Gurleen Singh - Academia.edu (original) (raw)

Papers by Gurleen Singh

Sensors

Parkinson’s disease affects millions worldwide with a large rise in expected burden over the comi... more Parkinson’s disease affects millions worldwide with a large rise in expected burden over the coming decades. More easily accessible tools and techniques to diagnose and monitor Parkinson’s disease can improve the quality of life of patients. With the advent of new wearable technologies such as smart rings and watches, this is within reach. However, it is unclear what method for these new technologies may provide the best opportunity to capture the patient-specific severity. This study investigates which locations on the hand can be used to capture and monitor maximal movement/tremor severity. Using a Leap Motion device and custom-made software the volume, velocity, acceleration, and frequency of Parkinson’s (n = 55, all right-handed, majority right-sided onset) patients’ hand locations (25 joints inclusive of all fingers/thumb and the wrist) were captured simultaneously. Distal locations of the right hand, i.e., the ends of fingers and the wrist showed significant trends (p < 0.0...

RSC Advances

Copper(i) catalyzed alkyne azide cycloaddition is the quintessential example of ‘Click Chemistry’... more Copper(i) catalyzed alkyne azide cycloaddition is the quintessential example of ‘Click Chemistry’, provides an adaptable platform for the synthesis of nanogels for sustained drug release at targeted sites owing to their better biocompatibility.

Catalysts

In the extensive terrain of catalytic procedures for the synthesis of organic molecules, metal–or... more In the extensive terrain of catalytic procedures for the synthesis of organic molecules, metal–organic frameworks (MOFs) as heterogenous catalysts have been investigated in a variety of chemical processes, including Friedel–Crafts reactions, condensation reactions, oxidations, and coupling reactions, and utilized owing to their specific properties such as high porosity, tuneability, extraordinary catalytic activity, and recyclability. The eminent copper-tailored MOF materials can be exceptionally dynamic and regioselective catalysts for click reactions (1,3-dipolar cycloaddition reaction). Considering the fact that Cu(I)-catalyzed alkyne–azide cycloaddition (CuAAC) reactions can be catalyzed by several other copper catalysts such as Cu (II)-β-cyclodextrin, Cu(OAc)2, Fe3O4@SiO2, picolinimidoamide–Cu(II) complex, and Cu(II) porphyrin graphene, the properties of sorption and reusability, as well as the high density of copper-MOFs, open an efficient and robust pathway for regimented cat...

Journal of Molecular Structure

Sustainable Chemistry and Pharmacy

Applied Organometallic Chemistry

Computer Networks allows access to information and services in an organized as well as controlled... more Computer Networks allows access to information and services in an organized as well as controlled manner. Security is needed to make your data immune to any kind of data breach or malicious virus attacks. Hardening is to make system hard to protect from unauthorized access and is an on-going process of providing security. As, LAN hardening is done to secure whole organization network from attacks. In this paper, model is proposed for LAN hardening to reduce security risk. LAN hardening is divided into three partsclient/server, hardware and topology hardening. By applying hardening techniques on all parts LAN is harden. In client hardening table is proposed to determine security steps of operating systems and server. In server hardening, concept of masking is introduced to protect user system and to create illusion for intruders. Hardware hardening is proposed using a Table to make whole network harder .hardening of topology can be done by choosing a best one. In this way hardening o...

Vertex cover problem relates to real time application as in any routing algorithm to find a route... more Vertex cover problem relates to real time application as in any routing algorithm to find a router that controls whole path which is defined by vertex cover problem only. Vertex Cover contains phases of covering and non-covering edges. There are various Polynomial time algorithms designed for vertex cover problem but it is bit difficult to find any perfect polynomial time algorithms. Greedy, Clever Greedy, Genetic and Alom Algorithms are analysed in this paper and Comparison among these algorithms is also shown and shows that Alom algorithm is performed better then all algorithms with respect to performance and complexity. There are some problems exists in Alom Algorithm which are to be improved so a new algorithm is proposedfor vertex cover problem which can work efficiently then Alom algorithm in case of performance and complexity.

Computer Networks and Internet has grown vastly in past decade. Computer Networks allows access t... more Computer Networks and Internet has grown vastly in past decade. Computer Networks allows access to information and services in an organized as well as controlled manner. Security is needed to make your data immune to any kind of data breach. In industries, the network and its security are vital issues, as the breach in the system can cause major problems. Hardening is to make system hard to protect from unauthorized access and is an on-going process of providing security. As, LAN hardening is done to secure whole organization network from attacks. It is divided into three partsclient/server, hardware and topology hardening. In this paper, a new model is proposed for LAN hardening to reduce security risk and main focus is to secure client/server. For client hardening model is proposed to audits the activities of attackers and maintains a log for all these activities. Virtualization is performed with the help of virtual machine. Other model is proposed for honeypot to solve the proble...

Journal of Organometallic Chemistry, 2021

Abstract This review emphasizes on the efficacy of various metals in their diverse oxidation stat... more Abstract This review emphasizes on the efficacy of various metals in their diverse oxidation states to efficiently sew terminal alkyne to azide to give triazole ring. The emergence of Alkyne-Azide Cycloaddition reaction as one of the finest tools for the tailoring of two unsaturated fragments has equipped researchers with a methodology to weave in the alkyne-azide groups into either 1,2,3- or 1,2,4-traizole. The use of metal catalysts have efficiency comparative to CuAAC but comes at an expensive cost. The use of different metals involving the mechanistic cycles, reusability studies, solvent system/reacting conditions have been discussed in the review.

Inorganica Chimica Acta, 2018

Abstract This work reports the synthesis and structural characterization of a new adenine based o... more Abstract This work reports the synthesis and structural characterization of a new adenine based organosilicon nucleobase using an efficient and biocompatible Click approach. Synthetic procedure included the preparation of a new N -acetylinic linked propyl silatrane 3 whose structure was confirmed through Single crystal X-ray crystallography. The designed silatrane L is found to be highly selective and sensitive for detection of Cu 2+ with a color change from colourless to yellowish orange. The stoichiometry ratio of L + Cu 2+ was obtained 1:1 by Job’s Plot. The binding of copper ions to the chemosensor was studied over wide pH range and the results demonstrated that the sensor worked well in the physiological range 6–9. Furthermore, the sensing of Cu 2+ was found to be reversible upon addition of EDTA. These results widen the scope of adenine based derivatives in the field of colorimetric probes. The newly synthesized silatrane 3 and the receptor L were successfully characterized by various spectroscopic techniques [IR, NMR ( 1 H, 13 C) and Mass] and elemental analysis.