Gisou Mohades - Academia.edu (original) (raw)

Papers by Gisou Mohades

African Journal of Pharmacy and Pharmacology, Sep 30, 2009

... Proc Nat. Acad. Sci. USA. 91: 3954 3958. Moosavi M, Naghdi N, Maghsoudi N, Zahedi AS (2006).... more ... Proc Nat. Acad. Sci. USA. 91: 3954 3958. Moosavi M, Naghdi N, Maghsoudi N, Zahedi AS (2006). The effect of intrahippocampal insulin microinjection on spatial learning and memory. Horm Behav. 50: 748-752. Morris R (1981). ...

Neuroscience Letters, Aug 1, 2019

 Methamphetamine administration impaired spatial memory  Methamphetamine administration increas... more  Methamphetamine administration impaired spatial memory  Methamphetamine administration increased hippocampal neurons apoptosis  Ghrelin treatment improved spatial memory in methamphetamine-received animals  Ghrelin treatment decreased neuronal apoptosis induced by methamphetamin

European Journal of Pharmacology, 2014

Iranian Journal of Basic Medical Sciences, 2011

PubMed, 2023

Objectives: Apoptosis is common and often comorbid with aging and stress-related mood disorders. ... more Objectives: Apoptosis is common and often comorbid with aging and stress-related mood disorders. Evidence suggests that fresh mitochondria could reverse age-related dysfunctions in organs, especially in the brain. Therefore, this study investigated the effect of young mitochondria administration on the apoptosis process in the prefrontal cortex (PFC) of aged rats exposed to chronic stress. Materials and methods: Aged (22 months old) male rats were randomly assigned into four groups: aged control (AC), aged rats treated with young mitochondria (A+M), aged rats subjected to chronic stress for four weeks (A+St), and aged rats subjected to chronic stress and treated with young mitochondria (A+St+M). A+M and A+St+M groups received a single ICV injection (10 μl) of fresh mitochondria isolated from the brain of young rats for five minutes (2 µl/min). Finally, the levels of Malondialdehyde (MDA), Cytochrome c (Cyt c), Bax, Bcl-2, and Caspase-3 expression were investigated in the PFC. Results: Young mitochondria administration reduced neuronal apoptosis in the PFC, associated with down-regulation of MDA, Bax, and Caspase-3 and up-regulation of Bcl-2. Moreover, fresh mitochondria partially improved the chronic stress-induced mitochondrial dysfunction in aged rats, as indicated by reduced cytochrome c (Cyt c) release from the mitochondria. Conclusion: These results suggest mitotherapy could reverse cell viability and mitochondrial dysfunction-induced apoptosis in the PFC tissue of aged rats subjected to stressful stimuli.

Research Square (Research Square), Apr 4, 2023

Along with altering brain responses to stress, aging may also impair recovery from depression sym... more Along with altering brain responses to stress, aging may also impair recovery from depression symptoms. In the present study, we investigated depressive-like behaviors in young and aged rats and assayed the levels of microRNA-101 (miR-101), Rac1/RhoA, PSD-95, and GluR1 in the prefrontal cortex (PFC) after stress cessation and after a recovery period. Young (3 months old) and aged (22 months old) male Wistar rats were divided into six groups; Young control (YNG), young rats received chronic stress for four weeks (YNG+CS), young rats received chronic stress for four weeks followed by a 6-week recovery period (YNG+CS+REC), Aged control (AGED), aged rats received chronic stress for four weeks (AGED+CS), and aged rats received chronic stress for four weeks followed by a 6-week recovery period (AGED+CS+REC). Stress-induced depression, evaluated by the sucrose preference test (SPT) and forced swimming test (FST), was yet observed after the recovery period in aged but not in young rats, which were accompanied by unchanged levels of miR-101, Rac1/RhoA, GluR1, and PSD-95 in the PFC of aged rats. These data suggested that impaired synaptic plasticity of glutamatergic synapses via the miR-101/Rac1/RhoA pathway may contribute to the delayed behavioral recovery after stress exposure observed in aging animals.

Advanced Pharmaceutical Bulletin, 2013

Short Communication Effects of treadmill running on extracellular basal levels of glutamate and G... more Short Communication Effects of treadmill running on extracellular basal levels of glutamate and GABA at dentate gyrus of streptozotocin-induced diabetic rats

Acta Endocrinologica, 2017

Methods. Ninety Wistar male rats were used in this study. Type 1 diabetes was induced by i.p inje... more Methods. Ninety Wistar male rats were used in this study. Type 1 diabetes was induced by i.p injection of 50 mg/kg of streptozotocin in all animals. After 42 days of treatment with testosterone (2mg/kg/day) or voluntary exercise alone or in combination, the heart of the rats has been removed and MicroRNA was extracted from the heart using miRCURYTM RNA isolation kit. Results. Our results showed that either testosterone or exercise increased miRNA-126 expression levels in the heart of diabetic rats. Treatment of diabetic rats with testosterone and exercise at the same time had a synergistic effect on miRNA-126 levels in the heart. Furthermore, in castrated diabetes group, miRNA-126 levels were significantly decreased in heart, whereas either testosterone treatment or exercise training enhanced expression of this miRNA. Also, simultaneous treatment of castrated diabetic rats with testosterone and exercise had an additive effect on miRNA-126 expression levels. Conclusion. This study showed that testosterone and exercise promote an increase in the expression of miRNA-126 in the heart tissue and this may be related to cardiac angiogenesis. These results may indicate that testosterone and exercise can help to prevent progression of diabetic cardiomyopathy due to impaired angiogenesis in the heart.

Archives of Physiology and Biochemistry, Aug 16, 2021

Alcoholic liver disease (ALD) and non-alcoholic fatty liver disease (NAFLD) are common causes of ... more Alcoholic liver disease (ALD) and non-alcoholic fatty liver disease (NAFLD) are common causes of chronic liver disease that share the range of steatosis, steatohepatitis, fibrosis, cirrhosis, and finally, hepatocellular carcinoma. They are identified by the dysregulation of disease-specific signalling pathways and unique microRNAs. Capsaicin is an active ingredient of chilli pepper that acts as an agonist of transient receptor potential vanilloid subfamily 1. It seems that the protective role of capsaicin against NAFLD and ALD is linked to its anti-steatotic, antioxidant, anti-inflammatory, and anti-fibrotic effects. Capsaicin-induced inhibiting metabolic syndrome and gut dysbiosis and increasing bile acids production are also involved in its anti-NAFLD role. This review summarises the different molecular mechanisms underlying the protective role of capsaicin against NAFLD and ALD. More experimental studies are needed to clarify the effects of capsaicin on the expression of genes involved in hepatic lipid metabolism and hepatocytes apoptosis in NAFLD and ALD.

Prenatal exposure to stress predisposes offspring to mental health problems in adulthood. However... more Prenatal exposure to stress predisposes offspring to mental health problems in adulthood. However, the underlying mechanisms remain obscure. The prefrontal cortex's (PFC) role is vital in regulating sleep and mood. Cryptochrome type 2 (CRY2), as a magnetoreceptor and an important part of the circadian system, has been linked to depression and anxiety. We aimed to determine CRY2 role in prenatal stress and extremely low-frequency electromagnetic fields (ELF-EMF) on the PFC of rat offspring and its relationship with behavior. Female Wistar rats were exposed to chronic mild stress (CMS) or electromagnetic field (EMF) (50 Hz, 100 μT, 4 h/day) for 21 days before and during pregnancy. Behavioral tests, including the elevated plus maze, open field, and forced swimming test, were conducted on the male offspring at postnatal day (PND) 80, 81, 90. The expressionof CRY2 in the PFC and levels of serum corticosterone (CORT) were also measured. The results showed that maternal stress exposure...

Neuroscience Letters, 2012

Iranian Journal of Medical Physics, 2018

Introduction: Depression is a common psychiatric disorder and about one in five people experience... more Introduction: Depression is a common psychiatric disorder and about one in five people experience depression during their lifespan. Despite the anti-depressive effects of drug therapy, problems such as non-targeting and dose-resistant lead to more effective approaches. Transcranial Photobiomodulation (TPBM) or transcranial low-level laser (TLLL) therapy is a novel and neuroprotective approach which its therapeutic potential has been experimentally examined for central nervous system disorders such as stroke, traumatic brain injury, Alzheimer disease, and Parkinson disease. In this safe and non-heating approach, the damaged and troubled brain areas are irradiated transcranially by near- infrared (NIR) and red (600-1100 nm) low power (less than 500 mW) diode lasers, lasers, and light emitting diodes. The functional mechanism in this approach is that NIR and red photons are absorbed by photo-receptors such as cytochrome c oxidase (COX) and then a number of biological processes includin...

Iranian Journal of Basic Medical Sciences, 2018

Objective(s): Maternal high-fat diet (HFD) is linked with metabolic and cognitive deficits in off... more Objective(s): Maternal high-fat diet (HFD) is linked with metabolic and cognitive deficits in offspring. Neuroprotective effects of troxerutin, a natural bioflavonoid, have been reported recently. This study aimed to investigate the effects of troxerutin on spatial memory and serum and hippocampal apelin levels in the male offspring of HFD fed mothers. Materials and Methods: Three-week-old female Wistar rats (n= 40) received HFD or control diet (CD) for 8 weeks. After mating, pregnant animals were divided into two subgroups according to the troxerutin (TRO) supplementation: CD, CD+TRO, HFD, and HFD+TRO. HFD continued to the end of lactation in HFD and HFD+TRO groups. TRO was gavaged (150 mg/kg/day) during pregnancy. After weaning, the male offspring were fed a normal diet until 12 weeks of age. Spatial memory was evaluated in the Morris water maze (MWM) on postnatal day (PND) 90. Total apelin concentration was measured in the serum of maternal rats before mating and after lactation ...

Neurochemical Research, 2021

Pathophysiology of depression in elderlies is linked to aging-associated increase in indoleamine ... more Pathophysiology of depression in elderlies is linked to aging-associated increase in indoleamine 2,3-dioxygenase (IDO) levels and activity and kynurenine (Kyn) metabolites. Moreover, these aging-induced changes may alter the brain’s responses to stress. Growing evidence suggested that young plasma can positively affect brain dysfunctions in old age. The present study aimed to investigate whether the antidepressant effects of young plasma administration in aged rats subjected to chronic unpredictable mild stress (CUMS) and underlying mechanisms, focusing on the prefrontal cortex (PFC). Young (3 months old) and aged (22 months old) male rats were divided into five groups; young control, aged control, aged rats subjected to CUMS (A + CUMS), aged rats subjected to CUMS and treated with young plasma (A + CUMS + YP), and aged rats subjected to CUMS and treated with old plasma (A + CUMS + OP). Plasma was injected (1 ml, intravenously) three times per week for four weeks. Young plasma significantly improved CUMS-induced depressive-like behaviors, evidenced by the increased sucrose consumption ratio in the sucrose preference test and the reduced immobility time in the forced swimming test. Furthermore, young plasma markedly reduced the levels of interferon-gamma (IFN-γ), IDO, Kyn, and Kyn to tryptophan (Kyn/Trp) ratio in PFC tissue. Expression levels of the serotonin transporter and growth-associated protein (GAP)-43 were also significantly increased after chronic administration of young plasma. These findings provide evidence for the antidepressant effect of young plasma in old age; however, whether it improves depressive behaviors or faster recovery from stress-induced deficits is required to be elucidated.

Journal of Diabetes & Metabolic Disorders, 2020

Purpose The purpose of the study was to evaluate the possible protective effects of low dose sodi... more Purpose The purpose of the study was to evaluate the possible protective effects of low dose sodium nitrate preconditioning on the peripheral neuropathy in streptozotocin (STZ)-induced diabetic model. Methods Male Wistar rats were randomly divided into five groups: control (no intervention), control treated sodium nitrate (100 mg/L in drinking water), diabetic (no intervention), diabetic treated NPH insulin (2-4 U), and diabetic treated sodium nitrate (100 mg/L in drinking water). Diabetes was induced by intraperitoneal injection of STZ (60 mg/kg). All interventions were done for 60 days immediately following diabetes confirmation. Thermal and mechanical algesia thresholds were measured by means of hot-plate test, von Frey test, and tail-withdrawal test before the diabetic induction and after diabetes confirmation. At the end of the experiment, serum NOx level and serum insulin level were assessed. Blood glucose concentration and body weight have recorded at the base and duration of the experiment. Results Both hypoalgesia, hyperalgesia along with allodynia developed in diabetic rats. Significant alterations including, decrease in tail withdrawal latency (30th day), decreased mechanical threshold (60th day), and an increase in hot plate latency (61st day) were displayed in diabetic rats compared to control rats. Nitrate and insulin preconditioning produced protective effects against diabetesinduced peripheral neuropathy. Data analysis also showed a significant increase in glucose level as well as a considerable reduction in serum insulin and body weight of diabetic rats, which restored by both insulin and nitrate preconditioning. Conclusion Sodium nitrate preconditioning produces a protective effect in diabetic neuropathy, which may be mediated by its antihyperglycemic effects and increased serum insulin level.

Brain Research Bulletin, 2019

This is a PDF file of an article that has undergone enhancements after acceptance, such as the ad... more This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.