Guilherme Nunes - Academia.edu (original) (raw)
Papers by Guilherme Nunes
Nephrology Dialysis Transplantation, May 1, 2014
Introduction and Aims: IgA nephropathy, the most common primary glomerulonephritis worldwide, can... more Introduction and Aims: IgA nephropathy, the most common primary glomerulonephritis worldwide, can lead to end-stage renal disease and kidney transplantation. Disease recurrence frequently occurs after transplantation. We investigated the predictive value of three markers including galactose-deficient (Gd) IgA1, IgG anti-IgA autoantibodies, IgA-soluble (s) CD89 complexes for IgA nephropathy recurrence. The efficacy of intravenous pulse steroid administration for treatment of recurrent IgA nephropathy was evaluated. Methods: The IgA nephropathy recurrent group (R group, n=11) was compared to matched patients transplanted for IgA nephropathy but without recurrence (NR group, n=13) and healthy subjects (n=22) for proportions of serum Gd-IgA1, IgA-IgG complexes and IgA-sCD89 complexes. Efficacy of pulse steroid therapy in reducing proteinuria was analysed in kidney transplant recipients R group. Results: Pre-transplantation serum proportion of Gd-IgA1 and IgA-IgG complexes were higher in R group compared to NR group or healthy controls (respectively p<0•01 and p<0•001). Both the R and NR groups had increased values of IgA-sCD89 complexes compared to healthy controls, but values were lower in R compared to NR (p<0•01). The ROC curve analysis identified the predictive power of each biomarker (AUCGd-IgA=0•85, p=0•003, CI 0•69-1; AUCIgA-IgG=0•94, p=0•0002, CI 0•86-1; AUCsCD89-IgA=0•89, p=0•001, CI 0•75-1). Finally, steroid treatment markedly reduced proteinuria in the R group (p<0•001) and restored all 3 markers back to their pre-transplantation level. Conclusions: The markers: Gd-IgA1, IgG-IgA and IgA-sCD89 complexes appeared as valuable biomarkers to predict disease recurrence. Intravenous pulse steroid therapy seemed to be an efficient and safe option for recurrent IgA nephropathy. Prospective studies on larger cohortes are needed to confirm these results.
Journal of Strength and Conditioning Research, 2020
Nunes, GS, Barton, CJ, and Serrão, FV. Impaired knee muscle capacity is correlated with impaired ... more Nunes, GS, Barton, CJ, and Serrão, FV. Impaired knee muscle capacity is correlated with impaired sagittal kinematics during jump landing in women with patellofemoral pain. J Strength Cond Res XX(X): 000-000, 2020-Knee and hip muscle capacity is impaired in women with patellofemoral pain (PFP), but little is known about the rate of force development (RFD) at the knee. Impaired muscle capacity may contribute to reduced sagittal plane movement at the knee and hip during jump landing in women with PFP. This study aimed to (a) compare knee extensor muscle capacity (including RFD), and hip abductor and extensor muscle capacity between women with and without PFP; and (b) evaluate the relationship between hip/knee muscle capacity and sagittal kinematics during single-legged drop jump landing in women with PFP. Fifty-two physically active women (26 with PFP and 26 controls) participated. Rate of force development (in %/ms), isometric, concentric, and eccentric torque (in N·m·kg × 100) were evaluated using isokinetic dynamometry, and knee and hip kinematics were evaluated using three-dimensional motion capture. Compared with the control group (CG), the PFP group (PFPG) presented lower isometric (12%, PFPG = 217.2 ± 46.0; CG = 246.5 ± 38.8; p = 0.02), concentric (21%, PFPG = 133.0 ± 42.6; CG = 169.2 ± 28.8; p < 0.01), and eccentric (17%, PFPG = 172.9 ± 56.7; CG = 208.4 ± 59.4; p = 0.03) knee extension torque; lower RFD until 30% (30%, PFPG = 0.57 ± 0.27; CG = 0.83 ± 0.37; p < 0.01) and 60% (31%, PFPG = 0.47 ± 0.24; CG = 0.67 ± 0.33; p = 0.01) of maximal isometric torque; and lower concentric hip abduction (13%, PFPG = 94.7 ± 19.1; CG = 108.4 ± 17.5; p = 0.01) and extension (17%, PFPG = 134.4 ± 34.3; CG = 162.6 ± 38.0; p < 0.01) torque. Significant correlations between reduced RFD for knee extension and reduced sagittal plane knee/hip range of motion during landing were identified (r = 0.39-0.49). In conclusion, women with PFP have impaired knee extensor isometric and dynamic strength, and RFD. Impaired knee extensor RFD is associated with a stiffer landing strategy (reduced movement).
The Journal of Physical Chemistry C, 2016
The pharmaceutical drug naproxen was loaded in three different silica hosts with pore diameters o... more The pharmaceutical drug naproxen was loaded in three different silica hosts with pore diameters of 2.4 (MCM), 3.2 (MCM), and 5.9 nm (SBA), respectively: nap MCM_2.4 nm , nap MCM_3.2 nm , and nap SBA_5.9 nm. To access the guest physical state in the prepared composites, differential scanning calorimetry (DSC), X-ray diffraction (XRD), and attenuated total reflectance Fourier transform infrared spectroscopy were used. The different techniques provided complementary information on a molecular population that was revealed to be distributed among different environments, namely the pore core, the inner pore wall, and the outer surface. It was found that naproxen is semicrystalline in the higher pore size matrix being able to crystallize inside pores; after melting it undergoes full amorphization. In the case of the lower pore size matrix, naproxen crystallizes outside pores due to an excess of filling while most of the remaining fraction is incorporated inside the pores as amorphous. Crystallinity in these two composites was observed by the emergence of the Bragg peaks in the XRD analysis, whereas for nap MCM_3.2 nm only the amorphous halo was detected. The latter only exhibits the step due to the glass transition by DSC remaining stable as amorphous at least for 12 months. The glass transition in the three composites is abnormally broad, shifting to higher temperatures as the pore size decreases, coherent with the slowing down of molecular mobility as probed by dielectric relaxation spectroscopy. For nap SBA_5.9 nm the dielectric response was deconvoluted in two processes: a hindered surface (S-) process due to molecules interacting with the inner pore wall and a faster α-relaxation associated with the dynamic glass transition due to molecules relaxing in the pore core, which seems a manifestation of true confinement effects. The drug incorporation inside a nanoporous matrix, mainly in 3.2 nm pores, was revealed to be a suitable strategy to stabilize the highly crystallizable drug naproxen in the amorphous/supercooled state and to control its release from the silica matrix, allowing full delivery after 90 min in basic media.
Fisioterapia em Movimento, 2015
Introduction : Sleep performs a restorative function for the body. Medical conditions such as Chr... more Introduction : Sleep performs a restorative function for the body. Medical conditions such as Chronic Low Back Pain (CLBP) may cause sleep changes and impair sleep quality. Objectives : To identify the prevalence of sleep disorders among individuals with CLBP, and investigate whether there is an association between these disorders and perceived functional disability. Materials and methods : This observational, descriptive study was conducted with 51 patients seen at the Clinic of the School of Physical Therapy of Santa Catarina State University. Data were collected through interviews addressing socio-demographic and clinical data, and administration of the Roland-Morris Disability Questionnaire (RMDQ) and Pittsburgh Sleep Quality Index (PSQI). Results : Participants had high levels of functional disability (mean, 16.71 ± 4.16 score points). 82.35% of patients had poor sleep quality (mean, 10.22 ± 4.84 score points). The PSQI components with the highest mean scores were: sleep latenc...
Fisioterapia em Movimento, 2013
INTRODUÇÃO: A técnica de hiperinsuflação manual (HM), também conhecida como "bag squeezing&q... more INTRODUÇÃO: A técnica de hiperinsuflação manual (HM), também conhecida como "bag squeezing" ou "bagging", foi inicialmente descrita como um recurso para melhorar a oxigenação pré e pós-aspiração traqueal, mobilizar o excesso de secreção brônquica e reexpandir áreas pulmonares colapsadas. OBJETIVO: Apresentar evidências científicas sobre os efeitos da manobra de HM como recurso fisioterapêutico, bem como suas indicações clínicas. MATERIAIS E MÉTODOS: Realizou-se uma busca nas bases de dados eletrônicas SciELO, ScienceDirect, PubMed e PEDro, utilizando-se os descritores "hiperinsuflação manual" (manual hyperinflation) e "fisioterapia" (physiotherapy). Como critério de inclusão considerou-se: conter os descritores no título ou resumo; ensaios clínicos que abordassem "hiperinsuflação manual" e fisioterapia; textos em inglês e português; publicações entre 1994 e 2011. RESULTADOS: Foram selecionados 25 estudos e todos apontaram a importânc...
Revista Brasileira de Reumatologia, 2010
The aim of this study was to describe clinical features and response to different therapeutic int... more The aim of this study was to describe clinical features and response to different therapeutic interventions, including anti-tumor necrosis factor (TNF) agents, in a case series of Takayasu arteritis (TA) from Brazil. A retrospective observational chart-review study was performed including all patients meeting the American College of Rheumatology TA classification criteria followed at the rheumatology outpatient clinic of a Brazilian university hospital. Fifteen patients were included, of which 14 (93.3%) were females, with a mean age of 29.6 years at diagnosis. Systemic hypertension (60.0%) and abolished upper limb pulses (53.3%) were the most common clinical features at the diagnosis. Subclavian and carotid arteries were the most commonly affected vessels. Twelve patients (80.0%) did not achieve sustained remission on therapy with corticosteroids alone and received immunosuppressive agents including methotrexate, azathioprine and cyclophosphamide. Surgical intervention was necessary and performed in 53.3% of cases. Three cases (20.0%) were refractory to corticosteroid plus diverse immunosuppressive therapy and were treated with anti-TNF agents, all of them with disease remission. In conclusion, a significant proportion of TA cases are refractory to traditional therapy. The use of anti-TNF agents may become a possible therapy for these patients.
BMC Medical Education, 2022
Background The execution of undergraduate thesis is a period in which students have an opportunit... more Background The execution of undergraduate thesis is a period in which students have an opportunity to develop their scientific knowledge. However, many barriers could prevent the learning process. This cross-sectional study aimed to analyze the scientific dissemination of results from undergraduate theses in physical therapy programs and verify the existence of barriers and challenges in the preparation of undergraduate thesis. Second, to investigate whether project characteristics and thesis development barriers were associated with the dissemination of undergraduate thesis results. Methods Physical therapists who graduated as of 2015, from 50 different educational institutions, answered an online questionnaire about barriers faced during the execution of undergraduate thesis and about scientific dissemination of their results. Results Of 324 participants, 43% (n = 138) of participants disseminated their results, and the main form of dissemination was publishing in national journal...
Fisioterapia em Movimento, 2017
Introduction: The risk of injuries related to physical activity and sports may increase if there ... more Introduction: The risk of injuries related to physical activity and sports may increase if there is predisposition, inappropriate training and/or coach guidance, and absence of sports medicine follow-up. Objective: To assess the frequency of injuries in athletes treated at a physiotherapy center specialized in sports. Methods: For the data collection was carried out the survey of injuries in records of athletes treated in eight years of activities. The data collected included: characteristics of patients, sport, injury kind, injury characteristics and affected body part. Results: From 1090 patient/athlete records, the average age was 25 years old, the athletes were spread across 44 different sports modalities, being the great majority men (75%). The most common type of injury was joint injury, followed by muscular and bone injuries. Chronic injury was the most frequent (47%), while the most common body part injured was the knee, followed by ankle and shoulder. Among all the sports, ...
Fisioterapia e Pesquisa, 2015
Ankle sprain is a common injury in soccer athletes and has a high relapse rate. Motor imagery (MI... more Ankle sprain is a common injury in soccer athletes and has a high relapse rate. Motor imagery (MI) may be an alternative treatment to diminish the neuromuscular consequences after the injury. Thus, this study aimed to verify the preliminary results of the effectiveness of MI in the rehabilitation of soccer athletes with acute ankle sprain. Twenty young athletes of the male sex participated in the study. They were randomly divided into two groups: intervention (IG) and control (CG). Participants underwent conventional rehabilitation (cryotherapy, electrotherapy and kinesiotherapy) for ankle sprain, but only the IG performed imagery exercises to try to recognize the ankle-foot figures, projected by a computer, from various perspectives and angles. The ranges of motion (ROM) were measured for dorsiflexion and plantar postural control, edema and functional stability. After treatment, no difference between groups were observed regarding dorsiflexion ROM (p=0.23), plantar flexion ROM (p=0...
Fisioterapia em Movimento, 2017
Introduction: A sphygmomanometer is an instrument commonly used to measure blood pressure that ca... more Introduction: A sphygmomanometer is an instrument commonly used to measure blood pressure that can potentially be used to objectively assess shoulder isometric muscle strength. Objective: To establish the criterion validity and the intra-rater reliability of the sphygmomanometer for the assessment of shoulder isometric muscular strength compared to the handheld dynamometer. To determine if there is a statistically significant difference for shoulder strength between dominant and non-dominant sides. Methods: A test-retest study design was developed, where a rater assessed shoulder flexion and abduction isometric strength of 13 healthy university students, using a commercially available sphygmomanometer and a handheld dynamometer. Results: The criterion validity of the sphygmomanometer was found to be good for both right and left shoulder flexion and abduction strength assessment (Pearson’s r = 0.90-0.97). The intra-rater reliability of the sphygmomanometer was calculated to be good f...
Fisioterapia e Pesquisa, 2015
Ankle sprain is a common injury in soccer athletes and has a high relapse rate. Motor imagery (MI... more Ankle sprain is a common injury in soccer athletes and has a high relapse rate. Motor imagery (MI) may be an alternative treatment to diminish the neuromuscular consequences after the injury. Thus, this study aimed to verify the preliminary results of the effectiveness of MI in the rehabilitation of soccer athletes with acute ankle sprain. Twenty young athletes of the male sex participated in the study. They were randomly divided into two groups: intervention (IG) and control (CG). Participants underwent conventional rehabilitation (cryotherapy, electrotherapy and kinesiotherapy) for ankle sprain, but only the IG performed imagery exercises to try to recognize the ankle-foot figures, projected by a computer, from various perspectives and angles. The ranges of motion (ROM) were measured for dorsiflexion and plantar postural control, edema and functional stability. After treatment, no difference between groups were observed regarding dorsiflexion ROM (p=0.23), plantar flexion ROM (p=0...
We aimed to verify the intrarater and interrater reliability of photogrammetry in the assessment ... more We aimed to verify the intrarater and interrater reliability of photogrammetry in the assessment of iliopsoas, hamstring, quadriceps and gastrocnemius muscle on two occasions. This data shows range of motion change in degrees, which was measured using photogrammetry by three novice raters. In order to analyze intrarater reliability, rater 1 analyzed the images of the same assessment day twice (gray cells in the data set). Participants were healthy, physically active adults.
Journal of Physiotherapy, 2019
Question: Does massage therapy reduce pain and perceived fatigue in the quadriceps, and improve t... more Question: Does massage therapy reduce pain and perceived fatigue in the quadriceps, and improve the mood and physical performance of runners after habitual sporting activity (10-km run)? Design: Randomised controlled trial with concealed allocation, intention-to-treat analysis and blinded assessment. Participants: Seventy-eight runners after sporting activity (10-km run). Intervention: The experimental group received 10 minutes of massage to the quadriceps aimed at recovery following sport practice, and the control group received a sham joint mobilisation. Outcome measures: Pain and perceived fatigue were each assessed using a 0-to-10 numerical rating scale; pain behaviour via the McGill Pain Questionnaire; mood profile via Brunel Mood Scale; quadriceps muscle flexibility using maximal knee flexion angle via inclinometer; isometric muscle strength of knee extensors via hand-held dynamometry; and vertical jump performance using jump height via My Jump 2 app. Evaluations were carried out immediately before and after the intervention, and at 24, 48 and 72 hours after the intervention. Generalised estimating equations were used to estimate a between-group difference (95% CI) using data across all time points. Results: The experimental group had significantly lower scores than the control group on the numerical rating scale for pain by 0.7 points (95% CI 0.1 to 1.3). There were no significant between-group differences for any of the other outcome measures. Conclusion: Massage therapy was effective at reducing pain intensity after application to the quadriceps of runners compared to a sham technique, but the magnitude of the effect was small. There were no significant effects on perceived fatigue, flexibility, strength or jump performance. Trial registration: Brazilian Registry of Clinical Trials, RBR-393m7m. [Bender PU, Luz CM, Feldkircher JM, Nunes GS (2019) Massage therapy slightly decreased pain intensity after habitual running, but had no effect on fatigue, mood or physical performance: a randomised trial.
Clinical Rehabilitation, 2019
Journal of sport rehabilitation, Jan 29, 2018
Ankle sprains are common injuries in sports, however it is unclear whether they are more likely t... more Ankle sprains are common injuries in sports, however it is unclear whether they are more likely to occur in a specific period of a sporting game. To systematically review the literature investigating when in a match ankle sprains most likely occurred. The databases CINAHL, EMBASE, MEDLINE and SPORTDiscus were searched up to August 2016, with no restriction of date or language. The search targeted studies that presented data on the time of occurrence of ankle sprains during sports matches. Data from included studies were analysed as percentage of ankle sprain occurrence by half time and by quarters. Meta-analyses were run using a random effects model. The Quality Assessment Tool for Quantitative Studies was used to assess the article's quality. The searches identified 1,142 studies and eight were included in this review. Five hundred ankle sprains were reported during follow up time that ranged from 1 to 15 years, in five different sports (soccer, rugby, futsal, American football...
Human Movement, 2017
Purpose: To verify the influence of neural mobilization (NM) applied to the lower limbs on functi... more Purpose: To verify the influence of neural mobilization (NM) applied to the lower limbs on functional performance and dynamic balance in asymptomatic individuals. Methods: Thirty asymptomatic participants (15 women and 15 men; age, 30.1 ± 6.7 years; height, 1.70 ± 0.1 m; body mass, 73.1 ± 13.4 kg) were enrolled in this cross-over randomized controlled trial. Participants received both, NM of the femoral, sciatic, and tibial nerves and static stretching (SS) of the following muscles: hamstring, lumbar, piriformis, hip adductors, hip flexors, quadriceps, and triceps surae. The order whether they received first NM or SS was randomly decided and the interventions were performed at least 48 hours apart. The functional performance was measured by performance in vertical jump (VJ) and dynamic balance was measured with the Start Excursion Balance Test (SEBT). Results: There were no differences between NM and SS for height (cm) in VJ (p=0.16), and in distance reached (%) in the SEBT, normali...
Journal of physiotherapy, 2016
Does Kinesio Taping reduce pain and swelling, and increase muscle strength, function and knee-rel... more Does Kinesio Taping reduce pain and swelling, and increase muscle strength, function and knee-related health status in older people with knee osteoarthritis? Randomised, controlled trial with concealed allocation, intention-to-treat analysis and blinded assessment. Seventy-six older people with knee osteoarthritis. The experimental group received three simultaneous Kinesio Taping techniques to treat pain, strength and swelling. The control group received sham taping. All participants kept the taping on for 4 days. The outcomes were: concentric muscle strength of knee extensors and flexors, measured by isokinetic dynamometry with an angular velocity of 60 deg/second normalised for body mass [(Nm/kg) x 100 (%)]; pressure pain threshold via digital pressure algometry (kgf/cm(2)); lower-limb swelling via volumetry (l) and perimetry (cm); physical function via the Lysholm Knee Scoring Scale (0 = worst to 100=best); and knee-related health status via the Western Ontario and McMaster (WOMA...
Journal of Physiotherapy, 2016
Journal of Physiotherapy, 2016
Research requires deep knowledge of the modality to be tested As associates of Dr Kenzo Kase, Fou... more Research requires deep knowledge of the modality to be tested As associates of Dr Kenzo Kase, Founder and Chairman of the Kinesio Taping Association International, we feel called upon to respond to published research and correspondence with regard to 'Kinesio Taping does not decrease swelling in acute, lateral ankle sprain of athletes: a randomised trial[ 5 _ T D $ D I F F ] ' by Nunes and colleagues. 1 [ 4 _ T D $ D I F F ] Nunes claims that the taping application used was drawn from Dr Kase's book, 2 but they only 'partially' followed the book's instructions. They tested two pieces of tape; they did not test the Kinesio Taping Method. As Kinesio Taping educators we found both the study itself and the follow-up communication puzzling. It is evident to anyone who is trained and experienced in the assessment and application protocols for lymphatic Kinesio Taping that the process used was simply wrong. The team does not appear to include anyone certified or extensively trained in the Kinesio Taping Method. Both the contents of the initial article 1 and the subsequent published correspondence 3,4 with Dr Lee indicate significant weaknesses. We share Lee's skepticism as to whether these researchers possess a solid understanding of the principles behind lymphatic Kinesio Taping. Their reply to him reinforces these doubts. The study is replete with troubling details. The subjects were varied in activity and condition. The applications were not blinded. Twenty minutes of icing and exercise with the Kinesio Taping treatment could have affected compliance and caused additional trauma. Many subjects did not complete the study. The technique used 1 suggests a formation of crisscross patterns around the lateral malleolus for lateral ankle sprain and around the medial malleolus for medial ankle sprain. However, with Kinesio Taping the pressure decreases due to lifting of the superficial skin, and blood and lymphatic circulation increase due to an increase in subcutaneous space. The 'control' taping was not inert but had 20% tension, and was applied on the anterior pathway of the lymphatics. As a control they had no no-treatment group. Multiple different investigators may have applied tape with no specifics on their training in Kinesio Taping. Voltmeter for the lower extremity is from foot to knee, so
Fisioterapia em Movimento, 2015
Introduction The Subjective Daily Assessment Scale (ESAD) is based on the visual analog scale (VA... more Introduction The Subjective Daily Assessment Scale (ESAD) is based on the visual analog scale (VAS) and assesses six parameters (pain, edema, heat, mobility, sensitivity, and confidence).Objective This study aimed to examine the association between the analyzed variables as assessed by the ESAD and physical therapy clinical discharge and return-to-play of injured athletes.Method Eighty-one patient records of athletes were analyzed; mean sample age was 23.9 ± 6.3 years. The athletes received treatment through the Sports Physical Therapy program of Santa Catarina State University, Brazil, between 2008 and 2011. Six parameters were ranked on a scale from 0 to 10, with 0 being the best possible condition and 10 the worst. Data analysis was conducted using stepwise Cox regression.Results At the time of the injury, the mean score for confidence was 5.82 ± 0.48, and at the time of return-to-play, it was 0.48 ± 1.1; the mean score for pain decreased from 3.7 ± 2.64 to 0.34 ± 0.83. However, ...
Nephrology Dialysis Transplantation, May 1, 2014
Introduction and Aims: IgA nephropathy, the most common primary glomerulonephritis worldwide, can... more Introduction and Aims: IgA nephropathy, the most common primary glomerulonephritis worldwide, can lead to end-stage renal disease and kidney transplantation. Disease recurrence frequently occurs after transplantation. We investigated the predictive value of three markers including galactose-deficient (Gd) IgA1, IgG anti-IgA autoantibodies, IgA-soluble (s) CD89 complexes for IgA nephropathy recurrence. The efficacy of intravenous pulse steroid administration for treatment of recurrent IgA nephropathy was evaluated. Methods: The IgA nephropathy recurrent group (R group, n=11) was compared to matched patients transplanted for IgA nephropathy but without recurrence (NR group, n=13) and healthy subjects (n=22) for proportions of serum Gd-IgA1, IgA-IgG complexes and IgA-sCD89 complexes. Efficacy of pulse steroid therapy in reducing proteinuria was analysed in kidney transplant recipients R group. Results: Pre-transplantation serum proportion of Gd-IgA1 and IgA-IgG complexes were higher in R group compared to NR group or healthy controls (respectively p<0•01 and p<0•001). Both the R and NR groups had increased values of IgA-sCD89 complexes compared to healthy controls, but values were lower in R compared to NR (p<0•01). The ROC curve analysis identified the predictive power of each biomarker (AUCGd-IgA=0•85, p=0•003, CI 0•69-1; AUCIgA-IgG=0•94, p=0•0002, CI 0•86-1; AUCsCD89-IgA=0•89, p=0•001, CI 0•75-1). Finally, steroid treatment markedly reduced proteinuria in the R group (p<0•001) and restored all 3 markers back to their pre-transplantation level. Conclusions: The markers: Gd-IgA1, IgG-IgA and IgA-sCD89 complexes appeared as valuable biomarkers to predict disease recurrence. Intravenous pulse steroid therapy seemed to be an efficient and safe option for recurrent IgA nephropathy. Prospective studies on larger cohortes are needed to confirm these results.
Journal of Strength and Conditioning Research, 2020
Nunes, GS, Barton, CJ, and Serrão, FV. Impaired knee muscle capacity is correlated with impaired ... more Nunes, GS, Barton, CJ, and Serrão, FV. Impaired knee muscle capacity is correlated with impaired sagittal kinematics during jump landing in women with patellofemoral pain. J Strength Cond Res XX(X): 000-000, 2020-Knee and hip muscle capacity is impaired in women with patellofemoral pain (PFP), but little is known about the rate of force development (RFD) at the knee. Impaired muscle capacity may contribute to reduced sagittal plane movement at the knee and hip during jump landing in women with PFP. This study aimed to (a) compare knee extensor muscle capacity (including RFD), and hip abductor and extensor muscle capacity between women with and without PFP; and (b) evaluate the relationship between hip/knee muscle capacity and sagittal kinematics during single-legged drop jump landing in women with PFP. Fifty-two physically active women (26 with PFP and 26 controls) participated. Rate of force development (in %/ms), isometric, concentric, and eccentric torque (in N·m·kg × 100) were evaluated using isokinetic dynamometry, and knee and hip kinematics were evaluated using three-dimensional motion capture. Compared with the control group (CG), the PFP group (PFPG) presented lower isometric (12%, PFPG = 217.2 ± 46.0; CG = 246.5 ± 38.8; p = 0.02), concentric (21%, PFPG = 133.0 ± 42.6; CG = 169.2 ± 28.8; p < 0.01), and eccentric (17%, PFPG = 172.9 ± 56.7; CG = 208.4 ± 59.4; p = 0.03) knee extension torque; lower RFD until 30% (30%, PFPG = 0.57 ± 0.27; CG = 0.83 ± 0.37; p < 0.01) and 60% (31%, PFPG = 0.47 ± 0.24; CG = 0.67 ± 0.33; p = 0.01) of maximal isometric torque; and lower concentric hip abduction (13%, PFPG = 94.7 ± 19.1; CG = 108.4 ± 17.5; p = 0.01) and extension (17%, PFPG = 134.4 ± 34.3; CG = 162.6 ± 38.0; p < 0.01) torque. Significant correlations between reduced RFD for knee extension and reduced sagittal plane knee/hip range of motion during landing were identified (r = 0.39-0.49). In conclusion, women with PFP have impaired knee extensor isometric and dynamic strength, and RFD. Impaired knee extensor RFD is associated with a stiffer landing strategy (reduced movement).
The Journal of Physical Chemistry C, 2016
The pharmaceutical drug naproxen was loaded in three different silica hosts with pore diameters o... more The pharmaceutical drug naproxen was loaded in three different silica hosts with pore diameters of 2.4 (MCM), 3.2 (MCM), and 5.9 nm (SBA), respectively: nap MCM_2.4 nm , nap MCM_3.2 nm , and nap SBA_5.9 nm. To access the guest physical state in the prepared composites, differential scanning calorimetry (DSC), X-ray diffraction (XRD), and attenuated total reflectance Fourier transform infrared spectroscopy were used. The different techniques provided complementary information on a molecular population that was revealed to be distributed among different environments, namely the pore core, the inner pore wall, and the outer surface. It was found that naproxen is semicrystalline in the higher pore size matrix being able to crystallize inside pores; after melting it undergoes full amorphization. In the case of the lower pore size matrix, naproxen crystallizes outside pores due to an excess of filling while most of the remaining fraction is incorporated inside the pores as amorphous. Crystallinity in these two composites was observed by the emergence of the Bragg peaks in the XRD analysis, whereas for nap MCM_3.2 nm only the amorphous halo was detected. The latter only exhibits the step due to the glass transition by DSC remaining stable as amorphous at least for 12 months. The glass transition in the three composites is abnormally broad, shifting to higher temperatures as the pore size decreases, coherent with the slowing down of molecular mobility as probed by dielectric relaxation spectroscopy. For nap SBA_5.9 nm the dielectric response was deconvoluted in two processes: a hindered surface (S-) process due to molecules interacting with the inner pore wall and a faster α-relaxation associated with the dynamic glass transition due to molecules relaxing in the pore core, which seems a manifestation of true confinement effects. The drug incorporation inside a nanoporous matrix, mainly in 3.2 nm pores, was revealed to be a suitable strategy to stabilize the highly crystallizable drug naproxen in the amorphous/supercooled state and to control its release from the silica matrix, allowing full delivery after 90 min in basic media.
Fisioterapia em Movimento, 2015
Introduction : Sleep performs a restorative function for the body. Medical conditions such as Chr... more Introduction : Sleep performs a restorative function for the body. Medical conditions such as Chronic Low Back Pain (CLBP) may cause sleep changes and impair sleep quality. Objectives : To identify the prevalence of sleep disorders among individuals with CLBP, and investigate whether there is an association between these disorders and perceived functional disability. Materials and methods : This observational, descriptive study was conducted with 51 patients seen at the Clinic of the School of Physical Therapy of Santa Catarina State University. Data were collected through interviews addressing socio-demographic and clinical data, and administration of the Roland-Morris Disability Questionnaire (RMDQ) and Pittsburgh Sleep Quality Index (PSQI). Results : Participants had high levels of functional disability (mean, 16.71 ± 4.16 score points). 82.35% of patients had poor sleep quality (mean, 10.22 ± 4.84 score points). The PSQI components with the highest mean scores were: sleep latenc...
Fisioterapia em Movimento, 2013
INTRODUÇÃO: A técnica de hiperinsuflação manual (HM), também conhecida como "bag squeezing&q... more INTRODUÇÃO: A técnica de hiperinsuflação manual (HM), também conhecida como "bag squeezing" ou "bagging", foi inicialmente descrita como um recurso para melhorar a oxigenação pré e pós-aspiração traqueal, mobilizar o excesso de secreção brônquica e reexpandir áreas pulmonares colapsadas. OBJETIVO: Apresentar evidências científicas sobre os efeitos da manobra de HM como recurso fisioterapêutico, bem como suas indicações clínicas. MATERIAIS E MÉTODOS: Realizou-se uma busca nas bases de dados eletrônicas SciELO, ScienceDirect, PubMed e PEDro, utilizando-se os descritores "hiperinsuflação manual" (manual hyperinflation) e "fisioterapia" (physiotherapy). Como critério de inclusão considerou-se: conter os descritores no título ou resumo; ensaios clínicos que abordassem "hiperinsuflação manual" e fisioterapia; textos em inglês e português; publicações entre 1994 e 2011. RESULTADOS: Foram selecionados 25 estudos e todos apontaram a importânc...
Revista Brasileira de Reumatologia, 2010
The aim of this study was to describe clinical features and response to different therapeutic int... more The aim of this study was to describe clinical features and response to different therapeutic interventions, including anti-tumor necrosis factor (TNF) agents, in a case series of Takayasu arteritis (TA) from Brazil. A retrospective observational chart-review study was performed including all patients meeting the American College of Rheumatology TA classification criteria followed at the rheumatology outpatient clinic of a Brazilian university hospital. Fifteen patients were included, of which 14 (93.3%) were females, with a mean age of 29.6 years at diagnosis. Systemic hypertension (60.0%) and abolished upper limb pulses (53.3%) were the most common clinical features at the diagnosis. Subclavian and carotid arteries were the most commonly affected vessels. Twelve patients (80.0%) did not achieve sustained remission on therapy with corticosteroids alone and received immunosuppressive agents including methotrexate, azathioprine and cyclophosphamide. Surgical intervention was necessary and performed in 53.3% of cases. Three cases (20.0%) were refractory to corticosteroid plus diverse immunosuppressive therapy and were treated with anti-TNF agents, all of them with disease remission. In conclusion, a significant proportion of TA cases are refractory to traditional therapy. The use of anti-TNF agents may become a possible therapy for these patients.
BMC Medical Education, 2022
Background The execution of undergraduate thesis is a period in which students have an opportunit... more Background The execution of undergraduate thesis is a period in which students have an opportunity to develop their scientific knowledge. However, many barriers could prevent the learning process. This cross-sectional study aimed to analyze the scientific dissemination of results from undergraduate theses in physical therapy programs and verify the existence of barriers and challenges in the preparation of undergraduate thesis. Second, to investigate whether project characteristics and thesis development barriers were associated with the dissemination of undergraduate thesis results. Methods Physical therapists who graduated as of 2015, from 50 different educational institutions, answered an online questionnaire about barriers faced during the execution of undergraduate thesis and about scientific dissemination of their results. Results Of 324 participants, 43% (n = 138) of participants disseminated their results, and the main form of dissemination was publishing in national journal...
Fisioterapia em Movimento, 2017
Introduction: The risk of injuries related to physical activity and sports may increase if there ... more Introduction: The risk of injuries related to physical activity and sports may increase if there is predisposition, inappropriate training and/or coach guidance, and absence of sports medicine follow-up. Objective: To assess the frequency of injuries in athletes treated at a physiotherapy center specialized in sports. Methods: For the data collection was carried out the survey of injuries in records of athletes treated in eight years of activities. The data collected included: characteristics of patients, sport, injury kind, injury characteristics and affected body part. Results: From 1090 patient/athlete records, the average age was 25 years old, the athletes were spread across 44 different sports modalities, being the great majority men (75%). The most common type of injury was joint injury, followed by muscular and bone injuries. Chronic injury was the most frequent (47%), while the most common body part injured was the knee, followed by ankle and shoulder. Among all the sports, ...
Fisioterapia e Pesquisa, 2015
Ankle sprain is a common injury in soccer athletes and has a high relapse rate. Motor imagery (MI... more Ankle sprain is a common injury in soccer athletes and has a high relapse rate. Motor imagery (MI) may be an alternative treatment to diminish the neuromuscular consequences after the injury. Thus, this study aimed to verify the preliminary results of the effectiveness of MI in the rehabilitation of soccer athletes with acute ankle sprain. Twenty young athletes of the male sex participated in the study. They were randomly divided into two groups: intervention (IG) and control (CG). Participants underwent conventional rehabilitation (cryotherapy, electrotherapy and kinesiotherapy) for ankle sprain, but only the IG performed imagery exercises to try to recognize the ankle-foot figures, projected by a computer, from various perspectives and angles. The ranges of motion (ROM) were measured for dorsiflexion and plantar postural control, edema and functional stability. After treatment, no difference between groups were observed regarding dorsiflexion ROM (p=0.23), plantar flexion ROM (p=0...
Fisioterapia em Movimento, 2017
Introduction: A sphygmomanometer is an instrument commonly used to measure blood pressure that ca... more Introduction: A sphygmomanometer is an instrument commonly used to measure blood pressure that can potentially be used to objectively assess shoulder isometric muscle strength. Objective: To establish the criterion validity and the intra-rater reliability of the sphygmomanometer for the assessment of shoulder isometric muscular strength compared to the handheld dynamometer. To determine if there is a statistically significant difference for shoulder strength between dominant and non-dominant sides. Methods: A test-retest study design was developed, where a rater assessed shoulder flexion and abduction isometric strength of 13 healthy university students, using a commercially available sphygmomanometer and a handheld dynamometer. Results: The criterion validity of the sphygmomanometer was found to be good for both right and left shoulder flexion and abduction strength assessment (Pearson’s r = 0.90-0.97). The intra-rater reliability of the sphygmomanometer was calculated to be good f...
Fisioterapia e Pesquisa, 2015
Ankle sprain is a common injury in soccer athletes and has a high relapse rate. Motor imagery (MI... more Ankle sprain is a common injury in soccer athletes and has a high relapse rate. Motor imagery (MI) may be an alternative treatment to diminish the neuromuscular consequences after the injury. Thus, this study aimed to verify the preliminary results of the effectiveness of MI in the rehabilitation of soccer athletes with acute ankle sprain. Twenty young athletes of the male sex participated in the study. They were randomly divided into two groups: intervention (IG) and control (CG). Participants underwent conventional rehabilitation (cryotherapy, electrotherapy and kinesiotherapy) for ankle sprain, but only the IG performed imagery exercises to try to recognize the ankle-foot figures, projected by a computer, from various perspectives and angles. The ranges of motion (ROM) were measured for dorsiflexion and plantar postural control, edema and functional stability. After treatment, no difference between groups were observed regarding dorsiflexion ROM (p=0.23), plantar flexion ROM (p=0...
We aimed to verify the intrarater and interrater reliability of photogrammetry in the assessment ... more We aimed to verify the intrarater and interrater reliability of photogrammetry in the assessment of iliopsoas, hamstring, quadriceps and gastrocnemius muscle on two occasions. This data shows range of motion change in degrees, which was measured using photogrammetry by three novice raters. In order to analyze intrarater reliability, rater 1 analyzed the images of the same assessment day twice (gray cells in the data set). Participants were healthy, physically active adults.
Journal of Physiotherapy, 2019
Question: Does massage therapy reduce pain and perceived fatigue in the quadriceps, and improve t... more Question: Does massage therapy reduce pain and perceived fatigue in the quadriceps, and improve the mood and physical performance of runners after habitual sporting activity (10-km run)? Design: Randomised controlled trial with concealed allocation, intention-to-treat analysis and blinded assessment. Participants: Seventy-eight runners after sporting activity (10-km run). Intervention: The experimental group received 10 minutes of massage to the quadriceps aimed at recovery following sport practice, and the control group received a sham joint mobilisation. Outcome measures: Pain and perceived fatigue were each assessed using a 0-to-10 numerical rating scale; pain behaviour via the McGill Pain Questionnaire; mood profile via Brunel Mood Scale; quadriceps muscle flexibility using maximal knee flexion angle via inclinometer; isometric muscle strength of knee extensors via hand-held dynamometry; and vertical jump performance using jump height via My Jump 2 app. Evaluations were carried out immediately before and after the intervention, and at 24, 48 and 72 hours after the intervention. Generalised estimating equations were used to estimate a between-group difference (95% CI) using data across all time points. Results: The experimental group had significantly lower scores than the control group on the numerical rating scale for pain by 0.7 points (95% CI 0.1 to 1.3). There were no significant between-group differences for any of the other outcome measures. Conclusion: Massage therapy was effective at reducing pain intensity after application to the quadriceps of runners compared to a sham technique, but the magnitude of the effect was small. There were no significant effects on perceived fatigue, flexibility, strength or jump performance. Trial registration: Brazilian Registry of Clinical Trials, RBR-393m7m. [Bender PU, Luz CM, Feldkircher JM, Nunes GS (2019) Massage therapy slightly decreased pain intensity after habitual running, but had no effect on fatigue, mood or physical performance: a randomised trial.
Clinical Rehabilitation, 2019
Journal of sport rehabilitation, Jan 29, 2018
Ankle sprains are common injuries in sports, however it is unclear whether they are more likely t... more Ankle sprains are common injuries in sports, however it is unclear whether they are more likely to occur in a specific period of a sporting game. To systematically review the literature investigating when in a match ankle sprains most likely occurred. The databases CINAHL, EMBASE, MEDLINE and SPORTDiscus were searched up to August 2016, with no restriction of date or language. The search targeted studies that presented data on the time of occurrence of ankle sprains during sports matches. Data from included studies were analysed as percentage of ankle sprain occurrence by half time and by quarters. Meta-analyses were run using a random effects model. The Quality Assessment Tool for Quantitative Studies was used to assess the article's quality. The searches identified 1,142 studies and eight were included in this review. Five hundred ankle sprains were reported during follow up time that ranged from 1 to 15 years, in five different sports (soccer, rugby, futsal, American football...
Human Movement, 2017
Purpose: To verify the influence of neural mobilization (NM) applied to the lower limbs on functi... more Purpose: To verify the influence of neural mobilization (NM) applied to the lower limbs on functional performance and dynamic balance in asymptomatic individuals. Methods: Thirty asymptomatic participants (15 women and 15 men; age, 30.1 ± 6.7 years; height, 1.70 ± 0.1 m; body mass, 73.1 ± 13.4 kg) were enrolled in this cross-over randomized controlled trial. Participants received both, NM of the femoral, sciatic, and tibial nerves and static stretching (SS) of the following muscles: hamstring, lumbar, piriformis, hip adductors, hip flexors, quadriceps, and triceps surae. The order whether they received first NM or SS was randomly decided and the interventions were performed at least 48 hours apart. The functional performance was measured by performance in vertical jump (VJ) and dynamic balance was measured with the Start Excursion Balance Test (SEBT). Results: There were no differences between NM and SS for height (cm) in VJ (p=0.16), and in distance reached (%) in the SEBT, normali...
Journal of physiotherapy, 2016
Does Kinesio Taping reduce pain and swelling, and increase muscle strength, function and knee-rel... more Does Kinesio Taping reduce pain and swelling, and increase muscle strength, function and knee-related health status in older people with knee osteoarthritis? Randomised, controlled trial with concealed allocation, intention-to-treat analysis and blinded assessment. Seventy-six older people with knee osteoarthritis. The experimental group received three simultaneous Kinesio Taping techniques to treat pain, strength and swelling. The control group received sham taping. All participants kept the taping on for 4 days. The outcomes were: concentric muscle strength of knee extensors and flexors, measured by isokinetic dynamometry with an angular velocity of 60 deg/second normalised for body mass [(Nm/kg) x 100 (%)]; pressure pain threshold via digital pressure algometry (kgf/cm(2)); lower-limb swelling via volumetry (l) and perimetry (cm); physical function via the Lysholm Knee Scoring Scale (0 = worst to 100=best); and knee-related health status via the Western Ontario and McMaster (WOMA...
Journal of Physiotherapy, 2016
Journal of Physiotherapy, 2016
Research requires deep knowledge of the modality to be tested As associates of Dr Kenzo Kase, Fou... more Research requires deep knowledge of the modality to be tested As associates of Dr Kenzo Kase, Founder and Chairman of the Kinesio Taping Association International, we feel called upon to respond to published research and correspondence with regard to 'Kinesio Taping does not decrease swelling in acute, lateral ankle sprain of athletes: a randomised trial[ 5 _ T D $ D I F F ] ' by Nunes and colleagues. 1 [ 4 _ T D $ D I F F ] Nunes claims that the taping application used was drawn from Dr Kase's book, 2 but they only 'partially' followed the book's instructions. They tested two pieces of tape; they did not test the Kinesio Taping Method. As Kinesio Taping educators we found both the study itself and the follow-up communication puzzling. It is evident to anyone who is trained and experienced in the assessment and application protocols for lymphatic Kinesio Taping that the process used was simply wrong. The team does not appear to include anyone certified or extensively trained in the Kinesio Taping Method. Both the contents of the initial article 1 and the subsequent published correspondence 3,4 with Dr Lee indicate significant weaknesses. We share Lee's skepticism as to whether these researchers possess a solid understanding of the principles behind lymphatic Kinesio Taping. Their reply to him reinforces these doubts. The study is replete with troubling details. The subjects were varied in activity and condition. The applications were not blinded. Twenty minutes of icing and exercise with the Kinesio Taping treatment could have affected compliance and caused additional trauma. Many subjects did not complete the study. The technique used 1 suggests a formation of crisscross patterns around the lateral malleolus for lateral ankle sprain and around the medial malleolus for medial ankle sprain. However, with Kinesio Taping the pressure decreases due to lifting of the superficial skin, and blood and lymphatic circulation increase due to an increase in subcutaneous space. The 'control' taping was not inert but had 20% tension, and was applied on the anterior pathway of the lymphatics. As a control they had no no-treatment group. Multiple different investigators may have applied tape with no specifics on their training in Kinesio Taping. Voltmeter for the lower extremity is from foot to knee, so
Fisioterapia em Movimento, 2015
Introduction The Subjective Daily Assessment Scale (ESAD) is based on the visual analog scale (VA... more Introduction The Subjective Daily Assessment Scale (ESAD) is based on the visual analog scale (VAS) and assesses six parameters (pain, edema, heat, mobility, sensitivity, and confidence).Objective This study aimed to examine the association between the analyzed variables as assessed by the ESAD and physical therapy clinical discharge and return-to-play of injured athletes.Method Eighty-one patient records of athletes were analyzed; mean sample age was 23.9 ± 6.3 years. The athletes received treatment through the Sports Physical Therapy program of Santa Catarina State University, Brazil, between 2008 and 2011. Six parameters were ranked on a scale from 0 to 10, with 0 being the best possible condition and 10 the worst. Data analysis was conducted using stepwise Cox regression.Results At the time of the injury, the mean score for confidence was 5.82 ± 0.48, and at the time of return-to-play, it was 0.48 ± 1.1; the mean score for pain decreased from 3.7 ± 2.64 to 0.34 ± 0.83. However, ...