Gyula Tircsó - Academia.edu (original) (raw)
Papers by Gyula Tircsó
Inorganic Chemistry, Aug 8, 2023
Angewandte Chemie, Dec 4, 2017
Lanthanide-based T2ex and CEST complexes provide new insights into the design of pH sensitive MRI... more Lanthanide-based T2ex and CEST complexes provide new insights into the design of pH sensitive MRI agents
RSC drug discovery series, 2011
Poster: "ECR 2013 / C-2436 / Comparing low-field and high field relaxometry properties of so... more Poster: "ECR 2013 / C-2436 / Comparing low-field and high field relaxometry properties of solutions and clinically used contrast agents" by: "L. I. Lanczi , E. Balazs, M. Beresova, G. Tircso, E. L. Berenyi; Debrecen/HU"
A pályázat keretében tervezett tudományos munka szorosan kapcsolódik a kutatócsoportunkban már ho... more A pályázat keretében tervezett tudományos munka szorosan kapcsolódik a kutatócsoportunkban már hosszú ideje folyó, a ritakföldfémek (lantanidák, La, Y, és Sc) nyíltláncú és makrociklusos aminopolikarboxilát és aminofoszfonát ligandumokkal képzett komplexei vizsgálatához. Az említett komplexek közül többet elterjedten alkalmaznak az orvosi diagnosztikában (Gd 3+ alapú MRI kontrasztanyagok) ritkábban a terápiában (90 Y, 153 Sm, 166 Ho és 177 Lu izotópok komplexei), így a munkánk bár alapkutatás jellegű, de
Journal of Inorganic Biochemistry
New Developments in NMR
Contrast agents for magnetic resonance imaging (MRI) currently used and approved by the Food and ... more Contrast agents for magnetic resonance imaging (MRI) currently used and approved by the Food and Drug Administration (FDA) of the United States of America are GdIII-based. Yet, GdIII complexes are only one class of contrast agents for MRI. The fundamentals described in this chapter are intended to assist with the design of future imaging agents for MRI. Ligands affect not only relaxivity but also thermodynamic stability and kinetic inertness of GdIII complexes, which in turn affect the safety profiles of contrast agents. Divided into four sections, this chapter describes syntheses and characterization of ligands and metal complexes as well as the determination of the stability and lability of metal complexes.
New Journal of Chemistry
Catalytic and stoichiometric H2O2oxidation by [MnII(N4Py*)]2+and [MnIV(N4Py*)(O)]2+complexes as c... more Catalytic and stoichiometric H2O2oxidation by [MnII(N4Py*)]2+and [MnIV(N4Py*)(O)]2+complexes as catalase mimics have been carried out.
Inorganic Chemistry Frontiers, 2022
Cu(ii) complexes formed with cross-bridged pentaazamacrocycle ligands exhibit high stability and ... more Cu(ii) complexes formed with cross-bridged pentaazamacrocycle ligands exhibit high stability and appropriate inertness, as well as fast complex formation auguring a bright future for this ligand family in radiotheranostic applications.
An entry from the Cambridge Structural Database, the world's repository for small molecule cr... more An entry from the Cambridge Structural Database, the world's repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
An entry from the Cambridge Structural Database, the world's repository for small molecule cr... more An entry from the Cambridge Structural Database, the world's repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
An entry from the Cambridge Structural Database, the world's repository for small molecule cr... more An entry from the Cambridge Structural Database, the world's repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
An entry from the Cambridge Structural Database, the world's repository for small molecule cr... more An entry from the Cambridge Structural Database, the world's repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
An entry from the Cambridge Structural Database, the world's repository for small molecule cr... more An entry from the Cambridge Structural Database, the world's repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
L'invention concerne les composes de formule generale (I), leurs isomeres, leurs sels physiol... more L'invention concerne les composes de formule generale (I), leurs isomeres, leurs sels physiologiquement acceptables et/ou des complexes Mn(II), Fe(II), Fe(III), Co(II) et Ni(II). Un autre objet de l'invention est l'application de ces composes. Les composes sont representes par la formule generale (I), dans laquelle un groupe -NRR 1 peut designer : a) -NRR 1 avec des atomes N dans le cycle designe un cycle de 4 a 7, qui dans certains cas peut contenir un autre heteroatome, et dans des cas particuliers le cycle peut etre remplace par un groupe aryle (de 5 a 7 atomes de carbone) substitue par un ester active de -COOH, -OH, -OCH 3 , -NO 2 , -NH 2 , -NCS, -NHS-, un groupe aryle (de 5 a 7 atomes de carbone), ou nitro, amino ou isothiocyanate, ou b) dans le groupe NRR 1 , R designe un atome H, un groupe alkyle, aryle, nitroaryle, aminoaryle ou isothiocyanate-aryle (de 1 a 6 atomes de carbone) et R 4 represente un atome H, un groupe alkyle (de 1 a 6 atomes de carbone) ou -(CH 2 ...
Toxicity concerns related to Gd(III)-based MRI agents prompted an intensive research towards thei... more Toxicity concerns related to Gd(III)-based MRI agents prompted an intensive research towards their replacement by complexes of essential Mn(II) ion. Here, we report a macrocyclic chelate, [Mn(PC2A-BP)], which possesses high thermodynamic stability and kinetic inertness as well as remarkable relaxivity (r 1p = 23.5 mM-1 s-1 , 20 MHz, 37 °C) in the presence of human serum albumin allowing a significant MRI signal intensity increase in the vasculature even at low dose (25 mol/kg) of the complex.
Inorganic Chemistry, Aug 8, 2023
Angewandte Chemie, Dec 4, 2017
Lanthanide-based T2ex and CEST complexes provide new insights into the design of pH sensitive MRI... more Lanthanide-based T2ex and CEST complexes provide new insights into the design of pH sensitive MRI agents
RSC drug discovery series, 2011
Poster: "ECR 2013 / C-2436 / Comparing low-field and high field relaxometry properties of so... more Poster: "ECR 2013 / C-2436 / Comparing low-field and high field relaxometry properties of solutions and clinically used contrast agents" by: "L. I. Lanczi , E. Balazs, M. Beresova, G. Tircso, E. L. Berenyi; Debrecen/HU"
A pályázat keretében tervezett tudományos munka szorosan kapcsolódik a kutatócsoportunkban már ho... more A pályázat keretében tervezett tudományos munka szorosan kapcsolódik a kutatócsoportunkban már hosszú ideje folyó, a ritakföldfémek (lantanidák, La, Y, és Sc) nyíltláncú és makrociklusos aminopolikarboxilát és aminofoszfonát ligandumokkal képzett komplexei vizsgálatához. Az említett komplexek közül többet elterjedten alkalmaznak az orvosi diagnosztikában (Gd 3+ alapú MRI kontrasztanyagok) ritkábban a terápiában (90 Y, 153 Sm, 166 Ho és 177 Lu izotópok komplexei), így a munkánk bár alapkutatás jellegű, de
Journal of Inorganic Biochemistry
New Developments in NMR
Contrast agents for magnetic resonance imaging (MRI) currently used and approved by the Food and ... more Contrast agents for magnetic resonance imaging (MRI) currently used and approved by the Food and Drug Administration (FDA) of the United States of America are GdIII-based. Yet, GdIII complexes are only one class of contrast agents for MRI. The fundamentals described in this chapter are intended to assist with the design of future imaging agents for MRI. Ligands affect not only relaxivity but also thermodynamic stability and kinetic inertness of GdIII complexes, which in turn affect the safety profiles of contrast agents. Divided into four sections, this chapter describes syntheses and characterization of ligands and metal complexes as well as the determination of the stability and lability of metal complexes.
New Journal of Chemistry
Catalytic and stoichiometric H2O2oxidation by [MnII(N4Py*)]2+and [MnIV(N4Py*)(O)]2+complexes as c... more Catalytic and stoichiometric H2O2oxidation by [MnII(N4Py*)]2+and [MnIV(N4Py*)(O)]2+complexes as catalase mimics have been carried out.
Inorganic Chemistry Frontiers, 2022
Cu(ii) complexes formed with cross-bridged pentaazamacrocycle ligands exhibit high stability and ... more Cu(ii) complexes formed with cross-bridged pentaazamacrocycle ligands exhibit high stability and appropriate inertness, as well as fast complex formation auguring a bright future for this ligand family in radiotheranostic applications.
An entry from the Cambridge Structural Database, the world's repository for small molecule cr... more An entry from the Cambridge Structural Database, the world's repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
An entry from the Cambridge Structural Database, the world's repository for small molecule cr... more An entry from the Cambridge Structural Database, the world's repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
An entry from the Cambridge Structural Database, the world's repository for small molecule cr... more An entry from the Cambridge Structural Database, the world's repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
An entry from the Cambridge Structural Database, the world's repository for small molecule cr... more An entry from the Cambridge Structural Database, the world's repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
An entry from the Cambridge Structural Database, the world's repository for small molecule cr... more An entry from the Cambridge Structural Database, the world's repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
L'invention concerne les composes de formule generale (I), leurs isomeres, leurs sels physiol... more L'invention concerne les composes de formule generale (I), leurs isomeres, leurs sels physiologiquement acceptables et/ou des complexes Mn(II), Fe(II), Fe(III), Co(II) et Ni(II). Un autre objet de l'invention est l'application de ces composes. Les composes sont representes par la formule generale (I), dans laquelle un groupe -NRR 1 peut designer : a) -NRR 1 avec des atomes N dans le cycle designe un cycle de 4 a 7, qui dans certains cas peut contenir un autre heteroatome, et dans des cas particuliers le cycle peut etre remplace par un groupe aryle (de 5 a 7 atomes de carbone) substitue par un ester active de -COOH, -OH, -OCH 3 , -NO 2 , -NH 2 , -NCS, -NHS-, un groupe aryle (de 5 a 7 atomes de carbone), ou nitro, amino ou isothiocyanate, ou b) dans le groupe NRR 1 , R designe un atome H, un groupe alkyle, aryle, nitroaryle, aminoaryle ou isothiocyanate-aryle (de 1 a 6 atomes de carbone) et R 4 represente un atome H, un groupe alkyle (de 1 a 6 atomes de carbone) ou -(CH 2 ...
Toxicity concerns related to Gd(III)-based MRI agents prompted an intensive research towards thei... more Toxicity concerns related to Gd(III)-based MRI agents prompted an intensive research towards their replacement by complexes of essential Mn(II) ion. Here, we report a macrocyclic chelate, [Mn(PC2A-BP)], which possesses high thermodynamic stability and kinetic inertness as well as remarkable relaxivity (r 1p = 23.5 mM-1 s-1 , 20 MHz, 37 °C) in the presence of human serum albumin allowing a significant MRI signal intensity increase in the vasculature even at low dose (25 mol/kg) of the complex.