Hafsa Elouazzani - Academia.edu (original) (raw)

Papers by Hafsa Elouazzani

Research Square (Research Square), Jan 17, 2023

Primary leptomeningeal melanoma is an extremely rare type of intracranial melanoma. It cannot be ... more Primary leptomeningeal melanoma is an extremely rare type of intracranial melanoma. It cannot be reliably distinguished from metastatic melanoma on neuroimaging and histopathological characteristics alone; its diagnosis is established only after exclusion of secondary metastatic disease from a cutaneous, mucosal or retinal primary. Prognosis is poor, partly due to its high rate of misdiagnosis. Herein, we report a case of a Primary Meningeal Melanoma of the skull base with Melanomatosis, in 31 years old man, mimicking Meningioma. Our aim is to highlight the diagnostic pitfalls and to discuss the histopathological differential diagnoses especially with other pigmented lesions of Central nervous system (CNS).

Background: Primary leptomeningeal melanoma is an extremely rare type of intracranial melanoma. I... more Background: Primary leptomeningeal melanoma is an extremely rare type of intracranial melanoma. It cannot be reliably distinguished from metastatic melanoma on neuroimaging and histopathological characteristics alone; its diagnosis is established only after exclusion of secondary metastatic disease from a cutaneous, mucosal or retinal primary [1, 2]. Prognosis is poor, partly due to its high rate of misdiagnosis. Case presentation: We report a case of a Primary Meningeal Melanoma of the skull base with Melanomatosis, in 31 years old man, mimicking clinical and radiological features of meningioma and whose delayed treatment has worsened the prognosis. Conclusion: Through this case, we highlight the diagnostic difficulties and we discuss the histopathological differential diagnoses especially with other pigmented lesions of Central nervous system (CNS).

Pan African Medical Journal

Clinical Medicine Insights. Case Reports, 2021

Squamous cell carcinoma is the most common mucosal malignancy of the head and neck. Adenoid pseud... more Squamous cell carcinoma is the most common mucosal malignancy of the head and neck. Adenoid pseudo-angiosarcomatous SCC is a rare variant occurring commonly in the skin of the head and neck. However, involvement of oral cavity is extremely rare, with only few case reports in the English literature. Morphologically, the tumor shows marked acantholysis, with anastomozing channels mimicking vascular neoplasms. This variant represents a diagnostic challenge for pathologists, and immunohistochemical analysis remains essential for an accurate diagnosis. Herein, we describe the case of a pseudovascular SCC of the oral cavity in a 67 years old man with a brief revue of the literature to raise awareness on this rare variant; presenting diagnostic difficulties.

Introduction : le Schwannome mélanotique sacré est une tumeur pigmentée rare des nerfs périphériq... more Introduction : le Schwannome mélanotique sacré est une tumeur pigmentée rare des nerfs périphériques. La croissance très lente de cette tumeur et l'adaptation progressive du contenu pelvien explique sa révélation tardive et son volume important compliquant son exérèse complète. Observation : nous rapportons un cas de Schwannome mélanotique sacré géant, se présentant sous forme d'une masse énorme et inextirpable de la cavité pelvienne, chez une femme âgée de 48ans, ayant consulté pour des lombalgies bilatérales associées à une insuffisance rénale. Discussion et conclusion : l'originalité de cette tumeur est soulignée par son évolution, son étiopathogénie et ses particularités histologiques et immunohistochimiques. A la lumière de cette observation, nous discutons les données de la littérature et nous exposons les difficultés diagnostiques et thérapeutiques.

Journal of Cancer Therapy, 2021

Introduction: Rhabdomyosarcoma (RMS) is the most common soft tissue tumor in children, with the h... more Introduction: Rhabdomyosarcoma (RMS) is the most common soft tissue tumor in children, with the head and neck location accounting for up to 40% of cases. The embryonal and alveolar histologic variants are more commonly seen in pediatric patients. The treatment is multimodal and the prognosis of this clinical entity is always gloomy. We report the case of nasopharyngeal rhabdomyosarcoma in a 7-year-old boy child with a good response to early post-therapy. Case Presentation: The patient was diagnosed with nasopharyngeal RMS revealed by a congested nose, ptosis and bilateral blindness, and who received induction chemotherapy followed by concurrent radiotherapy followed by adjuvant chemotherapy. The evolution is marked by a good clinical course but persistence of bilateral blindness. Conclusion: The RMS nasopharyngeal often presents with nonspecific symptoms. Multimodal therapy should be performed including surgery, chemotherapy and radiotherapy.

The Pan African Medical Journal, 2021

Le carcinome sarcomatoïde est une tumeur maligne rare, agressive de mauvais pronostic à pouvoir r... more Le carcinome sarcomatoïde est une tumeur maligne rare, agressive de mauvais pronostic à pouvoir récidivant très élevé. Sa localisation au niveau du sinus maxillaire est extrêmement rare. Nous rapportons le cas d´une femme de 42 ans, qui présentait un processus du maxillaire gauche dont une biopsie faite revenant en faveur d´un carcinome sarcomatoïde agressif à métastase ganglionnaire. La patiente a bénéficié d´une exérèse chirurgicale, un évidement ganglionnaire suivi d´une radiothérapie avec une bonne évolution. La rareté de cette tumeur en particulier en cette localisation pose une problématique diagnostique et de prise en charge à temps; cette dernière qui reste à ce jour la controversée. Cependant, une exérèse chirurgicale large reste le meilleur traitement. A travers ce cas nous avons mis le point sur les particularités anatomo-cliniques et surtout pronostiques de cette tumeur.

International Journal of Clinical Pathology and Diagnosis, 2021

Papillary Intralymphatic Angioendothelioma or Dabska's tumor is very rare tumor in children and y... more Papillary Intralymphatic Angioendothelioma or Dabska's tumor is very rare tumor in children and young adults, characterized by intraluminal papillary endothelial structures which are lined by plump cuboidal endothelial cells with hobnailed appearance [1]. It usually develops in the soft tissues of extremities. Deeper locations are exceptional and unusual, complicating its early diagnosis and adequate management.In this paper we report a new case about a recurrent and locally invasive oropharyngeal Dabska's tumor in a 34-year-old Moroccan woman.

International Journal of Clinical Pathology and Diagnosis, 2021

Chordoid glioma is a rare tumor of the Third Ventricle (V3), representing a very distinct clinico... more Chordoid glioma is a rare tumor of the Third Ventricle (V3), representing a very distinct clinico-pathological entity in the WHO classification of central nervous tumors, who classified it as grade II [1]. It has usually a slow growing. In this paper, we report the case of a rapidly progressive and lethal Chordoid Glioma (CG) in 48-year-old Moroccan a women. The rarity and the morphological similarities of this neoplasm with other suprasellar tumors constitute a challenge for the pathologist especially in extemporaneous condition, which complicates the diagnosis and the management.

Case Reports in Urology, 2021

Synchronous renal cell carcinomas (RCC) and angiomyolipomas (AML) occurring in the same kidney ar... more Synchronous renal cell carcinomas (RCC) and angiomyolipomas (AML) occurring in the same kidney are rare. Cases in the setting of tuberous sclerosis (TS) have been reported in the literature. However, the association of these tumors in the same kidney without TS is even more rare. We report here a case of a clear cell renal cell carcinoma (CCRCC) associated with an AML in the same kidney in a 42 years old female lacking the TS diagnostic criteria. The patient underwent a radical nephrectomy. Six months after surgery, the patient is healthy without signs of tumor recurrence or distant metastasis.

Case Reports in Pathology, 2021

Primary leiomyosarcomas (LMS) of vascular origin are rare tumors, and more than half of the cases... more Primary leiomyosarcomas (LMS) of vascular origin are rare tumors, and more than half of the cases arise in the inferior vena cava (IVC). Primary LMS of the renal vein are extremely rare tumors with only a few cases reported in the literature. Their diagnosis is made only by pathological features. Histologically, they are made of atypical spindle-shaped cells arranged in long intersecting fascicles. Tumor cells stain positive for myogenic markers in immunohistochemistry. Standard treatment consists of radical nephrectomy followed by chemotherapy and/or radiotherapy. Because of insufficient histological data and follow-up, the prognosis factors are not well identified. Overall prognosis of renal vein LMS is poor. We report here an exceptional case of a huge LMS of the right renal vein mimicking a primitive renal cell carcinoma, occurring in a 56-year-old male patient.

Journal of Surgical Case Reports, 2020

Angiomyofibroblastoma is a rare mesenchymal benign tumor that frequently occurs in young- to midd... more Angiomyofibroblastoma is a rare mesenchymal benign tumor that frequently occurs in young- to middle-aged women, arising from the genital tract. There are many overlapping radiological and immunohistochemical features with other stromal cell lesions, making the diagnosis difficult. We report here a case of a 29-year-old woman admitted for a pelvic mass, in whom, the histopathological and immunohistochemical studies led to the diagnosis of angiomyofibroblastoma.

Journal of Cancer Science and Clinical Therapeutics, 2020

Paratesticular leiomyosarcoma is a rare tumor of the mature adult who develops habitually in the ... more Paratesticular leiomyosarcoma is a rare tumor of the mature adult who develops habitually in the spermatic cord [1]. Preoperative diagnosis can be difficult because of nonspecific symptoms and non pathognomonic radiological features. In addition, its slow growing does not allow adequate differential diagnosis with respect to other scrotal tumors. We present a case of an uncommon paratesticular leiomyosarcoma: it's about a 64-year-old man with a history of painless enlargement of the left testis for 03 years. The scrotal ultrasound and MRI showed a paratesticular mass of 4.5cm in contact with spermatic cord. Patient underwent left high inguinal orchidectomy. Histopathological examination with immunostaining made the final diagnosis of grade 1 paratesticular leiomyosarcoma of NFFCS, with hepatic metastases in the abdominal CT.

International Journal of Clinical Pathology and Diagnosis, 2018

A didelphys uterus is one of the least common of Mullerian duct anomalies that arise from abnorma... more A didelphys uterus is one of the least common of Mullerian duct anomalies that arise from abnormal embryological development of the Mullerian ducts [1]. Embryologic anomaly of one Wolffian ducts-causing unilateral renal agenesis-is additionally seen in 15-30% of uterine didelphys [2]. In this paper, we report a first presentation-in our knowledge-of didelphys uterus with complex malformations in mother of two kids. It's about a 30-year-old Moroccan mother who successfully conceived and carried her pregnancies to term without complications. She suffered from chronic pelvic pain. The computed tomography scan revealed a left pelvic mass that was diagnosed as a mute pelvic kidney. The discovery of a didelphys uterus was fortuitous in pathological examination of the presumed nephrectomy. Indeed, we received an open cystic mass with thickened myomatous wall. Within the wall we found a rounded cavity with chocolate like contents. In histological examination, this mass corresponded to a uterine and endo-cervical wall, fallopian tube, residual ovarian parenchyma ovary and old hematosalpynx. There was no vagina. Thus, the final diagnosis was didelphys uterus, associated to ipsilateral vaginal and renal agenesis in mother.

International Journal of Clinical Pathology and Diagnosis, 2018

Placental Site Trophoblastic Tumor (PSTT) is a distinctive and rare form of Gestational Trophobla... more Placental Site Trophoblastic Tumor (PSTT) is a distinctive and rare form of Gestational Trophoblastic Neoplasm (GTN) [1]. The epidemiologic and risk factors are not well known. Usually, the relationship to previous gestations is uncertain. In addition, clinical and morphological features are very variable, which complicates the diagnosis [2]. In this paper, we report an uncommon presentation of PSTT in presumed post-menopausal woman reveled by uterine arterio-venous malformation. It's about a 44-year-old gravid 0 para 0 presumed post-menopausal Moroccan woman. She suffered from intolerable postmenopausal bleeding. Pelvic ultrasound showed a large sinusoid channels within the myometrium with colors showing multidirection on Doppler that suggested the diagnosis of pelvic Arterio-Venous Malformation (AVM). Computed Tomography and pelvic Angiography confirmed the diagnosis of an AVM. Thus, a preoperative embolization and total hysterectomy were performed. In the gross examination we noted variable seized thin-well cavities with blood clots within the myometrial tissues that are devoid of clearly obvious lesion. Microscopically, these ecstatic and congested vascular cavities were invaded by intermediate tophoblastic cells proliferation that infiltrates 60% of the myometrium. In immunohistochemical stain, the tumor cells expressed the Cytokeratin AE1/AE3 with Ki67 at 5%. Human chorionic gonadotropin (β-hCG), P63, smooth muscle markers and P53 were negative in the tumor cells. Through this case, we present a rare disease that often difficulty diagnosed and may be inappropriately treated.

Open Journal of Pathology, 2020

Urothelial carcinomas (UC) are likely to have particular morphological features that distinguish ... more Urothelial carcinomas (UC) are likely to have particular morphological features that distinguish them from the typical form. These original aspects are called "histological variants of urothelial carcinoma". They can constitute all or part of the tumor and concern mainly muscle invasive UC and high grade. Their frequency varies according to the type, but the knowledge of these variants is essential because of the diagnostic difficulties, and the implication of their presence on the prognosis.

Journal of Clinical Case Reports, 2017

Background: Bladder extrophy is a rare congenital anomaly, it is now well reconized that an exstr... more Background: Bladder extrophy is a rare congenital anomaly, it is now well reconized that an exstrophy of the bladder is associated with an increased risk of bladder cancer. Case presentation: We report the case of 34-year-old male with squamous cell carcinoma of an unreconstructed exstrophic bladder. Because of the locally advanced disease, he received neoadjuvant chemotherapy with favorable response. Then, he underwent a total cystectomy with uretero-intestinal anastamosis. Results: The patient progressed three months after the surgery. Chemotherapy was established and he received 2 cycles, however, he died 2 months later. Conclusion: Squamous cell carcinoma associated with bladder extrophy remains relatively high. These tumors tend to be aggressive, follow-up is mandatory in these cases.

BMC Research Notes, 2015

Background: Neurofibroma is a rare benign tumor. The isolated presence of such lesions in the pre... more Background: Neurofibroma is a rare benign tumor. The isolated presence of such lesions in the preperitoneal space with no evidence of systemic disease has never been reported in the literature. Case presentation: A 29-year-old white man presented with a 12 months history of progressive abdominal distension. Clinical examination revealed a bulky hypogastric mass. Abdominal computed tomography and pelvic magnetic resonance imaging showed a large, well defined preperitoneal tumor measuring 18 x 17cm extending in the pelvis. A computed tomography guided biopsy was performed which revealed a neurofibroma. Exploratory laparotomy showed a well encapsulated elastic soft tumor in the preperitoneal space which measured 17 x 18cm and weighted 2 Kg. The tumor was completely excised. No recurrence occurred after one year of follow-up. Conclusion: Solitary preperitoneal neurofibroma is an extremely rare benign tumor. Its clinical and radiological signs are nonspecific. Preoperative histology can be useful to guide the surgical approach which is the only curative treatment.

Journal Africain d'Hépato-Gastroentérologie, 2013

Journal of Clinical Imaging Science, 2014

Juxtaglomerular cell tumor (JGCT) is an unusual mesenchymal entity of the kidney. It is a benign ... more Juxtaglomerular cell tumor (JGCT) is an unusual mesenchymal entity of the kidney. It is a benign renin-secreting tumor causing hypertension and hypokalemia due to secondary hyperaldosteronism. It is curable if it is discovered early and surgically removed, but may cause a fatal outcome usually due to complications of associated hypertension.

Research Square (Research Square), Jan 17, 2023

Primary leptomeningeal melanoma is an extremely rare type of intracranial melanoma. It cannot be ... more Primary leptomeningeal melanoma is an extremely rare type of intracranial melanoma. It cannot be reliably distinguished from metastatic melanoma on neuroimaging and histopathological characteristics alone; its diagnosis is established only after exclusion of secondary metastatic disease from a cutaneous, mucosal or retinal primary. Prognosis is poor, partly due to its high rate of misdiagnosis. Herein, we report a case of a Primary Meningeal Melanoma of the skull base with Melanomatosis, in 31 years old man, mimicking Meningioma. Our aim is to highlight the diagnostic pitfalls and to discuss the histopathological differential diagnoses especially with other pigmented lesions of Central nervous system (CNS).

Background: Primary leptomeningeal melanoma is an extremely rare type of intracranial melanoma. I... more Background: Primary leptomeningeal melanoma is an extremely rare type of intracranial melanoma. It cannot be reliably distinguished from metastatic melanoma on neuroimaging and histopathological characteristics alone; its diagnosis is established only after exclusion of secondary metastatic disease from a cutaneous, mucosal or retinal primary [1, 2]. Prognosis is poor, partly due to its high rate of misdiagnosis. Case presentation: We report a case of a Primary Meningeal Melanoma of the skull base with Melanomatosis, in 31 years old man, mimicking clinical and radiological features of meningioma and whose delayed treatment has worsened the prognosis. Conclusion: Through this case, we highlight the diagnostic difficulties and we discuss the histopathological differential diagnoses especially with other pigmented lesions of Central nervous system (CNS).

Pan African Medical Journal

Clinical Medicine Insights. Case Reports, 2021

Squamous cell carcinoma is the most common mucosal malignancy of the head and neck. Adenoid pseud... more Squamous cell carcinoma is the most common mucosal malignancy of the head and neck. Adenoid pseudo-angiosarcomatous SCC is a rare variant occurring commonly in the skin of the head and neck. However, involvement of oral cavity is extremely rare, with only few case reports in the English literature. Morphologically, the tumor shows marked acantholysis, with anastomozing channels mimicking vascular neoplasms. This variant represents a diagnostic challenge for pathologists, and immunohistochemical analysis remains essential for an accurate diagnosis. Herein, we describe the case of a pseudovascular SCC of the oral cavity in a 67 years old man with a brief revue of the literature to raise awareness on this rare variant; presenting diagnostic difficulties.

Introduction : le Schwannome mélanotique sacré est une tumeur pigmentée rare des nerfs périphériq... more Introduction : le Schwannome mélanotique sacré est une tumeur pigmentée rare des nerfs périphériques. La croissance très lente de cette tumeur et l'adaptation progressive du contenu pelvien explique sa révélation tardive et son volume important compliquant son exérèse complète. Observation : nous rapportons un cas de Schwannome mélanotique sacré géant, se présentant sous forme d'une masse énorme et inextirpable de la cavité pelvienne, chez une femme âgée de 48ans, ayant consulté pour des lombalgies bilatérales associées à une insuffisance rénale. Discussion et conclusion : l'originalité de cette tumeur est soulignée par son évolution, son étiopathogénie et ses particularités histologiques et immunohistochimiques. A la lumière de cette observation, nous discutons les données de la littérature et nous exposons les difficultés diagnostiques et thérapeutiques.

Journal of Cancer Therapy, 2021

Introduction: Rhabdomyosarcoma (RMS) is the most common soft tissue tumor in children, with the h... more Introduction: Rhabdomyosarcoma (RMS) is the most common soft tissue tumor in children, with the head and neck location accounting for up to 40% of cases. The embryonal and alveolar histologic variants are more commonly seen in pediatric patients. The treatment is multimodal and the prognosis of this clinical entity is always gloomy. We report the case of nasopharyngeal rhabdomyosarcoma in a 7-year-old boy child with a good response to early post-therapy. Case Presentation: The patient was diagnosed with nasopharyngeal RMS revealed by a congested nose, ptosis and bilateral blindness, and who received induction chemotherapy followed by concurrent radiotherapy followed by adjuvant chemotherapy. The evolution is marked by a good clinical course but persistence of bilateral blindness. Conclusion: The RMS nasopharyngeal often presents with nonspecific symptoms. Multimodal therapy should be performed including surgery, chemotherapy and radiotherapy.

The Pan African Medical Journal, 2021

Le carcinome sarcomatoïde est une tumeur maligne rare, agressive de mauvais pronostic à pouvoir r... more Le carcinome sarcomatoïde est une tumeur maligne rare, agressive de mauvais pronostic à pouvoir récidivant très élevé. Sa localisation au niveau du sinus maxillaire est extrêmement rare. Nous rapportons le cas d´une femme de 42 ans, qui présentait un processus du maxillaire gauche dont une biopsie faite revenant en faveur d´un carcinome sarcomatoïde agressif à métastase ganglionnaire. La patiente a bénéficié d´une exérèse chirurgicale, un évidement ganglionnaire suivi d´une radiothérapie avec une bonne évolution. La rareté de cette tumeur en particulier en cette localisation pose une problématique diagnostique et de prise en charge à temps; cette dernière qui reste à ce jour la controversée. Cependant, une exérèse chirurgicale large reste le meilleur traitement. A travers ce cas nous avons mis le point sur les particularités anatomo-cliniques et surtout pronostiques de cette tumeur.

International Journal of Clinical Pathology and Diagnosis, 2021

Papillary Intralymphatic Angioendothelioma or Dabska's tumor is very rare tumor in children and y... more Papillary Intralymphatic Angioendothelioma or Dabska's tumor is very rare tumor in children and young adults, characterized by intraluminal papillary endothelial structures which are lined by plump cuboidal endothelial cells with hobnailed appearance [1]. It usually develops in the soft tissues of extremities. Deeper locations are exceptional and unusual, complicating its early diagnosis and adequate management.In this paper we report a new case about a recurrent and locally invasive oropharyngeal Dabska's tumor in a 34-year-old Moroccan woman.

International Journal of Clinical Pathology and Diagnosis, 2021

Chordoid glioma is a rare tumor of the Third Ventricle (V3), representing a very distinct clinico... more Chordoid glioma is a rare tumor of the Third Ventricle (V3), representing a very distinct clinico-pathological entity in the WHO classification of central nervous tumors, who classified it as grade II [1]. It has usually a slow growing. In this paper, we report the case of a rapidly progressive and lethal Chordoid Glioma (CG) in 48-year-old Moroccan a women. The rarity and the morphological similarities of this neoplasm with other suprasellar tumors constitute a challenge for the pathologist especially in extemporaneous condition, which complicates the diagnosis and the management.

Case Reports in Urology, 2021

Synchronous renal cell carcinomas (RCC) and angiomyolipomas (AML) occurring in the same kidney ar... more Synchronous renal cell carcinomas (RCC) and angiomyolipomas (AML) occurring in the same kidney are rare. Cases in the setting of tuberous sclerosis (TS) have been reported in the literature. However, the association of these tumors in the same kidney without TS is even more rare. We report here a case of a clear cell renal cell carcinoma (CCRCC) associated with an AML in the same kidney in a 42 years old female lacking the TS diagnostic criteria. The patient underwent a radical nephrectomy. Six months after surgery, the patient is healthy without signs of tumor recurrence or distant metastasis.

Case Reports in Pathology, 2021

Primary leiomyosarcomas (LMS) of vascular origin are rare tumors, and more than half of the cases... more Primary leiomyosarcomas (LMS) of vascular origin are rare tumors, and more than half of the cases arise in the inferior vena cava (IVC). Primary LMS of the renal vein are extremely rare tumors with only a few cases reported in the literature. Their diagnosis is made only by pathological features. Histologically, they are made of atypical spindle-shaped cells arranged in long intersecting fascicles. Tumor cells stain positive for myogenic markers in immunohistochemistry. Standard treatment consists of radical nephrectomy followed by chemotherapy and/or radiotherapy. Because of insufficient histological data and follow-up, the prognosis factors are not well identified. Overall prognosis of renal vein LMS is poor. We report here an exceptional case of a huge LMS of the right renal vein mimicking a primitive renal cell carcinoma, occurring in a 56-year-old male patient.

Journal of Surgical Case Reports, 2020

Angiomyofibroblastoma is a rare mesenchymal benign tumor that frequently occurs in young- to midd... more Angiomyofibroblastoma is a rare mesenchymal benign tumor that frequently occurs in young- to middle-aged women, arising from the genital tract. There are many overlapping radiological and immunohistochemical features with other stromal cell lesions, making the diagnosis difficult. We report here a case of a 29-year-old woman admitted for a pelvic mass, in whom, the histopathological and immunohistochemical studies led to the diagnosis of angiomyofibroblastoma.

Journal of Cancer Science and Clinical Therapeutics, 2020

Paratesticular leiomyosarcoma is a rare tumor of the mature adult who develops habitually in the ... more Paratesticular leiomyosarcoma is a rare tumor of the mature adult who develops habitually in the spermatic cord [1]. Preoperative diagnosis can be difficult because of nonspecific symptoms and non pathognomonic radiological features. In addition, its slow growing does not allow adequate differential diagnosis with respect to other scrotal tumors. We present a case of an uncommon paratesticular leiomyosarcoma: it's about a 64-year-old man with a history of painless enlargement of the left testis for 03 years. The scrotal ultrasound and MRI showed a paratesticular mass of 4.5cm in contact with spermatic cord. Patient underwent left high inguinal orchidectomy. Histopathological examination with immunostaining made the final diagnosis of grade 1 paratesticular leiomyosarcoma of NFFCS, with hepatic metastases in the abdominal CT.

International Journal of Clinical Pathology and Diagnosis, 2018

A didelphys uterus is one of the least common of Mullerian duct anomalies that arise from abnorma... more A didelphys uterus is one of the least common of Mullerian duct anomalies that arise from abnormal embryological development of the Mullerian ducts [1]. Embryologic anomaly of one Wolffian ducts-causing unilateral renal agenesis-is additionally seen in 15-30% of uterine didelphys [2]. In this paper, we report a first presentation-in our knowledge-of didelphys uterus with complex malformations in mother of two kids. It's about a 30-year-old Moroccan mother who successfully conceived and carried her pregnancies to term without complications. She suffered from chronic pelvic pain. The computed tomography scan revealed a left pelvic mass that was diagnosed as a mute pelvic kidney. The discovery of a didelphys uterus was fortuitous in pathological examination of the presumed nephrectomy. Indeed, we received an open cystic mass with thickened myomatous wall. Within the wall we found a rounded cavity with chocolate like contents. In histological examination, this mass corresponded to a uterine and endo-cervical wall, fallopian tube, residual ovarian parenchyma ovary and old hematosalpynx. There was no vagina. Thus, the final diagnosis was didelphys uterus, associated to ipsilateral vaginal and renal agenesis in mother.

International Journal of Clinical Pathology and Diagnosis, 2018

Placental Site Trophoblastic Tumor (PSTT) is a distinctive and rare form of Gestational Trophobla... more Placental Site Trophoblastic Tumor (PSTT) is a distinctive and rare form of Gestational Trophoblastic Neoplasm (GTN) [1]. The epidemiologic and risk factors are not well known. Usually, the relationship to previous gestations is uncertain. In addition, clinical and morphological features are very variable, which complicates the diagnosis [2]. In this paper, we report an uncommon presentation of PSTT in presumed post-menopausal woman reveled by uterine arterio-venous malformation. It's about a 44-year-old gravid 0 para 0 presumed post-menopausal Moroccan woman. She suffered from intolerable postmenopausal bleeding. Pelvic ultrasound showed a large sinusoid channels within the myometrium with colors showing multidirection on Doppler that suggested the diagnosis of pelvic Arterio-Venous Malformation (AVM). Computed Tomography and pelvic Angiography confirmed the diagnosis of an AVM. Thus, a preoperative embolization and total hysterectomy were performed. In the gross examination we noted variable seized thin-well cavities with blood clots within the myometrial tissues that are devoid of clearly obvious lesion. Microscopically, these ecstatic and congested vascular cavities were invaded by intermediate tophoblastic cells proliferation that infiltrates 60% of the myometrium. In immunohistochemical stain, the tumor cells expressed the Cytokeratin AE1/AE3 with Ki67 at 5%. Human chorionic gonadotropin (β-hCG), P63, smooth muscle markers and P53 were negative in the tumor cells. Through this case, we present a rare disease that often difficulty diagnosed and may be inappropriately treated.

Open Journal of Pathology, 2020

Urothelial carcinomas (UC) are likely to have particular morphological features that distinguish ... more Urothelial carcinomas (UC) are likely to have particular morphological features that distinguish them from the typical form. These original aspects are called "histological variants of urothelial carcinoma". They can constitute all or part of the tumor and concern mainly muscle invasive UC and high grade. Their frequency varies according to the type, but the knowledge of these variants is essential because of the diagnostic difficulties, and the implication of their presence on the prognosis.

Journal of Clinical Case Reports, 2017

Background: Bladder extrophy is a rare congenital anomaly, it is now well reconized that an exstr... more Background: Bladder extrophy is a rare congenital anomaly, it is now well reconized that an exstrophy of the bladder is associated with an increased risk of bladder cancer. Case presentation: We report the case of 34-year-old male with squamous cell carcinoma of an unreconstructed exstrophic bladder. Because of the locally advanced disease, he received neoadjuvant chemotherapy with favorable response. Then, he underwent a total cystectomy with uretero-intestinal anastamosis. Results: The patient progressed three months after the surgery. Chemotherapy was established and he received 2 cycles, however, he died 2 months later. Conclusion: Squamous cell carcinoma associated with bladder extrophy remains relatively high. These tumors tend to be aggressive, follow-up is mandatory in these cases.

BMC Research Notes, 2015

Background: Neurofibroma is a rare benign tumor. The isolated presence of such lesions in the pre... more Background: Neurofibroma is a rare benign tumor. The isolated presence of such lesions in the preperitoneal space with no evidence of systemic disease has never been reported in the literature. Case presentation: A 29-year-old white man presented with a 12 months history of progressive abdominal distension. Clinical examination revealed a bulky hypogastric mass. Abdominal computed tomography and pelvic magnetic resonance imaging showed a large, well defined preperitoneal tumor measuring 18 x 17cm extending in the pelvis. A computed tomography guided biopsy was performed which revealed a neurofibroma. Exploratory laparotomy showed a well encapsulated elastic soft tumor in the preperitoneal space which measured 17 x 18cm and weighted 2 Kg. The tumor was completely excised. No recurrence occurred after one year of follow-up. Conclusion: Solitary preperitoneal neurofibroma is an extremely rare benign tumor. Its clinical and radiological signs are nonspecific. Preoperative histology can be useful to guide the surgical approach which is the only curative treatment.

Journal Africain d'Hépato-Gastroentérologie, 2013

Journal of Clinical Imaging Science, 2014

Juxtaglomerular cell tumor (JGCT) is an unusual mesenchymal entity of the kidney. It is a benign ... more Juxtaglomerular cell tumor (JGCT) is an unusual mesenchymal entity of the kidney. It is a benign renin-secreting tumor causing hypertension and hypokalemia due to secondary hyperaldosteronism. It is curable if it is discovered early and surgically removed, but may cause a fatal outcome usually due to complications of associated hypertension.