Habip Almiş - Academia.edu (original) (raw)

Papers by Habip Almiş

Research paper thumbnail of A preventable problem: Isotretinoin embryopathy

DergiPark (Istanbul University), Mar 1, 2012

Research paper thumbnail of Meckel-Gruber Sendromu: Olgu Sunumu

İnönü Üniversitesi Tıp Fakültesi Dergisi, 2011

Meckel-Gruber sendromunun karakteristik triadi; oksipital meningo-ensefalosel, kistik displastik ... more Meckel-Gruber sendromunun karakteristik triadi; oksipital meningo-ensefalosel, kistik displastik bobrekler ve postaksiyel polidaktilidir. Bu sendrom olumculdur ve otozomal resesif gecislidir. Nadir gorulmekle birlikte tekrarlama riski yuksektir. Burada polidaktili olmayan bilateral polikistik bobrek ve ensefalosel ile tani koydugumuz Meckel-Gruber sendromlu bir yenidogan olgusunu; sonraki gebelikler icin genetik danismanligin onemine ve erken prenatal tanisina vurgu yapmak uzere sunmaktayiz.

Research paper thumbnail of Clinical characteristics of firearm-related injuries in children in turkey

The Turkish Journal of Pediatrics

Research paper thumbnail of Adiyaman İli̇nde Bebekli̇k Dönemi̇nde Beslenme Alişkanliğini Etki̇leyen Faktörleri̇n Değerlendi̇ri̇lmesi̇

GOBEKLİTEPE Saglik Bilimleri Dergisi

Breast milk is the ideal nutritional source that contains all kinds of nutritional values such as... more Breast milk is the ideal nutritional source that contains all kinds of nutritional values such as protein, fat, iron and vitamins that the baby needs for the first 6 months. The aim of this study was to evaluate the attitudes and behaviors of families in terms of breast milk and nutrition during infancy. Our study was conducted with mothers who had babies between 0-24 months in Adıyaman University Training and Research Hospital between March 15 and July 15, 2018. A total of 1010 mothers were administered a questionnaire consisting of 45 questions prepared by us to determine the sociodemographic data and breastfeeding status of infants and parents. In the study group consisting of mothers with low education and income levels, the mean age of mothers was 29.47 ± 5.61 (18-45) years, and the percentage of mothers working was 10.6%. The distribution of babies between boys and girls was 54.3% - 45.7%. The percentage of infants receiving breast milk in the first half hour was 53.6%, the pe...

Research paper thumbnail of Self-Concept, Depression, and Anxiety Levels of Adolescents with Polycystic Ovary Syndrome

Journal of Pediatric and Adolescent Gynecology

This is a PDF file of an article that has undergone enhancements after acceptance, such as the ad... more This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

Research paper thumbnail of The Evaluation of Patients Diagnosed with Monosymptomatic Nocturnal Enuresis

Journal of Pediatric Research, Sep 5, 2015

In this study, we aimed to investigate the factors associated with monosymptomatic nocturnal enur... more In this study, we aimed to investigate the factors associated with monosymptomatic nocturnal enuresis (MNE), as well as the sociodemographic characteristics and treatment modalities of children diagnosed with MNE. Metarials and Methods: Data were recorded on age, gender, frequency of nocturnal bedwetting, diurnal enuresis history, constipation, encopresis, history of urinary tract infection, number of siblings, familial history of enuresis, sleep habits, school performance status, income level of the family, education level of the parents, and treatment methods. Results: A total of 60 patients participated in the study; 36 (60%) were male and 24 (40%) were female. The mean age of the patients was 8.9±2.8 years. The average number of bedwetting days per week was 4.8±2.5 days. The average number of siblings was 4.2±2.4. Thirty-four (56.7%) patients had a history of deep sleep. In 95% of cases, patients had a family history of enuresis. Of patients in the study, 81.7% were from low-income families and 65% of the mothers were educated to primary school level or less. The treatment modalities applied to these patients were Desmopressin (11.7%), Imipramine (1.7%), and fluid restriction (13.3%). Twenty-five (41.7%) mothers thought that enuresis would decrease with advancing age, whereas 11 (18.3%) mothers worried that this condition may be permanent. Twentynine (48.3%) mothers believed that the medications would have an infertility effect on the children. Only five (8.3%) mothers had information about the alarm treatment. Conclusion: Although MNE is a common problem in childhood which leads to behavioral problems and decreased school performance, we observed a very low rate of MNE-related applications to the clinics. Considering the socio-demographic characteristics of these families, we believe there should be greater efforts to raise awareness of enuresis, its potential to lead to future problems and that it is a problem that should be treated.

Research paper thumbnail of Mean platelet volume in hepatitis A

PubMed, Jun 1, 2016

Objective: Hepatitis A virus (HAV) still continues to be a serious public health problem worldwid... more Objective: Hepatitis A virus (HAV) still continues to be a serious public health problem worldwide. Mean platelet volume (MPV) is a marker of platelet function and activation. This study aimed to evaluate the relationship between MPV in acute hepatitis A patients as compared to the control group and to assess MPV as an acute phase reactant in acute hepatitis A. Patients and methods: Seventy-six patients were enrolled in this study. The control group consisted of 41 healthy age- and sex-matched individuals. Alanine aminotransferase (ALT), aspartate aminotransferase (AST), bilirubin, prothrombin time (PT), platelet count (PC), serum albumin (ALB), and mean platelet volume (MPV) levels were recorded. The diagnosis of HAV infection was based on anti-HAV Ig M positivity. Results: The mean levels of MPV in the study group were significantly statistically lower than in the control group (p < 0.001). The MPV levels revealed no correlation with the ALT, AST, ALP, and GGT levels (p > 0.05), but the MPV levels correlated with the platelet counts (p < 0.05). A 9.75 fL [area under the curve (AUC: 0.756)] optimal cutoff level of MPV with a sensitivity of 69.7% and specificity of 68.3% was determined in the children with acute hepatitis A. Conclusions: MPV levels were significantly lower in the patients with acute hepatitis A as compared to the healthy control group. This study demonstrated that MPV may be a negative acute phase reactant for acute hepatitis A. Further studies will explain the role that MPV plays in inflammation and other viral infections.

Research paper thumbnail of The First Infant Death Associated With Human Coronavirus NL63 Infection

Pediatric Infectious Disease Journal, Feb 1, 2017

Human coronavirus NL63 (HCoV-NL63) primarily infects the upper respiratory tract. However, it may... more Human coronavirus NL63 (HCoV-NL63) primarily infects the upper respiratory tract. However, it may cause severe lower respiratory tract infection, and the clinical course may be severe in immunocompromised patients. To our knowledge, child death due to HCoV-NL63 has not been reported. We present a fatal lower respiratory tract disease associated with HCoV-NL63 in a 7-month-old malnourished infant.

Research paper thumbnail of An Ignored Cause of Acute Abdomen: Lower Lobe Pneumonia

İstanbul Kanuni Sultan Süleyman tıp dergisi, Dec 1, 2015

Alt lob pnömonisinin akut batın tablosuna neden olabileceği bilinmekle beraber, solunum sistemi i... more Alt lob pnömonisinin akut batın tablosuna neden olabileceği bilinmekle beraber, solunum sistemi ile ilgili yakınma ya da bulgu olmadığı zaman kolayca göz ardı edilebilmektedir. Olgu Sunumu: Dokuz yaşında erkek hasta şiddetli karın ağrısı ve hafif ateş yakınmaları ile acil servisimize başvurdu. Hastanın yakınmalarının dört gün önce başladığı ve bu nedenle iki kez acil servise başvurduğu öğrenildi. Fizik muayenede defans ve rebound saptandı ancak batın ultrasonografisi normal bulundu. Çocuk cerrahisi tarafından da akut batın olarak değerlendirilen hasta gözlem amacıyla çocuk servisine yatırıldı. Serviste yapılan ayrıntılı fizik muayenesinde sol akciğerde tuber sufl duyulan hastaya, yakınmalarının başlangıcından dört gün sonra alt lob pnömonisi tanısı konuldu. Sonuç: Bu olgu akut batın tablosu ile başvuran hastalarda dikkatli bir şekilde yapılmış fizik muayenenin, alt lob pnömonileri gibi karın dışı patolojilere tanı konulmasındaki önemini vurgulamak amacıyla sunuldu.

Research paper thumbnail of Evaluation of Platelet Parameters and Acute Phase Reactants in Pediatric Patients Presenting with Fever

Çocuk Enfeksiyon Dergisi, Sep 16, 2019

Ateşin artmasının viral ve bakteriyel ajanların üremesini baskıladığı ve vücudun akut faz yanıtın... more Ateşin artmasının viral ve bakteriyel ajanların üremesini baskıladığı ve vücudun akut faz yanıtını desteklediği gösterilmiştir. Akut faz reaktanları, trombosit sayısı, ortalama trombosit hacmi, trombosit dağılım genişliği ve plateletkrit gibi tüm parametrelerin viral ve bakteriyel enfeksiyonları seyrinde değişebilmektedir. Bu çalışmada çocukluk çağında ateş şikayeti ile başvuran hastalarda platelet parametreleri ve akut faz belirteçlerinin değerlendirilmesi amaçlandı. Gereç ve Yöntemler: Polikliniğe ateş nedeniyle başvuran hastalar çalışmaya dahil edildi. Hastalar ateş sürelerine göre üç gruba ayrıldı; Grup 1 < 24 saat, Grup 2 24-48 saat ve Grup 3 > 48 saat. Kontrol grubu hastaları ateşi olmayan ancak hasta çocuklardan seçildi. Ortalama trombosit hacmi, trombosit dağılım genişliği, plateletkrit, trombosit sayısı, eritrosit sedimentasyonu ve fibrinojen her hasta için incelendi. Bulgular: Çalışmaya 272 hasta dahil edildi. Gruplar arasında trombosit dağılım genişliği, plateletkrit ve trombosit sayısı açısından istatistiksel olarak anlamlı fark yoktu. Ancak, ortalama trombosit hacmi, eritrosit sedimentasyon hızı, C-reaktif protein, fibrinojen ve albumin açısından gruplar arasında istatistiksel olarak anlamlı fark vardı. Sonuç: Akut faz belirteçleri ve ortalama trombosit hacmi ateş süresinden etkilenmektedir.

Research paper thumbnail of Evaluation of perspectives and approaches of primary health care physicians to the rotavirus vaccine

Journal of Turgut Ozal Medical Center, 2017

Aim: Rotavirus is the most common cause of severe gastroenteritis in children. Rotavirus diarrhea... more Aim: Rotavirus is the most common cause of severe gastroenteritis in children. Rotavirus diarrhea can lead to complications of rotavirus-induced severe diarrhea death resulting in electrolyte imbalance and dehydration. Rotavirus vaccination is the most effective method of preventing severe rotavirus infection. The purpose of this study was to evaluate the knowledge levels and attitudes of primary health care providers physicians related to rotavirus vaccine, which is one of the vaccines not yet added to the vaccination schedule in Turkey. Materials and Methods: Physicians working in primary health care institutions in the province of Adıyaman in 2016 agreed to participate and were included in the study. The participants' demographic characteristics and data obtained from the questionnaire were analyzed using statistical methods on SPSS 22 software. Results: 38 participants, 24 (63.2%) male and 14 (36.8%) female were included in the study. The number of primary health care physicians who thought that rotavirus vaccine was effective 24 (63.2%), while 10 (26.3%) stated that it was not effective and 4 (10.5) had no opinion. Fifteen (39.5%) primary physicians thought that the rotavirus vaccine should be added to the routine vaccination schedule, 10 (26.3%) thought that it need not be added and 13 (34.2%) had no opinion. Conclusion: Rotavirus vaccine is not a well-known that vaccine recommended among primary care physicians. This derives from lack of knowledge of the protective nature of the vaccine and inadequate awareness of it. We think that increasing physicians' knowledge of vaccines through in-service training will reduce negative attitudes againts it concerning them.

Research paper thumbnail of Health of the Children with Intellectual Disability Being Cared at The Primary Care Center in Adıyaman

Journal of Pediatric Research, Apr 18, 2016

Dünyada milyonlarca insan aile içinde, okulda, işte zihinsel engelli bireylerle birlikte yaşamakt... more Dünyada milyonlarca insan aile içinde, okulda, işte zihinsel engelli bireylerle birlikte yaşamaktadır. Zihinsel engelli bireyler için devlet tarafından açılan ve yönetilen rehabilitasyon merkezleri bulunmaktadır. Bu çalışmada, Adıyaman 80. Yıl Zihinsel Engelliler ve Rehabilitasyon Merkezi'nde bakım görmekte olan çocukların sağlık tarama sonuçlarını incelemeyi amaçladık. Gereç ve Yöntemler: Rehabilitasyon merkezinde kalan 31 olgunun 2014 yılı Aralık ayı rutin sağlık tarama sonuçları geriye dönük değerlendirildi. Rutin tarama programı yoluyla elde edilen laboratuvar sonuçları, olguların tamamının ağırlıkları ve boyları, vücut kitle indeksi, ek hastalık varlığı, süreğen ilaç kullanımı ve IQ sonuçları kaydedildi. Bulgular: Çalışmaya, yaşları yedi ile 18 arasında değişen 31 erkek olgu alındı. On iki (%38,7) olgunun boyu ve sekiz (%25,8) olgunun ağırlığı üçüncü persentilin altında idi. Yirmi sekiz (%90,3) olgunun Hepatit B aşısı mevcut idi. Anti-HAV immünglobulin G pozitif olguların sayısı 25 (%80,6) idi. Değerlendirme yapılabilen 30 olgu, hastalığın ağırlığına göre gruplandırıldıklarında; 10'u (%33,3) hafif, 11'i (%36,7) orta, ikisi (%6,7) ağır, dördü (%13,3) çok ağır, üçü (%10) ağırlığı belirlenemeyen zihinsel engelli olarak sınıflandırıldılar. Bir olgu ise çalışma devam ederken başka bir merkeze transfer edilmesi nedeniyle çalışma dışı bırakıldı. Sonuç: Ülkemizde, dünya standartlarına uygun rehabilitasyon merkezlerinin bulunması sevindiricidir. Bu merkezlerin sayılarının artırılması ve merkezlerde kalan bireylerin sağlık tarama sonuçlarının paylaşılması gerektiğini düşünmekteyiz. Anahtar Kelimeler: Zihinsel engelli, çocukluk çağı, sağlık taraması, kurum bakımı Aim: Millions of people around the world live together with individuals with intellectual diasability in the family, at school, at work. There are rehabilitation centers opened and managed by the State for individuals with intellectual disabilities. In this study, we aimed to review the health screening results of patients being cared at The Adıyaman 80th Anniversary Mental Retardation and Rehabilitation Center. Materials and Methods: Thirty-one disabled male children's health screeing results from December 2014 routine were evaluated retrospectively. The weight and height measurements of all patients, body mass indices, nutritional status, presence of comorbid disease, chronic drug usage, and IQ scores were recorded. Results: Thirty-one male patients, ages ranging between 7 and 18 were included in the study. Twelve (% 38.7) patients' heights and eight (25.8%) patients' weights were less than the third percentile. Twenty eight (90.2 %) patients had had Hepatitis B Vaccine. The number of IgG anti-HAV positive patients was 25 (80.6%). When the patients were grouped according to the severity level of intellectual disability; ten (33.4 %) patients were mild, eleven (36.7 %) were moderate, two (% 6.6) patients were severe, four (% 13.4) were profound and three (% 9.9) patients were of severity undetermined. A patient was excluded because of being transferred to another center. Conclusion: Several rehabilitation centers of international standards are present in Turkey. The number of these centers should be increased, and the data pertaining to health screening results of residents should be available for use of other researchers.

Research paper thumbnail of Ateş Şikayeti ile Başvuran Çocuk Hastalarda Trombosit Parametreleri ve Akut Faz Belirteçlerinin Değerlendirilmesi*

Çocuk Enfeksiyon Dergisi, Sep 16, 2019

Ateşin artmasının viral ve bakteriyel ajanların üremesini baskıladığı ve vücudun akut faz yanıtın... more Ateşin artmasının viral ve bakteriyel ajanların üremesini baskıladığı ve vücudun akut faz yanıtını desteklediği gösterilmiştir. Akut faz reaktanları, trombosit sayısı, ortalama trombosit hacmi, trombosit dağılım genişliği ve plateletkrit gibi tüm parametrelerin viral ve bakteriyel enfeksiyonları seyrinde değişebilmektedir. Bu çalışmada çocukluk çağında ateş şikayeti ile başvuran hastalarda platelet parametreleri ve akut faz belirteçlerinin değerlendirilmesi amaçlandı. Gereç ve Yöntemler: Polikliniğe ateş nedeniyle başvuran hastalar çalışmaya dahil edildi. Hastalar ateş sürelerine göre üç gruba ayrıldı; Grup 1 < 24 saat, Grup 2 24-48 saat ve Grup 3 > 48 saat. Kontrol grubu hastaları ateşi olmayan ancak hasta çocuklardan seçildi. Ortalama trombosit hacmi, trombosit dağılım genişliği, plateletkrit, trombosit sayısı, eritrosit sedimentasyonu ve fibrinojen her hasta için incelendi. Bulgular: Çalışmaya 272 hasta dahil edildi. Gruplar arasında trombosit dağılım genişliği, plateletkrit ve trombosit sayısı açısından istatistiksel olarak anlamlı fark yoktu. Ancak, ortalama trombosit hacmi, eritrosit sedimentasyon hızı, C-reaktif protein, fibrinojen ve albumin açısından gruplar arasında istatistiksel olarak anlamlı fark vardı. Sonuç: Akut faz belirteçleri ve ortalama trombosit hacmi ateş süresinden etkilenmektedir.

Research paper thumbnail of The status of drug wastage in the pediatric emergency department of a tertiary hospital

Avicenna journal of medicine, 2020

Background: The aim of this study was to evaluate surplus drugs left over from medications used v... more Background: The aim of this study was to evaluate surplus drugs left over from medications used via the intravenous and intramuscular routes in a pediatric emergency unit of a tertiary hospital in Turkey and to determine the financial burden imposed by drug wastage. Materials and Methods: The study was planned prospectively on patients presenting to the pediatric emergency department of a tertiary university hospital between January 1 and April 30, 2017, on weekdays and between 08:00 and 16:00, for any reason, and receiving intravenous and/or intramuscular drug administration resulting in drug wastage after treatment. Results: The number of patients enrolled in the clinical trial was 1620 (35.9%). Twenty-one different medications were administered via the intravenous or intramuscular (IM) routes during the study. The proportion of total medication wastage at the end of trial was estimated to be 0.425. The drug with the highest proportion of mean wastage to drug form was paracetamol (1000mg vial) at 0.79. The total cost of the drugs used for the patients in the study was US$580.98, and the overall burden of drug wastage was US$288.09. The three medications involving the highest wastage costs were methylprednisolone, ondansetron, and dexamethasone. The total wastage cost/total drug cost ratio was 0.495. Conclusion: If commercial drugs with intravenous and IM formulations are used by the pediatric age group, then dosage formulations appropriate for pediatric age group use also need to be produced. The development by manufacturers of ampoules and similar products suitable for multiple use will also reduce drug wastage. Reducing levels of drug wastage will inevitably reduce the drug expenditure.

Research paper thumbnail of Evaluation of vitamin D levels in children with primary epistaxis

International Journal of Pediatric Otorhinolaryngology, Oct 1, 2016

Objective: This study aimed to investigate whether there is a relationship between 25-hydroxy vit... more Objective: This study aimed to investigate whether there is a relationship between 25-hydroxy vitamin D [25(OH)D 3] values and incidences of primary epistaxis among children. Methods: A total of 42 cases and 55 matched controls were included in our study. The study group and control group were well matched for age and gender. Age, gender, activated partial thromboplastin time (APTT) with reference to the international normalized ratio (INR), prothrombin time (PT), and 25(OH)D 3, parathormone (PTH), alkaline phosphatase (ALP), calcium (Ca), magnesium (Mg), and phosphorus (P) values were recorded for each participant. Results: Serum 25(OH) D values were found to be statistically significantly (P ¼ 0.03) lower in children with primary epistaxis than in the healthy control group. Our study also revealed that 25(OH) D values were considerably (P < 0.001) lower in the group with primary epistaxis and upper respiratory tract infections (RTI) than in the group with primary epistaxis without upper RTI. Univariate logistic regression analyses demonstrated that 25(OH)D 3 < 20 ng/ml [odds ratio (OR) 1.117, 95% confidence interval (CI) (1.019e1.225); P ¼ 0.019] and serum albumin level [OR 3.499, 95% CI (1072e11,426); P ¼ 0.038] ratio were significantly related to primary epistaxis. Furthermore, multivariate logistic regression analyses revealed that 25(OH)D 3 < 20 ng/ml [OR 1.141, 95% CI (1047e1242); P ¼ 0.003] and serum albumin level [OR 3.340, 95% CI (1068e10,446); P ¼ 0.038] ratio were significantly related to primary epistaxis. Conclusions: Many studies have revealed that vitamin D is a preventive and therapeutic agent for inflammation and infection, thereby providing benefits for children with primary epistaxis. In line with this, our study suggested that a patient's vitamin D status could also be important for the prevention of childhood primary epistaxis, although further studies are required to validate our findings.

Research paper thumbnail of Dikkat eksikliği hiperaktivite bozukluğu olan prepubertal bir erkekçocukta metilfenidatın indüklediği jinekomasti: Bir olgu sunumu

Anadolu psikiyatri dergisi, 2016

Research paper thumbnail of Sağlıklı Çocuklarda Herpes Zoster: Retrospektif Bir Çalışma

Turk Dermatoloji Dergisi, 2016

Research paper thumbnail of A Rare Case of Rotavirus-related Acute Benign Myositis

Pediatric Infectious Disease Journal, Jun 30, 2023

Research paper thumbnail of Yenidoğan Sarılık Ölçüm Yöntemleri ile Felix von Luschan Deri Rengi Skalasının Karşılaştırılması

Türkiye çocuk hastalıkları dergisi, Feb 24, 2021

Objective: This study aimed to compare invasive neonatal jaundice measurement methods (total bili... more Objective: This study aimed to compare invasive neonatal jaundice measurement methods (total bilirubin from venous blood, total bilirubin in blood gas, and microcapillary neonatal bilirubin from the heel) with the non-invasive Felix von Luschan skin color scale test. Material and Methods: The study was performed on 110 newborns admitted to the neonatal intensive care unit of Adiyaman University Training and Research Hospital, Turkey, because of jaundice. The non-invasive Felix von Luschan skin color scale test was compared with other, more invasive neonatal jaundice measurement methods. Results: The Felix von Luschan skin color scale test was found to have a significant relationship with other diagnostic methods (p<0.001) and deemed practical for the diagnosis of this disease. Conclusion: The timely diagnosis and management of neonatal jaundice are essential to prevent acute bilirubin encephalopathy and kernicterus. The Felix von Luschan skin color scale test is a non-invasive method that is reliable, fast and inexpensive. This method can be used for the diagnosis of neonatal jaundice.

Research paper thumbnail of The evaluation of chickenpox in the post-vaccination period in Turkey

Annals of medical research, 2019

Chickenpox is a viral infectious disease capable of causing severe morbidity, and even mortality.... more Chickenpox is a viral infectious disease capable of causing severe morbidity, and even mortality. The purpose of this study was to determine the current position and demographic characteristics of cases of chickenpox following the addition of chickenpox vaccination to the routine vaccine schedule in Turkey. Mateial and Methods: Patients aged 0-17 years presented to Adiyaman University Training and Research Hospital Pediatrics clinics and diagnosed with chickenpox between January 2013 and December 2016 were included in the study. Data were analyzed on Statistical Package for the Social Sciences (SPSS, version 22.0, Chicago, IL, USA) software. p<0.05 was regarded as statistically significant. Results: 314 patients diagnosed with chickenpox were included in the study. Mean age of the subjects included was 84.76 ± 41.67 months, and 54.1% were males and 46.9% females. A significant difference was observed between the groups in terms of age (p=0.001). Cases' ages decreased on a year-by-year basis. Fifty (15.9%) cases of chickenpox were identified as having been infected despite vaccine. A significant difference was determined between the mean ages of vaccinated and non-vaccinated patients with chickenpox. Conclusion: Although the addition of a single dose chickenpox vaccine to the national immunization schedule in Turkey reduces both severe complication and the incidence of the disease. In the light of our study we think that the addition of a second dose of chickenpox vaccination to our routine vaccine schedule will further reduce hospitalization numbers resulting from chickenpoxrelated complications. More comprehensive studies on the subject are now needed.

Research paper thumbnail of A preventable problem: Isotretinoin embryopathy

DergiPark (Istanbul University), Mar 1, 2012

Research paper thumbnail of Meckel-Gruber Sendromu: Olgu Sunumu

İnönü Üniversitesi Tıp Fakültesi Dergisi, 2011

Meckel-Gruber sendromunun karakteristik triadi; oksipital meningo-ensefalosel, kistik displastik ... more Meckel-Gruber sendromunun karakteristik triadi; oksipital meningo-ensefalosel, kistik displastik bobrekler ve postaksiyel polidaktilidir. Bu sendrom olumculdur ve otozomal resesif gecislidir. Nadir gorulmekle birlikte tekrarlama riski yuksektir. Burada polidaktili olmayan bilateral polikistik bobrek ve ensefalosel ile tani koydugumuz Meckel-Gruber sendromlu bir yenidogan olgusunu; sonraki gebelikler icin genetik danismanligin onemine ve erken prenatal tanisina vurgu yapmak uzere sunmaktayiz.

Research paper thumbnail of Clinical characteristics of firearm-related injuries in children in turkey

The Turkish Journal of Pediatrics

Research paper thumbnail of Adiyaman İli̇nde Bebekli̇k Dönemi̇nde Beslenme Alişkanliğini Etki̇leyen Faktörleri̇n Değerlendi̇ri̇lmesi̇

GOBEKLİTEPE Saglik Bilimleri Dergisi

Breast milk is the ideal nutritional source that contains all kinds of nutritional values such as... more Breast milk is the ideal nutritional source that contains all kinds of nutritional values such as protein, fat, iron and vitamins that the baby needs for the first 6 months. The aim of this study was to evaluate the attitudes and behaviors of families in terms of breast milk and nutrition during infancy. Our study was conducted with mothers who had babies between 0-24 months in Adıyaman University Training and Research Hospital between March 15 and July 15, 2018. A total of 1010 mothers were administered a questionnaire consisting of 45 questions prepared by us to determine the sociodemographic data and breastfeeding status of infants and parents. In the study group consisting of mothers with low education and income levels, the mean age of mothers was 29.47 ± 5.61 (18-45) years, and the percentage of mothers working was 10.6%. The distribution of babies between boys and girls was 54.3% - 45.7%. The percentage of infants receiving breast milk in the first half hour was 53.6%, the pe...

Research paper thumbnail of Self-Concept, Depression, and Anxiety Levels of Adolescents with Polycystic Ovary Syndrome

Journal of Pediatric and Adolescent Gynecology

This is a PDF file of an article that has undergone enhancements after acceptance, such as the ad... more This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

Research paper thumbnail of The Evaluation of Patients Diagnosed with Monosymptomatic Nocturnal Enuresis

Journal of Pediatric Research, Sep 5, 2015

In this study, we aimed to investigate the factors associated with monosymptomatic nocturnal enur... more In this study, we aimed to investigate the factors associated with monosymptomatic nocturnal enuresis (MNE), as well as the sociodemographic characteristics and treatment modalities of children diagnosed with MNE. Metarials and Methods: Data were recorded on age, gender, frequency of nocturnal bedwetting, diurnal enuresis history, constipation, encopresis, history of urinary tract infection, number of siblings, familial history of enuresis, sleep habits, school performance status, income level of the family, education level of the parents, and treatment methods. Results: A total of 60 patients participated in the study; 36 (60%) were male and 24 (40%) were female. The mean age of the patients was 8.9±2.8 years. The average number of bedwetting days per week was 4.8±2.5 days. The average number of siblings was 4.2±2.4. Thirty-four (56.7%) patients had a history of deep sleep. In 95% of cases, patients had a family history of enuresis. Of patients in the study, 81.7% were from low-income families and 65% of the mothers were educated to primary school level or less. The treatment modalities applied to these patients were Desmopressin (11.7%), Imipramine (1.7%), and fluid restriction (13.3%). Twenty-five (41.7%) mothers thought that enuresis would decrease with advancing age, whereas 11 (18.3%) mothers worried that this condition may be permanent. Twentynine (48.3%) mothers believed that the medications would have an infertility effect on the children. Only five (8.3%) mothers had information about the alarm treatment. Conclusion: Although MNE is a common problem in childhood which leads to behavioral problems and decreased school performance, we observed a very low rate of MNE-related applications to the clinics. Considering the socio-demographic characteristics of these families, we believe there should be greater efforts to raise awareness of enuresis, its potential to lead to future problems and that it is a problem that should be treated.

Research paper thumbnail of Mean platelet volume in hepatitis A

PubMed, Jun 1, 2016

Objective: Hepatitis A virus (HAV) still continues to be a serious public health problem worldwid... more Objective: Hepatitis A virus (HAV) still continues to be a serious public health problem worldwide. Mean platelet volume (MPV) is a marker of platelet function and activation. This study aimed to evaluate the relationship between MPV in acute hepatitis A patients as compared to the control group and to assess MPV as an acute phase reactant in acute hepatitis A. Patients and methods: Seventy-six patients were enrolled in this study. The control group consisted of 41 healthy age- and sex-matched individuals. Alanine aminotransferase (ALT), aspartate aminotransferase (AST), bilirubin, prothrombin time (PT), platelet count (PC), serum albumin (ALB), and mean platelet volume (MPV) levels were recorded. The diagnosis of HAV infection was based on anti-HAV Ig M positivity. Results: The mean levels of MPV in the study group were significantly statistically lower than in the control group (p < 0.001). The MPV levels revealed no correlation with the ALT, AST, ALP, and GGT levels (p > 0.05), but the MPV levels correlated with the platelet counts (p < 0.05). A 9.75 fL [area under the curve (AUC: 0.756)] optimal cutoff level of MPV with a sensitivity of 69.7% and specificity of 68.3% was determined in the children with acute hepatitis A. Conclusions: MPV levels were significantly lower in the patients with acute hepatitis A as compared to the healthy control group. This study demonstrated that MPV may be a negative acute phase reactant for acute hepatitis A. Further studies will explain the role that MPV plays in inflammation and other viral infections.

Research paper thumbnail of The First Infant Death Associated With Human Coronavirus NL63 Infection

Pediatric Infectious Disease Journal, Feb 1, 2017

Human coronavirus NL63 (HCoV-NL63) primarily infects the upper respiratory tract. However, it may... more Human coronavirus NL63 (HCoV-NL63) primarily infects the upper respiratory tract. However, it may cause severe lower respiratory tract infection, and the clinical course may be severe in immunocompromised patients. To our knowledge, child death due to HCoV-NL63 has not been reported. We present a fatal lower respiratory tract disease associated with HCoV-NL63 in a 7-month-old malnourished infant.

Research paper thumbnail of An Ignored Cause of Acute Abdomen: Lower Lobe Pneumonia

İstanbul Kanuni Sultan Süleyman tıp dergisi, Dec 1, 2015

Alt lob pnömonisinin akut batın tablosuna neden olabileceği bilinmekle beraber, solunum sistemi i... more Alt lob pnömonisinin akut batın tablosuna neden olabileceği bilinmekle beraber, solunum sistemi ile ilgili yakınma ya da bulgu olmadığı zaman kolayca göz ardı edilebilmektedir. Olgu Sunumu: Dokuz yaşında erkek hasta şiddetli karın ağrısı ve hafif ateş yakınmaları ile acil servisimize başvurdu. Hastanın yakınmalarının dört gün önce başladığı ve bu nedenle iki kez acil servise başvurduğu öğrenildi. Fizik muayenede defans ve rebound saptandı ancak batın ultrasonografisi normal bulundu. Çocuk cerrahisi tarafından da akut batın olarak değerlendirilen hasta gözlem amacıyla çocuk servisine yatırıldı. Serviste yapılan ayrıntılı fizik muayenesinde sol akciğerde tuber sufl duyulan hastaya, yakınmalarının başlangıcından dört gün sonra alt lob pnömonisi tanısı konuldu. Sonuç: Bu olgu akut batın tablosu ile başvuran hastalarda dikkatli bir şekilde yapılmış fizik muayenenin, alt lob pnömonileri gibi karın dışı patolojilere tanı konulmasındaki önemini vurgulamak amacıyla sunuldu.

Research paper thumbnail of Evaluation of Platelet Parameters and Acute Phase Reactants in Pediatric Patients Presenting with Fever

Çocuk Enfeksiyon Dergisi, Sep 16, 2019

Ateşin artmasının viral ve bakteriyel ajanların üremesini baskıladığı ve vücudun akut faz yanıtın... more Ateşin artmasının viral ve bakteriyel ajanların üremesini baskıladığı ve vücudun akut faz yanıtını desteklediği gösterilmiştir. Akut faz reaktanları, trombosit sayısı, ortalama trombosit hacmi, trombosit dağılım genişliği ve plateletkrit gibi tüm parametrelerin viral ve bakteriyel enfeksiyonları seyrinde değişebilmektedir. Bu çalışmada çocukluk çağında ateş şikayeti ile başvuran hastalarda platelet parametreleri ve akut faz belirteçlerinin değerlendirilmesi amaçlandı. Gereç ve Yöntemler: Polikliniğe ateş nedeniyle başvuran hastalar çalışmaya dahil edildi. Hastalar ateş sürelerine göre üç gruba ayrıldı; Grup 1 < 24 saat, Grup 2 24-48 saat ve Grup 3 > 48 saat. Kontrol grubu hastaları ateşi olmayan ancak hasta çocuklardan seçildi. Ortalama trombosit hacmi, trombosit dağılım genişliği, plateletkrit, trombosit sayısı, eritrosit sedimentasyonu ve fibrinojen her hasta için incelendi. Bulgular: Çalışmaya 272 hasta dahil edildi. Gruplar arasında trombosit dağılım genişliği, plateletkrit ve trombosit sayısı açısından istatistiksel olarak anlamlı fark yoktu. Ancak, ortalama trombosit hacmi, eritrosit sedimentasyon hızı, C-reaktif protein, fibrinojen ve albumin açısından gruplar arasında istatistiksel olarak anlamlı fark vardı. Sonuç: Akut faz belirteçleri ve ortalama trombosit hacmi ateş süresinden etkilenmektedir.

Research paper thumbnail of Evaluation of perspectives and approaches of primary health care physicians to the rotavirus vaccine

Journal of Turgut Ozal Medical Center, 2017

Aim: Rotavirus is the most common cause of severe gastroenteritis in children. Rotavirus diarrhea... more Aim: Rotavirus is the most common cause of severe gastroenteritis in children. Rotavirus diarrhea can lead to complications of rotavirus-induced severe diarrhea death resulting in electrolyte imbalance and dehydration. Rotavirus vaccination is the most effective method of preventing severe rotavirus infection. The purpose of this study was to evaluate the knowledge levels and attitudes of primary health care providers physicians related to rotavirus vaccine, which is one of the vaccines not yet added to the vaccination schedule in Turkey. Materials and Methods: Physicians working in primary health care institutions in the province of Adıyaman in 2016 agreed to participate and were included in the study. The participants' demographic characteristics and data obtained from the questionnaire were analyzed using statistical methods on SPSS 22 software. Results: 38 participants, 24 (63.2%) male and 14 (36.8%) female were included in the study. The number of primary health care physicians who thought that rotavirus vaccine was effective 24 (63.2%), while 10 (26.3%) stated that it was not effective and 4 (10.5) had no opinion. Fifteen (39.5%) primary physicians thought that the rotavirus vaccine should be added to the routine vaccination schedule, 10 (26.3%) thought that it need not be added and 13 (34.2%) had no opinion. Conclusion: Rotavirus vaccine is not a well-known that vaccine recommended among primary care physicians. This derives from lack of knowledge of the protective nature of the vaccine and inadequate awareness of it. We think that increasing physicians' knowledge of vaccines through in-service training will reduce negative attitudes againts it concerning them.

Research paper thumbnail of Health of the Children with Intellectual Disability Being Cared at The Primary Care Center in Adıyaman

Journal of Pediatric Research, Apr 18, 2016

Dünyada milyonlarca insan aile içinde, okulda, işte zihinsel engelli bireylerle birlikte yaşamakt... more Dünyada milyonlarca insan aile içinde, okulda, işte zihinsel engelli bireylerle birlikte yaşamaktadır. Zihinsel engelli bireyler için devlet tarafından açılan ve yönetilen rehabilitasyon merkezleri bulunmaktadır. Bu çalışmada, Adıyaman 80. Yıl Zihinsel Engelliler ve Rehabilitasyon Merkezi'nde bakım görmekte olan çocukların sağlık tarama sonuçlarını incelemeyi amaçladık. Gereç ve Yöntemler: Rehabilitasyon merkezinde kalan 31 olgunun 2014 yılı Aralık ayı rutin sağlık tarama sonuçları geriye dönük değerlendirildi. Rutin tarama programı yoluyla elde edilen laboratuvar sonuçları, olguların tamamının ağırlıkları ve boyları, vücut kitle indeksi, ek hastalık varlığı, süreğen ilaç kullanımı ve IQ sonuçları kaydedildi. Bulgular: Çalışmaya, yaşları yedi ile 18 arasında değişen 31 erkek olgu alındı. On iki (%38,7) olgunun boyu ve sekiz (%25,8) olgunun ağırlığı üçüncü persentilin altında idi. Yirmi sekiz (%90,3) olgunun Hepatit B aşısı mevcut idi. Anti-HAV immünglobulin G pozitif olguların sayısı 25 (%80,6) idi. Değerlendirme yapılabilen 30 olgu, hastalığın ağırlığına göre gruplandırıldıklarında; 10'u (%33,3) hafif, 11'i (%36,7) orta, ikisi (%6,7) ağır, dördü (%13,3) çok ağır, üçü (%10) ağırlığı belirlenemeyen zihinsel engelli olarak sınıflandırıldılar. Bir olgu ise çalışma devam ederken başka bir merkeze transfer edilmesi nedeniyle çalışma dışı bırakıldı. Sonuç: Ülkemizde, dünya standartlarına uygun rehabilitasyon merkezlerinin bulunması sevindiricidir. Bu merkezlerin sayılarının artırılması ve merkezlerde kalan bireylerin sağlık tarama sonuçlarının paylaşılması gerektiğini düşünmekteyiz. Anahtar Kelimeler: Zihinsel engelli, çocukluk çağı, sağlık taraması, kurum bakımı Aim: Millions of people around the world live together with individuals with intellectual diasability in the family, at school, at work. There are rehabilitation centers opened and managed by the State for individuals with intellectual disabilities. In this study, we aimed to review the health screening results of patients being cared at The Adıyaman 80th Anniversary Mental Retardation and Rehabilitation Center. Materials and Methods: Thirty-one disabled male children's health screeing results from December 2014 routine were evaluated retrospectively. The weight and height measurements of all patients, body mass indices, nutritional status, presence of comorbid disease, chronic drug usage, and IQ scores were recorded. Results: Thirty-one male patients, ages ranging between 7 and 18 were included in the study. Twelve (% 38.7) patients' heights and eight (25.8%) patients' weights were less than the third percentile. Twenty eight (90.2 %) patients had had Hepatitis B Vaccine. The number of IgG anti-HAV positive patients was 25 (80.6%). When the patients were grouped according to the severity level of intellectual disability; ten (33.4 %) patients were mild, eleven (36.7 %) were moderate, two (% 6.6) patients were severe, four (% 13.4) were profound and three (% 9.9) patients were of severity undetermined. A patient was excluded because of being transferred to another center. Conclusion: Several rehabilitation centers of international standards are present in Turkey. The number of these centers should be increased, and the data pertaining to health screening results of residents should be available for use of other researchers.

Research paper thumbnail of Ateş Şikayeti ile Başvuran Çocuk Hastalarda Trombosit Parametreleri ve Akut Faz Belirteçlerinin Değerlendirilmesi*

Çocuk Enfeksiyon Dergisi, Sep 16, 2019

Ateşin artmasının viral ve bakteriyel ajanların üremesini baskıladığı ve vücudun akut faz yanıtın... more Ateşin artmasının viral ve bakteriyel ajanların üremesini baskıladığı ve vücudun akut faz yanıtını desteklediği gösterilmiştir. Akut faz reaktanları, trombosit sayısı, ortalama trombosit hacmi, trombosit dağılım genişliği ve plateletkrit gibi tüm parametrelerin viral ve bakteriyel enfeksiyonları seyrinde değişebilmektedir. Bu çalışmada çocukluk çağında ateş şikayeti ile başvuran hastalarda platelet parametreleri ve akut faz belirteçlerinin değerlendirilmesi amaçlandı. Gereç ve Yöntemler: Polikliniğe ateş nedeniyle başvuran hastalar çalışmaya dahil edildi. Hastalar ateş sürelerine göre üç gruba ayrıldı; Grup 1 < 24 saat, Grup 2 24-48 saat ve Grup 3 > 48 saat. Kontrol grubu hastaları ateşi olmayan ancak hasta çocuklardan seçildi. Ortalama trombosit hacmi, trombosit dağılım genişliği, plateletkrit, trombosit sayısı, eritrosit sedimentasyonu ve fibrinojen her hasta için incelendi. Bulgular: Çalışmaya 272 hasta dahil edildi. Gruplar arasında trombosit dağılım genişliği, plateletkrit ve trombosit sayısı açısından istatistiksel olarak anlamlı fark yoktu. Ancak, ortalama trombosit hacmi, eritrosit sedimentasyon hızı, C-reaktif protein, fibrinojen ve albumin açısından gruplar arasında istatistiksel olarak anlamlı fark vardı. Sonuç: Akut faz belirteçleri ve ortalama trombosit hacmi ateş süresinden etkilenmektedir.

Research paper thumbnail of The status of drug wastage in the pediatric emergency department of a tertiary hospital

Avicenna journal of medicine, 2020

Background: The aim of this study was to evaluate surplus drugs left over from medications used v... more Background: The aim of this study was to evaluate surplus drugs left over from medications used via the intravenous and intramuscular routes in a pediatric emergency unit of a tertiary hospital in Turkey and to determine the financial burden imposed by drug wastage. Materials and Methods: The study was planned prospectively on patients presenting to the pediatric emergency department of a tertiary university hospital between January 1 and April 30, 2017, on weekdays and between 08:00 and 16:00, for any reason, and receiving intravenous and/or intramuscular drug administration resulting in drug wastage after treatment. Results: The number of patients enrolled in the clinical trial was 1620 (35.9%). Twenty-one different medications were administered via the intravenous or intramuscular (IM) routes during the study. The proportion of total medication wastage at the end of trial was estimated to be 0.425. The drug with the highest proportion of mean wastage to drug form was paracetamol (1000mg vial) at 0.79. The total cost of the drugs used for the patients in the study was US$580.98, and the overall burden of drug wastage was US$288.09. The three medications involving the highest wastage costs were methylprednisolone, ondansetron, and dexamethasone. The total wastage cost/total drug cost ratio was 0.495. Conclusion: If commercial drugs with intravenous and IM formulations are used by the pediatric age group, then dosage formulations appropriate for pediatric age group use also need to be produced. The development by manufacturers of ampoules and similar products suitable for multiple use will also reduce drug wastage. Reducing levels of drug wastage will inevitably reduce the drug expenditure.

Research paper thumbnail of Evaluation of vitamin D levels in children with primary epistaxis

International Journal of Pediatric Otorhinolaryngology, Oct 1, 2016

Objective: This study aimed to investigate whether there is a relationship between 25-hydroxy vit... more Objective: This study aimed to investigate whether there is a relationship between 25-hydroxy vitamin D [25(OH)D 3] values and incidences of primary epistaxis among children. Methods: A total of 42 cases and 55 matched controls were included in our study. The study group and control group were well matched for age and gender. Age, gender, activated partial thromboplastin time (APTT) with reference to the international normalized ratio (INR), prothrombin time (PT), and 25(OH)D 3, parathormone (PTH), alkaline phosphatase (ALP), calcium (Ca), magnesium (Mg), and phosphorus (P) values were recorded for each participant. Results: Serum 25(OH) D values were found to be statistically significantly (P ¼ 0.03) lower in children with primary epistaxis than in the healthy control group. Our study also revealed that 25(OH) D values were considerably (P < 0.001) lower in the group with primary epistaxis and upper respiratory tract infections (RTI) than in the group with primary epistaxis without upper RTI. Univariate logistic regression analyses demonstrated that 25(OH)D 3 < 20 ng/ml [odds ratio (OR) 1.117, 95% confidence interval (CI) (1.019e1.225); P ¼ 0.019] and serum albumin level [OR 3.499, 95% CI (1072e11,426); P ¼ 0.038] ratio were significantly related to primary epistaxis. Furthermore, multivariate logistic regression analyses revealed that 25(OH)D 3 < 20 ng/ml [OR 1.141, 95% CI (1047e1242); P ¼ 0.003] and serum albumin level [OR 3.340, 95% CI (1068e10,446); P ¼ 0.038] ratio were significantly related to primary epistaxis. Conclusions: Many studies have revealed that vitamin D is a preventive and therapeutic agent for inflammation and infection, thereby providing benefits for children with primary epistaxis. In line with this, our study suggested that a patient's vitamin D status could also be important for the prevention of childhood primary epistaxis, although further studies are required to validate our findings.

Research paper thumbnail of Dikkat eksikliği hiperaktivite bozukluğu olan prepubertal bir erkekçocukta metilfenidatın indüklediği jinekomasti: Bir olgu sunumu

Anadolu psikiyatri dergisi, 2016

Research paper thumbnail of Sağlıklı Çocuklarda Herpes Zoster: Retrospektif Bir Çalışma

Turk Dermatoloji Dergisi, 2016

Research paper thumbnail of A Rare Case of Rotavirus-related Acute Benign Myositis

Pediatric Infectious Disease Journal, Jun 30, 2023

Research paper thumbnail of Yenidoğan Sarılık Ölçüm Yöntemleri ile Felix von Luschan Deri Rengi Skalasının Karşılaştırılması

Türkiye çocuk hastalıkları dergisi, Feb 24, 2021

Objective: This study aimed to compare invasive neonatal jaundice measurement methods (total bili... more Objective: This study aimed to compare invasive neonatal jaundice measurement methods (total bilirubin from venous blood, total bilirubin in blood gas, and microcapillary neonatal bilirubin from the heel) with the non-invasive Felix von Luschan skin color scale test. Material and Methods: The study was performed on 110 newborns admitted to the neonatal intensive care unit of Adiyaman University Training and Research Hospital, Turkey, because of jaundice. The non-invasive Felix von Luschan skin color scale test was compared with other, more invasive neonatal jaundice measurement methods. Results: The Felix von Luschan skin color scale test was found to have a significant relationship with other diagnostic methods (p<0.001) and deemed practical for the diagnosis of this disease. Conclusion: The timely diagnosis and management of neonatal jaundice are essential to prevent acute bilirubin encephalopathy and kernicterus. The Felix von Luschan skin color scale test is a non-invasive method that is reliable, fast and inexpensive. This method can be used for the diagnosis of neonatal jaundice.

Research paper thumbnail of The evaluation of chickenpox in the post-vaccination period in Turkey

Annals of medical research, 2019

Chickenpox is a viral infectious disease capable of causing severe morbidity, and even mortality.... more Chickenpox is a viral infectious disease capable of causing severe morbidity, and even mortality. The purpose of this study was to determine the current position and demographic characteristics of cases of chickenpox following the addition of chickenpox vaccination to the routine vaccine schedule in Turkey. Mateial and Methods: Patients aged 0-17 years presented to Adiyaman University Training and Research Hospital Pediatrics clinics and diagnosed with chickenpox between January 2013 and December 2016 were included in the study. Data were analyzed on Statistical Package for the Social Sciences (SPSS, version 22.0, Chicago, IL, USA) software. p<0.05 was regarded as statistically significant. Results: 314 patients diagnosed with chickenpox were included in the study. Mean age of the subjects included was 84.76 ± 41.67 months, and 54.1% were males and 46.9% females. A significant difference was observed between the groups in terms of age (p=0.001). Cases' ages decreased on a year-by-year basis. Fifty (15.9%) cases of chickenpox were identified as having been infected despite vaccine. A significant difference was determined between the mean ages of vaccinated and non-vaccinated patients with chickenpox. Conclusion: Although the addition of a single dose chickenpox vaccine to the national immunization schedule in Turkey reduces both severe complication and the incidence of the disease. In the light of our study we think that the addition of a second dose of chickenpox vaccination to our routine vaccine schedule will further reduce hospitalization numbers resulting from chickenpoxrelated complications. More comprehensive studies on the subject are now needed.