Gulchekhra Kudeshova - Academia.edu (original) (raw)
doctor of filosophy of biological science
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Papers by Gulchekhra Kudeshova
East European journal of physics, Mar 5, 2024
Journal of Natural Remedies, Feb 1, 2024
Aim: This work aims to investigate the effect of quercetin on the development of small intestine ... more Aim: This work aims to investigate the effect of quercetin on the development of small intestine disaccharidase activity in the offspring intoxicated with lead acetate. Material and Methods: The experiments were carried out on white outbred rats. Rats were divided into control and three experimental groups. In the control and 3 rd experimental group, rats were nursed by intact mothers. In the 1 st and 2 nd experimental groups, rats were nursed by mothers who replaced drinking water with a 0.2% lead acetate solution. All experimental groups of rats were orally treated with quercetin (20 mg/kg/24 h) from the 3 rd to 20 th days of postnatal life. Body weight, small intestine weight as well as the activities of intestinal maltase and lactase were determined on the 7 th , 14 th , and 21 st days after birth. Results: In rats nursed by mothers who used a solution of lead acetate instead of drinking water а body weight and the small intestine mucosa weight decreased, but intestinal maltase and lactase activity increased. Treatment of lead-intoxicated growing rats with quercetin restored the body weight, small intestine mucosa weight, and development rate of maltase and lactase activity. Conclusion: The effect of quercetin on the activity of intestinal maltase and sucrase in growing rats nursed by lead acetate consumed mother is mediated through the restoration of intoxication damage since treatment of intact growing rats with quercetin in the same way and at the same time did not affect on the intestinal disaccharidases activity.
It has been shown the lead intoxication of growing rats result in increase the cavity and membran... more It has been shown the lead intoxication of growing rats result in increase the cavity and membrane carbohydrate hydrolysis and glucose absorption from small intestine which leads to hyperglicemiya. The oral treatment of intoxicated rats with inulin or lactulose results in decrease of carbohydrate assimilation in small intestine and content glucose level in blood. The correcting effect of lactulose on normalization of carbohydrate assimilation is more expressed in compare with inulin. So, inulin and/or lactulose take part in improving of adaptation of the carbohydrate assimilation system in the small intestine during intoxication with lead ions in growing rats. This suggests the prospect of their use as physiologically acceptable additives to stabilize carbohydrate digestion and blood glucose levels in lead and, possibly, other heavy metal intoxication in the growing organism.
East European journal of physics, Mar 5, 2024
Journal of Natural Remedies, Feb 1, 2024
Aim: This work aims to investigate the effect of quercetin on the development of small intestine ... more Aim: This work aims to investigate the effect of quercetin on the development of small intestine disaccharidase activity in the offspring intoxicated with lead acetate. Material and Methods: The experiments were carried out on white outbred rats. Rats were divided into control and three experimental groups. In the control and 3 rd experimental group, rats were nursed by intact mothers. In the 1 st and 2 nd experimental groups, rats were nursed by mothers who replaced drinking water with a 0.2% lead acetate solution. All experimental groups of rats were orally treated with quercetin (20 mg/kg/24 h) from the 3 rd to 20 th days of postnatal life. Body weight, small intestine weight as well as the activities of intestinal maltase and lactase were determined on the 7 th , 14 th , and 21 st days after birth. Results: In rats nursed by mothers who used a solution of lead acetate instead of drinking water а body weight and the small intestine mucosa weight decreased, but intestinal maltase and lactase activity increased. Treatment of lead-intoxicated growing rats with quercetin restored the body weight, small intestine mucosa weight, and development rate of maltase and lactase activity. Conclusion: The effect of quercetin on the activity of intestinal maltase and sucrase in growing rats nursed by lead acetate consumed mother is mediated through the restoration of intoxication damage since treatment of intact growing rats with quercetin in the same way and at the same time did not affect on the intestinal disaccharidases activity.
It has been shown the lead intoxication of growing rats result in increase the cavity and membran... more It has been shown the lead intoxication of growing rats result in increase the cavity and membrane carbohydrate hydrolysis and glucose absorption from small intestine which leads to hyperglicemiya. The oral treatment of intoxicated rats with inulin or lactulose results in decrease of carbohydrate assimilation in small intestine and content glucose level in blood. The correcting effect of lactulose on normalization of carbohydrate assimilation is more expressed in compare with inulin. So, inulin and/or lactulose take part in improving of adaptation of the carbohydrate assimilation system in the small intestine during intoxication with lead ions in growing rats. This suggests the prospect of their use as physiologically acceptable additives to stabilize carbohydrate digestion and blood glucose levels in lead and, possibly, other heavy metal intoxication in the growing organism.