Gonzalo Zuñiga - Academia.edu (original) (raw)
Papers by Gonzalo Zuñiga
Boletín de la Real Sociedad Bascongada de Amigos del País, 1962
Revista Medica De Chile, Aug 1, 2008
Niccolo Paganini is the most virtuous violinist of the history of music. He even received the nic... more Niccolo Paganini is the most virtuous violinist of the history of music. He even received the nick name of "the violinist of the evil" for his outstanding skills on stage performance. It has been suggested that he had syphilis and tuberculosis, the commonest diseases of that time, but this hypothesis remains speculative. There are suggestions that he was the victim of iatrogenic mercurial poisoning. Furthermore, his body build suggests the presence of Ehlers-Danlos syndrome which could give him special anatomical conditions allowing him to achieve an amazing level of vírtuousness in his art. We herein review the medical aspects of this brilliant musician's life.
Pleyade, 2013
Latina, con énfasis principal en el caso chileno. En la primera parte, se hace un recorrido por l... more Latina, con énfasis principal en el caso chileno. En la primera parte, se hace un recorrido por la trayectoria académica del profesor Steve J. Stern y su vínculo con la historia latinoamericana. En la segunda, se trabaja el concepto de memoria y se analizan sus implicancias para el estudio de la política chilena y, en la tercera, se proponen desafíos para el contexto actual y se analiza el modo en que la memoria cumple un rol necesario para comprender nuestro pasado reciente. Palabras clave: memoria, América Latina, historia política, derechos humanos, Chile. * Agradecemos profundamente la disposición del profesor a realizar esta entrevista, así como al Museo de la Memoria y Derechos Humanos que nos contactó con él en septiembre de 2011. Steve J. Stern es profesor en la University of Wisconsin-Madison, Estados Unidos y miembro del Comité Asesor Internacional de Revista Pléyade. Reconocido por sus trabajos sobre memoria en América Latina, ha trabajado el caso de la dictadura en Chile cercanamente, siendo reconocido como uno de sus exponentes principales a nivel mundial. Entre sus últimas publicaciones, se
Bol Hosp San Juan De Dios, Apr 1, 1994
Neurology, 1992
We present the hemodynamic and autonomic features of recurrent purely vasodepressor syncope episo... more We present the hemodynamic and autonomic features of recurrent purely vasodepressor syncope episodes in a patient with left-sided malignant cervical adenopathy involving the carotid sinus. Extreme hypotension lasting 10 to 30 minutes, without change in heart rate, occurred spontaneously and 20 seconds after head-turning. The baseline respiratory sinus arrhythmia, heart rate response to standing and Valsalva's maneuver, and cold-induced blood pressure elevation were normal, indicating normal baroreceptor function between episodes. The episodes abated after 1 week of bedrest but reappeared within 1 day of discharge from the hospital. Syncope no longer occurred after intracranial section of the left glossopharyngeal nerve and upper rootlets of the left vagus. Autonomic testing remained normal postoperatively. A review of the literature indicates that purely vasodepressor syncope has been more common with left carotid sinus lesions.
Revista médica de Chile, 2008
is the most virtuos violinist of the history of music. He even received the nick name of ˝the vio... more is the most virtuos violinist of the history of music. He even received the nick name of ˝the violinist of the evil˝ for his outstanding skills on stage performance. It has been suggested that he had syphilis and tuberculosis, the commonest diseases of that time, but this hypothesis remains speculative. There are suggestions that he was the victim of iatrogenic mercurial poisoning. Furthermore, his body build suggests the presence of Ehlers-Danlos syndrome which could give him special anatomical conditions allowing him to achieve an amazing level of virtuousness in his art. We herein review the medical aspects of this brilliant musician's life (Rev Méd Chile 2008; 136: 930-6).
acnweb.org
... J Urol 1980; 124: 259-262. - Borg-Stein J, Pine Z, Miller J, Brin M. Botulinum toxin for the ... more ... J Urol 1980; 124: 259-262. - Borg-Stein J, Pine Z, Miller J, Brin M. Botulinum toxin for the treatment of spasticity in multiple sclerosis: new observations. ... Isr J Med Sci 1989; 25: 720 - 721. - Kirkeby H, Poulsen E, Petersen T, Dorup J. Erectile dysfunction in multiple sclerosis. ...
Pediatric Neurology, 1992
Magnetic resonance imaging (MRI), pathologic examinations, and biochemical analyses were performe... more Magnetic resonance imaging (MRI), pathologic examinations, and biochemical analyses were performed on 2 different canine mutants with GM1 gangliosidosis (i.e., English Springer Spaniel and Portuguese Water Dog) and on age- and sex-matched controls. Serial MRI studies were also performed on a child with infantile-onset GM1 gangliosidosis. The affected dogs had abnormalities on MRI, including a relative increase in gray matter and an abnormal signal intensity of cerebral and cerebellar white matter observed on T2-weighted MRI. White matter changes on MRI were similar to white matter abnormalities observed in a 15-month-old boy with GM1 gangliosidosis. The weight ratio of white to gray matter from the frontal lobe was markedly reduced. Microscopic examination revealed characteristic ballooned neurons which stained lightly with Luxol-fast blue. The central cerebral and cerebellar folia white matter exhibited pallor and gliosis, while the corpus callosum and fornix stained normally with Luxol-fast blue. Axons appeared intact on Bodian staining. Ultrastructural studies revealed fewer myelinated axons in affected puppies. Total gangliosides in gray matter were elevated. Thin-layer chromatography demonstrated GM1 ganglioside as the predominant ganglioside. The amount of cerebrosides and sulfatides was reduced in the gray and white matter when compared to controls but the ratio in gray and white matter remained unchanged. Immunostaining of neutral glycolipids disclosed increased amounts of stage-specific embryonic antigen-1 glycolipid in gray matter. These findings suggest that canine models for GM1 gangliosidosis are associated with abnormal myelin development which may be similar to the human disease.
Neurology, 1991
We studied 10 patients with sarcoidosis and peripheral neuropathy. Six had a subacute or chronic ... more We studied 10 patients with sarcoidosis and peripheral neuropathy. Six had a subacute or chronic axonal sensorimotor neuropathy without cranial neuropathy, beginning months to years after established systemic sarcoidosis. One patient had severe enough diaphragmatic weakness to require mechanical ventilation. Four patients had atypical neuropathies: acute Guillain-Barré syndrome, mononeuritis multiplex, unilateral lumbosacral plexopathy, and a purely sensory neuropathy, all before systemic sarcoidosis became evident, and all except one had cranial nerve abnormalities. Autopsy in one patient with sensorimotor neuropathy showed only scattered foci of lymphocytes in spinal roots and ganglia with nerve fiber loss.
Journal of Neurochemistry, 1991
Myelin proteolipid protein (PLP) is an acylated protein which contains approximately 2 mol of est... more Myelin proteolipid protein (PLP) is an acylated protein which contains approximately 2 mol of ester-bound fatty acids. In this study, the amount and composition of fatty acids covalently bound to human myelin PLP were determined during development and in peroxisomal disorders. Palmitic, oleic, and stearic acids accounted for most of the PLP acyl chains. However, in contrast to PLP in other species, human PLP contains relatively more very long chain fatty acids (VLCFA). The fatty acid composition remained essentially unchanged between 1 day and 74 years of age. The total amount of fatty acid bound to PLP was not altered in any of the pathological cases examined. However, in the peroxi-soma1 disorder adrenoleukodystrophy, the proportions of saturated and, to a lesser extent, monounsaturated VLCFA bound to PLP were increased at the expense of oleic acid. Smaller, but significant, changes were observed in adrenomyeloneuropathy. The reduction in the levels of oleic acid
Acta Neurol Colomb, 2004
Introducción. La epilepsia debida a calcificaciones cerebrales puede considerarse como un modelo ... more Introducción. La epilepsia debida a calcificaciones cerebrales puede considerarse como un modelo humano de epilepsia. Las calcificaciones cerebrales son una causa frecuente de epilepsia en los países en desarrollo. ... Objetivo. Establecer una correlación entre las ...
Archives of Neurology, 1992
We studied the effects of acute intracranial lesions on the respiratory sinus arrhythmia (RSA) wi... more We studied the effects of acute intracranial lesions on the respiratory sinus arrhythmia (RSA) with the use of computerized measurements of the ratio of expiratory to inspiratory R-R intervals. The RSA was reduced below the 95th percentile for age in 20 of 27 patients, an average of 2 days after an acute event. Only four patients, without neurological deficits, had a normal RSA. Two patients, with signs of secondary brain-stem compression from a mass, had an increased RSA, without the bradycardia that is usually associated with Cushing's response. Twenty-three patients had their respiratory rate controlled by positive pressure ventilation during testing, and our preliminary findings suggested that this was not responsible for reducing the RSA. Acute intracranial lesions caused a diminished RSA, perhaps by reducing supratentorial influences on vagal cardioinhibitory activity. In contrast, once signs of secondary brain-stem compression occur, the RSA is greatly increased while the heart rate remains unchanged, offering a possible method of noninvasive monitoring for this complication.
Acta neurol. …, 2004
Base de dados : LILACS. Pesquisa : 424703 [Identificador único]. Referências encontradas : 1 [ref... more Base de dados : LILACS. Pesquisa : 424703 [Identificador único]. Referências encontradas : 1 [refinar]. Mostrando: 1 .. 1 no formato [Detalhado]. página 1 de 1, 1 / 1, LILACS, seleciona. para imprimir. Fotocópia. experimental, Documentos relacionados. Id: 424703. ...
Acta Neurol Colomb, Jun 1, 2000
Boletín de la Real Sociedad Bascongada de Amigos del País, 1962
Revista Medica De Chile, Aug 1, 2008
Niccolo Paganini is the most virtuous violinist of the history of music. He even received the nic... more Niccolo Paganini is the most virtuous violinist of the history of music. He even received the nick name of "the violinist of the evil" for his outstanding skills on stage performance. It has been suggested that he had syphilis and tuberculosis, the commonest diseases of that time, but this hypothesis remains speculative. There are suggestions that he was the victim of iatrogenic mercurial poisoning. Furthermore, his body build suggests the presence of Ehlers-Danlos syndrome which could give him special anatomical conditions allowing him to achieve an amazing level of vírtuousness in his art. We herein review the medical aspects of this brilliant musician's life.
Pleyade, 2013
Latina, con énfasis principal en el caso chileno. En la primera parte, se hace un recorrido por l... more Latina, con énfasis principal en el caso chileno. En la primera parte, se hace un recorrido por la trayectoria académica del profesor Steve J. Stern y su vínculo con la historia latinoamericana. En la segunda, se trabaja el concepto de memoria y se analizan sus implicancias para el estudio de la política chilena y, en la tercera, se proponen desafíos para el contexto actual y se analiza el modo en que la memoria cumple un rol necesario para comprender nuestro pasado reciente. Palabras clave: memoria, América Latina, historia política, derechos humanos, Chile. * Agradecemos profundamente la disposición del profesor a realizar esta entrevista, así como al Museo de la Memoria y Derechos Humanos que nos contactó con él en septiembre de 2011. Steve J. Stern es profesor en la University of Wisconsin-Madison, Estados Unidos y miembro del Comité Asesor Internacional de Revista Pléyade. Reconocido por sus trabajos sobre memoria en América Latina, ha trabajado el caso de la dictadura en Chile cercanamente, siendo reconocido como uno de sus exponentes principales a nivel mundial. Entre sus últimas publicaciones, se
Bol Hosp San Juan De Dios, Apr 1, 1994
Neurology, 1992
We present the hemodynamic and autonomic features of recurrent purely vasodepressor syncope episo... more We present the hemodynamic and autonomic features of recurrent purely vasodepressor syncope episodes in a patient with left-sided malignant cervical adenopathy involving the carotid sinus. Extreme hypotension lasting 10 to 30 minutes, without change in heart rate, occurred spontaneously and 20 seconds after head-turning. The baseline respiratory sinus arrhythmia, heart rate response to standing and Valsalva's maneuver, and cold-induced blood pressure elevation were normal, indicating normal baroreceptor function between episodes. The episodes abated after 1 week of bedrest but reappeared within 1 day of discharge from the hospital. Syncope no longer occurred after intracranial section of the left glossopharyngeal nerve and upper rootlets of the left vagus. Autonomic testing remained normal postoperatively. A review of the literature indicates that purely vasodepressor syncope has been more common with left carotid sinus lesions.
Revista médica de Chile, 2008
is the most virtuos violinist of the history of music. He even received the nick name of ˝the vio... more is the most virtuos violinist of the history of music. He even received the nick name of ˝the violinist of the evil˝ for his outstanding skills on stage performance. It has been suggested that he had syphilis and tuberculosis, the commonest diseases of that time, but this hypothesis remains speculative. There are suggestions that he was the victim of iatrogenic mercurial poisoning. Furthermore, his body build suggests the presence of Ehlers-Danlos syndrome which could give him special anatomical conditions allowing him to achieve an amazing level of virtuousness in his art. We herein review the medical aspects of this brilliant musician's life (Rev Méd Chile 2008; 136: 930-6).
acnweb.org
... J Urol 1980; 124: 259-262. - Borg-Stein J, Pine Z, Miller J, Brin M. Botulinum toxin for the ... more ... J Urol 1980; 124: 259-262. - Borg-Stein J, Pine Z, Miller J, Brin M. Botulinum toxin for the treatment of spasticity in multiple sclerosis: new observations. ... Isr J Med Sci 1989; 25: 720 - 721. - Kirkeby H, Poulsen E, Petersen T, Dorup J. Erectile dysfunction in multiple sclerosis. ...
Pediatric Neurology, 1992
Magnetic resonance imaging (MRI), pathologic examinations, and biochemical analyses were performe... more Magnetic resonance imaging (MRI), pathologic examinations, and biochemical analyses were performed on 2 different canine mutants with GM1 gangliosidosis (i.e., English Springer Spaniel and Portuguese Water Dog) and on age- and sex-matched controls. Serial MRI studies were also performed on a child with infantile-onset GM1 gangliosidosis. The affected dogs had abnormalities on MRI, including a relative increase in gray matter and an abnormal signal intensity of cerebral and cerebellar white matter observed on T2-weighted MRI. White matter changes on MRI were similar to white matter abnormalities observed in a 15-month-old boy with GM1 gangliosidosis. The weight ratio of white to gray matter from the frontal lobe was markedly reduced. Microscopic examination revealed characteristic ballooned neurons which stained lightly with Luxol-fast blue. The central cerebral and cerebellar folia white matter exhibited pallor and gliosis, while the corpus callosum and fornix stained normally with Luxol-fast blue. Axons appeared intact on Bodian staining. Ultrastructural studies revealed fewer myelinated axons in affected puppies. Total gangliosides in gray matter were elevated. Thin-layer chromatography demonstrated GM1 ganglioside as the predominant ganglioside. The amount of cerebrosides and sulfatides was reduced in the gray and white matter when compared to controls but the ratio in gray and white matter remained unchanged. Immunostaining of neutral glycolipids disclosed increased amounts of stage-specific embryonic antigen-1 glycolipid in gray matter. These findings suggest that canine models for GM1 gangliosidosis are associated with abnormal myelin development which may be similar to the human disease.
Neurology, 1991
We studied 10 patients with sarcoidosis and peripheral neuropathy. Six had a subacute or chronic ... more We studied 10 patients with sarcoidosis and peripheral neuropathy. Six had a subacute or chronic axonal sensorimotor neuropathy without cranial neuropathy, beginning months to years after established systemic sarcoidosis. One patient had severe enough diaphragmatic weakness to require mechanical ventilation. Four patients had atypical neuropathies: acute Guillain-Barré syndrome, mononeuritis multiplex, unilateral lumbosacral plexopathy, and a purely sensory neuropathy, all before systemic sarcoidosis became evident, and all except one had cranial nerve abnormalities. Autopsy in one patient with sensorimotor neuropathy showed only scattered foci of lymphocytes in spinal roots and ganglia with nerve fiber loss.
Journal of Neurochemistry, 1991
Myelin proteolipid protein (PLP) is an acylated protein which contains approximately 2 mol of est... more Myelin proteolipid protein (PLP) is an acylated protein which contains approximately 2 mol of ester-bound fatty acids. In this study, the amount and composition of fatty acids covalently bound to human myelin PLP were determined during development and in peroxisomal disorders. Palmitic, oleic, and stearic acids accounted for most of the PLP acyl chains. However, in contrast to PLP in other species, human PLP contains relatively more very long chain fatty acids (VLCFA). The fatty acid composition remained essentially unchanged between 1 day and 74 years of age. The total amount of fatty acid bound to PLP was not altered in any of the pathological cases examined. However, in the peroxi-soma1 disorder adrenoleukodystrophy, the proportions of saturated and, to a lesser extent, monounsaturated VLCFA bound to PLP were increased at the expense of oleic acid. Smaller, but significant, changes were observed in adrenomyeloneuropathy. The reduction in the levels of oleic acid
Acta Neurol Colomb, 2004
Introducción. La epilepsia debida a calcificaciones cerebrales puede considerarse como un modelo ... more Introducción. La epilepsia debida a calcificaciones cerebrales puede considerarse como un modelo humano de epilepsia. Las calcificaciones cerebrales son una causa frecuente de epilepsia en los países en desarrollo. ... Objetivo. Establecer una correlación entre las ...
Archives of Neurology, 1992
We studied the effects of acute intracranial lesions on the respiratory sinus arrhythmia (RSA) wi... more We studied the effects of acute intracranial lesions on the respiratory sinus arrhythmia (RSA) with the use of computerized measurements of the ratio of expiratory to inspiratory R-R intervals. The RSA was reduced below the 95th percentile for age in 20 of 27 patients, an average of 2 days after an acute event. Only four patients, without neurological deficits, had a normal RSA. Two patients, with signs of secondary brain-stem compression from a mass, had an increased RSA, without the bradycardia that is usually associated with Cushing's response. Twenty-three patients had their respiratory rate controlled by positive pressure ventilation during testing, and our preliminary findings suggested that this was not responsible for reducing the RSA. Acute intracranial lesions caused a diminished RSA, perhaps by reducing supratentorial influences on vagal cardioinhibitory activity. In contrast, once signs of secondary brain-stem compression occur, the RSA is greatly increased while the heart rate remains unchanged, offering a possible method of noninvasive monitoring for this complication.
Acta neurol. …, 2004
Base de dados : LILACS. Pesquisa : 424703 [Identificador único]. Referências encontradas : 1 [ref... more Base de dados : LILACS. Pesquisa : 424703 [Identificador único]. Referências encontradas : 1 [refinar]. Mostrando: 1 .. 1 no formato [Detalhado]. página 1 de 1, 1 / 1, LILACS, seleciona. para imprimir. Fotocópia. experimental, Documentos relacionados. Id: 424703. ...
Acta Neurol Colomb, Jun 1, 2000