Gordan Tometić - Academia.edu (original) (raw)

Papers by Gordan Tometić

Libri Oncologici : Croatian Journal of Oncology, Dec 28, 2016

Segmentectomy and sentinel lymph node biopsy is a golden standard for early breast cancer (clinic... more Segmentectomy and sentinel lymph node biopsy is a golden standard for early breast cancer (clinical and radiological cT1-2, c N0). Recently, superparamagnetic iron oxide (SPIO) nanoparticle tracer has been introduced enabling intraoperative tracer injection. We prospectively recorded data on tumor histology, marked lymph nodes and their fi nal histology and patient characteristics for early breast cancer patients who underwent breast conservative surgery. At 128 female breast cancer patients underwent sentinel lymph node biopsy by SentiMag. Three patients were excluded from further analysis because the postoperative pathology report was ductal carcinoma in situ (DCIS). The identifi cation rate was 95.2 % (119 of 125). Of the 19.2 % (24 of 125) patients with lymph node involvement, 1.6% (2 of 125) had micrometastasis, and 1 % (1 of 125) had single tumor cells within the sentinel, l at least a micrometastasis. Of 30 positive lymph nodes removed, 24 (80 %) were true sentinel nodes. The average lymph node retrieval rate was 2.3 nodes per patient. SentiMag's performance was comparable to published data and to standard sentinel with blue patent die and/or technetium. The benefi t of easier application and logistics is a great advantage.

Segmentectomy and sentinel lymph node biopsy is a golden standard for early breast cancer (clinic... more Segmentectomy and sentinel lymph node biopsy is a golden standard for early breast cancer (clinical and radiological cT1-2, c N0). Recently, superparamagnetic iron oxide (SPIO) nanoparticle tracer has been introduced enabling intraoperative tracer injection. We prospectively recorded data on tumor histology, marked lymph nodes and their final histology and patient characteristics for early breast cancer patients who underwent breast conservative surgery. At 128 female breast cancer patients underwent sentinel lymph node biopsy by SentiMag. Three patients were excluded from further analysis because the postoperative pathology report was ductal carcinoma in situ (DCIS). The identifi cation rate was 95.2 % (119 of 125). Of the 19.2 % (24 of 125) patients with lymph node involvement, 1.6% (2 of 125) had micrometastasis, and 1 % (1 of 125) had single tumor cells within the sentinel, l at least a micrometastasis. Of 30 positive lymph nodes removed, 24 (80 %) were true sentinel nodes. The ...

Approximately 50% of patients with colorectal cancer (CRC) will developduring their lifespan. Maj... more Approximately 50% of patients with colorectal cancer (CRC) will developduring their lifespan. Majority of colorectal liver metastases (CLM) patients will be unresectable at the time of diagnosis due to extensive intrahepatic and/or extrahepatic disease. R0 liver resection is still the only available treatment that allows long-term survival. In last two decades, the 5-year overall survival (OS) after curative liver resection of CLM has increased up to 58%. These improved outcomes are mainly due to multidisciplinary treatment of these patients. The definition of resectability has changed, so nowdays, the goal is the completion of R0 resection and normal liver function maintenance. Conversional (neoadjuvant) chemotherapy, portal vein embolization, two-stage hepatectomy, and tumour ablation are effective approaches to improve resectability for initially unresectable patients. The role of perioperative chemotherapy, for clearly resectable patients, still needs to be clarified. It results...

Ostomies are relatively frequent in emergent and elective abdominal surgery but often neglected a... more Ostomies are relatively frequent in emergent and elective abdominal surgery but often neglected and relegated to the junior or less experinced members of the operating team. In Croatia there are about 5000 patients with either ileostomy or colostomy. Patients do receive preoperative and postoperative counseling about living with a stoma. Most patients can be reassured and made more comfortable with the concept. It is important to stress the necessity of stoma formation: sometimes it is the only option after intestinal resection or in emergency setting surgery, protection from severe abdominal infection or improvement quality of life in most patients with disordered bowel function (colitis, incontinence). There are also patient groups dealing with the issue. However, concept and stygma of ostomies should be delt with in a more general fashion and the entire multidisciplinary team and people dealing with these patients on primary care level should be aware of it. Finally, development ...

Croatian Medical Journal, 2009

Approximately 50% of patients with colorectal cancer (CRC) will developduring their lifespan. Maj... more Approximately 50% of patients with colorectal cancer (CRC) will developduring their lifespan. Majority of colorectal liver metastases (CLM) patients will be unresectable at the time of diagnosis due to extensive intrahepatic and/or extrahepatic disease. R0 liver resection is still the only available treatment that allows long-term survival. In last two decades, the 5-year overall survival (OS) after curative liver resection of CLM has increased up to 58%. These improved outcomes are mainly due to multidisciplinary treatment of these patients. The definition of resectability has changed, so nowdays, the goal is the completion of R0 resection and normal liver function maintenance. Conversional (neoadjuvant) chemotherapy, portal vein embolization, two-stage hepatectomy, and tumour ablation are effective approaches to improve resectability for initially unresectable patients. The role of perioperative chemotherapy, for clearly resectable patients, still needs to be clarified. It results...

Incidence of rectal cancer in Croatia was 1174 cases in 2012. Most cases were diagnosed at an adv... more Incidence of rectal cancer in Croatia was 1174 cases in 2012. Most cases were diagnosed at an advanced stage, however there are a few diagnosed in cT1-2N0M0 stage which opens a window for transanal resection. These patients have to be staged meticulously not to disregard possible local spread of disease and nodal involvement. Endorectal ultrasound is not always easily available, therefore MRI is usually the method of choice for preoperative staging. Nevertheless, since the implementation of this mode of treatment advances in neoadjuvant and adjuvant therapy and multidisciplinary approach to treatment have blurred these clear cut indications. In this paper we discuss specificities in selection, treatment and follow up of these patients.

Neuroendocrinology, 2018

M. (2018) The role of the acute octreotide suppression test in detecting patients with neuroendoc... more M. (2018) The role of the acute octreotide suppression test in detecting patients with neuroendocrine neoplasms. Neuroendocrinology, 107 (3). pp.

Croatian Medical Journal, 2009

Libri Oncologici : Croatian Journal of Oncology, Dec 28, 2016

Segmentectomy and sentinel lymph node biopsy is a golden standard for early breast cancer (clinic... more Segmentectomy and sentinel lymph node biopsy is a golden standard for early breast cancer (clinical and radiological cT1-2, c N0). Recently, superparamagnetic iron oxide (SPIO) nanoparticle tracer has been introduced enabling intraoperative tracer injection. We prospectively recorded data on tumor histology, marked lymph nodes and their fi nal histology and patient characteristics for early breast cancer patients who underwent breast conservative surgery. At 128 female breast cancer patients underwent sentinel lymph node biopsy by SentiMag. Three patients were excluded from further analysis because the postoperative pathology report was ductal carcinoma in situ (DCIS). The identifi cation rate was 95.2 % (119 of 125). Of the 19.2 % (24 of 125) patients with lymph node involvement, 1.6% (2 of 125) had micrometastasis, and 1 % (1 of 125) had single tumor cells within the sentinel, l at least a micrometastasis. Of 30 positive lymph nodes removed, 24 (80 %) were true sentinel nodes. The average lymph node retrieval rate was 2.3 nodes per patient. SentiMag's performance was comparable to published data and to standard sentinel with blue patent die and/or technetium. The benefi t of easier application and logistics is a great advantage.

Segmentectomy and sentinel lymph node biopsy is a golden standard for early breast cancer (clinic... more Segmentectomy and sentinel lymph node biopsy is a golden standard for early breast cancer (clinical and radiological cT1-2, c N0). Recently, superparamagnetic iron oxide (SPIO) nanoparticle tracer has been introduced enabling intraoperative tracer injection. We prospectively recorded data on tumor histology, marked lymph nodes and their final histology and patient characteristics for early breast cancer patients who underwent breast conservative surgery. At 128 female breast cancer patients underwent sentinel lymph node biopsy by SentiMag. Three patients were excluded from further analysis because the postoperative pathology report was ductal carcinoma in situ (DCIS). The identifi cation rate was 95.2 % (119 of 125). Of the 19.2 % (24 of 125) patients with lymph node involvement, 1.6% (2 of 125) had micrometastasis, and 1 % (1 of 125) had single tumor cells within the sentinel, l at least a micrometastasis. Of 30 positive lymph nodes removed, 24 (80 %) were true sentinel nodes. The ...

Approximately 50% of patients with colorectal cancer (CRC) will developduring their lifespan. Maj... more Approximately 50% of patients with colorectal cancer (CRC) will developduring their lifespan. Majority of colorectal liver metastases (CLM) patients will be unresectable at the time of diagnosis due to extensive intrahepatic and/or extrahepatic disease. R0 liver resection is still the only available treatment that allows long-term survival. In last two decades, the 5-year overall survival (OS) after curative liver resection of CLM has increased up to 58%. These improved outcomes are mainly due to multidisciplinary treatment of these patients. The definition of resectability has changed, so nowdays, the goal is the completion of R0 resection and normal liver function maintenance. Conversional (neoadjuvant) chemotherapy, portal vein embolization, two-stage hepatectomy, and tumour ablation are effective approaches to improve resectability for initially unresectable patients. The role of perioperative chemotherapy, for clearly resectable patients, still needs to be clarified. It results...

Ostomies are relatively frequent in emergent and elective abdominal surgery but often neglected a... more Ostomies are relatively frequent in emergent and elective abdominal surgery but often neglected and relegated to the junior or less experinced members of the operating team. In Croatia there are about 5000 patients with either ileostomy or colostomy. Patients do receive preoperative and postoperative counseling about living with a stoma. Most patients can be reassured and made more comfortable with the concept. It is important to stress the necessity of stoma formation: sometimes it is the only option after intestinal resection or in emergency setting surgery, protection from severe abdominal infection or improvement quality of life in most patients with disordered bowel function (colitis, incontinence). There are also patient groups dealing with the issue. However, concept and stygma of ostomies should be delt with in a more general fashion and the entire multidisciplinary team and people dealing with these patients on primary care level should be aware of it. Finally, development ...

Croatian Medical Journal, 2009

Approximately 50% of patients with colorectal cancer (CRC) will developduring their lifespan. Maj... more Approximately 50% of patients with colorectal cancer (CRC) will developduring their lifespan. Majority of colorectal liver metastases (CLM) patients will be unresectable at the time of diagnosis due to extensive intrahepatic and/or extrahepatic disease. R0 liver resection is still the only available treatment that allows long-term survival. In last two decades, the 5-year overall survival (OS) after curative liver resection of CLM has increased up to 58%. These improved outcomes are mainly due to multidisciplinary treatment of these patients. The definition of resectability has changed, so nowdays, the goal is the completion of R0 resection and normal liver function maintenance. Conversional (neoadjuvant) chemotherapy, portal vein embolization, two-stage hepatectomy, and tumour ablation are effective approaches to improve resectability for initially unresectable patients. The role of perioperative chemotherapy, for clearly resectable patients, still needs to be clarified. It results...

Incidence of rectal cancer in Croatia was 1174 cases in 2012. Most cases were diagnosed at an adv... more Incidence of rectal cancer in Croatia was 1174 cases in 2012. Most cases were diagnosed at an advanced stage, however there are a few diagnosed in cT1-2N0M0 stage which opens a window for transanal resection. These patients have to be staged meticulously not to disregard possible local spread of disease and nodal involvement. Endorectal ultrasound is not always easily available, therefore MRI is usually the method of choice for preoperative staging. Nevertheless, since the implementation of this mode of treatment advances in neoadjuvant and adjuvant therapy and multidisciplinary approach to treatment have blurred these clear cut indications. In this paper we discuss specificities in selection, treatment and follow up of these patients.

Neuroendocrinology, 2018

M. (2018) The role of the acute octreotide suppression test in detecting patients with neuroendoc... more M. (2018) The role of the acute octreotide suppression test in detecting patients with neuroendocrine neoplasms. Neuroendocrinology, 107 (3). pp.

Croatian Medical Journal, 2009