Guy Cheron - Academia.edu (original) (raw)
Papers by Guy Cheron
Neuroreport, Jun 1, 2001
SCOPUS: le.jinfo:eu-repo/semantics/publishe
Frontiers in Aging Neuroscience, 2016
Molecular Brain, Jan 9, 2015
Scientific Reports, Feb 4, 2021
Neuroscience, Apr 1, 2008
InTech eBooks, Sep 15, 2011
Doctorat en Sciences de la motricitéinfo:eu-repo/semantics/nonPublishe
Scientific Reports, 2021
Although human adaptation to spaceflight has been studied for decades, little is known about its ... more Although human adaptation to spaceflight has been studied for decades, little is known about its long-term effects on brain and behavior. The present study investigated visuospatial performance and associated electrophysiological responses in astronauts before, during, and after an approximately half-year long mission to the International Space Station. Here we report findings demonstrating that cognitive performance can suffer marked decrements during spaceflight. Astronauts were slower and more error-prone on orbit than on Earth, while event-related brain potentials reflected diminished attentional resources. Our study is the first to provide evidence for impaired performance during both the initial (~ 8 days) and later (~ 50 days) stages of spaceflight, without any signs of adaptation. Results indicate restricted adaptability to spaceflight conditions and calls for new research prior to deep space explorations.
Transcranial direct-current stimulation (tDCS) is a non-invasive brain stimulation technique cons... more Transcranial direct-current stimulation (tDCS) is a non-invasive brain stimulation technique consisting in the application of weak electric currents on the scalp. Although previous studies have demonstrated the clinical value of tDCS for modulating sensory, motor, and cognitive functions, there are still huge gaps in the knowledge of the underlying physiological mechanisms. To define the immediate impact as well as the after-effects of tDCS on sensory processing, we first performed electrophysiological recordings in primary somatosensory cortex (S1) of alert mice during and after administration of S1-tDCS, and followed up with immunohistochemical analysis of the stimulated brain regions. During the application of cathodal and anodal transcranial currents we observed polarity-specific bidirectional changes in the N1 component of the sensory-evoked potentials (SEPs) and associated gamma oscillations. Regarding the long-term effects observed after 20 min of tDCS, cathodal stimulation p...
Research in Autism Spectrum Disorders, 2019
Journal of Neurophysiology, 1994
1. For horizontal eye movements, previous observations led to the hypothesis that the legendary n... more 1. For horizontal eye movements, previous observations led to the hypothesis that the legendary neural integrator necessary for correct gaze holding, adequate vestibuloocular reflex (VOR), and optokinetic nystagmus, was located in the region of the complex formed by the nucleus prepositus hypoglossi (NPH) and the medial vestibular nucleus (MVN). 2. The aim of the present study was to test the respective contributions of the NPH, of the rostral part of the MVN, which contains most second-order vestibular neurons, and of the central part of the MVN to the horizontal integrator. 3. An injection of muscimol was used to inactivate each of these three zones in the cat's brain. Muscimol is a gamma-aminobutyric acid (GABA) agonist. By binding to GABAA receptors, it induces a hyperpolarization of the neurons that nullifies their activity. Muscimol was injected into the brain stem of the alert cat through a micropipette by an air pressure system. 4. The search coil technique was used to r...
Frontiers in Aging Neuroscience, 2016
Neuromuscular Disorders, 2015
European Journal of Paediatric Neurology, 2013
Progress in Brain Research, 2000
Peer reviewe
PubMed, May 1, 2003
Angelman syndrome is a neurogenetic disorder characterized by developmental delay, absence of spe... more Angelman syndrome is a neurogenetic disorder characterized by developmental delay, absence of speech, motor impairment, epilepsy and a peculiar behavioural phenotype associated with abnormalities of chromosome 15q11-13. Precise diagnosis carries clinical and genetic counseling implications. However, many clinicians still seem unfamiliar with it despite the severity and typical aspects of presentation. Beyond individual situations, Angelman syndrome can serve as a model opening broad questioning of genetic and epigenetic influences in neurology, as well as of several concepts such as psychomotor development, cerebral palsy, behavioural phenotypes and epileptic syndromes. Recent advances in molecular biology and animal models of the syndrome provide new data which must be included in our interpretation of Angelman syndrome.
Doctorat en sciences médicalesinfo:eu-repo/semantics/nonPublishe
Neuroreport, Jun 1, 2001
SCOPUS: le.jinfo:eu-repo/semantics/publishe
Frontiers in Aging Neuroscience, 2016
Molecular Brain, Jan 9, 2015
Scientific Reports, Feb 4, 2021
Neuroscience, Apr 1, 2008
InTech eBooks, Sep 15, 2011
Doctorat en Sciences de la motricitéinfo:eu-repo/semantics/nonPublishe
Scientific Reports, 2021
Although human adaptation to spaceflight has been studied for decades, little is known about its ... more Although human adaptation to spaceflight has been studied for decades, little is known about its long-term effects on brain and behavior. The present study investigated visuospatial performance and associated electrophysiological responses in astronauts before, during, and after an approximately half-year long mission to the International Space Station. Here we report findings demonstrating that cognitive performance can suffer marked decrements during spaceflight. Astronauts were slower and more error-prone on orbit than on Earth, while event-related brain potentials reflected diminished attentional resources. Our study is the first to provide evidence for impaired performance during both the initial (~ 8 days) and later (~ 50 days) stages of spaceflight, without any signs of adaptation. Results indicate restricted adaptability to spaceflight conditions and calls for new research prior to deep space explorations.
Transcranial direct-current stimulation (tDCS) is a non-invasive brain stimulation technique cons... more Transcranial direct-current stimulation (tDCS) is a non-invasive brain stimulation technique consisting in the application of weak electric currents on the scalp. Although previous studies have demonstrated the clinical value of tDCS for modulating sensory, motor, and cognitive functions, there are still huge gaps in the knowledge of the underlying physiological mechanisms. To define the immediate impact as well as the after-effects of tDCS on sensory processing, we first performed electrophysiological recordings in primary somatosensory cortex (S1) of alert mice during and after administration of S1-tDCS, and followed up with immunohistochemical analysis of the stimulated brain regions. During the application of cathodal and anodal transcranial currents we observed polarity-specific bidirectional changes in the N1 component of the sensory-evoked potentials (SEPs) and associated gamma oscillations. Regarding the long-term effects observed after 20 min of tDCS, cathodal stimulation p...
Research in Autism Spectrum Disorders, 2019
Journal of Neurophysiology, 1994
1. For horizontal eye movements, previous observations led to the hypothesis that the legendary n... more 1. For horizontal eye movements, previous observations led to the hypothesis that the legendary neural integrator necessary for correct gaze holding, adequate vestibuloocular reflex (VOR), and optokinetic nystagmus, was located in the region of the complex formed by the nucleus prepositus hypoglossi (NPH) and the medial vestibular nucleus (MVN). 2. The aim of the present study was to test the respective contributions of the NPH, of the rostral part of the MVN, which contains most second-order vestibular neurons, and of the central part of the MVN to the horizontal integrator. 3. An injection of muscimol was used to inactivate each of these three zones in the cat's brain. Muscimol is a gamma-aminobutyric acid (GABA) agonist. By binding to GABAA receptors, it induces a hyperpolarization of the neurons that nullifies their activity. Muscimol was injected into the brain stem of the alert cat through a micropipette by an air pressure system. 4. The search coil technique was used to r...
Frontiers in Aging Neuroscience, 2016
Neuromuscular Disorders, 2015
European Journal of Paediatric Neurology, 2013
Progress in Brain Research, 2000
Peer reviewe
PubMed, May 1, 2003
Angelman syndrome is a neurogenetic disorder characterized by developmental delay, absence of spe... more Angelman syndrome is a neurogenetic disorder characterized by developmental delay, absence of speech, motor impairment, epilepsy and a peculiar behavioural phenotype associated with abnormalities of chromosome 15q11-13. Precise diagnosis carries clinical and genetic counseling implications. However, many clinicians still seem unfamiliar with it despite the severity and typical aspects of presentation. Beyond individual situations, Angelman syndrome can serve as a model opening broad questioning of genetic and epigenetic influences in neurology, as well as of several concepts such as psychomotor development, cerebral palsy, behavioural phenotypes and epileptic syndromes. Recent advances in molecular biology and animal models of the syndrome provide new data which must be included in our interpretation of Angelman syndrome.
Doctorat en sciences médicalesinfo:eu-repo/semantics/nonPublishe