was diagnostic in a variety of congenital anomalies, aided understanding of the parents-to-be and improved prenatal counseling and perinatal management.

Journal of the Turkish German Gynecological Association, 2016

Our objective was to describe early embryo/fetus anatomy and abnormalities provided by three and ... more Our objective was to describe early embryo/fetus anatomy and abnormalities provided by three and four-dimensional (3D/4D) ultrasound using HDlive rendering technology in the first trimester of pregnancy. Normal and pathologic embryonic and fetal volume data set with postprocessing using HDlive rendering mode. Virtual fetoscopic imaging of the normal and pathologic fetus even at early stage of development with increasing maternal-fetal bonding process. HDlive represents a novel and valuable lightening system for 3D/4D ultrasound application that may aid the prenatal interpretation of early congenital malformations although limitations and cautions are still needed for inclusion in obstetric clinical practice.

American Journal of Obstetrics and Gynecology, 2016

To describe seven cases of gastrointestinal tract (GIT) obstructions and to report a skewed revie... more To describe seven cases of gastrointestinal tract (GIT) obstructions and to report a skewed review of the literature. We performed a search of our permanent perinatal database about cases with prenatal ultrasound and MRI diagnosis of gastrointestinal tract obstructions between 2006 and 2013. All cases were followed until hospital discharge and prenatal diagnosis were confirmed by fetal MRI, postnatal imaging and/or intra-operative findings. Maternal age, parity, gestational age at diagnosis, ultrasound findings, gestational age at delivery, Apgar scores at 1 and 5 min, and postnatal outcome have been recorded. We identified seven cases of gastric and small bowel atresia. Karyotype was normal in six cases and abnormal in one co-twin [46,XY dup (20) (qq13.1q13.3)dn] of a dichorionic-diamniotic pregnancy. The mean ± SD for maternal age, gestational age at diagnosis, gestational at delivery, birth weight and Apgar scores at 1 and 5 min were 30.8 ± 4.8 years, 29.8 ± 3.7 weeks, 2507.5 ± 7...

The Journal of Maternal-Fetal & Neonatal Medicine, 2015

Prenatal Diagnosis, 2013

Objective To describe the application of a novel 3D ultrasound reconstructing technique (OMNIVIEW... more Objective To describe the application of a novel 3D ultrasound reconstructing technique (OMNIVIEW) that may facilitate the evaluation of cerebral midline structures at the second trimester anatomy scan.

Child's Nervous System, 2014

A rare immature teratoma of the tela chorioidea of the third ventricle: late onset, intrapartum d... more A rare immature teratoma of the tela chorioidea of the third ventricle: late onset, intrapartum diagnosis and postnatal outcome

Congenital Anomalies, 2014

The Majewski syndrome or short rib-polydactyly syndrome (SRPS) type II is a lethal skeletal dyspl... more The Majewski syndrome or short rib-polydactyly syndrome (SRPS) type II is a lethal skeletal dysplasia characterized by severe IUGR (intrauterine growth restriction) and dysmorphic face, polydactyly, relatively proportionate head size at birth with later progression to microcephaly. A case of second trimester ultrasound diagnosis of SRPS type II is reported with review of the medical record of previous observed cases. Postmortem examination and radiogram confirmed the clinical diagnosis. Histological examination of the femoral epypheseal chondral plate showed an expanded and irregular hypertrophic zone. Moreover, characteristic cortico-medullary cysts of both kidneys and portal fibrosis were also demonstrated; findings consistent with the broad phenotypic spectrum of this rare skeletal disease.