HYUNTAE PARK - Academia.edu (original) (raw)
Papers by HYUNTAE PARK
Journal of Ecosystems and Management
Inspired by collaborative work among researchers from the two jurisdictions, we explore the comme... more Inspired by collaborative work among researchers from the two jurisdictions, we explore the commercial mushroom industry in the Republic of Korea and British Columbia, Canada, searching for similarities and differences that may guide future development. First, we provide a history of forest mushroom use in both areas and summarize the development of the cultivated mushroom industry. Second, we describe the forest-harvested commercial mushrooms. We focus on pine mushroom (Tricholoma magnivelare) and provide an overview of the management in Korea of the closely related matsutake (Tricholoma matsutake) that could be translated to pine mushroom management in British Columbia. Generally, the cultivated mushroom industry in Korea is much larger and more diverse, reflecting local traditions of mushroom use. There is potential for expansion of the industries in both jurisdictions, especially in British Columbia, through the exploration and exploitation of novel native forest mushrooms and t...
Circulation, Oct 16, 2007
<jats:p> <jats:bold>Introduction.</jats:bold> Hypertriglyceridemia is an import... more <jats:p> <jats:bold>Introduction.</jats:bold> Hypertriglyceridemia is an important risk factor for coronary heart disease. The purpose of the present study was to identify gene polymorphisms associated with hypertriglyceridemia (serum triglyceride concentration, ≥1.65 mmol/L) for assessment of the genetic risk for this condition. </jats:p> <jats:p> <jats:bold>Methods.</jats:bold> A total of 5206 individuals from two independent populations was examined: Subject panel A comprised 3787 individuals who either visited outpatient clinics of or were admitted to the participating hospitals because of various symptoms or for a health checkup; subject panel B comprised 1419 community-dwelling elderly individuals. The genotypes for 100 polymorphisms of 65 candidate genes were determined by a method that combines the polymerase chain reaction and sequence-specific oligonucleotide probes with suspension array technology. Given the multiple comparisons of genotypes with hypertriglyceridemia, we adopted the criterion of a false discovery rate (FDR) of <0.05 for significant association in initial screening with the chi-square test. </jats:p> <jats:p> <jats:bold>Results.</jats:bold> Evaluation of genotype distributions by the chi-square test and subsequent multivariable logistic regression analysis with adjustment for age and sex revealed that seven polymorphisms [−1131T→ C, −3A→G, and 553G→T (Gly185Cys) of <jats:italic>APOA5</jats:italic> ; 1100C→T of <jats:italic>APOC3</jats:italic> ; 85T→C of <jats:italic>APOA1</jats:italic> ; 41A→G (Glu14Gly) of <jats:italic>ACAT2</jats:italic> ; C→G (Ser47Stop) of <jats:italic>LPL</jats:italic> ] were significantly (FDR < 0.05) associated with hypertriglyceridemia in subject panel A. To validate these associations, we examined the same polymorphisms in subject panel B. The six polymorphisms of <jats:italic>APOA5</jats:italic> , <jats:italic>APOC3</jats:italic> , <jats:italic>APOA1</jats:italic> , and <jats:italic>LPL</jats:italic> , but not that of <jats:italic>ACAT2</jats:italic> , were again significantly associated with hypertriglyceridemia. Serum triglyceride concentrations differed significantly ( <jats:italic>P<</jats:italic> 0.05, ANOVA) among genotypes of each of these six polymorphisms in both subject panels. The three polymorphisms of <jats:italic>APOA5</jats:italic> were in linkage disequilibrium. </jats:p> <jats:p> <jats:bold>Conclusions.</jats:bold> Polymorphisms of <jats:italic>APOA5</jats:italic> , <jats:italic>APOC3</jats:italic> , <jats:italic>APOA1</jats:italic> , and <jats:italic>LPL</jats:italic> are determinants of hypertriglyceridemia. Genotyping of these polymorphisms may prove informative for assessment of the genetic risk for hypertriglyceridemia and may contribute to the personalized prevention of this condition. </jats:p>
Fertility and Sterility, 2021
OBJECTIVE To investigate the relationship between polycystic ovary syndrome (PCOS) and type 2 dia... more OBJECTIVE To investigate the relationship between polycystic ovary syndrome (PCOS) and type 2 diabetes mellitus (T2DM) in Korean women. DESIGN Longitudinal case-control study. SETTING Not applicable. PATIENT(S) PCOS patients aged 15 to 44 years (n = 1,136) and control individuals (n = 5,675), matched 1:5 by age group, income, and region of residence. INTERVENTION(S) Not applicable. MAIN OUTCOME MEASURE(S) The occurrence of T2DM. RESULT(S) In the PCOS and control groups, 15.7% and 14.4%, respectively, were obese (body mass index ≥25 kg/m2). The incidence rate of T2DM was 15.84/1,000 and 5.80/1,000 person-years in the PCOS and control groups, respectively. The unadjusted hazard ratio (HR) of T2DM in women with PCOS was 2.6-fold higher than that in control individuals. Women with PCOS still had a higher HR of T2DM than did control individuals after adjustment for body mass index, family history of T2DM, physical exercise level, and total cholesterol. PCOS was significantly associated with T2DM in women both with and without obesity. CONCLUSION(S) PCOS is independently associated with an increased incidence of T2DM in both obese and nonobese women. Screening for T2DM should be considered for both obese and nonobese women with PCOS in Korea.
Circulation, 2007
Introduction. A low serum concentration of HDL-cholesterol and a high serum concentration of LDL-... more Introduction. A low serum concentration of HDL-cholesterol and a high serum concentration of LDL-cholesterol are risk factors for atherosclerosis. Our goal was to identify genetic variants that confer susceptibility to a low serum concentration of HDL-cholesterol (<1.04 mmol/L) or a high serum concentration of LDL-cholesterol (≥3.64 mmol/L). Methods. A total of 5213 individuals from two independent populations was examined: Subject panel A comprised 3794 individuals who either visited outpatient clinics of or were admitted to the participating hospitals because of various symptoms or for a health checkup; subject panel B comprised 1419 community-dwelling elderly individuals. The genotypes for 100 polymorphisms of 65 candidate genes were determined. Given the multiple comparisons of genotypes with these conditions, we adopted the criterion of a false discovery rate (FDR) of <0.05 for significant association in initial screening with the chi-square test. Results. Examination of ...
Journal of Korean Medical Science, 2021
Background: To analyze the factors associated with women's vasomotor symptoms (VMS) using machine... more Background: To analyze the factors associated with women's vasomotor symptoms (VMS) using machine learning. Methods: Data on 3,298 women, aged 40-80 years, who attended their general health checkup from January 2010 to December 2012 were obtained from Korea University Anam Hospital in Seoul, Korea. Five machine learning methods were applied and compared for the prediction of VMS, measured by the Menopause Rating Scale. Variable importance, the effect of a variable on model performance, was used for identifying the major factors associated with VMS. Results: In terms of the mean squared error, the random forest (0.9326) was much better than linear regression (12.4856) and artificial neural networks with one, two, and three hidden layers (1.5576, 1.5184, and 1.5833, respectively). Based on the variable importance from the random forest, the most important factors associated with VMS were age, menopause age, thyroid-stimulating hormone, and monocyte, triglyceride, gamma glutamyl transferase, blood urea nitrogen, cancer antigen 19-9, C-reactive protein, and low-density lipoprotein cholesterol levels. Indeed, the following variables were ranked within the top 20 in terms of variable importance: cancer antigen 125, total cholesterol, insulin, free thyroxine, forced vital capacity, alanine aminotransferase, forced expired volume in 1 second, height, homeostatic model assessment for insulin resistance, and carcinoembryonic antigen. Conclusion: Machine learning provides an invaluable decision support system for the prediction of VMS. For managing VMS, comprehensive consideration is needed regarding thyroid function, lipid profile, liver function, inflammation markers, insulin resistance, monocyte count, cancer antigens, and lung function.
Journal of Physiological Anthropology, 2007
Journal of Pediatric Endocrinology and Metabolism, 2003
... 論文名, 著者名, 著者所属, 刊行物名, ISSN, 巻, 号, ページ, 出版者, 参考文献, 出版年, 年から 年まで. すべて CiNiiに本文あり CiNiiに本文あり、または... more ... 論文名, 著者名, 著者所属, 刊行物名, ISSN, 巻, 号, ページ, 出版者, 参考文献, 出版年, 年から 年まで. すべて CiNiiに本文あり CiNiiに本文あり、または連携サービスへのリンクあり. Effect of Aerobic Exercise on Visceral Fat and Cardiac Function in Obese Adolescent. ...
In menopausal woman, bone loss with aging worsens rapidly and the risk of osteoporotic fracture i... more In menopausal woman, bone loss with aging worsens rapidly and the risk of osteoporotic fracture increases. Hormone therapy (HT) has been studied to be effective in prevention of postmenopausal osteoporosis and fractures. Therefore, this study aims to investigate the effect of HT on fractures in large cohort of Korean menopausal women. Methods: The study included women over 50 years old who were diagnosed with menopause from 2004 to 2007. Patients who had history of cancer, stroke, myocardial infarction, or who received hormonal treatment less than 1 year were excluded. We evaluated the impact of 3 HT regimens: estrogen/progestogen, estrogen only, tibolone only, and control group consisting of patients who received no HT. We analyzed the effect of HT on fracture risk of the spine, radius and tibia. Additionally, we performed subgroup analysis by age stratification. Result: Compared to the control group, the hazard ratio of spine, radius, tibia fracture was significantly lower in HT group (spine: HR=0.338; 95% CI 0.281-0.407, p=<.0001 radius: HR=0.37; 95% CI0.256-0.537, p=<.0001 tibia: HR=0.443; 95% CI 0.303-0.649., p=<.0001). Analyzing 3 different HT regimen groups respectively, all group had risk reducing effect compared to control group. Conclusion: According to our large cohort study of Korean menopausal women, the HT group had definite benefit for lowering bone fracture risk compared to the control group and fracture risk was significantly reduced in all 3 groups of HT regimen, respectively. Therefore, HT may serve as effective treatment for prevention of menopausal osteoporosis and osteoporosis-related fractures in Korean women.
Journal of Pediatric Endocrinology and Metabolism, 2005
Journal of Pediatric Endocrinology and Metabolism, 2004
... 論文名, 著者名, 著者所属, 刊行物名, ISSN, 巻, 号, ページ, 出版者, 参考文献, 出版年, 年から 年まで. すべて CiNiiに本文あり CiNiiに本文あり、または... more ... 論文名, 著者名, 著者所属, 刊行物名, ISSN, 巻, 号, ページ, 出版者, 参考文献, 出版年, 年から 年まで. すべて CiNiiに本文あり CiNiiに本文あり、または連携サービスへのリンクあり. The Effect of Combined Training on Visceral Fat and Insulin Resistance in Middle-Aged Korean Obese Women ...
International Journal of Environmental Research and Public Health, 2020
During low-intensity exercise stages of the lactate threshold test, blood lactate concentrations ... more During low-intensity exercise stages of the lactate threshold test, blood lactate concentrations gradually diminish due to the predominant utilization of total fat oxidation. However, it is unclear why blood glucose is also reduced in well-trained athletes who also exhibit decreased lactate concentrations. This review focuses on decreased glucose and lactate concentrations at low-exercise intensity performed in well-trained athletes. During low-intensity exercise, the accrued resting lactate may predominantly be transported via blood from the muscle cell to the liver/kidney. Accordingly, there is increased hepatic blood flow with relatively more hepatic glucose output than skeletal muscle glucose output. Hepatic lactate uptake and lactate output of skeletal muscle during recovery time remained similar which may support a predominant Cori cycle (re-synthesis). However, this pathway may be insufficient to produce the necessary glucose level because of the low concentration of lactate ...
International Journal of Environmental Research and Public Health, 2020
The fruit of Schisandra chinensis (SC) is a well-known traditional herb used for pharmacological ... more The fruit of Schisandra chinensis (SC) is a well-known traditional herb used for pharmacological purposes in Asian countries (e.g., Korea, China, and Japan). In animal studies, SC extract supplementation had beneficial effects on muscle strength and lactate level. However, the effect of SC extract supplementation on skeletal muscle strength and lactate at rest in humans remains unclear. The purpose of this study was to evaluate the effect of SC extract supplementation on quadriceps muscle strength (QMS) and lactate at rest in adult women. Forty five healthy post-menopausal middle-aged women (61.9 ± 8.4 years) were randomly divided into the SC (n = 24) or the placebo group (n = 21). The SC group consumed 1000 mg of SC extract per day, whereas the placebo group consumed 1000 mg of starch per day for 12 weeks. The difference in muscle mass, physical function, and biomarkers and the relative changes between baseline and 12 weeks were evaluated. We used two-factor repeated measures analy...
International Journal of Environmental Research and Public Health, 2020
The intima–media thickness (IMT), luminal diameters (LDs), flow velocities (FVs), compliance, and... more The intima–media thickness (IMT), luminal diameters (LDs), flow velocities (FVs), compliance, and β-stiffness of the carotid artery (CA) are considered as independent risk factors for cardiovascular diseases (CVDs). Pre-hypertension (PHT) is also an independent CVD risk factor. This study investigated the association between CA damage (CAD) and PHT. A total of 544 adults participated; their blood pressures (BPs) and CA characteristics were measured using a mercury-free sphygmomanometer and ultrasound. Analysis of covariance (ANCOVA) was performed to assess the differences in the CA characteristics according to the BPs, multinomial logistic regression to evaluate the risk of CAD associated with PHT. In ANCOVA, the CA characteristics of PHT were significantly different from normotensive. The odds ratios (ORs) of IMTmax, LDmax, LDmin, peak-systolic FV (PFV), end-diastolic FV (EFV), PFV/LDmin, EFV/LDmax, compliance, and β-stiffness of PHT were 4.20, 2.70, 3.52, 2.41, 3.06, 3.55, 3.29, 2...
Journal of Clinical Medicine, 2020
The aim of this study was to examine cortical thickness changes associated with a multicomponent ... more The aim of this study was to examine cortical thickness changes associated with a multicomponent exercise intervention combining physical exercise and cognitive training in older adults with cognitive decline. This study involved a secondary analysis of neuroimaging data from a randomized controlled trial with 280 older adults having cognitive decline who were randomly assigned to either a multicomponent exercise group (n = 140) that attended weekly 90-minute exercise and cognitive training sessions or a health education control group (n = 140). The cortical thickness and cognitive performance were assessed at the baseline and at trial completion (10 months). The cortical thickness in the frontal and temporal regions was determined using FreeSurfer software. Cognitive performance was evaluated using the Gerontology-Functional Assessment Tool (NCGG-FAT). The cortical thickness significantly increased in the middle temporal (p < 0.001) and temporal pole (p < 0.001) in the multic...
Maturitas, 2020
To determine the prevalence and severity of menopausal symptoms and their related risk factors am... more To determine the prevalence and severity of menopausal symptoms and their related risk factors among middle-aged Korean women according to their reproductive stages. Methods: This cross-sectional study included 3039 Korean women, aged 45-65 years, who attended their routine health checkup. Their scores from the Menopause Rating Scale (MRS) were compared and participants were categorized into four groups according to stage of menopause: premenopause, early menopause (≤2 years from their last menstruation), mid-menopause (2-8 years), and late menopause (> 8 years). Results: The mean age of the participants was 52.81 ± 5.39 years, and 98.5 % of them reported one or more symptoms included in the MRS. The most common symptom was physical/mental exhaustion, experienced by 86.7 % of participants. The prevalence of moderate to severe symptoms, including vasomotor symptoms, heart discomfort, sleep problems, sexual problems, vaginal dryness, and joint/muscular discomfort, increased in the early menopausal period. This increased in the late menopausal period compared with its prevalence at premenopause. The prevalence of moderate to severe psychological symptoms, heart discomfort, and sleep problems followed a U-shaped trend after menopause: high at early menopause, low at mid-menopause, and high again at late menopause. A low level of physical exercise was an independent risk factor for a high total MRS score; however, the menopausal stages, age, and weight were also variously associated with menopausal symptoms. Conclusions: Several menopausal symptoms remain severe, or are aggravated, until the late menopausal period among Korean women. More attention is warranted to manage these symptoms in postmenopausal women.
Alzheimer's & Dementia, 2018
Alzheimer's & Dementia, 2019
International Dairy Journal, 2015
ABSTRACT A randomised, double-blind, placebo-controlled trial was performed to investigate the ef... more ABSTRACT A randomised, double-blind, placebo-controlled trial was performed to investigate the effects of enteric-coated lactoferrin (LF) supplementation on the immune function of healthy, elderly individuals. Sixty-two healthy men and women were randomly divided into LF (300 mg of bovine LF intake per day) and placebo groups, who consumed the assigned supplements once daily for 3 months. The blood cell count, peripheral blood lymphocyte subset ratios, neutrophil phagocytic function, natural killer (NK) cell cytotoxicity, and serum granulysin and lysozyme concentrations were measured every month. By the third month of treatment, significant inter-group differences were observed in peripheral blood lymphocyte subset ratios, neutrophil phagocytic function, and NK cell cytotoxicity. Our findings suggest that immune competent cells of the innate immune system in elderly individuals are specifically activated by LF intake; therefore, enteric LF supplementation may have beneficial effects on immune function in elderly individuals.
Maturitas, 2018
To evaluate the association between vasomotor symptoms (VMS) and non-alcoholic fatty liver diseas... more To evaluate the association between vasomotor symptoms (VMS) and non-alcoholic fatty liver disease (NAFLD) in postmenopausal women. This cross-sectional study included 1793 Korean postmenopausal women aged 45-65 years who attended a routine health check at a Korean institution from January 2010 to December 2012. Their scores on the Menopause Rating Scale were used to assess VMS. Moderate to severe VMS included ratings of moderate, severe, and very severe. NAFLD was diagnosed by abdominal ultrasound among those who indicated that their ethanol intake was less than 70 g/week. The mean age of these participants was 54.51 ± 4.74 years and the mean duration of menopause was 5.36 ± 4.41 years. A total of 602 (33.6%) women reported mild VMS while 435 (24.3%) reported moderate to severe VMS. The prevalence of NAFLD differed significantly according to the severity of VMS (none, 31.7%; mild, 34.9%; moderate to severe, 39.1%; p = 0.037). Levels of the liver enzymes alanine aminotransferase, a...
Journal of Ecosystems and Management
Inspired by collaborative work among researchers from the two jurisdictions, we explore the comme... more Inspired by collaborative work among researchers from the two jurisdictions, we explore the commercial mushroom industry in the Republic of Korea and British Columbia, Canada, searching for similarities and differences that may guide future development. First, we provide a history of forest mushroom use in both areas and summarize the development of the cultivated mushroom industry. Second, we describe the forest-harvested commercial mushrooms. We focus on pine mushroom (Tricholoma magnivelare) and provide an overview of the management in Korea of the closely related matsutake (Tricholoma matsutake) that could be translated to pine mushroom management in British Columbia. Generally, the cultivated mushroom industry in Korea is much larger and more diverse, reflecting local traditions of mushroom use. There is potential for expansion of the industries in both jurisdictions, especially in British Columbia, through the exploration and exploitation of novel native forest mushrooms and t...
Circulation, Oct 16, 2007
<jats:p> <jats:bold>Introduction.</jats:bold> Hypertriglyceridemia is an import... more <jats:p> <jats:bold>Introduction.</jats:bold> Hypertriglyceridemia is an important risk factor for coronary heart disease. The purpose of the present study was to identify gene polymorphisms associated with hypertriglyceridemia (serum triglyceride concentration, ≥1.65 mmol/L) for assessment of the genetic risk for this condition. </jats:p> <jats:p> <jats:bold>Methods.</jats:bold> A total of 5206 individuals from two independent populations was examined: Subject panel A comprised 3787 individuals who either visited outpatient clinics of or were admitted to the participating hospitals because of various symptoms or for a health checkup; subject panel B comprised 1419 community-dwelling elderly individuals. The genotypes for 100 polymorphisms of 65 candidate genes were determined by a method that combines the polymerase chain reaction and sequence-specific oligonucleotide probes with suspension array technology. Given the multiple comparisons of genotypes with hypertriglyceridemia, we adopted the criterion of a false discovery rate (FDR) of <0.05 for significant association in initial screening with the chi-square test. </jats:p> <jats:p> <jats:bold>Results.</jats:bold> Evaluation of genotype distributions by the chi-square test and subsequent multivariable logistic regression analysis with adjustment for age and sex revealed that seven polymorphisms [−1131T→ C, −3A→G, and 553G→T (Gly185Cys) of <jats:italic>APOA5</jats:italic> ; 1100C→T of <jats:italic>APOC3</jats:italic> ; 85T→C of <jats:italic>APOA1</jats:italic> ; 41A→G (Glu14Gly) of <jats:italic>ACAT2</jats:italic> ; C→G (Ser47Stop) of <jats:italic>LPL</jats:italic> ] were significantly (FDR < 0.05) associated with hypertriglyceridemia in subject panel A. To validate these associations, we examined the same polymorphisms in subject panel B. The six polymorphisms of <jats:italic>APOA5</jats:italic> , <jats:italic>APOC3</jats:italic> , <jats:italic>APOA1</jats:italic> , and <jats:italic>LPL</jats:italic> , but not that of <jats:italic>ACAT2</jats:italic> , were again significantly associated with hypertriglyceridemia. Serum triglyceride concentrations differed significantly ( <jats:italic>P<</jats:italic> 0.05, ANOVA) among genotypes of each of these six polymorphisms in both subject panels. The three polymorphisms of <jats:italic>APOA5</jats:italic> were in linkage disequilibrium. </jats:p> <jats:p> <jats:bold>Conclusions.</jats:bold> Polymorphisms of <jats:italic>APOA5</jats:italic> , <jats:italic>APOC3</jats:italic> , <jats:italic>APOA1</jats:italic> , and <jats:italic>LPL</jats:italic> are determinants of hypertriglyceridemia. Genotyping of these polymorphisms may prove informative for assessment of the genetic risk for hypertriglyceridemia and may contribute to the personalized prevention of this condition. </jats:p>
Fertility and Sterility, 2021
OBJECTIVE To investigate the relationship between polycystic ovary syndrome (PCOS) and type 2 dia... more OBJECTIVE To investigate the relationship between polycystic ovary syndrome (PCOS) and type 2 diabetes mellitus (T2DM) in Korean women. DESIGN Longitudinal case-control study. SETTING Not applicable. PATIENT(S) PCOS patients aged 15 to 44 years (n = 1,136) and control individuals (n = 5,675), matched 1:5 by age group, income, and region of residence. INTERVENTION(S) Not applicable. MAIN OUTCOME MEASURE(S) The occurrence of T2DM. RESULT(S) In the PCOS and control groups, 15.7% and 14.4%, respectively, were obese (body mass index ≥25 kg/m2). The incidence rate of T2DM was 15.84/1,000 and 5.80/1,000 person-years in the PCOS and control groups, respectively. The unadjusted hazard ratio (HR) of T2DM in women with PCOS was 2.6-fold higher than that in control individuals. Women with PCOS still had a higher HR of T2DM than did control individuals after adjustment for body mass index, family history of T2DM, physical exercise level, and total cholesterol. PCOS was significantly associated with T2DM in women both with and without obesity. CONCLUSION(S) PCOS is independently associated with an increased incidence of T2DM in both obese and nonobese women. Screening for T2DM should be considered for both obese and nonobese women with PCOS in Korea.
Circulation, 2007
Introduction. A low serum concentration of HDL-cholesterol and a high serum concentration of LDL-... more Introduction. A low serum concentration of HDL-cholesterol and a high serum concentration of LDL-cholesterol are risk factors for atherosclerosis. Our goal was to identify genetic variants that confer susceptibility to a low serum concentration of HDL-cholesterol (<1.04 mmol/L) or a high serum concentration of LDL-cholesterol (≥3.64 mmol/L). Methods. A total of 5213 individuals from two independent populations was examined: Subject panel A comprised 3794 individuals who either visited outpatient clinics of or were admitted to the participating hospitals because of various symptoms or for a health checkup; subject panel B comprised 1419 community-dwelling elderly individuals. The genotypes for 100 polymorphisms of 65 candidate genes were determined. Given the multiple comparisons of genotypes with these conditions, we adopted the criterion of a false discovery rate (FDR) of <0.05 for significant association in initial screening with the chi-square test. Results. Examination of ...
Journal of Korean Medical Science, 2021
Background: To analyze the factors associated with women's vasomotor symptoms (VMS) using machine... more Background: To analyze the factors associated with women's vasomotor symptoms (VMS) using machine learning. Methods: Data on 3,298 women, aged 40-80 years, who attended their general health checkup from January 2010 to December 2012 were obtained from Korea University Anam Hospital in Seoul, Korea. Five machine learning methods were applied and compared for the prediction of VMS, measured by the Menopause Rating Scale. Variable importance, the effect of a variable on model performance, was used for identifying the major factors associated with VMS. Results: In terms of the mean squared error, the random forest (0.9326) was much better than linear regression (12.4856) and artificial neural networks with one, two, and three hidden layers (1.5576, 1.5184, and 1.5833, respectively). Based on the variable importance from the random forest, the most important factors associated with VMS were age, menopause age, thyroid-stimulating hormone, and monocyte, triglyceride, gamma glutamyl transferase, blood urea nitrogen, cancer antigen 19-9, C-reactive protein, and low-density lipoprotein cholesterol levels. Indeed, the following variables were ranked within the top 20 in terms of variable importance: cancer antigen 125, total cholesterol, insulin, free thyroxine, forced vital capacity, alanine aminotransferase, forced expired volume in 1 second, height, homeostatic model assessment for insulin resistance, and carcinoembryonic antigen. Conclusion: Machine learning provides an invaluable decision support system for the prediction of VMS. For managing VMS, comprehensive consideration is needed regarding thyroid function, lipid profile, liver function, inflammation markers, insulin resistance, monocyte count, cancer antigens, and lung function.
Journal of Physiological Anthropology, 2007
Journal of Pediatric Endocrinology and Metabolism, 2003
... 論文名, 著者名, 著者所属, 刊行物名, ISSN, 巻, 号, ページ, 出版者, 参考文献, 出版年, 年から 年まで. すべて CiNiiに本文あり CiNiiに本文あり、または... more ... 論文名, 著者名, 著者所属, 刊行物名, ISSN, 巻, 号, ページ, 出版者, 参考文献, 出版年, 年から 年まで. すべて CiNiiに本文あり CiNiiに本文あり、または連携サービスへのリンクあり. Effect of Aerobic Exercise on Visceral Fat and Cardiac Function in Obese Adolescent. ...
In menopausal woman, bone loss with aging worsens rapidly and the risk of osteoporotic fracture i... more In menopausal woman, bone loss with aging worsens rapidly and the risk of osteoporotic fracture increases. Hormone therapy (HT) has been studied to be effective in prevention of postmenopausal osteoporosis and fractures. Therefore, this study aims to investigate the effect of HT on fractures in large cohort of Korean menopausal women. Methods: The study included women over 50 years old who were diagnosed with menopause from 2004 to 2007. Patients who had history of cancer, stroke, myocardial infarction, or who received hormonal treatment less than 1 year were excluded. We evaluated the impact of 3 HT regimens: estrogen/progestogen, estrogen only, tibolone only, and control group consisting of patients who received no HT. We analyzed the effect of HT on fracture risk of the spine, radius and tibia. Additionally, we performed subgroup analysis by age stratification. Result: Compared to the control group, the hazard ratio of spine, radius, tibia fracture was significantly lower in HT group (spine: HR=0.338; 95% CI 0.281-0.407, p=<.0001 radius: HR=0.37; 95% CI0.256-0.537, p=<.0001 tibia: HR=0.443; 95% CI 0.303-0.649., p=<.0001). Analyzing 3 different HT regimen groups respectively, all group had risk reducing effect compared to control group. Conclusion: According to our large cohort study of Korean menopausal women, the HT group had definite benefit for lowering bone fracture risk compared to the control group and fracture risk was significantly reduced in all 3 groups of HT regimen, respectively. Therefore, HT may serve as effective treatment for prevention of menopausal osteoporosis and osteoporosis-related fractures in Korean women.
Journal of Pediatric Endocrinology and Metabolism, 2005
Journal of Pediatric Endocrinology and Metabolism, 2004
... 論文名, 著者名, 著者所属, 刊行物名, ISSN, 巻, 号, ページ, 出版者, 参考文献, 出版年, 年から 年まで. すべて CiNiiに本文あり CiNiiに本文あり、または... more ... 論文名, 著者名, 著者所属, 刊行物名, ISSN, 巻, 号, ページ, 出版者, 参考文献, 出版年, 年から 年まで. すべて CiNiiに本文あり CiNiiに本文あり、または連携サービスへのリンクあり. The Effect of Combined Training on Visceral Fat and Insulin Resistance in Middle-Aged Korean Obese Women ...
International Journal of Environmental Research and Public Health, 2020
During low-intensity exercise stages of the lactate threshold test, blood lactate concentrations ... more During low-intensity exercise stages of the lactate threshold test, blood lactate concentrations gradually diminish due to the predominant utilization of total fat oxidation. However, it is unclear why blood glucose is also reduced in well-trained athletes who also exhibit decreased lactate concentrations. This review focuses on decreased glucose and lactate concentrations at low-exercise intensity performed in well-trained athletes. During low-intensity exercise, the accrued resting lactate may predominantly be transported via blood from the muscle cell to the liver/kidney. Accordingly, there is increased hepatic blood flow with relatively more hepatic glucose output than skeletal muscle glucose output. Hepatic lactate uptake and lactate output of skeletal muscle during recovery time remained similar which may support a predominant Cori cycle (re-synthesis). However, this pathway may be insufficient to produce the necessary glucose level because of the low concentration of lactate ...
International Journal of Environmental Research and Public Health, 2020
The fruit of Schisandra chinensis (SC) is a well-known traditional herb used for pharmacological ... more The fruit of Schisandra chinensis (SC) is a well-known traditional herb used for pharmacological purposes in Asian countries (e.g., Korea, China, and Japan). In animal studies, SC extract supplementation had beneficial effects on muscle strength and lactate level. However, the effect of SC extract supplementation on skeletal muscle strength and lactate at rest in humans remains unclear. The purpose of this study was to evaluate the effect of SC extract supplementation on quadriceps muscle strength (QMS) and lactate at rest in adult women. Forty five healthy post-menopausal middle-aged women (61.9 ± 8.4 years) were randomly divided into the SC (n = 24) or the placebo group (n = 21). The SC group consumed 1000 mg of SC extract per day, whereas the placebo group consumed 1000 mg of starch per day for 12 weeks. The difference in muscle mass, physical function, and biomarkers and the relative changes between baseline and 12 weeks were evaluated. We used two-factor repeated measures analy...
International Journal of Environmental Research and Public Health, 2020
The intima–media thickness (IMT), luminal diameters (LDs), flow velocities (FVs), compliance, and... more The intima–media thickness (IMT), luminal diameters (LDs), flow velocities (FVs), compliance, and β-stiffness of the carotid artery (CA) are considered as independent risk factors for cardiovascular diseases (CVDs). Pre-hypertension (PHT) is also an independent CVD risk factor. This study investigated the association between CA damage (CAD) and PHT. A total of 544 adults participated; their blood pressures (BPs) and CA characteristics were measured using a mercury-free sphygmomanometer and ultrasound. Analysis of covariance (ANCOVA) was performed to assess the differences in the CA characteristics according to the BPs, multinomial logistic regression to evaluate the risk of CAD associated with PHT. In ANCOVA, the CA characteristics of PHT were significantly different from normotensive. The odds ratios (ORs) of IMTmax, LDmax, LDmin, peak-systolic FV (PFV), end-diastolic FV (EFV), PFV/LDmin, EFV/LDmax, compliance, and β-stiffness of PHT were 4.20, 2.70, 3.52, 2.41, 3.06, 3.55, 3.29, 2...
Journal of Clinical Medicine, 2020
The aim of this study was to examine cortical thickness changes associated with a multicomponent ... more The aim of this study was to examine cortical thickness changes associated with a multicomponent exercise intervention combining physical exercise and cognitive training in older adults with cognitive decline. This study involved a secondary analysis of neuroimaging data from a randomized controlled trial with 280 older adults having cognitive decline who were randomly assigned to either a multicomponent exercise group (n = 140) that attended weekly 90-minute exercise and cognitive training sessions or a health education control group (n = 140). The cortical thickness and cognitive performance were assessed at the baseline and at trial completion (10 months). The cortical thickness in the frontal and temporal regions was determined using FreeSurfer software. Cognitive performance was evaluated using the Gerontology-Functional Assessment Tool (NCGG-FAT). The cortical thickness significantly increased in the middle temporal (p < 0.001) and temporal pole (p < 0.001) in the multic...
Maturitas, 2020
To determine the prevalence and severity of menopausal symptoms and their related risk factors am... more To determine the prevalence and severity of menopausal symptoms and their related risk factors among middle-aged Korean women according to their reproductive stages. Methods: This cross-sectional study included 3039 Korean women, aged 45-65 years, who attended their routine health checkup. Their scores from the Menopause Rating Scale (MRS) were compared and participants were categorized into four groups according to stage of menopause: premenopause, early menopause (≤2 years from their last menstruation), mid-menopause (2-8 years), and late menopause (> 8 years). Results: The mean age of the participants was 52.81 ± 5.39 years, and 98.5 % of them reported one or more symptoms included in the MRS. The most common symptom was physical/mental exhaustion, experienced by 86.7 % of participants. The prevalence of moderate to severe symptoms, including vasomotor symptoms, heart discomfort, sleep problems, sexual problems, vaginal dryness, and joint/muscular discomfort, increased in the early menopausal period. This increased in the late menopausal period compared with its prevalence at premenopause. The prevalence of moderate to severe psychological symptoms, heart discomfort, and sleep problems followed a U-shaped trend after menopause: high at early menopause, low at mid-menopause, and high again at late menopause. A low level of physical exercise was an independent risk factor for a high total MRS score; however, the menopausal stages, age, and weight were also variously associated with menopausal symptoms. Conclusions: Several menopausal symptoms remain severe, or are aggravated, until the late menopausal period among Korean women. More attention is warranted to manage these symptoms in postmenopausal women.
Alzheimer's & Dementia, 2018
Alzheimer's & Dementia, 2019
International Dairy Journal, 2015
ABSTRACT A randomised, double-blind, placebo-controlled trial was performed to investigate the ef... more ABSTRACT A randomised, double-blind, placebo-controlled trial was performed to investigate the effects of enteric-coated lactoferrin (LF) supplementation on the immune function of healthy, elderly individuals. Sixty-two healthy men and women were randomly divided into LF (300 mg of bovine LF intake per day) and placebo groups, who consumed the assigned supplements once daily for 3 months. The blood cell count, peripheral blood lymphocyte subset ratios, neutrophil phagocytic function, natural killer (NK) cell cytotoxicity, and serum granulysin and lysozyme concentrations were measured every month. By the third month of treatment, significant inter-group differences were observed in peripheral blood lymphocyte subset ratios, neutrophil phagocytic function, and NK cell cytotoxicity. Our findings suggest that immune competent cells of the innate immune system in elderly individuals are specifically activated by LF intake; therefore, enteric LF supplementation may have beneficial effects on immune function in elderly individuals.
Maturitas, 2018
To evaluate the association between vasomotor symptoms (VMS) and non-alcoholic fatty liver diseas... more To evaluate the association between vasomotor symptoms (VMS) and non-alcoholic fatty liver disease (NAFLD) in postmenopausal women. This cross-sectional study included 1793 Korean postmenopausal women aged 45-65 years who attended a routine health check at a Korean institution from January 2010 to December 2012. Their scores on the Menopause Rating Scale were used to assess VMS. Moderate to severe VMS included ratings of moderate, severe, and very severe. NAFLD was diagnosed by abdominal ultrasound among those who indicated that their ethanol intake was less than 70 g/week. The mean age of these participants was 54.51 ± 4.74 years and the mean duration of menopause was 5.36 ± 4.41 years. A total of 602 (33.6%) women reported mild VMS while 435 (24.3%) reported moderate to severe VMS. The prevalence of NAFLD differed significantly according to the severity of VMS (none, 31.7%; mild, 34.9%; moderate to severe, 39.1%; p = 0.037). Levels of the liver enzymes alanine aminotransferase, a...