Guorong Sun - Academia.edu (original) (raw)

Papers by Guorong Sun

Binding to the extracellular matrix, one of the most abundant human protein complexes, signifi-ca... more Binding to the extracellular matrix, one of the most abundant human protein complexes, signifi-cantly affects drug disposition. Specifically, the interactions with extracellular matrix determine the free concentrations of small molecules acting in tissues, including signaling peptides, inhibitors of tissue remodeling enzymes such as matrix metalloproteinases, and other drug candidates. The nature of extracellular matrix binding was elucidated for 63 matrix metallo-proteinase inhibitors, for which the association constants to an extracellular matrix mimic were reported here. The data did not correlate with lipophilicity as a common determinant of structure-nonspecific, orientation-averaged bind-

Theses and Dissertations (ETDs) by an authorized administrator of Washington University Open Scho... more Theses and Dissertations (ETDs) by an authorized administrator of Washington University Open Scholarship. For more information, please contact

mannose, 4a and dinitrophenyl groups as antigens 4c have been placed on the surface of SCK nanopa... more mannose, 4a and dinitrophenyl groups as antigens 4c have been placed on the surface of SCK nanoparticles via a mixed micelle methodology. The conjugation of ligands with pre-established SCK nanoparticles, which is the most versatile and straightforward method, has been achieved via various strategies, including amidation 5 and click chemistry, 6 and the results have suggested that it was effective, but sometimes unpredictable. In order to provide better understanding of the chemistry between ligands and nanoparticles, we have investigated the functionalization of SCK nanoparticles with two types of DOTA molecules through two different pathways. Comparison of the post-modification of pre-established SCKs (Scheme 1: Method A) with pre-conjugation of DOTA to the block copolymers, followed by SCK assembly (Scheme 1: Method B) has provided many new insights into the design of ligands and manipulation of SCKs. Results and Discussion Amphiphilic diblock copolymers, poly(acrylic acid)-b-pol...

ACS Applied Materials & Interfaces

Nanoparticles have been widely used for preclinical cancer imaging. However, their successful cli... more Nanoparticles have been widely used for preclinical cancer imaging. However, their successful clinical translation is largely hampered by potential toxicity, unsatisfactory detection of malignancy at early stages, inaccurate diagnosis of tumor biomarkers, and histology for imaging-guided treatment. Herein, a targeted copper nanocluster (CuNC) is reported with high potential to address these challenges for future translation. Its ultrasmall structure enables efficient renal/bowel clearance, minimized off-target effects in nontargeted organs, and low nonspecific tumor retention. The pH-dependent in vivo dissolution of CuNCs affords minimal toxicity and potentially selective drug delivery to tumors. The intrinsic radiolabeling through the direct addition of 64Cu to CuNC (64Cu-CuNCs-FC131) synthesis offers high specific activity for sensitive and accurate detection of CXCR4 via FC131-directed targeting in novel triple negative breast cancer (TNBC) patient-derived xenograft mouse models and human TNBC tissues. In summary, this study not only reveals the potential of CXCR4-targeted 64Cu-CuNCs for TNBC imaging in clinical settings, but also provides a useful strategy to design and assess the translational potential of nanoparticles for cancer theranostics.

Langmuir : the ACS journal of surfaces and colloids, Jan 22, 2018

A zwitterionic polyphosphoester (zPPE), specifically l-cysteine-functionalized poly(but-3-yn-1-yl... more A zwitterionic polyphosphoester (zPPE), specifically l-cysteine-functionalized poly(but-3-yn-1-yloxy)-2-oxo-1,3,2-dioxaphospholane (zPBYP), has been developed as a poly(ethylene glycol) (PEG) alternative coating material for gold nanoparticles (AuNPs), the most extensively investigated metal nanoparticulate platform toward molecular imaging, photothermal therapy, and drug delivery applications. Thiol-yne conjugation of cysteine transformed an initial azido-terminated and alkynyl-functionalized PBYP homopolymer into zPBYP, offering hydrolytic degradability, biocompatibility, and versatile reactive moieties for installation of a range of functional groups. Despite minor degradation during purification, zPPEs were able to stabilize AuNPs presumably through multivalent interactions between combinations of the side chain zwitterions (thioether and phosphoester groups of the zPPEs with the AuNPs). P NMR studies in DO revealed ca. 20% hydrolysis of the phosphoester moieties of the repeat u...

Journal of Polymer Science Part A: Polymer Chemistry

Society of Nuclear Medicine Annual Meeting Abstracts, May 1, 2008

for offering collaborative opportunities and for providing generous supports. Finally, I wish to ... more for offering collaborative opportunities and for providing generous supports. Finally, I wish to express numerous thanks to my wife, Rui Wang, for her companionship across the country, for her understanding and sacrifice, and for her love and support. I owe her too much. I would like to say thanks to my parents for raising me up and giving their continuous love, to my sister for their unconditional love and support. Without their love, encouragement, and support, nothing here was possible.

Chemical Reviews, 2015

Medical diagnosis and therapy are essential for providing patients with proper care, although ine... more Medical diagnosis and therapy are essential for providing patients with proper care, although inefficient diagnosis and therapy are usually associated with either improper detection of the diseases, unsatisfactory therapeutic outcomes, and/or serious adverse reactions. Advances in the design of various diagnostic and therapeutic agents, and the recent trend of utilizing molecules for both therapeutic and diagnostic applications (i.e., theranostics), still have not achieved the maximum benefits of controlling the navigation and biodistribution of these molecules within the biological system.

Macromolecules, Jan 20, 2007

The direct reversible addition fragmentation chain transfer (RAFT) polymerization of 4-vinylbenza... more The direct reversible addition fragmentation chain transfer (RAFT) polymerization of 4-vinylbenzaldehyde (VBA) was established as a new synthetic method for the preparation of well-defined poly(vinylbenzaldehyde) (PVBA), a polymer having reactive aldehyde side chain substiuents. RAFT polymerization of VBA was investigated using S-1-dodecyl-S'-(α,α'-dimethyl-α"-acetic acid)trithiocarbonate (DDMAT) as chain transfer agent (CTA) and 2,2'-azobis(isobutyronitrile) (AIBN) as initiator in 1,4-dioxane or 2-butanone at 70-75 °C for 7.5-22.5 h. With 45-76% of monomer conversion, the resulting PVBA had well controlled number-average molecular weight (M(n)) and low polydispersity (PDI < 1.17). The living characteristic of the RAFT polymerization process was confirmed by the linearity between the M(n) values of PVBA and monomer conversions. Well-defined PVBA was further used as a macromolecular chain transfer agent (macro-CTA) in RAFT polymerization of styrene (St), and a blo...

Journal of Polymer Science Part A: Polymer Chemistry, 2014

With recent technological improvements, fabrication of integrated circuit elements on shrinking s... more With recent technological improvements, fabrication of integrated circuit elements on shrinking scales is required to meet the demand for massive storage and fast data processing. As the fabrication of high resolution patterns requires short wavelength radiation sources, extreme ultraviolet and electron beam techniques have been developed as radiation sources for next-generation lithography. Advancements of lithography techniques accompany the evolution of resist materials for the synchronous fulfillment of high sensitivity, high resolution, and high structural integrity. Our strategy for nanofabrication is a combination of bottom-up synthesis and top-down lithography. The use of cylindrical brush polymers, which can vertically align on substrates, affords access to electron-beam-generated patterns with the minimum pixel size determined by the cylinder diameter. Cylindrical brush polymers for negative-and positive-tone photoresist materials were synthesized by controlled radical and olefin metathesis polymerization. Macromonomers with well-defined size variations were prepared by reversible additionfragmentation chain transfer polymerization of monomers having surface energy reducing, substrate adhesion enhancing, and lithographically functioning moieties. Then, sequential ring-opening metathesis polymerization of the macromonomers via a "grafting-through" strategy allows precise control of concentric and lengthwise dimensions and compositions in the brush polymer structures. x

ACS Macro Letters, 2012

ABSTRACT Dumbbell-shaped triblock molecular brushes were synthesized by ring-opening metathesis p... more ABSTRACT Dumbbell-shaped triblock molecular brushes were synthesized by ring-opening metathesis polymerization (ROMP) of poly(lactide) macromonomers with terminal norbornene groups (NB-PLA) in a sequential addition manner. By changing the macromonomer size and the feed ratio of Grubbs’ catalyst to macromonomer, the dimensions of the “ball” and “bar” of the dumbbell-shaped molecular brushes were controlled. The growth and production of well-defined structures were verified by gel permeation chromatography (GPC), and the final dumbbell-shaped architectures were visualized by atomic force microscopy (AFM). This synthetic methodology represents a rapid and convenient route to unique macromolecular topologies.

Soft Matter, 2009

... Guorong Sun a, Nam S. Lee a, William L. Neumann *bc, John N. Freskos b, Jeng J. Shieh b,Richa... more ... Guorong Sun a, Nam S. Lee a, William L. Neumann *bc, John N. Freskos b, Jeng J. Shieh b,Richard B. Dorshow *b and Karen L. Wooley *ad. a Department of Chemistry and Department of Radiology, Washington University in Saint Louis, Saint Louis, MO 63130, USA. b ...