Hakan Cinemre - Academia.edu (original) (raw)
Papers by Hakan Cinemre
Current Opinion in Gastroenterology, 2010
Sakarya tıp dergisi, 2017
Journal of Human Rhythm, Mar 30, 2017
Gastric cancer is the fi fth most common cancer in the world, and about one million new cases dev... more Gastric cancer is the fi fth most common cancer in the world, and about one million new cases develop globally each year. Early Gastric Cancer (EGC) is a stage that tumor invades gastric mucosa or submucosa with or without involvement of the lymph nodes (LN). Endoscopic resection techniques are endoscopic mucosal resection (EMR) and endoscopic submucosal dissection (ESD), latter of which is more popular now. Gastrectomy is the standard choice of treatment but, is highly invasive that requires longer stay at hospital, with higher costs and complication rates, especially at the anastomotic site. EMR was used more frequently before the development of ESD but, now give its popularity to ESD and EMR depends on the region and experience of the center. EMR is more convenient method for smaller lesions, associated with lower bleeding risk and shorter duration of operation compared to ESD. On the other hand, ESD has lower en-block resection rates and recurrence rates compared to EMR. In this review, we analyzed over than 10.000 patients' oncologic outcomes including overall survival, disease free survival and recurrence rates. In conclusion, many newly diagnosed gastric cancer patients are seeking micro-invasive treatment modalities around the World for their early stage cancers. Endoscopic submucosal resection and endoscopic mucosal resection are safe and convenient procedures and had comparable oncologic outcomes with surgery. Additionally, these techniques can easily be used in patients who are not surgical candidates.
Archives of Rheumatology, 2008
Bisphosphonates are the drugs which modulate bone turnover and reduce bone reabsorbsion. Hence, t... more Bisphosphonates are the drugs which modulate bone turnover and reduce bone reabsorbsion. Hence, they are used in postmenopausal osteoporosis, multiple myeloma or osteolisis associated with malign cancer. The rare complications are appearing more often now because of their wide use in treatments. Most important possible adverse effects belong to gastrointestinal systems; esophagitis, gastric ulcers, dyspepsia, heartburn and rarely oral ulcers, osteonecrosis on jaws and esophagial stricturs are illustrated
Türk romatoloji dergisi, Jun 1, 2010
Online türk sağlık bilimleri dergisi, Mar 1, 2022
Bu çalışmada, pankr eatit hastalar ının hastalık şiddetinin izlenmesinde nötrofil-lenfosit oranı ... more Bu çalışmada, pankr eatit hastalar ının hastalık şiddetinin izlenmesinde nötrofil-lenfosit oranı (NLO) ve trombosit-lenfosit oranlarının (TLO) bir parametre olarak kullanılıp kullanılamayacağını göstermeyi amaçladık. Materyal ve Metot: Akut pankr eatit tanısı ile gastr oenteroloji servisinde yatan ve takip edilen, dosyaları retrospektif olarak incelenen toplam 200 hasta çalışmaya dahil edildi. Akut pankreatitin şiddeti ve prognozu Atlanta sınıflaması ile değerlendirildi. Bulgular: NLO or talaması hasta gr ubunda 9,84±9,60, kontrol grubunda ise 2,00±0,86 idi. Hasta grubunda NLO düzeyi yüksek saptandı ve cutoff değeri 2,85 olarak bulundu (Duyarlılık: %86 ve özgüllük: %81). Hastalık şiddetine göre NLO ortalamasında anlamlı bir değişiklik bulunmamakla birlikte, gruplar arasında NLO ortalamasındaki düşüş 48 saatte anlamlı bulundu. Sonuç: Sadece ilk 48 saatteki NLO düzeyindeki değişikliğin hastalık şiddeti ile ilişkili olabileceğini bulduk. NLO'nun kullanılabilecek, uygulanabilecek ve kolay ulaşılabilecek bir parametre olduğunu gördük Anahtar Kelimeler: Akut pankr eatit, platelet, pr ognostik faktörler, NLO ve TLO ABSTRACT Objective: In this study, we aim at demonstr ating whether we can use neutrophil-lymphocyte ratio (NLR) and platelet-lymphocyte ratios (PLR) as a parameter in monitoring the disease severity of Pancreatitis Patients. Materials and Methods: A total of 200 patients diagnosed with acute pancreatitis, hospitalized and monitored in gastroenterology service, whose files had retrospectively been studied, were included in the study. The severity and prognosis of acute pancreatitis were evaluated with the Atlanta classification. Results: The aver age of NLR was 9.84±9.60 in the patient group but 2.00±0.86 in the control group. The NLR level was found higher in the patient group. The cutoff value was found as 2.85 (Sensitivity: 86% and specificity: 81%). Although no significant change was found in terms of the average of NLR concerning the disease severity, the decrease in the average of NLR among the groups was found significant in 48 hours. Conclusion: We have found that only the change in NLR level in the first 48th-hour could be associated with the disease severity. We found NLR as a parameter that can be used, applied, and accessed easily.
Tıp Araştırmaları Dergisi, 2007
... Feyzi Gökosmanoğlu, Hakan Cinemre, Cemil Bilir ... Hastanın daha önceki takip-leri sırasında ... more ... Feyzi Gökosmanoğlu, Hakan Cinemre, Cemil Bilir ... Hastanın daha önceki takip-leri sırasında serum ve idrar protein elektroforezinde, beta-gama arasında dar tabanlı, keskin kenarlı band görüldü (monoklonal gamapati) ve idrarda serbest hafif zincirlere yönelik antiserumla ...
Tüberküloz ve toraks, 2006
To investigate the value of simultaneously obtained brain computed tomography (CT) and magnetic r... more To investigate the value of simultaneously obtained brain computed tomography (CT) and magnetic resonance imaging (MRI) to diagnose brain metastasis in non-small cell lung cancer (NSCLC) patients with or without neurological symptoms. Sixty-two patients (58 male, 4 female) who were admitted to Yedikule Chest Hospital and Thoracic Surgery Center between January 2000-December 2003 and whom were diagnosed with NSCLC were included in the study. Ages of patients varied between 40-85 (61 +/- 11). All patients had hemogram and routine blood chemistry as well as chest X-ray, thorax CT, brain CT, brain MRI, FOB and a complete neurological exam. Brain metastasis were detected in 22 of 62 (35.5%) patients by using brain MRI and 16 (72.7%) of these hadn't had any neurological symptoms or signs. The difference to detect the brain metastasis between brain MRI and CT was statistically significant (p < 0.01). Nine of the 22 cases (14.5%) who were found to have brain metastasis by using MRI were stage I. While brain CT showed solitary brain metastasis in five patients, 4 (80%) of them were found to have multiple metastases when MRI studies were used. We concluded that, in an attempt to make correct staging and treatment of NSCLC and hence to investigate the brain metastasis in NSCLC patients including early stage ones, brain MRI is superior to brain CT study.
International Journal of Basic and Clinical Medicine, 2015
Ozet Amac Calismamizin amaci gestasyonel diabetes mellituslu (GDM) gebelerde, saglikli gebelerde ... more Ozet Amac Calismamizin amaci gestasyonel diabetes mellituslu (GDM) gebelerde, saglikli gebelerde ve saglikli gebe olmayan olgularda bazi biyokimyasal ve tam kan sayimi parametreleri ile plazma viskozitesinin olcumu ve plazma viskozitesi ile bu parametreler arasindaki iliskinin arastirilmasidir. Materyal ve Metod GDM’li 27 gebe hasta grubu, 25 saglikli gebe olan ve 24 saglikli gebe olmayan gruplarda aclik kan sekeri, insulin, total protein, albumin, total kolesterol, trigliserid, HDL-Kolesterol, LDL-kolesterol, HOMA-IR, HbA1c, Hct, Hb, PLT, MPV duzeyleri otoanalizorde, plazma viskozitesi kapiler viskozimetre ile olculdu. Bulgular GDM’li hasta grubunda saglikli gebe olan ve gebe olmayan gruplara gore plazma viskozitesi, total protein, albumin, total kolesterol, LDL-kolesterol, aclik kan sekeri ve insulin, HOMA-IR ve HbA1c’nin arttigi saptandi. Trigliserid duzeylerinin GDM’li grupta saglikli gebe olan kontrol grubuna gore arttigi belirlendi. Ayrica plazma viskozitesi ile total kolester...
Background: Aim of this study is the investigation of the association between Serum Asymmetric Di... more Background: Aim of this study is the investigation of the association between Serum Asymmetric Dimethyl Arginine (ADMA) levels and menstrual pain intensity as assessed by Visual Analogue Scale in primary dysmenorrhea patients. Methods : Eighty-nine young women with primary dysmenorrhea (PD) were selected as study group. PD pain was graded using Visual Analogue Scale (VAS), as mild, moderate and severe. Serum ADMA levels was measured in all subjects. Results: Mean age of study population was 21.08±2.21 and mean VAS score was 5.9101±2.18. Serum ADMA levels were 35.2(24) in mild, 54.0(28.7) in moderate and 56.5(32.8) in severe pain groups, (P= 0.029 and P=0.001, respectively). Mean ADMA levels difference were -18.8, p=0.046 in mild to moderate; -2.52, p=0. 945 in moderate to severe and 21.32 p=0.048 in severe to mild pain groups. Conclusion: Menstrual p ain intensity is correlated with the serum ADMA levels as assessed by VAS pain score in PD patients
Vertikal diplopi ile prezente olan nonptotik oküler myasteni gravis: Olgu sunumu Myasteni gravis ... more Vertikal diplopi ile prezente olan nonptotik oküler myasteni gravis: Olgu sunumu Myasteni gravis iskelet kaslar›nda nöromuskuler bileflkedeki disfonksiyon sonucu güç kayb›yla karakterize, otoimmun komponenti de olan bir hastal›kt›r. S›kl›kla adolesan ve genç eriflkinlik döneminde bafllar. Myasteni gravis okulomotor kaslar› tutarsa oküler myasteni olarak adland›r›l›r. Myasteni gravis hastalar›n›n yaklafl›k yar›s›nda okuler semptom ve bulgular mevcutken, %15'i sadece oküler myasteni klini¤i ile seyrederler. Ptozis, diplopi ve orbikularis okuli kas›nda zay›fl›k klasik triad›n› oluflturur. Olgular›n %90'›nda ptozis efllik etmekte olup, nadiren sadece ptozisle uzun dönem seyreder. Oküler Myasteni gravis (OMG)'lilerin 2/3'ü jeneralize myasteniye dönüflürken, 1/3'ü oküler myasteni olarak kal›r. Vertikal diplopi ile klini¤imize baflvuran nonptotik 67 yafl›nda bir oküler myasteni olgusu sunduk.
Turkiye Klinikleri Tip Bilimleri Dergisi, 2008
... Erişkin Bir Herediter Sferositoz Hastasındaparvovirüs B19'a Bağlı Aplastik Kriz Adem... more ... Erişkin Bir Herediter Sferositoz Hastasındaparvovirüs B19'a Bağlı Aplastik Kriz Adem GÜNGÖR, MD a ,Cemil BİLİR, MD a ,Elif ÖNDER, MD a ,Uğur ... 29 yaşında erkek hasta halsizlik, ateş ve yaygın eklem ve kas ağrısı yakınmaları ile başvurması üzerine dahiliye servisine yatırıldı. ...
Turkish Journal of Geriatrics-Turk Geriatri Dergisi, 2010
S tevens Johnson Syndrome (SJS) is a severe skin reaction related to drugs and infections, charac... more S tevens Johnson Syndrome (SJS) is a severe skin reaction related to drugs and infections, characterized by fever, stomatitis and conjunctivitis. Although seen in all age groups it is more common in the 2nd and 4th decades. SJS is rare in the elderly. Many drug related SJS cases have been reported in literature but amoxicillin related SJS cases are rare. In this article, a case of amoxicillin related severe SJS in a geriatric patient during treatment of pneumonia has been reported. A 74 year old patient admitted to our emergency room with severe skin lesions, swollen red eyelids and dyspnoea after the second day of amoxicillin treatment. He was hospitalized with a diagnosis of acute renal failure, pneumonia and severe drug eruption (SJS). After clinical and histopathological evaluations, the severe skin lesions were diagnosed as amoxicillin related SJS and intravenous corticosteroid therapy was initiated. Steroid therapy led to a marked improvement in skin lesions and was decreased gradually and stopped. Use of beta-lactam antibiotics and especially amoxicillin is common in all age groups including the geriatric patients. It should be kept in mind that, although rare, amoxicillin related severe life threatening skin lesions (SJS) may develop in elderly patients.
12th European Congress of Endocrinology, Apr 1, 2010
Introduction: Insulin resistance is the decrease sensitivity of tissues in the body to insulin ef... more Introduction: Insulin resistance is the decrease sensitivity of tissues in the body to insulin effect. Obesity, advanced age, sedentary life and smoking are the factors leading to an increase in insulin resistance. In our study, we aimed to evaluate the relationship between the ...
12th European Congress of Endocrinology, Apr 1, 2010
Introduction: Recent conducted studies show that clinical hypothyroidism (CH) has similar cardiov... more Introduction: Recent conducted studies show that clinical hypothyroidism (CH) has similar cardiovascular risk with subclinical hypothyroidism (SCH). Carotid intima media thickness (CIMT) that is an important marker of early atherosclerotic changes is an indicator of cardiovascular events. In our ...
The American Journal of the Medical Sciences, 2012
Objective: To demonstrate the prevalence and prognostic value of electrocardiographic abnormaliti... more Objective: To demonstrate the prevalence and prognostic value of electrocardiographic abnormalities in patients with chronic spinal cord injury. Methods: All electrocardiographs obtained in the Palo Alto Veterans Affairs Medical Center since 1987 have been digitally recorded and stored in a computerized database. For this study, only the first electrocardiograph was considered for analysis. The subjects were divided according to age and level of spinal cord injury. The Social Security Death Index was used to ascertain vital status as of December 1999. Results: Annual mortality was similar in those with chronic spinal cord injury and the able-bodied. However, individuals with a higher level of injury had a significantly higher death rate than those with a lower level of injury. The prognostic characteristics of electrocardiographic abnormalities were similar in both the able-bodied and those with spinal cord injury. Conclusion: In general, electrocardiographic abnormalities had the same prevalence in the spinal cord injury subjects as in the able-bodied ones. The prognostic value of electrocardiographic abnormalities in subjects with spinal cord injury is similar to that observed in able-bodied subjects.
Turkish Journal of …, 2010
Stevens Johnson Sendromu (SJS) genellikle ilaçlara ve enfeksiyonlara karşı oluşan, ateş, stomatit... more Stevens Johnson Sendromu (SJS) genellikle ilaçlara ve enfeksiyonlara karşı oluşan, ateş, stomatit ve konjonktivit ile karakterize ağır bir cilt reaksiyonudur. Her yaş ve cinsiyette ortaya çıkabilmekle birlikle genellikle 2.-4. dekatta görülür, ileri yaşlarda nadir olarak görülmektedir. ...
Journal of Human Rhythm, Dec 27, 2018
Amaç İnsan vücudunda normal metabolizma ürünü olarak ya da ekzojen kaynaklarla oluşturulan reakti... more Amaç İnsan vücudunda normal metabolizma ürünü olarak ya da ekzojen kaynaklarla oluşturulan reaktif oksijen türleri (ROT) ve diğer serbest radikallerin, çok sayıda fi zyolojik ve patolojik olayda yer aldığı bilinmektedir. Bu reaktif türler eşleşmemiş elektrona sahip oldukları için, hücrenin pek çok bileşeni, DNA, protein ve lipid içerikleriyle kolaylıkla reaksiyona girerek, normal hücre fonksiyonlarını bozabilme yeteneğindedir. Bu çalışmada, oksidan stres modeli olarak seçilen nötrofi llerin okside olmuş düşük dansiteli lipoprotein (ox-LDL) ile aktive edilmesi sonucu oluşan hasarı Komet Assay ile göstermeyi amaçladık. Gereç ve yöntemler Bu çalışmada LDL, "short-run ultracentrifugation" yöntemiyle izole edildikten sonra CuCl� ile okside edildi. Ficoll-Hypaque gradientcentrifi ıgation" yöntemi ile de tam kandan izole edilen nötrofi ller ox-LDL ile sitümüle edildi. %1 LMP-agoraz içinde yatay elektroforezde yürütüldü ve propidyum iyodidle boyanarak, fl oresan mikroskopu (Leica-DMLB) ile değerlendirildi. Sonuçlar, sayılan 100 hücreden komet oluşturmuş hücrelerin yüzdesi olarak bildirildi. Bulgular Komet yöntemi ile Ox-LDL ile muamele edilen hücrelerde Komet oluşumu %30,0 ± 4,6 olarak tespit edildi. Aynı oran kontrol hücre grubunda %5,2 ± 1,9 olarak bulundu. Bu sonuçlara göre ox-LDL ile indüklenen oksidatif stres durumunda Komet oluşturan hücrelerin yüzdesinin belirgin olarak arttığı gözlendi (p<0.001). Aynı hücre gruplarında tripan mavisi ile tespit edilen hücre canlılığı %53,4 ± 3,9 (oksidan stres durumunda); %84,7± 3,2 (kontrol grubunda) olarak belirlendi (p<0.001). Sonuç Nötrofi llerin ox-LDL ile muameleye aktivasyonla yanıt verdiği ve bunun sonucu DNA hasarında istatistiksel olarak anlamlı bir yükselme olduğu Komet yöntemi ile göstermek mümkün olmuştur. Bu DNA hasarının nötrofi llerin doğal immünitedeki koruyucu fonksiyonlarının aksine kronik infl amatuar hastalıklar, kanser oluşumu gibi pek çok hastalığın etyopatogenezindeki rollerini açıklamada önemli olacaktır.
Current Opinion in Gastroenterology, 2010
Sakarya tıp dergisi, 2017
Journal of Human Rhythm, Mar 30, 2017
Gastric cancer is the fi fth most common cancer in the world, and about one million new cases dev... more Gastric cancer is the fi fth most common cancer in the world, and about one million new cases develop globally each year. Early Gastric Cancer (EGC) is a stage that tumor invades gastric mucosa or submucosa with or without involvement of the lymph nodes (LN). Endoscopic resection techniques are endoscopic mucosal resection (EMR) and endoscopic submucosal dissection (ESD), latter of which is more popular now. Gastrectomy is the standard choice of treatment but, is highly invasive that requires longer stay at hospital, with higher costs and complication rates, especially at the anastomotic site. EMR was used more frequently before the development of ESD but, now give its popularity to ESD and EMR depends on the region and experience of the center. EMR is more convenient method for smaller lesions, associated with lower bleeding risk and shorter duration of operation compared to ESD. On the other hand, ESD has lower en-block resection rates and recurrence rates compared to EMR. In this review, we analyzed over than 10.000 patients' oncologic outcomes including overall survival, disease free survival and recurrence rates. In conclusion, many newly diagnosed gastric cancer patients are seeking micro-invasive treatment modalities around the World for their early stage cancers. Endoscopic submucosal resection and endoscopic mucosal resection are safe and convenient procedures and had comparable oncologic outcomes with surgery. Additionally, these techniques can easily be used in patients who are not surgical candidates.
Archives of Rheumatology, 2008
Bisphosphonates are the drugs which modulate bone turnover and reduce bone reabsorbsion. Hence, t... more Bisphosphonates are the drugs which modulate bone turnover and reduce bone reabsorbsion. Hence, they are used in postmenopausal osteoporosis, multiple myeloma or osteolisis associated with malign cancer. The rare complications are appearing more often now because of their wide use in treatments. Most important possible adverse effects belong to gastrointestinal systems; esophagitis, gastric ulcers, dyspepsia, heartburn and rarely oral ulcers, osteonecrosis on jaws and esophagial stricturs are illustrated
Türk romatoloji dergisi, Jun 1, 2010
Online türk sağlık bilimleri dergisi, Mar 1, 2022
Bu çalışmada, pankr eatit hastalar ının hastalık şiddetinin izlenmesinde nötrofil-lenfosit oranı ... more Bu çalışmada, pankr eatit hastalar ının hastalık şiddetinin izlenmesinde nötrofil-lenfosit oranı (NLO) ve trombosit-lenfosit oranlarının (TLO) bir parametre olarak kullanılıp kullanılamayacağını göstermeyi amaçladık. Materyal ve Metot: Akut pankr eatit tanısı ile gastr oenteroloji servisinde yatan ve takip edilen, dosyaları retrospektif olarak incelenen toplam 200 hasta çalışmaya dahil edildi. Akut pankreatitin şiddeti ve prognozu Atlanta sınıflaması ile değerlendirildi. Bulgular: NLO or talaması hasta gr ubunda 9,84±9,60, kontrol grubunda ise 2,00±0,86 idi. Hasta grubunda NLO düzeyi yüksek saptandı ve cutoff değeri 2,85 olarak bulundu (Duyarlılık: %86 ve özgüllük: %81). Hastalık şiddetine göre NLO ortalamasında anlamlı bir değişiklik bulunmamakla birlikte, gruplar arasında NLO ortalamasındaki düşüş 48 saatte anlamlı bulundu. Sonuç: Sadece ilk 48 saatteki NLO düzeyindeki değişikliğin hastalık şiddeti ile ilişkili olabileceğini bulduk. NLO'nun kullanılabilecek, uygulanabilecek ve kolay ulaşılabilecek bir parametre olduğunu gördük Anahtar Kelimeler: Akut pankr eatit, platelet, pr ognostik faktörler, NLO ve TLO ABSTRACT Objective: In this study, we aim at demonstr ating whether we can use neutrophil-lymphocyte ratio (NLR) and platelet-lymphocyte ratios (PLR) as a parameter in monitoring the disease severity of Pancreatitis Patients. Materials and Methods: A total of 200 patients diagnosed with acute pancreatitis, hospitalized and monitored in gastroenterology service, whose files had retrospectively been studied, were included in the study. The severity and prognosis of acute pancreatitis were evaluated with the Atlanta classification. Results: The aver age of NLR was 9.84±9.60 in the patient group but 2.00±0.86 in the control group. The NLR level was found higher in the patient group. The cutoff value was found as 2.85 (Sensitivity: 86% and specificity: 81%). Although no significant change was found in terms of the average of NLR concerning the disease severity, the decrease in the average of NLR among the groups was found significant in 48 hours. Conclusion: We have found that only the change in NLR level in the first 48th-hour could be associated with the disease severity. We found NLR as a parameter that can be used, applied, and accessed easily.
Tıp Araştırmaları Dergisi, 2007
... Feyzi Gökosmanoğlu, Hakan Cinemre, Cemil Bilir ... Hastanın daha önceki takip-leri sırasında ... more ... Feyzi Gökosmanoğlu, Hakan Cinemre, Cemil Bilir ... Hastanın daha önceki takip-leri sırasında serum ve idrar protein elektroforezinde, beta-gama arasında dar tabanlı, keskin kenarlı band görüldü (monoklonal gamapati) ve idrarda serbest hafif zincirlere yönelik antiserumla ...
Tüberküloz ve toraks, 2006
To investigate the value of simultaneously obtained brain computed tomography (CT) and magnetic r... more To investigate the value of simultaneously obtained brain computed tomography (CT) and magnetic resonance imaging (MRI) to diagnose brain metastasis in non-small cell lung cancer (NSCLC) patients with or without neurological symptoms. Sixty-two patients (58 male, 4 female) who were admitted to Yedikule Chest Hospital and Thoracic Surgery Center between January 2000-December 2003 and whom were diagnosed with NSCLC were included in the study. Ages of patients varied between 40-85 (61 +/- 11). All patients had hemogram and routine blood chemistry as well as chest X-ray, thorax CT, brain CT, brain MRI, FOB and a complete neurological exam. Brain metastasis were detected in 22 of 62 (35.5%) patients by using brain MRI and 16 (72.7%) of these hadn't had any neurological symptoms or signs. The difference to detect the brain metastasis between brain MRI and CT was statistically significant (p < 0.01). Nine of the 22 cases (14.5%) who were found to have brain metastasis by using MRI were stage I. While brain CT showed solitary brain metastasis in five patients, 4 (80%) of them were found to have multiple metastases when MRI studies were used. We concluded that, in an attempt to make correct staging and treatment of NSCLC and hence to investigate the brain metastasis in NSCLC patients including early stage ones, brain MRI is superior to brain CT study.
International Journal of Basic and Clinical Medicine, 2015
Ozet Amac Calismamizin amaci gestasyonel diabetes mellituslu (GDM) gebelerde, saglikli gebelerde ... more Ozet Amac Calismamizin amaci gestasyonel diabetes mellituslu (GDM) gebelerde, saglikli gebelerde ve saglikli gebe olmayan olgularda bazi biyokimyasal ve tam kan sayimi parametreleri ile plazma viskozitesinin olcumu ve plazma viskozitesi ile bu parametreler arasindaki iliskinin arastirilmasidir. Materyal ve Metod GDM’li 27 gebe hasta grubu, 25 saglikli gebe olan ve 24 saglikli gebe olmayan gruplarda aclik kan sekeri, insulin, total protein, albumin, total kolesterol, trigliserid, HDL-Kolesterol, LDL-kolesterol, HOMA-IR, HbA1c, Hct, Hb, PLT, MPV duzeyleri otoanalizorde, plazma viskozitesi kapiler viskozimetre ile olculdu. Bulgular GDM’li hasta grubunda saglikli gebe olan ve gebe olmayan gruplara gore plazma viskozitesi, total protein, albumin, total kolesterol, LDL-kolesterol, aclik kan sekeri ve insulin, HOMA-IR ve HbA1c’nin arttigi saptandi. Trigliserid duzeylerinin GDM’li grupta saglikli gebe olan kontrol grubuna gore arttigi belirlendi. Ayrica plazma viskozitesi ile total kolester...
Background: Aim of this study is the investigation of the association between Serum Asymmetric Di... more Background: Aim of this study is the investigation of the association between Serum Asymmetric Dimethyl Arginine (ADMA) levels and menstrual pain intensity as assessed by Visual Analogue Scale in primary dysmenorrhea patients. Methods : Eighty-nine young women with primary dysmenorrhea (PD) were selected as study group. PD pain was graded using Visual Analogue Scale (VAS), as mild, moderate and severe. Serum ADMA levels was measured in all subjects. Results: Mean age of study population was 21.08±2.21 and mean VAS score was 5.9101±2.18. Serum ADMA levels were 35.2(24) in mild, 54.0(28.7) in moderate and 56.5(32.8) in severe pain groups, (P= 0.029 and P=0.001, respectively). Mean ADMA levels difference were -18.8, p=0.046 in mild to moderate; -2.52, p=0. 945 in moderate to severe and 21.32 p=0.048 in severe to mild pain groups. Conclusion: Menstrual p ain intensity is correlated with the serum ADMA levels as assessed by VAS pain score in PD patients
Vertikal diplopi ile prezente olan nonptotik oküler myasteni gravis: Olgu sunumu Myasteni gravis ... more Vertikal diplopi ile prezente olan nonptotik oküler myasteni gravis: Olgu sunumu Myasteni gravis iskelet kaslar›nda nöromuskuler bileflkedeki disfonksiyon sonucu güç kayb›yla karakterize, otoimmun komponenti de olan bir hastal›kt›r. S›kl›kla adolesan ve genç eriflkinlik döneminde bafllar. Myasteni gravis okulomotor kaslar› tutarsa oküler myasteni olarak adland›r›l›r. Myasteni gravis hastalar›n›n yaklafl›k yar›s›nda okuler semptom ve bulgular mevcutken, %15'i sadece oküler myasteni klini¤i ile seyrederler. Ptozis, diplopi ve orbikularis okuli kas›nda zay›fl›k klasik triad›n› oluflturur. Olgular›n %90'›nda ptozis efllik etmekte olup, nadiren sadece ptozisle uzun dönem seyreder. Oküler Myasteni gravis (OMG)'lilerin 2/3'ü jeneralize myasteniye dönüflürken, 1/3'ü oküler myasteni olarak kal›r. Vertikal diplopi ile klini¤imize baflvuran nonptotik 67 yafl›nda bir oküler myasteni olgusu sunduk.
Turkiye Klinikleri Tip Bilimleri Dergisi, 2008
... Erişkin Bir Herediter Sferositoz Hastasındaparvovirüs B19'a Bağlı Aplastik Kriz Adem... more ... Erişkin Bir Herediter Sferositoz Hastasındaparvovirüs B19'a Bağlı Aplastik Kriz Adem GÜNGÖR, MD a ,Cemil BİLİR, MD a ,Elif ÖNDER, MD a ,Uğur ... 29 yaşında erkek hasta halsizlik, ateş ve yaygın eklem ve kas ağrısı yakınmaları ile başvurması üzerine dahiliye servisine yatırıldı. ...
Turkish Journal of Geriatrics-Turk Geriatri Dergisi, 2010
S tevens Johnson Syndrome (SJS) is a severe skin reaction related to drugs and infections, charac... more S tevens Johnson Syndrome (SJS) is a severe skin reaction related to drugs and infections, characterized by fever, stomatitis and conjunctivitis. Although seen in all age groups it is more common in the 2nd and 4th decades. SJS is rare in the elderly. Many drug related SJS cases have been reported in literature but amoxicillin related SJS cases are rare. In this article, a case of amoxicillin related severe SJS in a geriatric patient during treatment of pneumonia has been reported. A 74 year old patient admitted to our emergency room with severe skin lesions, swollen red eyelids and dyspnoea after the second day of amoxicillin treatment. He was hospitalized with a diagnosis of acute renal failure, pneumonia and severe drug eruption (SJS). After clinical and histopathological evaluations, the severe skin lesions were diagnosed as amoxicillin related SJS and intravenous corticosteroid therapy was initiated. Steroid therapy led to a marked improvement in skin lesions and was decreased gradually and stopped. Use of beta-lactam antibiotics and especially amoxicillin is common in all age groups including the geriatric patients. It should be kept in mind that, although rare, amoxicillin related severe life threatening skin lesions (SJS) may develop in elderly patients.
12th European Congress of Endocrinology, Apr 1, 2010
Introduction: Insulin resistance is the decrease sensitivity of tissues in the body to insulin ef... more Introduction: Insulin resistance is the decrease sensitivity of tissues in the body to insulin effect. Obesity, advanced age, sedentary life and smoking are the factors leading to an increase in insulin resistance. In our study, we aimed to evaluate the relationship between the ...
12th European Congress of Endocrinology, Apr 1, 2010
Introduction: Recent conducted studies show that clinical hypothyroidism (CH) has similar cardiov... more Introduction: Recent conducted studies show that clinical hypothyroidism (CH) has similar cardiovascular risk with subclinical hypothyroidism (SCH). Carotid intima media thickness (CIMT) that is an important marker of early atherosclerotic changes is an indicator of cardiovascular events. In our ...
The American Journal of the Medical Sciences, 2012
Objective: To demonstrate the prevalence and prognostic value of electrocardiographic abnormaliti... more Objective: To demonstrate the prevalence and prognostic value of electrocardiographic abnormalities in patients with chronic spinal cord injury. Methods: All electrocardiographs obtained in the Palo Alto Veterans Affairs Medical Center since 1987 have been digitally recorded and stored in a computerized database. For this study, only the first electrocardiograph was considered for analysis. The subjects were divided according to age and level of spinal cord injury. The Social Security Death Index was used to ascertain vital status as of December 1999. Results: Annual mortality was similar in those with chronic spinal cord injury and the able-bodied. However, individuals with a higher level of injury had a significantly higher death rate than those with a lower level of injury. The prognostic characteristics of electrocardiographic abnormalities were similar in both the able-bodied and those with spinal cord injury. Conclusion: In general, electrocardiographic abnormalities had the same prevalence in the spinal cord injury subjects as in the able-bodied ones. The prognostic value of electrocardiographic abnormalities in subjects with spinal cord injury is similar to that observed in able-bodied subjects.
Turkish Journal of …, 2010
Stevens Johnson Sendromu (SJS) genellikle ilaçlara ve enfeksiyonlara karşı oluşan, ateş, stomatit... more Stevens Johnson Sendromu (SJS) genellikle ilaçlara ve enfeksiyonlara karşı oluşan, ateş, stomatit ve konjonktivit ile karakterize ağır bir cilt reaksiyonudur. Her yaş ve cinsiyette ortaya çıkabilmekle birlikle genellikle 2.-4. dekatta görülür, ileri yaşlarda nadir olarak görülmektedir. ...
Journal of Human Rhythm, Dec 27, 2018
Amaç İnsan vücudunda normal metabolizma ürünü olarak ya da ekzojen kaynaklarla oluşturulan reakti... more Amaç İnsan vücudunda normal metabolizma ürünü olarak ya da ekzojen kaynaklarla oluşturulan reaktif oksijen türleri (ROT) ve diğer serbest radikallerin, çok sayıda fi zyolojik ve patolojik olayda yer aldığı bilinmektedir. Bu reaktif türler eşleşmemiş elektrona sahip oldukları için, hücrenin pek çok bileşeni, DNA, protein ve lipid içerikleriyle kolaylıkla reaksiyona girerek, normal hücre fonksiyonlarını bozabilme yeteneğindedir. Bu çalışmada, oksidan stres modeli olarak seçilen nötrofi llerin okside olmuş düşük dansiteli lipoprotein (ox-LDL) ile aktive edilmesi sonucu oluşan hasarı Komet Assay ile göstermeyi amaçladık. Gereç ve yöntemler Bu çalışmada LDL, "short-run ultracentrifugation" yöntemiyle izole edildikten sonra CuCl� ile okside edildi. Ficoll-Hypaque gradientcentrifi ıgation" yöntemi ile de tam kandan izole edilen nötrofi ller ox-LDL ile sitümüle edildi. %1 LMP-agoraz içinde yatay elektroforezde yürütüldü ve propidyum iyodidle boyanarak, fl oresan mikroskopu (Leica-DMLB) ile değerlendirildi. Sonuçlar, sayılan 100 hücreden komet oluşturmuş hücrelerin yüzdesi olarak bildirildi. Bulgular Komet yöntemi ile Ox-LDL ile muamele edilen hücrelerde Komet oluşumu %30,0 ± 4,6 olarak tespit edildi. Aynı oran kontrol hücre grubunda %5,2 ± 1,9 olarak bulundu. Bu sonuçlara göre ox-LDL ile indüklenen oksidatif stres durumunda Komet oluşturan hücrelerin yüzdesinin belirgin olarak arttığı gözlendi (p<0.001). Aynı hücre gruplarında tripan mavisi ile tespit edilen hücre canlılığı %53,4 ± 3,9 (oksidan stres durumunda); %84,7± 3,2 (kontrol grubunda) olarak belirlendi (p<0.001). Sonuç Nötrofi llerin ox-LDL ile muameleye aktivasyonla yanıt verdiği ve bunun sonucu DNA hasarında istatistiksel olarak anlamlı bir yükselme olduğu Komet yöntemi ile göstermek mümkün olmuştur. Bu DNA hasarının nötrofi llerin doğal immünitedeki koruyucu fonksiyonlarının aksine kronik infl amatuar hastalıklar, kanser oluşumu gibi pek çok hastalığın etyopatogenezindeki rollerini açıklamada önemli olacaktır.