Gregory Lecouvey - Academia.edu (original) (raw)
Papers by Gregory Lecouvey
Cerebral Cortex, Sep 20, 2022
Time-based prospective memory (TBPM) is defined as the ability to remember to perform intended ac... more Time-based prospective memory (TBPM) is defined as the ability to remember to perform intended actions at a specific time in the future. TBPM is impaired in ageing, and this decline has been associated with white matter alterations within the superior fronto-occipital fasciculus. In the present study, we used resting-state functional magnetic resonance imaging from 22 healthy young (26 ± 5.2 years) and 23 older (63 ± 6.1 years) participants to investigate how age-related alterations in restingstate functional connectivity are related to TBPM performance, and whether these alterations are associated with the white matter disruptions we have previously observed with diffusion tensor imaging. Whole-brain analyses revealed lower resting-state functional connectivity in older participants compared to younger ones, which in turn correlated with TBPM performance. These correlations were mainly located in the salience network and the parietal part of the fronto-parietal network. Our findings suggest that resting-state functional connectivity alterations contribute to the age-related decline in TBPM.
Revue De Neuropsychologie, 2020
Le souvenir flash correspond au souvenir detaille et vivace des circonstances dans lesquelles un ... more Le souvenir flash correspond au souvenir detaille et vivace des circonstances dans lesquelles un individu est informe de la survenue d’un evenement marquant sur le plan individuel et social. La nature des processus a l’œuvre lors de sa memorisation et de sa rememoration fait encore debat dans la litterature. Certains auteurs supposent la participation de processus mnesiques analogues a ceux qui contribuent au fonctionnement de la memoire autobiographique episodique alors que d’autres proposent l’existence d’un mecanisme mnesique dedie. Le premier objectif de cette revue est de presenter les etudes qui ont evalue les particularites du souvenir flash et tente de determiner les processus cognitifs et neuraux qui sous-tendent sa formation et sa rememoration. En outre, puisque le souvenir flash est forme suite a la prise de connaissance d’un evenement souvent decrit comme historique pour un groupe d’individus, la seconde partie de cette revue est consacree a la place privilegiee qu’occupe le souvenir flash au croisement de la memoire individuelle et de la memoire collective. Dans cette optique, seront rapportees dans cette revue les etudes qui ont evalue l’influence de la culture sur la formation du souvenir flash et la contribution de ce type de souvenir a la construction d’une identite individuelle et collective.
Revue de neuropsychologie, neurosciences cognitives et cliniques, Oct 1, 2015
Distribution électronique Cairn.info pour John Libbey Eurotext. Distribution électronique Cairn.i... more Distribution électronique Cairn.info pour John Libbey Eurotext. Distribution électronique Cairn.info pour John Libbey Eurotext. La reproduction ou représentation de cet article, notamment par photocopie, n'est autorisée que dans les limites des conditions générales d'utilisation du site ou, le cas échéant, des conditions générales de la licence souscrite par votre établissement. Toute autre reproduction ou représentation, en tout ou partie, sous quelque forme et de quelque manière que ce soit, est interdite sauf accord préalable et écrit de l'éditeur, en dehors des cas prévus par la législation en vigueur en France. Il est précisé que son stockage dans une base de données est également interdit. Article disponible en ligne à l'adresse Article disponible en ligne à l'adresse https://www.cairn.info/revue-de-neuropsychologie-2015-3-page-207.htm Découvrir le sommaire de ce numéro, suivre la revue par email, s'abonner... Flashez ce QR Code pour accéder à la page de ce numéro sur Cairn.info.
La memoire prospective nous permet de nous souvenir de realiser une action a un moment predetermi... more La memoire prospective nous permet de nous souvenir de realiser une action a un moment predetermine du futur. La litterature rapporte un effet paradoxal de l’âge sur la memoire prospective, l’effet benefique de l’âge en milieu naturel contrastant avec l’effet deletere souvent rapporte en laboratoire. Elle indique egalement un deficit tres marque du rappel prospectif des le stade leger de la maladie d’Alzheimer. L’objectif de cette these etait de mieux comprendre le fonctionnement de la memoire prospective en differenciant les caracteristiques de son declin au cours du vieillissement normal et de son atteinte dans la maladie d’Alzheimer. Dans cette optique, nous avons tout d’abord compare les performances de sujets jeunes et de sujets âges sains puis de sujets âges sains et de patients Alzheimer lors d’une epreuve de memoire prospective realisee dans une ville virtuelle. Nos resultats montrent un declin global lie a l’âge plus marque lorsque des processus de recherche strategique en memoire de l’intention sont engages. L’atteinte est plus generalisee chez les patients Alzheimer qui echouent quelle que soit la nature des processus mis en jeu. Dans notre derniere etude, nous avons explore l’effet du sommeil sur le rappel prospectif grâce a une epreuve originale invitant des sujets jeunes a rappeler des intentions au sein d’une replique virtuelle du musee du Memorial de Caen. Nos resultats indiquent que l’effet benefique du sommeil s’exprime particulierement lorsque le rappel d’intentions implique des processus de recuperation reflexifs-associatifs sous-tendus par l’hippocampe. Enfin, l’integration de ces donnees nous a permis de revisiter le concept de memoire prospective.
Revue De Neuropsychologie, 2021
Prospective memory refers to the ability to remember to perform an action at a specific moment in... more Prospective memory refers to the ability to remember to perform an action at a specific moment in the future, either after a period of time (time-based) or in response to the occurrence of an event (event-based). Its evaluation in clinical practice could contribute to the objectification of prospective memory complaints often reported by people who consult for a neuropsychological examination. This article presents a prospective memory test called Mem-Pro clinic, composed of four tasks (two time-based, two event-based). Preliminary data were collected from fifty participants including thirty-five young and elderly healthy participants, thirteen patients with Alzheimer’s disease, and two patients with mild cognitive impairment. Results showed that the Mem-Pro clinic tool is sensitive to the prospective memory decline that is often reported during normal aging. It is also particularly sensitive to the pronounced and generalized deficit of prospective memory that characterizes Alzheimer’s disease, which also corroborates the complaints reported by patients. These results underline the usefulness of integrating this type of tool into neuropsychological assessments in order, for example, to better understand the difficulties encountered by patients with a subjective memory complaint that is not objectified by conventional tests.
Cerebral Cortex, 2020
Time-based prospective memory (TBPM) allows us to remember to perform intended actions at a speci... more Time-based prospective memory (TBPM) allows us to remember to perform intended actions at a specific time in the future. TBPM is sensitive to the effects of age, but the neural substrates of this decline are still poorly understood. The aim of the present study was thus to better characterize the brain substrates of the age-related decline in TBPM, focusing on macrostructural gray matter and microstructural white matter integrity. We administered a TBPM task to 22 healthy young (26 ± 5.2 years) and 23 older (63 ± 5.9 years) participants, who also underwent volumetric magnetic resonance imaging and diffusion tensor imaging scans. Neuroimaging analyses revealed lower gray matter volumes in several brain areas in older participants, but these did not correlate with TBPM performance. By contrast, an age-related decline in fractional anisotropy in several white-matter tracts connecting frontal and occipital regions did correlate with TBPM performance, whereas there was no significant cor...
Revue de neuropsychologie, 2015
Distribution électronique Cairn.info pour John Libbey Eurotext. Distribution électronique Cairn.i... more Distribution électronique Cairn.info pour John Libbey Eurotext. Distribution électronique Cairn.info pour John Libbey Eurotext. La reproduction ou représentation de cet article, notamment par photocopie, n'est autorisée que dans les limites des conditions générales d'utilisation du site ou, le cas échéant, des conditions générales de la licence souscrite par votre établissement. Toute autre reproduction ou représentation, en tout ou partie, sous quelque forme et de quelque manière que ce soit, est interdite sauf accord préalable et écrit de l'éditeur, en dehors des cas prévus par la législation en vigueur en France. Il est précisé que son stockage dans une base de données est également interdit. Article disponible en ligne à l'adresse Article disponible en ligne à l'adresse https://www.cairn.info/revue-de-neuropsychologie-2015-3-page-199.htm Découvrir le sommaire de ce numéro, suivre la revue par email, s'abonner... Flashez ce QR Code pour accéder à la page de ce numéro sur Cairn.info.
Clocks & Sleep, 2019
Prospective memory (PM) refers to our ability to perform actions at the appropriate moment, eithe... more Prospective memory (PM) refers to our ability to perform actions at the appropriate moment, either when a predetermined event occurs (event-based, EB) or after a predetermined amount of time (time-based, TB). Sleep favors the consolidation of both EB and TB intentions, but whether this benefit is preserved during ageing is still subject to debate. PM was assessed in 28 young and 27 older healthy volunteers using a virtual environment. Participants had to learn and execute intentions after intervals filled with either daytime wakefulness or nighttime sleep. Intentions consisted of four TB, four EB with a strong link between the cue triggering retrieval and the action to be performed (EB-link) and four with no link (EB-nolink). PM was not affected by age, whatever the type of intention and the nature of the retention interval. While sleep reinforced all types of intentions in young participants, this benefit was only observed for TB and EB-link intentions in older adults. Sleep also r...
Frontiers in Psychology, 2019
Objective: Research suggests that prospective memory (PM) is impaired from the very early stages ... more Objective: Research suggests that prospective memory (PM) is impaired from the very early stages of Alzheimer's disease (AD). We sought to further characterize this impairment in patients with mild AD, using a virtual reality (VR) task to provide ecological assessment of PM. Methods: Fifteen cognitively normal older individuals (76.47 years old ± 4.14, MMSE: 28.80 ± 1.21), and 17 patients with mild AD (79.29 years old ± 4.45, MMSE: 22.82 ± 2.83) were asked to recall the prospective and retrospective components of seven intentions in a virtual town task. Six intentions were event-based, where the prospective cue was either highly (three intentions) or weakly (three intentions) associated with the retrospective component. The remaining intention was time-based. All participants completed a neuropsychological assessment of episodic memory, semantic memory and executive functioning. Non-parametric tests were used to compare the two groups on the different intentions types and components. Correlations between cognition and PM scores were then realized to further understand the cognitive correlates of the PM impairment in patients with AD. Results: Overall, patients with Alzheimer disease recalled fewer intentions than controls, with the retrospective component and time-based intentions being the most challenging for them. The strength of the association between the prospective and retrospective components, however, had no effect on their performance. Event-based PM impairment, as well as deficit in the recall of prospective component correlated with memory and executive functions performance. Conclusion: PM is impaired in AD. Both automatic and controlled processes of PM retrieval are disturbed. This study also confirms the reliability of VR for assessing complex cognitive functions such as PM.
European Journal of Psychotraumatology
Memory, 2021
HAL is a multidisciplinary open access archive for the deposit and dissemination of scientific re... more HAL is a multidisciplinary open access archive for the deposit and dissemination of scientific research documents, whether they are published or not. The documents may come from teaching and research institutions in France or abroad, or from public or private research centers. L'archive ouverte pluridisciplinaire HAL, est destinée au dépôt et à la diffusion de documents scientifiques de niveau recherche, publiés ou non, émanant des établissements d'enseignement et de recherche français ou étrangers, des laboratoires publics ou privés. Distributed under a Creative Commons Attribution-NonCommercial-NoDerivatives| 4.0 International License Changes over 10 years in the retelling of the flashbulb memories of the attack of
Brain Imaging and Behavior, 2016
Prospective memory (PM) refers to the ability to remember to execute an intention at the appropri... more Prospective memory (PM) refers to the ability to remember to execute an intention at the appropriate moment in the future, which can be performed either at the appearance of an event (event-based, EBPM) or after a certain amount of time (time-based, TBPM). PM is generally impaired during aging but the cerebral substrates of this decline have been little investigated. Using functional Magnetic Resonance Imaging (fMRI), we investigated the neural bases of PM in 20 young and 20 healthy older adults. They were proposed a task of semantic categorisation of pictures (ongoing task). For some blocks, participants only had to perform this ongoing task while, for others, a PM instruction was added. In this case, a supplementary answer in response to a specific colour of border for EBPM or at specific time intervals for TBPM was expected. PM, and more particularly TBPM, declined in older adults. For both PM conditions, older adults recruited additional brain areas, but also showed reduced deactivations of other regions. These results are discussed in light of models of the aging brain.
Frontiers in Human Neuroscience, 2015
Some studies highlight similarities between Autism Spectrum Disorder (ASD) and healthy aging. Ind... more Some studies highlight similarities between Autism Spectrum Disorder (ASD) and healthy aging. Indeed, the decline in older individuals' ability to create a unified representation of the individual features of an event is thought to arise from a disruption of binding within the episodic buffer of working memory (WM) as the same way as observed in ASD. In both cases, this deficit may result from an abnormal engagement of a frontohippocampal network. The objective of the present study is to identify both cognitive processes and neural substrates associated with the deficit of binding in WM in healthy aging. We studied the capacity of binding and the cognitive processes that might subtend its decline in 72 healthy participants aged 18-84 years. We examined the behavioral data in relation to the changes in brain metabolism associated with the age-related decline in a subgroup of 34 healthy participants aged 20-77 years using the resting-state [ 18 F] fluorodeoxyglucose positron emission tomography (18 F-FDG PET). Forward stepwise regression analyses showed that the age-related decline in binding was partially explained by a decline in inhibition and processing speed. PET correlation analyses indicated that metabolism of the frontal regions, anterior and middle cingulate cortices is implicated in this phenomenon. These data suggest that executive functions and processing speed may play a crucial role in the capacity to integrate unified representations in memory in aging. Possible implications are discussed in ASD.
Virtual Reality (VR) is a very relevant tool for the study of complex cognitive functions, such a... more Virtual Reality (VR) is a very relevant tool for the study of complex cognitive functions, such as Prospective Memory (PM; remember to execute an intention at an appropriate time in the future). Thirty-five young subjects performed a PM task while immersed in a virtual city. On a theoretical level, we reached a better characterisation of PM functioning, notably regarding the influence of the link between the "when" and "what" components of PM on performance in event-and time-based PM tasks. This work validates utility of VR in PM assessment and opens perspectives in evaluation and rehabilitation of PM deficits.
Revue de neuropsychologie, 2012
Distribution électronique Cairn.info pour John Libbey Eurotext. © John Libbey Eurotext. Tous droi... more Distribution électronique Cairn.info pour John Libbey Eurotext. © John Libbey Eurotext. Tous droits réservés pour tous pays. La reproduction ou représentation de cet article, notamment par photocopie, n'est autorisée que dans les limites des conditions générales d'utilisation du site ou, le cas échéant, des conditions générales de la licence souscrite par votre établissement. Toute autre reproduction ou représentation, en tout ou partie, sous quelque forme et de quelque manière que ce soit, est interdite sauf accord préalable et écrit de l'éditeur, en dehors des cas prévus par la législation en vigueur en France. Il est précisé que son stockage dans une base de données est également interdit.
Socioaffective neuroscience & psychology, 2017
Objective: This study was designed to improve our understanding of prospective memory (PM) change... more Objective: This study was designed to improve our understanding of prospective memory (PM) changes in ageing, and to identify the cognitive correlates of PM decline, using a virtual environment, to provide a more realistic assessment than traditional laboratory tasks. Design: Thirty-five young and 29 older individuals exposed to a virtual town were asked to recall three event-based intentions with a strong link between prospective and retrospective components, three event-based intentions with a weak link, and three time-based intentions. They also underwent retrospective episodic memory, executive functions, binding in working memory, processing speed, and time estimation assessments. Results: Older individuals recalled fewer intentions than young adults. While age-related PM decline affected the recall of both prospective and retrospective components, the recall of the latter seemed more challenging for older individuals when the link was weak. This PM decline was linked to an age...
BMC cancer, Jan 3, 2018
Breast cancer (BC) is the most frequent cancer in women with more than 70% of BC patients being t... more Breast cancer (BC) is the most frequent cancer in women with more than 70% of BC patients being treated with hormonal therapy (HT). Among these patients, some report difficulties in remembering what they are supposed to do at the right moment, referring to prospective memory (PM). PM is essential for autonomy and medical adherence of patients, and requires an ecological assessment. Virtual reality, that recreates naturalistic environment, seems to be a promising method to evaluate PM. Several BC patients also report sleep disturbances. Given the role of sleep on memory consolidation, it is imperative to explore the influence of sleep quality on PM in BC patients treated with HT. The purpose of PROSOM-K study is to assess PM functioning using virtual reality and sleep quality in BC treated or not with HT. PROSOM-K is a prospective study including post-menopausal BC patients ≤70 years old treated with radiotherapy (n = 25) or with radiotherapy and HT (n = 25), and healthy post-menopau...
Cerebral Cortex, Sep 20, 2022
Time-based prospective memory (TBPM) is defined as the ability to remember to perform intended ac... more Time-based prospective memory (TBPM) is defined as the ability to remember to perform intended actions at a specific time in the future. TBPM is impaired in ageing, and this decline has been associated with white matter alterations within the superior fronto-occipital fasciculus. In the present study, we used resting-state functional magnetic resonance imaging from 22 healthy young (26 ± 5.2 years) and 23 older (63 ± 6.1 years) participants to investigate how age-related alterations in restingstate functional connectivity are related to TBPM performance, and whether these alterations are associated with the white matter disruptions we have previously observed with diffusion tensor imaging. Whole-brain analyses revealed lower resting-state functional connectivity in older participants compared to younger ones, which in turn correlated with TBPM performance. These correlations were mainly located in the salience network and the parietal part of the fronto-parietal network. Our findings suggest that resting-state functional connectivity alterations contribute to the age-related decline in TBPM.
Revue De Neuropsychologie, 2020
Le souvenir flash correspond au souvenir detaille et vivace des circonstances dans lesquelles un ... more Le souvenir flash correspond au souvenir detaille et vivace des circonstances dans lesquelles un individu est informe de la survenue d’un evenement marquant sur le plan individuel et social. La nature des processus a l’œuvre lors de sa memorisation et de sa rememoration fait encore debat dans la litterature. Certains auteurs supposent la participation de processus mnesiques analogues a ceux qui contribuent au fonctionnement de la memoire autobiographique episodique alors que d’autres proposent l’existence d’un mecanisme mnesique dedie. Le premier objectif de cette revue est de presenter les etudes qui ont evalue les particularites du souvenir flash et tente de determiner les processus cognitifs et neuraux qui sous-tendent sa formation et sa rememoration. En outre, puisque le souvenir flash est forme suite a la prise de connaissance d’un evenement souvent decrit comme historique pour un groupe d’individus, la seconde partie de cette revue est consacree a la place privilegiee qu’occupe le souvenir flash au croisement de la memoire individuelle et de la memoire collective. Dans cette optique, seront rapportees dans cette revue les etudes qui ont evalue l’influence de la culture sur la formation du souvenir flash et la contribution de ce type de souvenir a la construction d’une identite individuelle et collective.
Revue de neuropsychologie, neurosciences cognitives et cliniques, Oct 1, 2015
Distribution électronique Cairn.info pour John Libbey Eurotext. Distribution électronique Cairn.i... more Distribution électronique Cairn.info pour John Libbey Eurotext. Distribution électronique Cairn.info pour John Libbey Eurotext. La reproduction ou représentation de cet article, notamment par photocopie, n'est autorisée que dans les limites des conditions générales d'utilisation du site ou, le cas échéant, des conditions générales de la licence souscrite par votre établissement. Toute autre reproduction ou représentation, en tout ou partie, sous quelque forme et de quelque manière que ce soit, est interdite sauf accord préalable et écrit de l'éditeur, en dehors des cas prévus par la législation en vigueur en France. Il est précisé que son stockage dans une base de données est également interdit. Article disponible en ligne à l'adresse Article disponible en ligne à l'adresse https://www.cairn.info/revue-de-neuropsychologie-2015-3-page-207.htm Découvrir le sommaire de ce numéro, suivre la revue par email, s'abonner... Flashez ce QR Code pour accéder à la page de ce numéro sur Cairn.info.
La memoire prospective nous permet de nous souvenir de realiser une action a un moment predetermi... more La memoire prospective nous permet de nous souvenir de realiser une action a un moment predetermine du futur. La litterature rapporte un effet paradoxal de l’âge sur la memoire prospective, l’effet benefique de l’âge en milieu naturel contrastant avec l’effet deletere souvent rapporte en laboratoire. Elle indique egalement un deficit tres marque du rappel prospectif des le stade leger de la maladie d’Alzheimer. L’objectif de cette these etait de mieux comprendre le fonctionnement de la memoire prospective en differenciant les caracteristiques de son declin au cours du vieillissement normal et de son atteinte dans la maladie d’Alzheimer. Dans cette optique, nous avons tout d’abord compare les performances de sujets jeunes et de sujets âges sains puis de sujets âges sains et de patients Alzheimer lors d’une epreuve de memoire prospective realisee dans une ville virtuelle. Nos resultats montrent un declin global lie a l’âge plus marque lorsque des processus de recherche strategique en memoire de l’intention sont engages. L’atteinte est plus generalisee chez les patients Alzheimer qui echouent quelle que soit la nature des processus mis en jeu. Dans notre derniere etude, nous avons explore l’effet du sommeil sur le rappel prospectif grâce a une epreuve originale invitant des sujets jeunes a rappeler des intentions au sein d’une replique virtuelle du musee du Memorial de Caen. Nos resultats indiquent que l’effet benefique du sommeil s’exprime particulierement lorsque le rappel d’intentions implique des processus de recuperation reflexifs-associatifs sous-tendus par l’hippocampe. Enfin, l’integration de ces donnees nous a permis de revisiter le concept de memoire prospective.
Revue De Neuropsychologie, 2021
Prospective memory refers to the ability to remember to perform an action at a specific moment in... more Prospective memory refers to the ability to remember to perform an action at a specific moment in the future, either after a period of time (time-based) or in response to the occurrence of an event (event-based). Its evaluation in clinical practice could contribute to the objectification of prospective memory complaints often reported by people who consult for a neuropsychological examination. This article presents a prospective memory test called Mem-Pro clinic, composed of four tasks (two time-based, two event-based). Preliminary data were collected from fifty participants including thirty-five young and elderly healthy participants, thirteen patients with Alzheimer’s disease, and two patients with mild cognitive impairment. Results showed that the Mem-Pro clinic tool is sensitive to the prospective memory decline that is often reported during normal aging. It is also particularly sensitive to the pronounced and generalized deficit of prospective memory that characterizes Alzheimer’s disease, which also corroborates the complaints reported by patients. These results underline the usefulness of integrating this type of tool into neuropsychological assessments in order, for example, to better understand the difficulties encountered by patients with a subjective memory complaint that is not objectified by conventional tests.
Cerebral Cortex, 2020
Time-based prospective memory (TBPM) allows us to remember to perform intended actions at a speci... more Time-based prospective memory (TBPM) allows us to remember to perform intended actions at a specific time in the future. TBPM is sensitive to the effects of age, but the neural substrates of this decline are still poorly understood. The aim of the present study was thus to better characterize the brain substrates of the age-related decline in TBPM, focusing on macrostructural gray matter and microstructural white matter integrity. We administered a TBPM task to 22 healthy young (26 ± 5.2 years) and 23 older (63 ± 5.9 years) participants, who also underwent volumetric magnetic resonance imaging and diffusion tensor imaging scans. Neuroimaging analyses revealed lower gray matter volumes in several brain areas in older participants, but these did not correlate with TBPM performance. By contrast, an age-related decline in fractional anisotropy in several white-matter tracts connecting frontal and occipital regions did correlate with TBPM performance, whereas there was no significant cor...
Revue de neuropsychologie, 2015
Distribution électronique Cairn.info pour John Libbey Eurotext. Distribution électronique Cairn.i... more Distribution électronique Cairn.info pour John Libbey Eurotext. Distribution électronique Cairn.info pour John Libbey Eurotext. La reproduction ou représentation de cet article, notamment par photocopie, n'est autorisée que dans les limites des conditions générales d'utilisation du site ou, le cas échéant, des conditions générales de la licence souscrite par votre établissement. Toute autre reproduction ou représentation, en tout ou partie, sous quelque forme et de quelque manière que ce soit, est interdite sauf accord préalable et écrit de l'éditeur, en dehors des cas prévus par la législation en vigueur en France. Il est précisé que son stockage dans une base de données est également interdit. Article disponible en ligne à l'adresse Article disponible en ligne à l'adresse https://www.cairn.info/revue-de-neuropsychologie-2015-3-page-199.htm Découvrir le sommaire de ce numéro, suivre la revue par email, s'abonner... Flashez ce QR Code pour accéder à la page de ce numéro sur Cairn.info.
Clocks & Sleep, 2019
Prospective memory (PM) refers to our ability to perform actions at the appropriate moment, eithe... more Prospective memory (PM) refers to our ability to perform actions at the appropriate moment, either when a predetermined event occurs (event-based, EB) or after a predetermined amount of time (time-based, TB). Sleep favors the consolidation of both EB and TB intentions, but whether this benefit is preserved during ageing is still subject to debate. PM was assessed in 28 young and 27 older healthy volunteers using a virtual environment. Participants had to learn and execute intentions after intervals filled with either daytime wakefulness or nighttime sleep. Intentions consisted of four TB, four EB with a strong link between the cue triggering retrieval and the action to be performed (EB-link) and four with no link (EB-nolink). PM was not affected by age, whatever the type of intention and the nature of the retention interval. While sleep reinforced all types of intentions in young participants, this benefit was only observed for TB and EB-link intentions in older adults. Sleep also r...
Frontiers in Psychology, 2019
Objective: Research suggests that prospective memory (PM) is impaired from the very early stages ... more Objective: Research suggests that prospective memory (PM) is impaired from the very early stages of Alzheimer's disease (AD). We sought to further characterize this impairment in patients with mild AD, using a virtual reality (VR) task to provide ecological assessment of PM. Methods: Fifteen cognitively normal older individuals (76.47 years old ± 4.14, MMSE: 28.80 ± 1.21), and 17 patients with mild AD (79.29 years old ± 4.45, MMSE: 22.82 ± 2.83) were asked to recall the prospective and retrospective components of seven intentions in a virtual town task. Six intentions were event-based, where the prospective cue was either highly (three intentions) or weakly (three intentions) associated with the retrospective component. The remaining intention was time-based. All participants completed a neuropsychological assessment of episodic memory, semantic memory and executive functioning. Non-parametric tests were used to compare the two groups on the different intentions types and components. Correlations between cognition and PM scores were then realized to further understand the cognitive correlates of the PM impairment in patients with AD. Results: Overall, patients with Alzheimer disease recalled fewer intentions than controls, with the retrospective component and time-based intentions being the most challenging for them. The strength of the association between the prospective and retrospective components, however, had no effect on their performance. Event-based PM impairment, as well as deficit in the recall of prospective component correlated with memory and executive functions performance. Conclusion: PM is impaired in AD. Both automatic and controlled processes of PM retrieval are disturbed. This study also confirms the reliability of VR for assessing complex cognitive functions such as PM.
European Journal of Psychotraumatology
Memory, 2021
HAL is a multidisciplinary open access archive for the deposit and dissemination of scientific re... more HAL is a multidisciplinary open access archive for the deposit and dissemination of scientific research documents, whether they are published or not. The documents may come from teaching and research institutions in France or abroad, or from public or private research centers. L'archive ouverte pluridisciplinaire HAL, est destinée au dépôt et à la diffusion de documents scientifiques de niveau recherche, publiés ou non, émanant des établissements d'enseignement et de recherche français ou étrangers, des laboratoires publics ou privés. Distributed under a Creative Commons Attribution-NonCommercial-NoDerivatives| 4.0 International License Changes over 10 years in the retelling of the flashbulb memories of the attack of
Brain Imaging and Behavior, 2016
Prospective memory (PM) refers to the ability to remember to execute an intention at the appropri... more Prospective memory (PM) refers to the ability to remember to execute an intention at the appropriate moment in the future, which can be performed either at the appearance of an event (event-based, EBPM) or after a certain amount of time (time-based, TBPM). PM is generally impaired during aging but the cerebral substrates of this decline have been little investigated. Using functional Magnetic Resonance Imaging (fMRI), we investigated the neural bases of PM in 20 young and 20 healthy older adults. They were proposed a task of semantic categorisation of pictures (ongoing task). For some blocks, participants only had to perform this ongoing task while, for others, a PM instruction was added. In this case, a supplementary answer in response to a specific colour of border for EBPM or at specific time intervals for TBPM was expected. PM, and more particularly TBPM, declined in older adults. For both PM conditions, older adults recruited additional brain areas, but also showed reduced deactivations of other regions. These results are discussed in light of models of the aging brain.
Frontiers in Human Neuroscience, 2015
Some studies highlight similarities between Autism Spectrum Disorder (ASD) and healthy aging. Ind... more Some studies highlight similarities between Autism Spectrum Disorder (ASD) and healthy aging. Indeed, the decline in older individuals' ability to create a unified representation of the individual features of an event is thought to arise from a disruption of binding within the episodic buffer of working memory (WM) as the same way as observed in ASD. In both cases, this deficit may result from an abnormal engagement of a frontohippocampal network. The objective of the present study is to identify both cognitive processes and neural substrates associated with the deficit of binding in WM in healthy aging. We studied the capacity of binding and the cognitive processes that might subtend its decline in 72 healthy participants aged 18-84 years. We examined the behavioral data in relation to the changes in brain metabolism associated with the age-related decline in a subgroup of 34 healthy participants aged 20-77 years using the resting-state [ 18 F] fluorodeoxyglucose positron emission tomography (18 F-FDG PET). Forward stepwise regression analyses showed that the age-related decline in binding was partially explained by a decline in inhibition and processing speed. PET correlation analyses indicated that metabolism of the frontal regions, anterior and middle cingulate cortices is implicated in this phenomenon. These data suggest that executive functions and processing speed may play a crucial role in the capacity to integrate unified representations in memory in aging. Possible implications are discussed in ASD.
Virtual Reality (VR) is a very relevant tool for the study of complex cognitive functions, such a... more Virtual Reality (VR) is a very relevant tool for the study of complex cognitive functions, such as Prospective Memory (PM; remember to execute an intention at an appropriate time in the future). Thirty-five young subjects performed a PM task while immersed in a virtual city. On a theoretical level, we reached a better characterisation of PM functioning, notably regarding the influence of the link between the "when" and "what" components of PM on performance in event-and time-based PM tasks. This work validates utility of VR in PM assessment and opens perspectives in evaluation and rehabilitation of PM deficits.
Revue de neuropsychologie, 2012
Distribution électronique Cairn.info pour John Libbey Eurotext. © John Libbey Eurotext. Tous droi... more Distribution électronique Cairn.info pour John Libbey Eurotext. © John Libbey Eurotext. Tous droits réservés pour tous pays. La reproduction ou représentation de cet article, notamment par photocopie, n'est autorisée que dans les limites des conditions générales d'utilisation du site ou, le cas échéant, des conditions générales de la licence souscrite par votre établissement. Toute autre reproduction ou représentation, en tout ou partie, sous quelque forme et de quelque manière que ce soit, est interdite sauf accord préalable et écrit de l'éditeur, en dehors des cas prévus par la législation en vigueur en France. Il est précisé que son stockage dans une base de données est également interdit.
Socioaffective neuroscience & psychology, 2017
Objective: This study was designed to improve our understanding of prospective memory (PM) change... more Objective: This study was designed to improve our understanding of prospective memory (PM) changes in ageing, and to identify the cognitive correlates of PM decline, using a virtual environment, to provide a more realistic assessment than traditional laboratory tasks. Design: Thirty-five young and 29 older individuals exposed to a virtual town were asked to recall three event-based intentions with a strong link between prospective and retrospective components, three event-based intentions with a weak link, and three time-based intentions. They also underwent retrospective episodic memory, executive functions, binding in working memory, processing speed, and time estimation assessments. Results: Older individuals recalled fewer intentions than young adults. While age-related PM decline affected the recall of both prospective and retrospective components, the recall of the latter seemed more challenging for older individuals when the link was weak. This PM decline was linked to an age...
BMC cancer, Jan 3, 2018
Breast cancer (BC) is the most frequent cancer in women with more than 70% of BC patients being t... more Breast cancer (BC) is the most frequent cancer in women with more than 70% of BC patients being treated with hormonal therapy (HT). Among these patients, some report difficulties in remembering what they are supposed to do at the right moment, referring to prospective memory (PM). PM is essential for autonomy and medical adherence of patients, and requires an ecological assessment. Virtual reality, that recreates naturalistic environment, seems to be a promising method to evaluate PM. Several BC patients also report sleep disturbances. Given the role of sleep on memory consolidation, it is imperative to explore the influence of sleep quality on PM in BC patients treated with HT. The purpose of PROSOM-K study is to assess PM functioning using virtual reality and sleep quality in BC treated or not with HT. PROSOM-K is a prospective study including post-menopausal BC patients ≤70 years old treated with radiotherapy (n = 25) or with radiotherapy and HT (n = 25), and healthy post-menopau...