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Research paper thumbnail of CLINICAL UTILITY OF QUANTITATIVE CYTOMEGALOVIRUS VIRAL LOAD DETERMINATION FOR PREDICTING CYTOMEGALOVIRUS DISEASE IN LIVER TRANSPLANT RECIPIENTS1

Transplantation, 1999

The early detection of cytomegalovirus (CMV) reactivation after liver transplantation may fonn th... more The early detection of cytomegalovirus (CMV) reactivation after liver transplantation may fonn the basis of a pre-ernptive strategy for prevention of active CMV disease. We prospectively analyzed the clinical utility of weekly CMV plasma viral load determinations by quantitative PCR and the antigenemia assay in predicting CMV disease in 97 liver transplant recipients. CMV disease occurred in 21/97 (21.7%) patients a mean of 60 days post-transplant. Using a threshold of >400 copieslml plasma, PCR had a sensitivity of 100°h, specificity 47.4%, positive predictive value (PPV) 34.4 % and negative predictive value (NPV) 100% for prediction of CMV disease. Respective values for a positive antigenemia (threshold > O positive cells per 150,000 examined)

Research paper thumbnail of CLINICAL UTILITY OF QUANTITATIVE CYTOMEGALOVIRUS VIRAL LOAD DETERMINATION FOR PREDICTING CYTOMEGALOVIRUS DISEASE IN LIVER TRANSPLANT RECIPIENTS1

Transplantation, 1999

The early detection of cytomegalovirus (CMV) reactivation after liver transplantation may fonn th... more The early detection of cytomegalovirus (CMV) reactivation after liver transplantation may fonn the basis of a pre-ernptive strategy for prevention of active CMV disease. We prospectively analyzed the clinical utility of weekly CMV plasma viral load determinations by quantitative PCR and the antigenemia assay in predicting CMV disease in 97 liver transplant recipients. CMV disease occurred in 21/97 (21.7%) patients a mean of 60 days post-transplant. Using a threshold of >400 copieslml plasma, PCR had a sensitivity of 100°h, specificity 47.4%, positive predictive value (PPV) 34.4 % and negative predictive value (NPV) 100% for prediction of CMV disease. Respective values for a positive antigenemia (threshold > O positive cells per 150,000 examined)

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