Sheryl Green - Academia.edu (original) (raw)

Papers by Sheryl Green

American Journal of Clinical Oncology, 2012

During breast cancer radiotherapy, nearly all patients will experience radiodermatitis. Study obj... more During breast cancer radiotherapy, nearly all patients will experience radiodermatitis. Study objectives were to: 1) systematically review the literature on radiodermatitis and breast cancer; 2) summarize and describe patient-rated radiodermatitis measures; 3) determine whether consensus exists regarding subjective radiodermatitis measurement; and 4) provide recommendations for future research. PubMed and CINAHL were searched from their inception through August 2009. Study inclusion/exclusion criteria were: full abstract available; manuscript in English; focused on radiodermatitis resulting from breast cancer radiotherapy, and described a patient-rated empirical assessment of radiodermatitis. Three reviewers examined abstracts, and decisions about inclusion were reached by consensus. 22/237 mutually identified studies met selection criteria. Using a standardized abstraction form, three authors independently extracted relevant information. Results indicated that: 1) only 9% of the studies reviewed included a patient-rated measure; 2) generally, extant scales are very brief and focus almost exclusively on physical reactions, and 3) there is no "gold standard" measure of patient-rated radiodermatitis at this time. We conclude that significantly more research is needed to determine the best (most valid, reliable, sensitive, comprehensive) measure(s) to evaluate the experience of radiodermatitis from the patient's perspective, and that further scale development efforts are needed.

Supportive Care in Cancer, 2012

Psycho-Oncology, 2011

Objectives-One of the most common acute side effects of breast cancer radiotherapy is treatment i... more Objectives-One of the most common acute side effects of breast cancer radiotherapy is treatment induced skin changes, referred to as skin toxicity. Yet no research to date has focused expressly on skin toxicity-related quality of life in breast cancer radiotherapy patients. Therefore, our aim was to use qualitative approaches to better understand the impact of skin toxicity on quality of life. Methods-Semi-structured interviews were conducted with 20 women (Stage 0-III breast cancer), during their last week of external beam radiotherapy. Each interview was transcribed verbatim, and thematic analysis was performed. Results-Three themes were identified based on the interview responses: First, skin changes affect multiple dimensions of quality of life. They cause physical discomfort, body image disturbance, emotional distress, and impair both day-today functioning and satisfaction with radiation treatment. Second, individual differences affect women's experiences. Generally African-American women, younger women, women who are not currently in a relationship, women who are being treated during the summer, and women who are more invested in their appearance are more distressed by skin toxicity. Third, women use a variety of symptom management strategies including self-medication, complementary/alternative medicine approaches, and psychological strategies. Conclusions-Implications of results are: 1) Skin toxicity affects numerous dimensions of quality of life, and assessment approaches and psychosocial interventions should address this; 2) individual differences may affect the experience of skin toxicity, and should be considered in treatment and education approaches; and 3) participants' own creativity and problem-solving should be used to improve the treatment experience.

Some concern has arisen about adverse health effects of cell phones, especially the possibility t... more Some concern has arisen about adverse health effects of cell phones, especially the possibility that the low power microwave-frequency signal transmitted by the antennas on handsets might cause brain tumors or accelerate the growth of subclinical tumors. We analyzed data from the

Highlights on Medicine and Medical Science Vol. 18, 2021

Aim: Volumetric modulated arc therapy (VMAT) has been utilized to plan and treat multiple cranial... more Aim: Volumetric modulated arc therapy (VMAT) has been utilized to plan and treat multiple cranial lesion metastases using a single isocenter due to its ability to provide steep dose gradients around targets as well as low doses to critical structures. VMAT treatment is delivered in a much shorter time compared to using a single isocenter for the treatment of each lesion. However, there is a need to develop methods to reduce the treatment planning time for these cases while also standardizing the plan quality. In this work we demonstrate the use of RapidPlan, which is a knowledge-based treatment (KBP) planning software to plan multiple cranial SRS cases. Methods: 66 patient plans with 125 lesions (range 1-4, median 1) were used to train a model. In addition, the model was validated using 10 cases that were previously treated and chosen randomly. The clinical plans were compared to plans generated by RapidPlan for target coverage and critical organ dose. Results: Coverage to the target volume, gradient index (GI), conformity index (CI) and minimum dose to the target showed no significant difference between the original clinical plan versus the plan generated by KBP. A comparison of doses to the critical organs namely the brainstem, brain, chiasm, eyes, optic nerves and lenses showed no significant difference. Target dose homogeneity was slightly better with the clinical plan, however this difference was also statistically insignificant. Conclusion: This work demonstrates that KBP can be trained and efficiently utilized to help decrease the treatment planning time while standardizing and optimizing treatment plan quality.

28 n APPLIED RADIATION ONCOLOGY www.appliedradiationoncology.com September 2017 CASE SUMMARY A 56... more 28 n APPLIED RADIATION ONCOLOGY www.appliedradiationoncology.com September 2017 CASE SUMMARY A 56-year-old postmenopausal woman initially presented in October 2013 with complaints of intermittent left breast pain, redness and a left axillary mass for several months. Clinical examination was notable for an edematous and erythematous left breast with peau d’orange and a palpable underlying 6-cm mass with bulky axillary lymphadenopathy. Core biopsies of the left breast and left axilla demonstrated poorly differentiated ductal carcinoma, ER-/PR-/Her2-. Skin biopsy was negative. Workup was negative for metastatic disease, and the cancer was staged IIIB cT4d N2a M0. Beginning in December 2013, the patient was treated with neoadjuvant chemotherapy consisting of 4 cycles of dose dense Adriamycin and cyclophosphamide (AC) followed by Taxol and carboplatin (TC), which consisted of 12 cycles of Taxol and 3 cycles of carboplatin (the last dose of carboplatin was held due to electrolyte wasting)...

Brain Tumor Research and Treatment, 2019

Journal of Cancer Metastasis and Treatment, 2019

Cancer Genomics - Proteomics, 2019

Anticancer Research, 2016

Brain Tumor Research and Treatment, 2015

Journal of caffeine research, 2013

There has been some speculation that caffeine consumption may affect breast cancer. Most case-con... more There has been some speculation that caffeine consumption may affect breast cancer. Most case-control studies have not documented evidence of a caffeine-breast cancer incidence link; however, there has been very little analysis of the possible effects of caffeine consumption on breast cancer survival. We examined overall a 20-year survival of 96 women treated for breast cancer between 1990 and 1994. As part of their health history, these women were asked about coffee drinking. Fifty-three women drank one cup a day (79.2% survival), 22 women had two cups a day (72.7% survival), and 21 women drank three or more cups a day (42.9% survival). The effect of coffee consumption on survival was significant (p=0.006, the log rank test). To exclude the effects of lymph node involvement, age at diagnosis, and smoking history, Cox regression was performed. The effect of coffee was significant (p=0.001), independent of the effects of lymph node involvement (p=0.012) and age at diagnosis (p=0.014)...

Anticancer research, 2011

Glioblastoma multiforme is the most common and most aggressive type of primary brain tumor, accou... more Glioblastoma multiforme is the most common and most aggressive type of primary brain tumor, accounting for 52% of all primary brain tumor cases and 20% of all intracranial tumors. Recently, evidence for a viral cause has been postulated, possibly SV40 or more likely cytomegalovirus (CMV). One report indicated that 80% of patients with newly diagnosed glioblastoma multiforme have detectable cytomegalovirus DNA in their peripheral blood, while sero-positive normal donors and other surgical patients did not exhibit detectable virus. In the current study, we examined peripheral blood of 5 patients with newly diagnosed glioblastoma multiforme. Peripheral blood was collected in anticoagulated tubes from five patients with newly diagnosed glioblastoma multiforme referred for radiation therapy. We used standard methods for detecting CMV by reverse transcriptase-polymerase chain reaction (RT-PCR) and peripheral blood culture. None of our patients had circulating CMV. There are four subtypes ...

Case Reports in Oncological Medicine, 2015

We are reporting a case of a 34-year-old woman with occult primary breast cancer discovered after... more We are reporting a case of a 34-year-old woman with occult primary breast cancer discovered after initially presenting with neurological symptoms. She was successfully treated with neoadjuvant chemotherapy followed by definitive axillary lymph node dissection and ipsilateral whole breast radiotherapy. The case presented is unique due to the rarity of occult primary breast cancer, especially in light of her initial confounding neurological signs and symptoms, which highlights the importance of careful staging.

Advances in Genomics and Genetics, 2014

Surgical Neurology International, 2012