Gustavo Castro - Academia.edu (original) (raw)
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Papers by Gustavo Castro
Infection, Genetics and Evolution, 2015
Porcine Circovirus Type 2 (PCV2) is a worldwide distributed virus and is considered an important ... more Porcine Circovirus Type 2 (PCV2) is a worldwide distributed virus and is considered an important emerg-27 ing pathogen related to several distinct disease syndromes in pigs. 28 PCV2 strains are classified into three genotypes: PCV2a, with five subtypes (2A-2E), PCV2b with three 29 subtypes (1A-1C) and PCV2c, only found in Denmark. 30 Recently, several reports suggested the circulation of newly emerging PCV2b mutants (mPCV2b) iso-31 lated from pigs with PCVAD in cases of suspected vaccine failure. 32 In this work, we report for the first time the identification of mPCV2b in pigs from Uruguay, providing 33 an additional evidence of a global circulation. Complete genome characterization and phylogenetic anal-34 ysis reveal that Uruguayan strains, as well as mPCV2b previously reported are closely related to other 35 sequences already classified as PCV2b-1C. Furthermore, results showed that mPCV2b presented different 36 genetic markers in the capsid protein compared with classical PCV2a/b strains. Further investigation 37 about antigenic shift of the mPCV2b strains including the Uruguayan isolates is needed. 38
Infection, Genetics and Evolution, 2015
Porcine Circovirus Type 2 (PCV2) is a worldwide distributed virus and is considered an important ... more Porcine Circovirus Type 2 (PCV2) is a worldwide distributed virus and is considered an important emerg-27 ing pathogen related to several distinct disease syndromes in pigs. 28 PCV2 strains are classified into three genotypes: PCV2a, with five subtypes (2A-2E), PCV2b with three 29 subtypes (1A-1C) and PCV2c, only found in Denmark. 30 Recently, several reports suggested the circulation of newly emerging PCV2b mutants (mPCV2b) iso-31 lated from pigs with PCVAD in cases of suspected vaccine failure. 32 In this work, we report for the first time the identification of mPCV2b in pigs from Uruguay, providing 33 an additional evidence of a global circulation. Complete genome characterization and phylogenetic anal-34 ysis reveal that Uruguayan strains, as well as mPCV2b previously reported are closely related to other 35 sequences already classified as PCV2b-1C. Furthermore, results showed that mPCV2b presented different 36 genetic markers in the capsid protein compared with classical PCV2a/b strains. Further investigation 37 about antigenic shift of the mPCV2b strains including the Uruguayan isolates is needed. 38