Guido Wilms - Academia.edu (original) (raw)

Papers by Guido Wilms

SUMMARY – We describe three cases of incidentally found lesions in the dural venous sinuses on ma... more SUMMARY – We describe three cases of incidentally found lesions in the dural venous sinuses on magnetic resonance imaging, that other had erroneously considered pathological entities. We made the diagnosis of giant arachnoid granulations. The differential diagnosis with thrombosis or intrasinusal tumoral lesions was easily made on the basis of three typical radiological features of the granulations: the hyperintensity of the lesions on FLAIR, a blood vessel within the lesion and bone erosion.

Stroke

Background and Purpose: Functional outcome after stroke may be related to preexisting brain healt... more Background and Purpose: Functional outcome after stroke may be related to preexisting brain health. Several imaging markers of brain frailty have been described including brain atrophy and markers of small vessel disease. We investigated the association of these imaging markers with functional outcome after acute ischemic stroke. Methods: We retrospectively studied patients with acute ischemic stroke enrolled in the AXIS-2 trial (AX200 in Ischemic Stroke Trial), a randomized controlled clinical trial of granulocyte colony-stimulating factor versus placebo. We assessed the ratio of brain parenchymal volume to total intracerebral volumes (ie, the brain parenchymal fraction) and total brain volumes from routine baseline magnetic resonance imaging data obtained within 9 hours of symptom onset using the unified segmentation algorithm in SPM12. Enlarged perivascular spaces, white matter hyperintensities, lacunes, as well as a small vessel disease burden, were rated visually. Functional ou...

Neuroradiology, 2010

October 2010 Bologna, Italy October 4–9, 2010 XIX Symposium Neuroradiologicum The world congress ... more October 2010 Bologna, Italy October 4–9, 2010 XIX Symposium Neuroradiologicum The world congress of Neuroradiology For more information: www.symposium neuroradiologicum.org President: Prof. Marco Leonardi marco.leonardi@symposiumneuroradiolo gicum.org Barcelona, Spain, October 28–31, 2010 The 4th World Congress on Controversies in Neurology (CONy) For more information: visit the website: www.comtecmed.com/cony

Journal of computer assisted tomography, 2013

We present a case in which mitochondrial encephalomyopathy, lactic acidosis, and stroke-like epis... more We present a case in which mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes syndrome mimicked the clinical and radiological signs of herpes simplex encephalitis. In a patient with subacute encephalopathy, on computed tomography and magnetic resonance imaging, lesions were present in both temporal lobes extending to both insular regions with sparing of the lentiform nuclei and in both posterior straight and cingulate gyri. Final diagnosis of mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes syndrome was based on biochemical investigations on cerebrospinal fluid, electromyogram, muscle biopsy, and genetic analysis. On diffusion-weighted imaging, diffusion restriction was present in some parts of the lesions but not throughout the entire lesions. We suggest that this could be an important sign in the differential diagnosis with herpes simplex encephalitis.

Obstetric Anesthesia Digest

Neuroradiology

Spinal intradural extramedullary cavernous hemangiomas are very rare. Mixed intensities on T1- an... more Spinal intradural extramedullary cavernous hemangiomas are very rare. Mixed intensities on T1- andT2-weighted images due to repeated hemorrhages and poor to absent contrast-enhancement are the most common imaging features of the disease allowing accurate differentiation from the far more frequent meningiomas and schwannomas of similar location.

Journal of Neurotrauma

Observer variability in local radiological reading is a major concern in large-scale multi-center... more Observer variability in local radiological reading is a major concern in large-scale multi-center traumatic brain injury (TBI) studies. A central review process has been advocated to minimize this variability. The aim of this study is to compare central with local reading of TBI imaging datasets and to investigate the added value of central review. A total of 2050 admission computed tomography (CT) scans from subjects enrolled in the Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury (CENTER-TBI) study were analyzed for seven main CT characteristics. Kappa statistics were used to calculate agreement between central and local evaluations and a center-specific analysis was performed. The McNemar test was used to detect whether discordances were significant. Central interobserver and intra-observer agreement was calculated in a subset of patients. Good agreement was found between central and local assessment for the presence or absence of structural pathology (CT+, CT-, κ = 0.73) and most CT characteristics (κ = 0.62 to 0.71), except for traumatic axonal injury lesions (κ = 0.37). Despite good kappa values, discordances were significant in four of seven CT characteristics (i.e., midline shift, contusion, traumatic subarachnoid hemorrhage, and cisternal compression; p = 0.0005). Central reviewers showed substantial to excellent interobserver and intra-observer agreement (κ = 0.73 to κ = 0.96), contrasted by considerable variability in local radiological reading. Compared with local evaluation, a central review process offers a more consistent radiological reading of acute CT characteristics in TBI. It generates reliable, reproducible data and should be recommended for use in multi-center TBI studies.

Journal of Neuroradiology

Neuroradiology, 2016

For the winners, ESNR offers a free registration for the ESNR meeting where the prize is awarded.... more For the winners, ESNR offers a free registration for the ESNR meeting where the prize is awarded. Since then, three prizes were awarded [1-3]. It was not surprising to see that all three prizes went to an interventional paper, since in this field a high turnover of innovative techniques tends to be reported, leading to many citations. Since the majority of papers though deal with diagnostic neuroradiology, we felt it was unfair that this was not rewarded.

Neuroradiology, 2016

Erratum to the list of founding members of the ESNR, as mentioned in the supplement to the Septem... more Erratum to the list of founding members of the ESNR, as mentioned in the supplement to the September 2015 issue of the journal with the abstracts of the annual meeting in Naples 2015 (page S7) as well as in the September 2016 issue with the abstracts of the annual meeting in Belgrade (page S4).

European Radiology, Apr 1, 2005

The radiological diagnosis and differential diagnosis of intra-axial tumours no longer relies on ... more The radiological diagnosis and differential diagnosis of intra-axial tumours no longer relies on CT scan and routine MR sequences alone. Standard multiplanar imaging has to be combined with fMRI to allow the exact anatomic location of the lesion and precise determination of the extension of the tumour. Perfusion and diffusion MR is becoming more and more important in the differential diagnosis of cerebral mass lesions and in the grading and typing of gliomas. More sophisticated techniques such as diffusion tensor imaging and spectroscopy will further enhance the value of the radiological studies.

International journal of stroke : official journal of the International Stroke Society, 2016

Recent trials have shown a clear benefit of endovascular therapy for stroke patients presenting w... more Recent trials have shown a clear benefit of endovascular therapy for stroke patients presenting within 6 h after stroke onset. Imaging-based selection may identify a cohort with a favorable response to endovascular therapy, in an even later time window. We performed an indirect comparison between outcomes seen in DEFUSE 2, a prospective cohort study of patients who received a baseline MRI before endovascular therapy, and a control group from AXIS 2 receiving standard medical care up to 12 h after symptom onset. Patients from AXIS 2 with a confirmed large vessel occlusion were selected as a control group for DEFUSE 2-patients. The primary endpoint was good functional outcome at day 90 (Modified Rankin Score 0-2). We performed a stratified analysis based on the presence of the target mismatch for both studies and reperfusion status in DEFUSE 2. We compared good functional outcome in 108 patients from AXIS 2 and 99 patients from DEFUSE 2. In DEFUSE 2-patients with the target mismatch p...

American Journal of Neuroradiology, 1990

Acta Gastro Enterologica Belgica, 2006

Leptomeningeal carcinomatosis (LC) is a rare complication of solid tumours. We report two cases o... more Leptomeningeal carcinomatosis (LC) is a rare complication of solid tumours. We report two cases of leptomeningeal carcinomatosis in patients with oesophageal adenocarcinoma. Diagnosis of LC can be overlooked without a high index of suspicion. Multifocality of symptoms and signs is the hallmark of LC. The combination of cerebrospinal fluid cytology and magnetic resonance imaging has a high diagnostic accuracy. The prognosis remains poor and therefore all therapies are still palliative.

Journal belge de radiologie

Fourteen percutaneous transhepatic venous samplings of the pancreas were performed in 13 patients... more Fourteen percutaneous transhepatic venous samplings of the pancreas were performed in 13 patients. Ten patients undergoing 11 samplings were operated, while 3 patients were not operated. Surgical intervention disclosed a single tumor in 8 patients, a double tumor in 1 patient and diffuse hyperplasia in 1 patient. The method allowed correct localization of 5 insulinomas and correct regionalizing of 4 insulinomas in 9 of 10 small tumoral lesions. In 1 double localization of the pancreatic body percutaneous venous sampling only detected 1 lesion. In 1 case of diffuse hyperplasia of the pancreatic tail, the venous sampling was suggestive for a tumor in the pancreatic tail. The method appears to be highly accurate in diagnosing and localizing insulinomas of the pancreas. However, a need persists for 3-dimensional localization of the lesions to facilitate enucleation. Intraoperative ultrasound could become the method of choice for localization of insulinomas.

Journal belge de radiologie

A case of isolated unilateral extraocular muscle myositis following an acute upper respiratory tr... more A case of isolated unilateral extraocular muscle myositis following an acute upper respiratory tract infection is reported. Painful eye movements, restricted eye motility and exophthalmus but a normal visual acuity are the most important clinical findings. High resolution contrast enhanced CT and MRI are the imaging modalities of choice to differentiate from other orbital pathologies. The solitary enlarged muscle was clearly seen on both the contrast enhanced CT and the MR examination. Preseptal cellulitis was better seen on MRI, whereas high resolution CT was superior in the demonstration of periscleritis. Graves' ophthalmopathy and orbital cellulitis first have to be excluded. Corticosteroids are the therapy of choice in orbital myositis. A control, contrast enhanced CT after 4 weeks showed an almost normal muscle.

Ophthalmic Surgery, Lasers and Imaging Retina, 2015

SUMMARY – We describe three cases of incidentally found lesions in the dural venous sinuses on ma... more SUMMARY – We describe three cases of incidentally found lesions in the dural venous sinuses on magnetic resonance imaging, that other had erroneously considered pathological entities. We made the diagnosis of giant arachnoid granulations. The differential diagnosis with thrombosis or intrasinusal tumoral lesions was easily made on the basis of three typical radiological features of the granulations: the hyperintensity of the lesions on FLAIR, a blood vessel within the lesion and bone erosion.

Stroke

Background and Purpose: Functional outcome after stroke may be related to preexisting brain healt... more Background and Purpose: Functional outcome after stroke may be related to preexisting brain health. Several imaging markers of brain frailty have been described including brain atrophy and markers of small vessel disease. We investigated the association of these imaging markers with functional outcome after acute ischemic stroke. Methods: We retrospectively studied patients with acute ischemic stroke enrolled in the AXIS-2 trial (AX200 in Ischemic Stroke Trial), a randomized controlled clinical trial of granulocyte colony-stimulating factor versus placebo. We assessed the ratio of brain parenchymal volume to total intracerebral volumes (ie, the brain parenchymal fraction) and total brain volumes from routine baseline magnetic resonance imaging data obtained within 9 hours of symptom onset using the unified segmentation algorithm in SPM12. Enlarged perivascular spaces, white matter hyperintensities, lacunes, as well as a small vessel disease burden, were rated visually. Functional ou...

Neuroradiology, 2010

October 2010 Bologna, Italy October 4–9, 2010 XIX Symposium Neuroradiologicum The world congress ... more October 2010 Bologna, Italy October 4–9, 2010 XIX Symposium Neuroradiologicum The world congress of Neuroradiology For more information: www.symposium neuroradiologicum.org President: Prof. Marco Leonardi marco.leonardi@symposiumneuroradiolo gicum.org Barcelona, Spain, October 28–31, 2010 The 4th World Congress on Controversies in Neurology (CONy) For more information: visit the website: www.comtecmed.com/cony

Journal of computer assisted tomography, 2013

We present a case in which mitochondrial encephalomyopathy, lactic acidosis, and stroke-like epis... more We present a case in which mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes syndrome mimicked the clinical and radiological signs of herpes simplex encephalitis. In a patient with subacute encephalopathy, on computed tomography and magnetic resonance imaging, lesions were present in both temporal lobes extending to both insular regions with sparing of the lentiform nuclei and in both posterior straight and cingulate gyri. Final diagnosis of mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes syndrome was based on biochemical investigations on cerebrospinal fluid, electromyogram, muscle biopsy, and genetic analysis. On diffusion-weighted imaging, diffusion restriction was present in some parts of the lesions but not throughout the entire lesions. We suggest that this could be an important sign in the differential diagnosis with herpes simplex encephalitis.

Obstetric Anesthesia Digest

Neuroradiology

Spinal intradural extramedullary cavernous hemangiomas are very rare. Mixed intensities on T1- an... more Spinal intradural extramedullary cavernous hemangiomas are very rare. Mixed intensities on T1- andT2-weighted images due to repeated hemorrhages and poor to absent contrast-enhancement are the most common imaging features of the disease allowing accurate differentiation from the far more frequent meningiomas and schwannomas of similar location.

Journal of Neurotrauma

Observer variability in local radiological reading is a major concern in large-scale multi-center... more Observer variability in local radiological reading is a major concern in large-scale multi-center traumatic brain injury (TBI) studies. A central review process has been advocated to minimize this variability. The aim of this study is to compare central with local reading of TBI imaging datasets and to investigate the added value of central review. A total of 2050 admission computed tomography (CT) scans from subjects enrolled in the Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury (CENTER-TBI) study were analyzed for seven main CT characteristics. Kappa statistics were used to calculate agreement between central and local evaluations and a center-specific analysis was performed. The McNemar test was used to detect whether discordances were significant. Central interobserver and intra-observer agreement was calculated in a subset of patients. Good agreement was found between central and local assessment for the presence or absence of structural pathology (CT+, CT-, κ = 0.73) and most CT characteristics (κ = 0.62 to 0.71), except for traumatic axonal injury lesions (κ = 0.37). Despite good kappa values, discordances were significant in four of seven CT characteristics (i.e., midline shift, contusion, traumatic subarachnoid hemorrhage, and cisternal compression; p = 0.0005). Central reviewers showed substantial to excellent interobserver and intra-observer agreement (κ = 0.73 to κ = 0.96), contrasted by considerable variability in local radiological reading. Compared with local evaluation, a central review process offers a more consistent radiological reading of acute CT characteristics in TBI. It generates reliable, reproducible data and should be recommended for use in multi-center TBI studies.

Journal of Neuroradiology

Neuroradiology, 2016

For the winners, ESNR offers a free registration for the ESNR meeting where the prize is awarded.... more For the winners, ESNR offers a free registration for the ESNR meeting where the prize is awarded. Since then, three prizes were awarded [1-3]. It was not surprising to see that all three prizes went to an interventional paper, since in this field a high turnover of innovative techniques tends to be reported, leading to many citations. Since the majority of papers though deal with diagnostic neuroradiology, we felt it was unfair that this was not rewarded.

Neuroradiology, 2016

Erratum to the list of founding members of the ESNR, as mentioned in the supplement to the Septem... more Erratum to the list of founding members of the ESNR, as mentioned in the supplement to the September 2015 issue of the journal with the abstracts of the annual meeting in Naples 2015 (page S7) as well as in the September 2016 issue with the abstracts of the annual meeting in Belgrade (page S4).

European Radiology, Apr 1, 2005

The radiological diagnosis and differential diagnosis of intra-axial tumours no longer relies on ... more The radiological diagnosis and differential diagnosis of intra-axial tumours no longer relies on CT scan and routine MR sequences alone. Standard multiplanar imaging has to be combined with fMRI to allow the exact anatomic location of the lesion and precise determination of the extension of the tumour. Perfusion and diffusion MR is becoming more and more important in the differential diagnosis of cerebral mass lesions and in the grading and typing of gliomas. More sophisticated techniques such as diffusion tensor imaging and spectroscopy will further enhance the value of the radiological studies.

International journal of stroke : official journal of the International Stroke Society, 2016

Recent trials have shown a clear benefit of endovascular therapy for stroke patients presenting w... more Recent trials have shown a clear benefit of endovascular therapy for stroke patients presenting within 6 h after stroke onset. Imaging-based selection may identify a cohort with a favorable response to endovascular therapy, in an even later time window. We performed an indirect comparison between outcomes seen in DEFUSE 2, a prospective cohort study of patients who received a baseline MRI before endovascular therapy, and a control group from AXIS 2 receiving standard medical care up to 12 h after symptom onset. Patients from AXIS 2 with a confirmed large vessel occlusion were selected as a control group for DEFUSE 2-patients. The primary endpoint was good functional outcome at day 90 (Modified Rankin Score 0-2). We performed a stratified analysis based on the presence of the target mismatch for both studies and reperfusion status in DEFUSE 2. We compared good functional outcome in 108 patients from AXIS 2 and 99 patients from DEFUSE 2. In DEFUSE 2-patients with the target mismatch p...

American Journal of Neuroradiology, 1990

Acta Gastro Enterologica Belgica, 2006

Leptomeningeal carcinomatosis (LC) is a rare complication of solid tumours. We report two cases o... more Leptomeningeal carcinomatosis (LC) is a rare complication of solid tumours. We report two cases of leptomeningeal carcinomatosis in patients with oesophageal adenocarcinoma. Diagnosis of LC can be overlooked without a high index of suspicion. Multifocality of symptoms and signs is the hallmark of LC. The combination of cerebrospinal fluid cytology and magnetic resonance imaging has a high diagnostic accuracy. The prognosis remains poor and therefore all therapies are still palliative.

Journal belge de radiologie

Fourteen percutaneous transhepatic venous samplings of the pancreas were performed in 13 patients... more Fourteen percutaneous transhepatic venous samplings of the pancreas were performed in 13 patients. Ten patients undergoing 11 samplings were operated, while 3 patients were not operated. Surgical intervention disclosed a single tumor in 8 patients, a double tumor in 1 patient and diffuse hyperplasia in 1 patient. The method allowed correct localization of 5 insulinomas and correct regionalizing of 4 insulinomas in 9 of 10 small tumoral lesions. In 1 double localization of the pancreatic body percutaneous venous sampling only detected 1 lesion. In 1 case of diffuse hyperplasia of the pancreatic tail, the venous sampling was suggestive for a tumor in the pancreatic tail. The method appears to be highly accurate in diagnosing and localizing insulinomas of the pancreas. However, a need persists for 3-dimensional localization of the lesions to facilitate enucleation. Intraoperative ultrasound could become the method of choice for localization of insulinomas.

Journal belge de radiologie

A case of isolated unilateral extraocular muscle myositis following an acute upper respiratory tr... more A case of isolated unilateral extraocular muscle myositis following an acute upper respiratory tract infection is reported. Painful eye movements, restricted eye motility and exophthalmus but a normal visual acuity are the most important clinical findings. High resolution contrast enhanced CT and MRI are the imaging modalities of choice to differentiate from other orbital pathologies. The solitary enlarged muscle was clearly seen on both the contrast enhanced CT and the MR examination. Preseptal cellulitis was better seen on MRI, whereas high resolution CT was superior in the demonstration of periscleritis. Graves' ophthalmopathy and orbital cellulitis first have to be excluded. Corticosteroids are the therapy of choice in orbital myositis. A control, contrast enhanced CT after 4 weeks showed an almost normal muscle.

Ophthalmic Surgery, Lasers and Imaging Retina, 2015