H. Ceyran - Academia.edu (original) (raw)

Papers by H. Ceyran

erciyes medical journal, 2011

Primary cardiac leiomyosarcoma is one of the rare primary malign cardiac tumors and it has a poor... more Primary cardiac leiomyosarcoma is one of the rare primary malign cardiac tumors and it has a poor prognosis. In this report we present a case who had an operation for left ventricle leiomyosarcoma and a review of literature and principles of treatment.

erciyes medical journal, 2009

Purpose: In this study, we examined the etiology of occlusion of acute arterial occlusion (AAO), ... more Purpose: In this study, we examined the etiology of occlusion of acute arterial occlusion (AAO), surgical techniques and early results of patients which were operated AAO. Material and Methods: Forty-three patients operated between 29 November 2005 and 24 December 2007 with upper extremity AAO. Eighteen patients were male (41.8%) and 25 female (58.2%). Mean age was found 47.2 (8-86) years. The reason was embolus in 18 (41.8%), thrombus in 18 (41.8%) and 7 (16.4%) of them could not be differentiated. Thirtyseven patients (86%) were dignosed with physical examination and hand dupplex and anjiography needed only in 6 (14%). Initially brachial thrombectomy was performed to all patients. Subclavian endarterectomy was needed in 2 patients and synthetic graft interposition in 1 patient between common carotid and brachial artery. Results: Rethrombectomy was performed in 10 patients (1 times in 5, 2 times in 3, 3 times in 1 and 9 times in 1 patient). In 4 patients amputation should be perfor...

Acta chirurgica Hungarica, 1999

BACKGROUND Pectus deformities and atypical costal anomalies are congenital thoracic wall defects ... more BACKGROUND Pectus deformities and atypical costal anomalies are congenital thoracic wall defects that can cause a marked cosmetic defect with attendant psychological trauma and limited physical performance. PATIENTS AND METHODS We reviewed 43 patients with chest wall deformities, 24 (55.8%) were pectus excavatum, 13 (30.2%) pectus carinatum and 6 (14%) atypical costal anomalies, in the last sixteen years. There were nine female and 34 (79.1%) male patients. The mean age of the patients was 14.4 years (range, 5 to 23). Scoliosis (13.5%), Poland's syndrome (5.4%), Marfan's syndrome (5.4%), neurofibromatosis (2.7%), atrial septal defect (2.7%) and mitral valve prolapse (13.5%) were associated with pectus deformities. The modified Ravitch's technique was used in pectus cases. Concomitant surgery was performed in two patients with pectus carinatum. RESULTS The complications of pectus deformity repair were pneumothorax (24.3%), wound infection (8.1%), and local tissue necrosis...

The Journal of cardiovascular surgery, 2002

Turkiye Klinikleri Journal of Cardiovascular Surgery Special Topics, 2014

International journal of clinical and experimental pathology, 2015

The thymus slowly involutes with age after puberty. Various stress conditions accelerate the invo... more The thymus slowly involutes with age after puberty. Various stress conditions accelerate the involution of the thymus and cause changes in the histologic structure of the gland. The present study performed histomorphological and immunohistochemical (IHC) evaluations of the thymus glands removed during surgical repair in patients with cyanotic or acyanotic congenital heart disease (CHD). The thymus glands in the hypoxic group were compared to those in the non-hypoxic group. This study suggested that the activation of HIF-1 alpha promotes tumor progression and impair prognosis due to the inhibition of apoptosis, increased population of stem cells, and induction of angiogenesis also suggested that inactivation of HIF-1 alpha in tumor-infiltrated tissues could halt tumor progression and improve prognosis. The study included 76 thymus glands removed from patients who underwent an operation due to CHD. Of these cases, 38 had cyanotic CHD, and constituted the hypoxic group. The remaining 3...

The Heart Surgery Forum, 2015

Background: Increased blood flow may trigger pulmonary arterial wall inflammation, which may infl... more Background: Increased blood flow may trigger pulmonary arterial wall inflammation, which may influence progression of pulmonary artery hypertension in patients with congenital heart disease. In this study, we aimed to investigate the correlation between preoperative inflammation markers and pulmonary arterial hypertension. Methods: A total of 201 patients with pulmonary hypertension were enrolled in this study retrospectively; they had undergone open heart surgery between January 2012 and December 2013. Patients’ preoperative C-reactive protein (CRP), neutrophil to lymphocyte ratio, red blood cell distribution width, pulmonary pressures, and postoperative outcomes were evaluated.Results: Patient age, neutrophil to lymphocyte ratio, red blood cell distribution width, and CRP were found to be significantly correlated with both preoperative peak and mean pulmonary artery pressures. These data were entered into a linear logistic regression analysis. Patient age, neutrophil to lymphocyte...

Perspectives in vascular surgery and endovascular therapy, 2009

In the authors' institution, 27 patients with gluteal injuries were treated surgically during... more In the authors' institution, 27 patients with gluteal injuries were treated surgically during the past 17 years. All patients were males, and the mean age was 32.4 years. Most patients (89%) had stab wounds. The lesion was on the right buttock in 16 (59%) patients and on the left buttock in 11 (41%) patients. Bleeding was the most common presenting sign. The superior gluteal artery and its branches were the most commonly injured arteries (89%). Surgical procedure was arterial ligation alone in all but one case, whereas one patient underwent coil embolization. Mortality was 11% and included 1 death on arrival to the medical center and 2 intraoperative deaths. To achieve a low rate of morbidity and mortality with such injuries, careful physical examination and immediate surgical or endovascular treatment is needed.

Erciyes Tıp Dergisi/Erciyes Medical Journal, 2014

Objective: In this present study, the association of hyperlactatemia frequency with probable risk... more Objective: In this present study, the association of hyperlactatemia frequency with probable risk factors, postoperative morbidity and mortality were investigated in patients undergoing paediatric open heart surgery. Materials and Methods: The present study included 45 consecutive paediatric patients who had undergone open heart surgery with hypothermic cardiopulmonary bypass in the cardiovascular surgery clinic between January 2008 and July 2008. Four blood samples for lactate analysis were collected from each of the patients preoperatively, intraoperatively and at 1 and 12 hours postoperatively. The patients were divided into two groups according to blood lactate levels as the high lactate group (mean lactate level≥ 3 mmol/L) and the normal lactate group (mean lactate level <3 mmol/L). Hyperlactatemia frequency, associated risk factors, and the relationship with morbidity and mortality were statistically analysed. Results: Of 45 cases, 33 (73.3%) were included in the normal lactate (NL) group, and 12 (26.7%) were included in the high lactate (HL) group. A borderline association was found between lactate levels and mortality in the HL group (p=0.052). Body surface area, age, low cardiac output syndrome, intraoperative and postoperative inotropic support requirement, duration of mechanical ventilation were determined as risk factors associated with mortality (p<0.05), and low cardiac output syndrome, urine output and metabolic acidosis were determined as risk factors associated with hyperlactatemia (p<0.05). Conclusion: In patients followed up in the intensive care unit, lactate concentration is a good indicator for disease severity. Blood lactate levels seems to be a parameter that can be used in routine follow-up.

Artificial Organs, 2015

To the Editor,Tricuspid atresia, a congenital heart defect (CHD)with unknown etiology, occurs 0.0... more To the Editor,Tricuspid atresia, a congenital heart defect (CHD)with unknown etiology, occurs 0.056 per 100 livebirthsandisinvariablyassociatedwithrightventricu-lar hypoplasia, and atrial/ventricular septal defects(1). Recently, many of associations have beenreported between mitochondrial DNA (mtDNA)and a variety of diseases (2). Next-generationsequencing has overcome many limitations ofmtDNA studies, such as estimation of heteroplasmylevel and its effects on the severity of mitochondrialdiseases (3).A 5-year-old girl with a complex CHD wasreferred to our institution. Echocardiography showeddextrocardia, tricuspid valve atresia, perimembranousinlet ventricular septal defect, atrial septal defect,serious pulmonary/subpulmonary stenosis, and ven-triculoarterial discordance. Surgery was performed ona normothermic beating heart where a bidirectionalcavopulmonary shunt was constructed between thesuperior vena cava and the right pulmonary artery.The postoperative course was uneventful, and thepatient was discharged on postoperative day 7. Theright atrial appendage tissue sample that was collectedduring the operation was cryopreserved for mtDNAanalysis.Following genomic DNA extraction, the mtDNAwas amplified in two overlapping PCR fragments(9731 bp and 12 083 bp) using Roche Expand LongRange PCR dNTPack (Roche Applied ScienceIndianapolis, IN, USA). Next-generation sequencingwas performed using GS FLX 454 Life Sciences(Roche) platform. The sequence reads (averagelength 237 bp) were aligned according to the revisedCambridge Reference Sequence (rCRS) (4).In total, 1 732 120 bases were sequenced. 1 396 979bases were mapped to rCRS with 237 bp averagefragment length, and the average depth was ∼84.30Xfor whole mtDNA. Twenty-six homoplasmic and 46heteroplasmic variations were detected (Table 1).All homoplasmic and heteroplasmic variations (withthe 10% cut-off) have been determined and evalu-ated. A nonsynonymous heterozygous unreportedmutation was detected at the mitochondriallyencoded NADH dehydrogenase 1 (MT-ND1) geneposition 3839 C > T Ser178Leu. The patient wasclearly in haplogroup M7d.Mitochondrial diseases have marked clinical het-erogeneity, which is mostly unexplained. MT-ND1 ispart of a large enzyme complex located within themitochondrial inner membrane, playing an activerole in oxidative phosphorylation. We identified anovel missense mutation in the MT-ND1gene, 3839C > T Ser178Leu causing a Serine to Leucine aminoacid conversion, which leads to a drastic polaritychange in the protein product. We could thus specu-late that this final conformational change of theproteincanleadtoseriousmitochondrialdysfunctionleading to congenital defects. Although CHD is acomplex trait with a well-documented genetic com-ponent, it is not based on a single gene of majoreffect, but on interactions among multiple genes;however, noncoding RNA can also insert epigeneticmodification, in other words genetic studies may failto replicate our findings. Evaluating the complexcharacteristics of mtDNA diseases in that perspec-tive and using advanced models to characterize theassociation between multiple gene polymorphismswill increase the knowledge of the genetic mecha-nisms of CHDs. MT-ND1 C > T Ser178Leu mutationserves us as a starting point for our ongoing study ina larger patient group with CHD.

… Klinikleri Journal of …, 2003

... Cilt: 4 / Sayı: 3. Koroner Arter Cerrahisinden Sonra Atriyal Fibrilasyonun Önlenmesinde Metop... more ... Cilt: 4 / Sayı: 3. Koroner Arter Cerrahisinden Sonra Atriyal Fibrilasyonun Önlenmesinde Metoprolol'ün Etkisi Hakan CEYRAN * , Tevfik ... Amaç: Koroner arter baypas cerrahisinden sonra ortaya çıkan aritmi komplikasyonları arasında en sık atriyal fibrilasyon (AF) görülmektedir. ...

Pediatric Critical Care Medicine, 2014

Pediatric Critical Care Medicine, 2014

Pediatric Cardiology, 2008

Rheumatic fever is the main etiology for valvular heart diseases in children. Valvular insufficie... more Rheumatic fever is the main etiology for valvular heart diseases in children. Valvular insufficiencies are frequent, and development of disease at an earlier age results in severe valvular damage. In this report we present a 9-year-old child with rheumatic heart disease who was admitted to our clinic with hemoptysis and haematemesis caused by mitral stenosis (MS) resulting in pulmonary venous hypertension. The child was treated with mitral balloon valvuloplasty by hybrid approach. Percutaneous mitral balloon valvuloplasty is used for management of MS in adults, but it is less frequently used in children because of its high rate of complications. Because of the severity of disease with which this patient presented, as well as her younger age and lower weight, we preferred to use the hybrid approach, and the results were favorable. In conclusion, in patients with special conditions, hybrid mitral valvuloplasty through the right upper pulmonary vein should be considered when managing children with similar conditions.

tipdergisi.erciyes.edu.tr

... Tevfik TEZCANER1, Fatih AŞGÜN2, Hakan CEYRAN3, Kutay TAŞDEMİR4, Benhür CAN5, Orhan BOZOĞLAN2,... more ... Tevfik TEZCANER1, Fatih AŞGÜN2, Hakan CEYRAN3, Kutay TAŞDEMİR4, Benhür CAN5, Orhan BOZOĞLAN2, Ö.Naci EMİROĞULLARI6 ... Telekardiyogramında ileri derecede kardiyomegali bulunan hastanın elektrokardiyogramında spesifik olmayan ST segment ve T dalga ...

International Journal of Cardiology, 2013

Clinical Biochemistry, 1997

To evaluate the protective effect of tryptophan on an experimentally produced hypoxic myocardial ... more To evaluate the protective effect of tryptophan on an experimentally produced hypoxic myocardial injury via biochemical and pathological parameters. Materials and methods: A total of 26 rabbits were divided into 3 groups. Group 1 (n = 9) was only exposed to hypoxia. Group 2 (n = 10) was exposed to hypoxia and received L-tryptophan (200 mg/kg per day, orally for 5 days). Group 3 (n = 7) was the control group. Before the hypoxic injury and after the delivery of the medication, serum samples were taken for troponin-I, creatine kinase myocardial isoenzymes (CK-MB), lactate dehydrogenase (LDH), glutathione peroxidase (GSH-Px), superoxide dismutase (SOD), malondialdehyde (MDA), and nitric oxide (NO) analysis, and then the rabbits were sacrificed. Next, the myocardium samples were taken and the myocardial NO, MDA, SOD, and GSH-Px enzyme activity levels were studied histopathologically. Results: In group 1, Serum GSH-Px and SOD activities were decreased. Conversely, troponin-I, CK-MB, and LDH were elevated. Severe cardiac injury was observed histopathologically. In group 2, serum troponin-I and SOD values were increased. Mild cardiac injury was demonstrated histopathologically. When groups 1 and 2 were compared, tissue NO and MDA levels in group 1 were higher compared to group 2, but GSH-Px level was found decreased in group 1. Conclusion: Our findings support that there is a clear effect of the free oxygen radicals and the lipid peroxidation products on hypoxic cardiac injury. In addition, L-tryptophan supplementation has a strong protective effect on hypoxic heart by antioxidant activity.

… Klinikleri Journal of …, 2003

Amaç: Ülkemizde romatizmal kapak hastalıkları oldukça fazladır. Buna bağlı olarak çok sayıda kapa... more Amaç: Ülkemizde romatizmal kapak hastalıkları oldukça fazladır. Buna bağlı olarak çok sayıda kapak replasmanları yapılmaktadır. Prostetik kapak disfonksiyonları bu olguların en önemli mortalite ve morbidite sebeplerinden bir tanesidir. Hastalar ve Metod: Kliniğimizde ...

… Klinikleri Journal of …, 2000

Erciyes Üniversitesi Tıp Fakültesi Göğüs Kalp ve Damar Cerrahisi Anabilim Dalında 1 Ekim 1990-31 ... more Erciyes Üniversitesi Tıp Fakültesi Göğüs Kalp ve Damar Cerrahisi Anabilim Dalında 1 Ekim 1990-31 Aralık 1998 tarihleri arasında kapak cerrahisi uygulanan ve triküspid kapağına da müdahale edilen 60 hasta retrospektif olarak incelenmiştir. Yaşları 10 ile 70 (ortalama 37.3) ...

erciyes medical journal, 2011

Primary cardiac leiomyosarcoma is one of the rare primary malign cardiac tumors and it has a poor... more Primary cardiac leiomyosarcoma is one of the rare primary malign cardiac tumors and it has a poor prognosis. In this report we present a case who had an operation for left ventricle leiomyosarcoma and a review of literature and principles of treatment.

erciyes medical journal, 2009

Purpose: In this study, we examined the etiology of occlusion of acute arterial occlusion (AAO), ... more Purpose: In this study, we examined the etiology of occlusion of acute arterial occlusion (AAO), surgical techniques and early results of patients which were operated AAO. Material and Methods: Forty-three patients operated between 29 November 2005 and 24 December 2007 with upper extremity AAO. Eighteen patients were male (41.8%) and 25 female (58.2%). Mean age was found 47.2 (8-86) years. The reason was embolus in 18 (41.8%), thrombus in 18 (41.8%) and 7 (16.4%) of them could not be differentiated. Thirtyseven patients (86%) were dignosed with physical examination and hand dupplex and anjiography needed only in 6 (14%). Initially brachial thrombectomy was performed to all patients. Subclavian endarterectomy was needed in 2 patients and synthetic graft interposition in 1 patient between common carotid and brachial artery. Results: Rethrombectomy was performed in 10 patients (1 times in 5, 2 times in 3, 3 times in 1 and 9 times in 1 patient). In 4 patients amputation should be perfor...

Acta chirurgica Hungarica, 1999

BACKGROUND Pectus deformities and atypical costal anomalies are congenital thoracic wall defects ... more BACKGROUND Pectus deformities and atypical costal anomalies are congenital thoracic wall defects that can cause a marked cosmetic defect with attendant psychological trauma and limited physical performance. PATIENTS AND METHODS We reviewed 43 patients with chest wall deformities, 24 (55.8%) were pectus excavatum, 13 (30.2%) pectus carinatum and 6 (14%) atypical costal anomalies, in the last sixteen years. There were nine female and 34 (79.1%) male patients. The mean age of the patients was 14.4 years (range, 5 to 23). Scoliosis (13.5%), Poland's syndrome (5.4%), Marfan's syndrome (5.4%), neurofibromatosis (2.7%), atrial septal defect (2.7%) and mitral valve prolapse (13.5%) were associated with pectus deformities. The modified Ravitch's technique was used in pectus cases. Concomitant surgery was performed in two patients with pectus carinatum. RESULTS The complications of pectus deformity repair were pneumothorax (24.3%), wound infection (8.1%), and local tissue necrosis...

The Journal of cardiovascular surgery, 2002

Turkiye Klinikleri Journal of Cardiovascular Surgery Special Topics, 2014

International journal of clinical and experimental pathology, 2015

The thymus slowly involutes with age after puberty. Various stress conditions accelerate the invo... more The thymus slowly involutes with age after puberty. Various stress conditions accelerate the involution of the thymus and cause changes in the histologic structure of the gland. The present study performed histomorphological and immunohistochemical (IHC) evaluations of the thymus glands removed during surgical repair in patients with cyanotic or acyanotic congenital heart disease (CHD). The thymus glands in the hypoxic group were compared to those in the non-hypoxic group. This study suggested that the activation of HIF-1 alpha promotes tumor progression and impair prognosis due to the inhibition of apoptosis, increased population of stem cells, and induction of angiogenesis also suggested that inactivation of HIF-1 alpha in tumor-infiltrated tissues could halt tumor progression and improve prognosis. The study included 76 thymus glands removed from patients who underwent an operation due to CHD. Of these cases, 38 had cyanotic CHD, and constituted the hypoxic group. The remaining 3...

The Heart Surgery Forum, 2015

Background: Increased blood flow may trigger pulmonary arterial wall inflammation, which may infl... more Background: Increased blood flow may trigger pulmonary arterial wall inflammation, which may influence progression of pulmonary artery hypertension in patients with congenital heart disease. In this study, we aimed to investigate the correlation between preoperative inflammation markers and pulmonary arterial hypertension. Methods: A total of 201 patients with pulmonary hypertension were enrolled in this study retrospectively; they had undergone open heart surgery between January 2012 and December 2013. Patients’ preoperative C-reactive protein (CRP), neutrophil to lymphocyte ratio, red blood cell distribution width, pulmonary pressures, and postoperative outcomes were evaluated.Results: Patient age, neutrophil to lymphocyte ratio, red blood cell distribution width, and CRP were found to be significantly correlated with both preoperative peak and mean pulmonary artery pressures. These data were entered into a linear logistic regression analysis. Patient age, neutrophil to lymphocyte...

Perspectives in vascular surgery and endovascular therapy, 2009

In the authors' institution, 27 patients with gluteal injuries were treated surgically during... more In the authors' institution, 27 patients with gluteal injuries were treated surgically during the past 17 years. All patients were males, and the mean age was 32.4 years. Most patients (89%) had stab wounds. The lesion was on the right buttock in 16 (59%) patients and on the left buttock in 11 (41%) patients. Bleeding was the most common presenting sign. The superior gluteal artery and its branches were the most commonly injured arteries (89%). Surgical procedure was arterial ligation alone in all but one case, whereas one patient underwent coil embolization. Mortality was 11% and included 1 death on arrival to the medical center and 2 intraoperative deaths. To achieve a low rate of morbidity and mortality with such injuries, careful physical examination and immediate surgical or endovascular treatment is needed.

Erciyes Tıp Dergisi/Erciyes Medical Journal, 2014

Objective: In this present study, the association of hyperlactatemia frequency with probable risk... more Objective: In this present study, the association of hyperlactatemia frequency with probable risk factors, postoperative morbidity and mortality were investigated in patients undergoing paediatric open heart surgery. Materials and Methods: The present study included 45 consecutive paediatric patients who had undergone open heart surgery with hypothermic cardiopulmonary bypass in the cardiovascular surgery clinic between January 2008 and July 2008. Four blood samples for lactate analysis were collected from each of the patients preoperatively, intraoperatively and at 1 and 12 hours postoperatively. The patients were divided into two groups according to blood lactate levels as the high lactate group (mean lactate level≥ 3 mmol/L) and the normal lactate group (mean lactate level <3 mmol/L). Hyperlactatemia frequency, associated risk factors, and the relationship with morbidity and mortality were statistically analysed. Results: Of 45 cases, 33 (73.3%) were included in the normal lactate (NL) group, and 12 (26.7%) were included in the high lactate (HL) group. A borderline association was found between lactate levels and mortality in the HL group (p=0.052). Body surface area, age, low cardiac output syndrome, intraoperative and postoperative inotropic support requirement, duration of mechanical ventilation were determined as risk factors associated with mortality (p<0.05), and low cardiac output syndrome, urine output and metabolic acidosis were determined as risk factors associated with hyperlactatemia (p<0.05). Conclusion: In patients followed up in the intensive care unit, lactate concentration is a good indicator for disease severity. Blood lactate levels seems to be a parameter that can be used in routine follow-up.

Artificial Organs, 2015

To the Editor,Tricuspid atresia, a congenital heart defect (CHD)with unknown etiology, occurs 0.0... more To the Editor,Tricuspid atresia, a congenital heart defect (CHD)with unknown etiology, occurs 0.056 per 100 livebirthsandisinvariablyassociatedwithrightventricu-lar hypoplasia, and atrial/ventricular septal defects(1). Recently, many of associations have beenreported between mitochondrial DNA (mtDNA)and a variety of diseases (2). Next-generationsequencing has overcome many limitations ofmtDNA studies, such as estimation of heteroplasmylevel and its effects on the severity of mitochondrialdiseases (3).A 5-year-old girl with a complex CHD wasreferred to our institution. Echocardiography showeddextrocardia, tricuspid valve atresia, perimembranousinlet ventricular septal defect, atrial septal defect,serious pulmonary/subpulmonary stenosis, and ven-triculoarterial discordance. Surgery was performed ona normothermic beating heart where a bidirectionalcavopulmonary shunt was constructed between thesuperior vena cava and the right pulmonary artery.The postoperative course was uneventful, and thepatient was discharged on postoperative day 7. Theright atrial appendage tissue sample that was collectedduring the operation was cryopreserved for mtDNAanalysis.Following genomic DNA extraction, the mtDNAwas amplified in two overlapping PCR fragments(9731 bp and 12 083 bp) using Roche Expand LongRange PCR dNTPack (Roche Applied ScienceIndianapolis, IN, USA). Next-generation sequencingwas performed using GS FLX 454 Life Sciences(Roche) platform. The sequence reads (averagelength 237 bp) were aligned according to the revisedCambridge Reference Sequence (rCRS) (4).In total, 1 732 120 bases were sequenced. 1 396 979bases were mapped to rCRS with 237 bp averagefragment length, and the average depth was ∼84.30Xfor whole mtDNA. Twenty-six homoplasmic and 46heteroplasmic variations were detected (Table 1).All homoplasmic and heteroplasmic variations (withthe 10% cut-off) have been determined and evalu-ated. A nonsynonymous heterozygous unreportedmutation was detected at the mitochondriallyencoded NADH dehydrogenase 1 (MT-ND1) geneposition 3839 C > T Ser178Leu. The patient wasclearly in haplogroup M7d.Mitochondrial diseases have marked clinical het-erogeneity, which is mostly unexplained. MT-ND1 ispart of a large enzyme complex located within themitochondrial inner membrane, playing an activerole in oxidative phosphorylation. We identified anovel missense mutation in the MT-ND1gene, 3839C > T Ser178Leu causing a Serine to Leucine aminoacid conversion, which leads to a drastic polaritychange in the protein product. We could thus specu-late that this final conformational change of theproteincanleadtoseriousmitochondrialdysfunctionleading to congenital defects. Although CHD is acomplex trait with a well-documented genetic com-ponent, it is not based on a single gene of majoreffect, but on interactions among multiple genes;however, noncoding RNA can also insert epigeneticmodification, in other words genetic studies may failto replicate our findings. Evaluating the complexcharacteristics of mtDNA diseases in that perspec-tive and using advanced models to characterize theassociation between multiple gene polymorphismswill increase the knowledge of the genetic mecha-nisms of CHDs. MT-ND1 C > T Ser178Leu mutationserves us as a starting point for our ongoing study ina larger patient group with CHD.

… Klinikleri Journal of …, 2003

... Cilt: 4 / Sayı: 3. Koroner Arter Cerrahisinden Sonra Atriyal Fibrilasyonun Önlenmesinde Metop... more ... Cilt: 4 / Sayı: 3. Koroner Arter Cerrahisinden Sonra Atriyal Fibrilasyonun Önlenmesinde Metoprolol'ün Etkisi Hakan CEYRAN * , Tevfik ... Amaç: Koroner arter baypas cerrahisinden sonra ortaya çıkan aritmi komplikasyonları arasında en sık atriyal fibrilasyon (AF) görülmektedir. ...

Pediatric Critical Care Medicine, 2014

Pediatric Critical Care Medicine, 2014

Pediatric Cardiology, 2008

Rheumatic fever is the main etiology for valvular heart diseases in children. Valvular insufficie... more Rheumatic fever is the main etiology for valvular heart diseases in children. Valvular insufficiencies are frequent, and development of disease at an earlier age results in severe valvular damage. In this report we present a 9-year-old child with rheumatic heart disease who was admitted to our clinic with hemoptysis and haematemesis caused by mitral stenosis (MS) resulting in pulmonary venous hypertension. The child was treated with mitral balloon valvuloplasty by hybrid approach. Percutaneous mitral balloon valvuloplasty is used for management of MS in adults, but it is less frequently used in children because of its high rate of complications. Because of the severity of disease with which this patient presented, as well as her younger age and lower weight, we preferred to use the hybrid approach, and the results were favorable. In conclusion, in patients with special conditions, hybrid mitral valvuloplasty through the right upper pulmonary vein should be considered when managing children with similar conditions.

tipdergisi.erciyes.edu.tr

... Tevfik TEZCANER1, Fatih AŞGÜN2, Hakan CEYRAN3, Kutay TAŞDEMİR4, Benhür CAN5, Orhan BOZOĞLAN2,... more ... Tevfik TEZCANER1, Fatih AŞGÜN2, Hakan CEYRAN3, Kutay TAŞDEMİR4, Benhür CAN5, Orhan BOZOĞLAN2, Ö.Naci EMİROĞULLARI6 ... Telekardiyogramında ileri derecede kardiyomegali bulunan hastanın elektrokardiyogramında spesifik olmayan ST segment ve T dalga ...

International Journal of Cardiology, 2013

Clinical Biochemistry, 1997

To evaluate the protective effect of tryptophan on an experimentally produced hypoxic myocardial ... more To evaluate the protective effect of tryptophan on an experimentally produced hypoxic myocardial injury via biochemical and pathological parameters. Materials and methods: A total of 26 rabbits were divided into 3 groups. Group 1 (n = 9) was only exposed to hypoxia. Group 2 (n = 10) was exposed to hypoxia and received L-tryptophan (200 mg/kg per day, orally for 5 days). Group 3 (n = 7) was the control group. Before the hypoxic injury and after the delivery of the medication, serum samples were taken for troponin-I, creatine kinase myocardial isoenzymes (CK-MB), lactate dehydrogenase (LDH), glutathione peroxidase (GSH-Px), superoxide dismutase (SOD), malondialdehyde (MDA), and nitric oxide (NO) analysis, and then the rabbits were sacrificed. Next, the myocardium samples were taken and the myocardial NO, MDA, SOD, and GSH-Px enzyme activity levels were studied histopathologically. Results: In group 1, Serum GSH-Px and SOD activities were decreased. Conversely, troponin-I, CK-MB, and LDH were elevated. Severe cardiac injury was observed histopathologically. In group 2, serum troponin-I and SOD values were increased. Mild cardiac injury was demonstrated histopathologically. When groups 1 and 2 were compared, tissue NO and MDA levels in group 1 were higher compared to group 2, but GSH-Px level was found decreased in group 1. Conclusion: Our findings support that there is a clear effect of the free oxygen radicals and the lipid peroxidation products on hypoxic cardiac injury. In addition, L-tryptophan supplementation has a strong protective effect on hypoxic heart by antioxidant activity.

… Klinikleri Journal of …, 2003

Amaç: Ülkemizde romatizmal kapak hastalıkları oldukça fazladır. Buna bağlı olarak çok sayıda kapa... more Amaç: Ülkemizde romatizmal kapak hastalıkları oldukça fazladır. Buna bağlı olarak çok sayıda kapak replasmanları yapılmaktadır. Prostetik kapak disfonksiyonları bu olguların en önemli mortalite ve morbidite sebeplerinden bir tanesidir. Hastalar ve Metod: Kliniğimizde ...

… Klinikleri Journal of …, 2000

Erciyes Üniversitesi Tıp Fakültesi Göğüs Kalp ve Damar Cerrahisi Anabilim Dalında 1 Ekim 1990-31 ... more Erciyes Üniversitesi Tıp Fakültesi Göğüs Kalp ve Damar Cerrahisi Anabilim Dalında 1 Ekim 1990-31 Aralık 1998 tarihleri arasında kapak cerrahisi uygulanan ve triküspid kapağına da müdahale edilen 60 hasta retrospektif olarak incelenmiştir. Yaşları 10 ile 70 (ortalama 37.3) ...