Greta Ulikhanyan - Academia.edu (original) (raw)
Uploads
Papers by Greta Ulikhanyan
Brazilian Journal of Pharmaceutical Sciences
Plants are valuable sources of biologically active substances which exhibit specific biological a... more Plants are valuable sources of biologically active substances which exhibit specific biological activity and are important components for the development of new medicines. From this point of view, some endemic plants of the Lamiaceae family which have been used in traditional medicine in different countries from early times are quite interesting. These plants are mainly studied as sources of essential oils and phenolic compounds, especially flavanoids, which determine their biological (antioxidant, anti-inflammatory, cytotoxic, etc.) activity. In recent decades, scientific articles have focused on the study of the antioxidant effect of flavonoids (Kaur,
Bulletin of the Medical Institute after Mehrabyan, 2022
Целью настоящего исследования является исследование антиоксидантной активности экстрактов, получе... more Целью настоящего исследования является исследование антиоксидантной активности экстрактов, полученных из сырья Ziziphora clinopodioides Lam. Дикорастущего во флорах Армении и Арцаха и выращенного в условиях гидропоники. Определение антиоксидантной активности проводили спектрофотометрическим методом, при котором природный антиоксидант взаимодействует со стабильным хромоген радикалом ДФПГ(2,2-дифенил-1-пикрилгидразил). Результаты исследования показали, что экстракты разных образцов Z. clinopodioides обладают различной антиоксидантной активностью. / The aim of the current study was to determine antioxidant activities of the extracts obtained from the raw material of wild growing Ziziphora clinopodioides Lam. in the floras of Armenia and Artsakh, and cultivated in the hydroponic conditions. The antioxidant activity determination was carried out by means of the spectrophotometric method, in which the natural antioxidant interacts with the stable chromogen radical of DPPH (2,2-diphenyl-1-...
FARMACIA
The aim of the current study was the qualitative and quantitative analysis of the extracts obtain... more The aim of the current study was the qualitative and quantitative analysis of the extracts obtained from Ziziphora clinopodioides by HPLC and spectrophotometric methods. By the HPLC assay there were confirmed the qualitative-quantitative phenolic compositions of the substances in ethanol extracts; apigenin and verbascoside previously identified by thin layer chromatography. The study is using a modified spectrophotometric method for the characterization of the total amount of flavonoids with respect to 7-methyl sudahitin. HPLC analysis showed that the apigenin content ranged from 0.0024 to 0.01 mg/mL and the verbascoside-ranged from 0.114 to 0.504 mg/mL in Ziziphora dry extracts. It was shown that the plant Ziziphora accumulated a significant quantity of flavonoids of the total amount, 2.57% up to 4.18%. The current study indicated that the raw material of wild growing Ziziphora in floras of South-Caucasian region, cultivated in soil and in hydroponics conditions could represent a source of flavonoids, the quantity of which varies not only due to natural climatic conditions, but also due to the growing conditions. Rezumat Scopul prezentului studiu a fost analiza calitativă și cantitativă a extractelor obținute din Ziziphora clinopodioides, prin HPLC și metode spectrofotometrice. Prin metoda HPLC s-au confirmat compozițiile fenolice calitativ-cantitative din extractele etanolice: apigenină și verbascozidă, identificate anterior prin cromatografie în strat subțire. Articolul prezintă utilizarea unei metodei spectrofotometrice modificate pentru definirea cantității totale de flavonoide în raport cu 7-metil sudahitina. Analiza HPLC a arătat că apigenina a variat de la 0,0024 la 0,01 mg/mL și verbascozida de la 0,114 la 0,504 mg/mL în extractele uscate de Ziziphora. S-a demonstrat că specia Ziziphora a acumulat o cantitate semnificativă de flavonoide, a căror cantitate totală a fost de 2,57% până la 4,18%. Studiul actual a indicat că materia primă Ziziphora, sălbatică în flora sud-caucaziană, cultivată în sol sau în condiții hidroponice, ar putea fi o sursă de flavonoide, a căror cantitate variază nu numai datorită condițiilor climatice naturale, dar şi în funcție de condiţiile de creştere.
Brazilian Journal of Pharmaceutical Sciences
Plants are valuable sources of biologically active substances which exhibit specific biological a... more Plants are valuable sources of biologically active substances which exhibit specific biological activity and are important components for the development of new medicines. From this point of view, some endemic plants of the Lamiaceae family which have been used in traditional medicine in different countries from early times are quite interesting. These plants are mainly studied as sources of essential oils and phenolic compounds, especially flavanoids, which determine their biological (antioxidant, anti-inflammatory, cytotoxic, etc.) activity. In recent decades, scientific articles have focused on the study of the antioxidant effect of flavonoids (Kaur,
Bulletin of the Medical Institute after Mehrabyan, 2022
Целью настоящего исследования является исследование антиоксидантной активности экстрактов, получе... more Целью настоящего исследования является исследование антиоксидантной активности экстрактов, полученных из сырья Ziziphora clinopodioides Lam. Дикорастущего во флорах Армении и Арцаха и выращенного в условиях гидропоники. Определение антиоксидантной активности проводили спектрофотометрическим методом, при котором природный антиоксидант взаимодействует со стабильным хромоген радикалом ДФПГ(2,2-дифенил-1-пикрилгидразил). Результаты исследования показали, что экстракты разных образцов Z. clinopodioides обладают различной антиоксидантной активностью. / The aim of the current study was to determine antioxidant activities of the extracts obtained from the raw material of wild growing Ziziphora clinopodioides Lam. in the floras of Armenia and Artsakh, and cultivated in the hydroponic conditions. The antioxidant activity determination was carried out by means of the spectrophotometric method, in which the natural antioxidant interacts with the stable chromogen radical of DPPH (2,2-diphenyl-1-...
FARMACIA
The aim of the current study was the qualitative and quantitative analysis of the extracts obtain... more The aim of the current study was the qualitative and quantitative analysis of the extracts obtained from Ziziphora clinopodioides by HPLC and spectrophotometric methods. By the HPLC assay there were confirmed the qualitative-quantitative phenolic compositions of the substances in ethanol extracts; apigenin and verbascoside previously identified by thin layer chromatography. The study is using a modified spectrophotometric method for the characterization of the total amount of flavonoids with respect to 7-methyl sudahitin. HPLC analysis showed that the apigenin content ranged from 0.0024 to 0.01 mg/mL and the verbascoside-ranged from 0.114 to 0.504 mg/mL in Ziziphora dry extracts. It was shown that the plant Ziziphora accumulated a significant quantity of flavonoids of the total amount, 2.57% up to 4.18%. The current study indicated that the raw material of wild growing Ziziphora in floras of South-Caucasian region, cultivated in soil and in hydroponics conditions could represent a source of flavonoids, the quantity of which varies not only due to natural climatic conditions, but also due to the growing conditions. Rezumat Scopul prezentului studiu a fost analiza calitativă și cantitativă a extractelor obținute din Ziziphora clinopodioides, prin HPLC și metode spectrofotometrice. Prin metoda HPLC s-au confirmat compozițiile fenolice calitativ-cantitative din extractele etanolice: apigenină și verbascozidă, identificate anterior prin cromatografie în strat subțire. Articolul prezintă utilizarea unei metodei spectrofotometrice modificate pentru definirea cantității totale de flavonoide în raport cu 7-metil sudahitina. Analiza HPLC a arătat că apigenina a variat de la 0,0024 la 0,01 mg/mL și verbascozida de la 0,114 la 0,504 mg/mL în extractele uscate de Ziziphora. S-a demonstrat că specia Ziziphora a acumulat o cantitate semnificativă de flavonoide, a căror cantitate totală a fost de 2,57% până la 4,18%. Studiul actual a indicat că materia primă Ziziphora, sălbatică în flora sud-caucaziană, cultivată în sol sau în condiții hidroponice, ar putea fi o sursă de flavonoide, a căror cantitate variază nu numai datorită condițiilor climatice naturale, dar şi în funcție de condiţiile de creştere.