Gladys Queiroz - Academia.edu (original) (raw)

Papers by Gladys Queiroz

Journal of Allergy and Clinical Immunology, 2019

RATIONALE: Drug hypersensitivity reactions (DHR) affect about 7% of the general population; they ... more RATIONALE: Drug hypersensitivity reactions (DHR) affect about 7% of the general population; they may be unpredictable and represent a lifethreatening risk. The study aimed to analyze the clinical profile and possible differences between children and adults that presented a DHR. METHODS: Retrospective data analysis of patients evaluated in 10 specialized centers in Brazil, from March 2016 to June 2018. Cases with probable or confirmed diagnosis were included. Children (less than 18 years old) and adults were compared according to clinical and epidemiological data, and a 5% level of significance was established (p<0,05). RESULTS: Eighty-one percent of patients (262/321) had a probable or confirmed diagnosis of DHR. Female gender was predominant in adults (83%) and children (55%). Immediate reactions were more frequent in adults (68%) than in children (48%), where non-immediate reactions were prevailing (52%). Fever and/or infectious diseases were observed in 59% of children with DHR, compared to 12% of adults. NSAIDs were reported as the culprit drug in 74% of adults and 53% of children. On the other hand, antibiotics were involved in 46% of the reactions in children, but just in 12% of adults. There were no significant differences between groups regarding clinical presentation, severity of symptoms, personal history of atopy or family history of DHR. CONCLUSIONS: The DHR profile in adults and children differs in time to reaction, presence of related co-factors and drugs involved. These differences may represent essential tools to help the diagnosis and management of DHR in clinical practice.

Clinical and Translational Allergy, 2014

Background Drug hypersensitivity is one of the most frequent reasons for consultations with an al... more Background Drug hypersensitivity is one of the most frequent reasons for consultations with an allergist in Brazil. However, drug hypersensitivity epidemiology data in children is scarce. The aim of this study was to investigate children reporting suspected drug hypersensitivity reaction (DHR).

Arquivos de Asmas Alergia e Imunologia, 2021

Rev Cir Traumatol Buco Maxilo Fac, Dec 1, 2008

Introdução: O sistema imunológico engloba uma série de elementos celulares e humorais cuja função... more Introdução: O sistema imunológico engloba uma série de elementos celulares e humorais cuja função é a de proteger o organismo contra agentes agressores. Porém, pode responder de modo inadequado e causar reações de hipersensibilidade ou reações alérgicas. Dentre as várias substâncias que causam essas reações, destacam-se os anestésicos locais. A alergia aos anestésicos locais foi considerada durante muito tempo, uma reação pseudo-alérgica, mas se sabe atualmente que eles podem causar reações do tipo anafilática ou do tipo de hipersensibilidade retardada 2,8 . Os anestésicos locais são muito utilizados, e as reações alérgicas que eles desencadeiam podem ser muito graves, embora pouco freqüentes. Objetivos: Realizar revisão não-sistemática da literatura, visando atualizar profissionais que fazem uso destas medicações sobre o mecanismo de ação destas drogas, a maneira como elas desencadeiam as reações alérgicas, como se faz o diagnóstico das alergias, como se faz o manejo nos casos de reações e qual o papel do alergologista nestes casos. Metodologia: A fonte de dados foram artigos originais e revisões, publicados no período de 1994 a 2008 e indexados no MEDLINE e

Jornal brasileiro de pneumologia : publicaça̋o oficial da Sociedade Brasileira de Pneumologia e Tisilogia

To determine whether the children and adolescents with acute asthma attacks admitted to two publi... more To determine whether the children and adolescents with acute asthma attacks admitted to two public hospitals in the city of Recife, Brazil underwent outpatient follow-up treatment for the prevention and control of asthma. A prospective case series study of hospitalized patients with asthma. The patients were asked to complete a questionnaire at admission in order to determine the frequency of prophylactic outpatient follow-up treatment. Patients presenting two or more attacks of asthma that were responsive to bronchodilators were classified as having asthma. In the intervals between asthma attacks, 67% (112/167--data regarding 2 patients were not available) of the patients had been treated only in the emergency room. Although 53.3%(89/167--data regarding 2 patients were not provided) of the patients had been referred to outpatient treatment, only 16% (27/169) had visited an outpatient asthma clinic regularly for preventive treatment, and only 13% (22/169) had used prophylactic medic...

Jornal Brasileiro de Pneumologia, 2007

Clinical and Translational Allergy, 2014

Journal of Allergy and Clinical Immunology, 2019

RATIONALE: Drug hypersensitivity reactions (DHR) affect about 7% of the general population; they ... more RATIONALE: Drug hypersensitivity reactions (DHR) affect about 7% of the general population; they may be unpredictable and represent a lifethreatening risk. The study aimed to analyze the clinical profile and possible differences between children and adults that presented a DHR. METHODS: Retrospective data analysis of patients evaluated in 10 specialized centers in Brazil, from March 2016 to June 2018. Cases with probable or confirmed diagnosis were included. Children (less than 18 years old) and adults were compared according to clinical and epidemiological data, and a 5% level of significance was established (p<0,05). RESULTS: Eighty-one percent of patients (262/321) had a probable or confirmed diagnosis of DHR. Female gender was predominant in adults (83%) and children (55%). Immediate reactions were more frequent in adults (68%) than in children (48%), where non-immediate reactions were prevailing (52%). Fever and/or infectious diseases were observed in 59% of children with DHR, compared to 12% of adults. NSAIDs were reported as the culprit drug in 74% of adults and 53% of children. On the other hand, antibiotics were involved in 46% of the reactions in children, but just in 12% of adults. There were no significant differences between groups regarding clinical presentation, severity of symptoms, personal history of atopy or family history of DHR. CONCLUSIONS: The DHR profile in adults and children differs in time to reaction, presence of related co-factors and drugs involved. These differences may represent essential tools to help the diagnosis and management of DHR in clinical practice.

Clinical and Translational Allergy, 2014

Background Drug hypersensitivity is one of the most frequent reasons for consultations with an al... more Background Drug hypersensitivity is one of the most frequent reasons for consultations with an allergist in Brazil. However, drug hypersensitivity epidemiology data in children is scarce. The aim of this study was to investigate children reporting suspected drug hypersensitivity reaction (DHR).

Arquivos de Asmas Alergia e Imunologia, 2021

Rev Cir Traumatol Buco Maxilo Fac, Dec 1, 2008

Introdução: O sistema imunológico engloba uma série de elementos celulares e humorais cuja função... more Introdução: O sistema imunológico engloba uma série de elementos celulares e humorais cuja função é a de proteger o organismo contra agentes agressores. Porém, pode responder de modo inadequado e causar reações de hipersensibilidade ou reações alérgicas. Dentre as várias substâncias que causam essas reações, destacam-se os anestésicos locais. A alergia aos anestésicos locais foi considerada durante muito tempo, uma reação pseudo-alérgica, mas se sabe atualmente que eles podem causar reações do tipo anafilática ou do tipo de hipersensibilidade retardada 2,8 . Os anestésicos locais são muito utilizados, e as reações alérgicas que eles desencadeiam podem ser muito graves, embora pouco freqüentes. Objetivos: Realizar revisão não-sistemática da literatura, visando atualizar profissionais que fazem uso destas medicações sobre o mecanismo de ação destas drogas, a maneira como elas desencadeiam as reações alérgicas, como se faz o diagnóstico das alergias, como se faz o manejo nos casos de reações e qual o papel do alergologista nestes casos. Metodologia: A fonte de dados foram artigos originais e revisões, publicados no período de 1994 a 2008 e indexados no MEDLINE e

Jornal brasileiro de pneumologia : publicaça̋o oficial da Sociedade Brasileira de Pneumologia e Tisilogia

To determine whether the children and adolescents with acute asthma attacks admitted to two publi... more To determine whether the children and adolescents with acute asthma attacks admitted to two public hospitals in the city of Recife, Brazil underwent outpatient follow-up treatment for the prevention and control of asthma. A prospective case series study of hospitalized patients with asthma. The patients were asked to complete a questionnaire at admission in order to determine the frequency of prophylactic outpatient follow-up treatment. Patients presenting two or more attacks of asthma that were responsive to bronchodilators were classified as having asthma. In the intervals between asthma attacks, 67% (112/167--data regarding 2 patients were not available) of the patients had been treated only in the emergency room. Although 53.3%(89/167--data regarding 2 patients were not provided) of the patients had been referred to outpatient treatment, only 16% (27/169) had visited an outpatient asthma clinic regularly for preventive treatment, and only 13% (22/169) had used prophylactic medic...

Jornal Brasileiro de Pneumologia, 2007

Clinical and Translational Allergy, 2014