Halil Sağınç - Academia.edu (original) (raw)

Papers by Halil Sağınç

Research paper thumbnail of The Effect of Continuing Chemotherapy after Chemoradiotherapy during the Time to Surgery on Tumor Response and Survival for Local Advanced Rectal Cancer

Journal of Oncology

Aim. The current standard treatment of locally advanced rectal carcinoma is total mesorectal exci... more Aim. The current standard treatment of locally advanced rectal carcinoma is total mesorectal excision and postoperative adjuvant chemotherapy after neoadjuvant concurrent chemoradiotherapy (NCRT). Many studies have shown that pathological complete response (pCR) is an important prognostic factor for patients receiving NCRT. Many studies have therefore been conducted to increase pCR rates by changing the perioperative treatment strategies. Prolonging the chemotherapy time may be a reasonable way to increase the effectiveness of NCRT, pCR, and survival rates. We investigated whether neoadjuvant consolidation chemotherapy had an effect on tumor response and survival. Methods. The data of 163 patients diagnosed with locally advanced rectal carcinoma were evaluated. The data of 107 patients (Group 1) who were radiologically T3–T4 and/or N+ and received chemotherapy after NCRT until their operations were compared with the data of 56 patients (Group 2) who were operated after NCRT. Results...

Research paper thumbnail of Assessment of Arm Lymphedema and Late Skin Side Effects in Breast Cancer Patients Who Recieved Postoperative Adjuvant Radiotherapy

Turkiye Klinikleri Journal of Medical Sciences, 2018

Research paper thumbnail of Acute toxicities of three-dimensional conformal radiotherapy in the treatment of gynecological cancer, and retrospective dosimetric comparison of three dimensional conformal radiotherapy and invers intensity-modulated radiotherapy

Journal of Surgery and Medicine, 2018

How to cite / Atıf için: Sağınç H, Yıldırım Ö, Baltalarlı B. Acute toxicities of three-dimensiona... more How to cite / Atıf için: Sağınç H, Yıldırım Ö, Baltalarlı B. Acute toxicities of three-dimensional conformal radiotherapy in the treatment of gynecological cancer, and retrospective dosimetric comparison of three dimensional conformal radiotherapy and invers intensity-modulated radiotherapy.

Research paper thumbnail of Hidradenitis süppürativalı bir olgunun tedavisi

Pamukkale Medical Journal, 2021

Hidradenitis süppürativa apokrin salgı bezlerinde genellikle ağrılı, derin yerleşimli ve inflamat... more Hidradenitis süppürativa apokrin salgı bezlerinde genellikle ağrılı, derin yerleşimli ve inflamatuvar lezyonlu kıl folliküllerinin tekrarlayan kronik inflamatuvar bir deri hastalığıdır. Hastalık aksiller, inguinal, perineal ve genital bölgelerde görülür. Radyoterapi dirençli hastalıkta tedavi seçeneğidir. Burada diğer tedavilere dirençli radyoterapi ile lezyonlarında belirgin gerileme olan hidradenitis süppürativalı bir olgu sunduk. Olgu 47 yaşında üç yıldır hidradenitis süppürativa tanılı erkek hastaydı. Bilateral aksiller bölgesinde ağrılı, akıntılı Hurley 3. evre nodülokistik lezyonlara sahipti. Hastalık hastanın yaşam kalitesini bozmuştu. Olgu düzenli olarak alkol ve sigara kullanıyordu. Olgu 103 kilogram, vücut kitle indeksi 31,1 kg/m 2 'ydi. Bilateral aksiller bölgeye 2,5 Gy/gün toplam 7,5 Gy konformal radyoterapi uyguladık. Radyoterapiden üç ay sonraki muayenesinde semptomlar belirgin azaldı. Nodüller ve akıntılı lezyonlar belirgin iyileşti.

Research paper thumbnail of The effectiveness of gamma knife radiosurgery for the management of residual high-grade gliomas: A single institutional study

Journal of Clinical Neuroscience

Research paper thumbnail of Hidradenitis süppürativalı bir olgunun tedavisi

Pamukkale Medical Journal, 2021

Hidradenitis süppürativa apokrin salgı bezlerinde genellikle ağrılı, derin yerleşimli ve inflamat... more Hidradenitis süppürativa apokrin salgı bezlerinde genellikle ağrılı, derin yerleşimli ve inflamatuvar lezyonlu kıl folliküllerinin tekrarlayan kronik inflamatuvar bir deri hastalığıdır. Hastalık aksiller, inguinal, perineal ve genital bölgelerde görülür. Radyoterapi dirençli hastalıkta tedavi seçeneğidir. Burada diğer tedavilere dirençli radyoterapi ile lezyonlarında belirgin gerileme olan hidradenitis süppürativalı bir olgu sunduk. Olgu 47 yaşında üç yıldır hidradenitis süppürativa tanılı erkek hastaydı. Bilateral aksiller bölgesinde ağrılı, akıntılı Hurley 3. evre nodülokistik lezyonlara sahipti. Hastalık hastanın yaşam kalitesini bozmuştu. Olgu düzenli olarak alkol ve sigara kullanıyordu. Olgu 103 kilogram, vücut kitle indeksi 31,1 kg/m 2 'ydi. Bilateral aksiller bölgeye 2,5 Gy/gün toplam 7,5 Gy konformal radyoterapi uyguladık. Radyoterapiden üç ay sonraki muayenesinde semptomlar belirgin azaldı. Nodüller ve akıntılı lezyonlar belirgin iyileşti.

Research paper thumbnail of Yatarak tedavi gören hastalarda intihar öyküsünün araştırılması

Amac: Bu calismanin amaci, intihar girisiminde bulunanlarin sosyodemografik ve klinik ozellikleri... more Amac: Bu calismanin amaci, intihar girisiminde bulunanlarin sosyodemografik ve klinik ozelliklerini saptamak ve ilgili literatur bilgileriyle karsilastirmaktir. Yontem: Bu calismaya Ocak 1993 - Ekim 1999 tarihleri arasinda Cumhuriyet Universitesi Tip Fakultesi Psikiyatri Klinigi'nde yatarak tedavi goren 1050 hasta alinmis ve intihar girisimi oykusu olan 108 hasta (% 10.2) sosyodemografik bilgi formu kullanilarak intihar oykusune iliskin sosyodemografik ve klinik ozellikleri acisindan retrospektif olarak degerlendirilmistir. Sonuclar: Calismanin sonucunda intihar girisimlerinin en sik 15-44 yas grubunda (yas ortalamasi=28.02±10.05), daha siklikla kadinlarda (% 69.4) ve calismayanlarda (%54.6), en sik ilac alinmasi yoluyla (% 56.5) ve daha cok 8-12. aylar arasinda (% 38) oldugu, deneklerin intihar girisimi nedeni olarak en sik ailesel/kisisel nedenleri gosterdigi (% 54.8), intihar girisimi sonrasi en sik konulan psikiyatrik taninin depresyon (% 48.1) oldugu bulunmustur. Intihar gi...

Research paper thumbnail of Analysis of Survival of the Patients with Brain Metastases from Lung Cancer according to Treatment Modalities and Prognostic Indexes

Turkish Journal of Oncology, 2020

METHODS Ninety-five patients with brain metastases from lung cancer were retrospectively evaluate... more METHODS Ninety-five patients with brain metastases from lung cancer were retrospectively evaluated using age, sex, lung cancer histological type, extracranial metastases, primary tumor control, number of brain metastases, total brain metastases volume, brain metastasectomy, chemotherapy, EGFR mutation, EGFR-TKI therapy, Karnofsky Performance Status (KPS), Recursive Partitioning Analysis (RPA) Class, Basic Score for Brain Metastases (BS-BM), Graded Prognostic Assessment Index (DS-GPA) and Modified Lung-Specific between 2015 and 2018. Univariate analysis of OS was performed using the Kaplan–Meier method supplemented by the log-rank test. We also applied multivariate survival analysis using the Cox Regression Model.

Research paper thumbnail of Analysis of survival of patients with brain metastases according to prognostic indexes and treatment strategies

Turkish Neurosurgery

This study aimed to retrospectively evaluate overall survival (OS) of the patients with brain met... more This study aimed to retrospectively evaluate overall survival (OS) of the patients with brain metastases (BM) from lung cancer who had been treated with whole-brain radiotherapy (WBRT) and gamma knife (GK) according to prognostic factors and prognostic score indexes. METHODS Ninety-five patients with brain metastases from lung cancer were retrospectively evaluated using age, sex, lung cancer histological type, extracranial metastases, primary tumor control, number of brain metastases, total brain metastases volume, brain metastasectomy, chemotherapy, EGFR mutation, EGFR-TKI therapy, Karnofsky Performance Status (KPS), Recursive Partitioning Analysis (RPA) Class, Basic Score for Brain Metastases (BS-BM), Graded Prognostic Assessment Index (DS-GPA) and Modified Lung-Specific between 2015 and 2018. Univariate analysis of OS was performed using the Kaplan-Meier method supplemented by the log-rank test. We also applied multivariate survival analysis using the Cox Regression Model. RESULTS The median OS for all patients with brain metastases from lung cancer was six months± SE: 0.807 (range: 1-42 months; 95% CI: 4.419-7.581) and one-year overall survival rate was 25.3%. The median OS was four months, four months, 12 months in the WBRT arm, the GK arm and the combined WBRT-GK arm, respectively (p=0.004). In multivariate analysis, treatment with WBRT-GK (p=0.030), brain metastasectomy (p=0.019), controlled primary tumor (p=0.004), chemotherapy (p=0.001) were significantly correlated with overall survival. BS-BM (p=0.033) was closely related to overall survival compared to other prognostic score indexes on the multivariate analysis. CONCLUSION The patients with BM benefited from WBRT and GK combined therapy. BS-BM for the survival of patients with BM from lung cancer is the most appropriate prognostic index.

Research paper thumbnail of The Effect of Continuing Chemotherapy after Chemoradiotherapy during the Time to Surgery on Tumor Response and Survival for Local Advanced Rectal Cancer

Journal of Oncology

Aim. The current standard treatment of locally advanced rectal carcinoma is total mesorectal exci... more Aim. The current standard treatment of locally advanced rectal carcinoma is total mesorectal excision and postoperative adjuvant chemotherapy after neoadjuvant concurrent chemoradiotherapy (NCRT). Many studies have shown that pathological complete response (pCR) is an important prognostic factor for patients receiving NCRT. Many studies have therefore been conducted to increase pCR rates by changing the perioperative treatment strategies. Prolonging the chemotherapy time may be a reasonable way to increase the effectiveness of NCRT, pCR, and survival rates. We investigated whether neoadjuvant consolidation chemotherapy had an effect on tumor response and survival. Methods. The data of 163 patients diagnosed with locally advanced rectal carcinoma were evaluated. The data of 107 patients (Group 1) who were radiologically T3–T4 and/or N+ and received chemotherapy after NCRT until their operations were compared with the data of 56 patients (Group 2) who were operated after NCRT. Results...

Research paper thumbnail of Assessment of Arm Lymphedema and Late Skin Side Effects in Breast Cancer Patients Who Recieved Postoperative Adjuvant Radiotherapy

Turkiye Klinikleri Journal of Medical Sciences, 2018

Research paper thumbnail of Acute toxicities of three-dimensional conformal radiotherapy in the treatment of gynecological cancer, and retrospective dosimetric comparison of three dimensional conformal radiotherapy and invers intensity-modulated radiotherapy

Journal of Surgery and Medicine, 2018

How to cite / Atıf için: Sağınç H, Yıldırım Ö, Baltalarlı B. Acute toxicities of three-dimensiona... more How to cite / Atıf için: Sağınç H, Yıldırım Ö, Baltalarlı B. Acute toxicities of three-dimensional conformal radiotherapy in the treatment of gynecological cancer, and retrospective dosimetric comparison of three dimensional conformal radiotherapy and invers intensity-modulated radiotherapy.

Research paper thumbnail of Hidradenitis süppürativalı bir olgunun tedavisi

Pamukkale Medical Journal, 2021

Hidradenitis süppürativa apokrin salgı bezlerinde genellikle ağrılı, derin yerleşimli ve inflamat... more Hidradenitis süppürativa apokrin salgı bezlerinde genellikle ağrılı, derin yerleşimli ve inflamatuvar lezyonlu kıl folliküllerinin tekrarlayan kronik inflamatuvar bir deri hastalığıdır. Hastalık aksiller, inguinal, perineal ve genital bölgelerde görülür. Radyoterapi dirençli hastalıkta tedavi seçeneğidir. Burada diğer tedavilere dirençli radyoterapi ile lezyonlarında belirgin gerileme olan hidradenitis süppürativalı bir olgu sunduk. Olgu 47 yaşında üç yıldır hidradenitis süppürativa tanılı erkek hastaydı. Bilateral aksiller bölgesinde ağrılı, akıntılı Hurley 3. evre nodülokistik lezyonlara sahipti. Hastalık hastanın yaşam kalitesini bozmuştu. Olgu düzenli olarak alkol ve sigara kullanıyordu. Olgu 103 kilogram, vücut kitle indeksi 31,1 kg/m 2 'ydi. Bilateral aksiller bölgeye 2,5 Gy/gün toplam 7,5 Gy konformal radyoterapi uyguladık. Radyoterapiden üç ay sonraki muayenesinde semptomlar belirgin azaldı. Nodüller ve akıntılı lezyonlar belirgin iyileşti.

Research paper thumbnail of The effectiveness of gamma knife radiosurgery for the management of residual high-grade gliomas: A single institutional study

Journal of Clinical Neuroscience

Research paper thumbnail of Hidradenitis süppürativalı bir olgunun tedavisi

Pamukkale Medical Journal, 2021

Hidradenitis süppürativa apokrin salgı bezlerinde genellikle ağrılı, derin yerleşimli ve inflamat... more Hidradenitis süppürativa apokrin salgı bezlerinde genellikle ağrılı, derin yerleşimli ve inflamatuvar lezyonlu kıl folliküllerinin tekrarlayan kronik inflamatuvar bir deri hastalığıdır. Hastalık aksiller, inguinal, perineal ve genital bölgelerde görülür. Radyoterapi dirençli hastalıkta tedavi seçeneğidir. Burada diğer tedavilere dirençli radyoterapi ile lezyonlarında belirgin gerileme olan hidradenitis süppürativalı bir olgu sunduk. Olgu 47 yaşında üç yıldır hidradenitis süppürativa tanılı erkek hastaydı. Bilateral aksiller bölgesinde ağrılı, akıntılı Hurley 3. evre nodülokistik lezyonlara sahipti. Hastalık hastanın yaşam kalitesini bozmuştu. Olgu düzenli olarak alkol ve sigara kullanıyordu. Olgu 103 kilogram, vücut kitle indeksi 31,1 kg/m 2 'ydi. Bilateral aksiller bölgeye 2,5 Gy/gün toplam 7,5 Gy konformal radyoterapi uyguladık. Radyoterapiden üç ay sonraki muayenesinde semptomlar belirgin azaldı. Nodüller ve akıntılı lezyonlar belirgin iyileşti.

Research paper thumbnail of Yatarak tedavi gören hastalarda intihar öyküsünün araştırılması

Amac: Bu calismanin amaci, intihar girisiminde bulunanlarin sosyodemografik ve klinik ozellikleri... more Amac: Bu calismanin amaci, intihar girisiminde bulunanlarin sosyodemografik ve klinik ozelliklerini saptamak ve ilgili literatur bilgileriyle karsilastirmaktir. Yontem: Bu calismaya Ocak 1993 - Ekim 1999 tarihleri arasinda Cumhuriyet Universitesi Tip Fakultesi Psikiyatri Klinigi'nde yatarak tedavi goren 1050 hasta alinmis ve intihar girisimi oykusu olan 108 hasta (% 10.2) sosyodemografik bilgi formu kullanilarak intihar oykusune iliskin sosyodemografik ve klinik ozellikleri acisindan retrospektif olarak degerlendirilmistir. Sonuclar: Calismanin sonucunda intihar girisimlerinin en sik 15-44 yas grubunda (yas ortalamasi=28.02±10.05), daha siklikla kadinlarda (% 69.4) ve calismayanlarda (%54.6), en sik ilac alinmasi yoluyla (% 56.5) ve daha cok 8-12. aylar arasinda (% 38) oldugu, deneklerin intihar girisimi nedeni olarak en sik ailesel/kisisel nedenleri gosterdigi (% 54.8), intihar girisimi sonrasi en sik konulan psikiyatrik taninin depresyon (% 48.1) oldugu bulunmustur. Intihar gi...

Research paper thumbnail of Analysis of Survival of the Patients with Brain Metastases from Lung Cancer according to Treatment Modalities and Prognostic Indexes

Turkish Journal of Oncology, 2020

METHODS Ninety-five patients with brain metastases from lung cancer were retrospectively evaluate... more METHODS Ninety-five patients with brain metastases from lung cancer were retrospectively evaluated using age, sex, lung cancer histological type, extracranial metastases, primary tumor control, number of brain metastases, total brain metastases volume, brain metastasectomy, chemotherapy, EGFR mutation, EGFR-TKI therapy, Karnofsky Performance Status (KPS), Recursive Partitioning Analysis (RPA) Class, Basic Score for Brain Metastases (BS-BM), Graded Prognostic Assessment Index (DS-GPA) and Modified Lung-Specific between 2015 and 2018. Univariate analysis of OS was performed using the Kaplan–Meier method supplemented by the log-rank test. We also applied multivariate survival analysis using the Cox Regression Model.

Research paper thumbnail of Analysis of survival of patients with brain metastases according to prognostic indexes and treatment strategies

Turkish Neurosurgery

This study aimed to retrospectively evaluate overall survival (OS) of the patients with brain met... more This study aimed to retrospectively evaluate overall survival (OS) of the patients with brain metastases (BM) from lung cancer who had been treated with whole-brain radiotherapy (WBRT) and gamma knife (GK) according to prognostic factors and prognostic score indexes. METHODS Ninety-five patients with brain metastases from lung cancer were retrospectively evaluated using age, sex, lung cancer histological type, extracranial metastases, primary tumor control, number of brain metastases, total brain metastases volume, brain metastasectomy, chemotherapy, EGFR mutation, EGFR-TKI therapy, Karnofsky Performance Status (KPS), Recursive Partitioning Analysis (RPA) Class, Basic Score for Brain Metastases (BS-BM), Graded Prognostic Assessment Index (DS-GPA) and Modified Lung-Specific between 2015 and 2018. Univariate analysis of OS was performed using the Kaplan-Meier method supplemented by the log-rank test. We also applied multivariate survival analysis using the Cox Regression Model. RESULTS The median OS for all patients with brain metastases from lung cancer was six months± SE: 0.807 (range: 1-42 months; 95% CI: 4.419-7.581) and one-year overall survival rate was 25.3%. The median OS was four months, four months, 12 months in the WBRT arm, the GK arm and the combined WBRT-GK arm, respectively (p=0.004). In multivariate analysis, treatment with WBRT-GK (p=0.030), brain metastasectomy (p=0.019), controlled primary tumor (p=0.004), chemotherapy (p=0.001) were significantly correlated with overall survival. BS-BM (p=0.033) was closely related to overall survival compared to other prognostic score indexes on the multivariate analysis. CONCLUSION The patients with BM benefited from WBRT and GK combined therapy. BS-BM for the survival of patients with BM from lung cancer is the most appropriate prognostic index.