Hamza khan Khan - Academia.edu (original) (raw)
Papers by Hamza khan Khan
Brazilian Dental Science
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Scientific Reports
Protein functional effector sncRNAs (pfeRNAs) are approximately 30–60 nucleotides (nt), of which ... more Protein functional effector sncRNAs (pfeRNAs) are approximately 30–60 nucleotides (nt), of which the extraction method from plasma has not yet been reported. Silver staining in a high-resolution polyacrylamide gel suggested that the majority of plasma sncRNAs extracted by some broadly used commercial kits were sncRNAs from 100 nt upwards. Additionally, TRIzol’s protocol is for long RNA but not sncRNA recovery. Here, we report a TRIzol-based frozen precipitation method (TFP method), which shows rigor and reproducibility in high yield and quality for plasma sncRNAs approximately 30–60 nt. In contrast to the yields by the commercial kit, plasma sncRNAs extracted by the TFP method enriched more sncRNAs. We used four different pfeRNAs of 34 nt, 45 nt, 53 nt, and 58 nt to represent typical sizes of sncRNAs from 30 to 60 nt and compared their levels in the recovered sncRNAs by the TFP method and by the commercial kit. The TFP method showed lower cycle threshold (CT) values by 2.01–9.17 cyc...
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Non-Coding RNA, 2021
The ability to differentiate between benign, suspicious, and malignant pulmonary nodules is imper... more The ability to differentiate between benign, suspicious, and malignant pulmonary nodules is imperative for definitive intervention in patients with early stage lung cancers. Here, we report that plasma protein functional effector sncRNAs (pfeRNAs) serve as non-invasive biomarkers for determining both the existence and the nature of pulmonary nodules in a three-stage study that included the healthy group, patients with benign pulmonary nodules, patients with suspicious nodules, and patients with malignant nodules. Following the standards required for a clinical laboratory improvement amendments (CLIA)-compliant laboratory-developed test (LDT), we identified a pfeRNA classifier containing 8 pfeRNAs in 108 biospecimens from 60 patients by sncRNA deep sequencing, deduced prediction rules using a separate training cohort of 198 plasma specimens, and then applied the prediction rules to another 230 plasma specimens in an independent validation cohort. The pfeRNA classifier could (1) diffe...
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Groundwater Law and Management in India, 2021
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Journal of Rehman Medical Institute, 2021
Introduction: Even though frequency of depression is documented globally, the spectrum of depress... more Introduction: Even though frequency of depression is documented globally, the spectrum of depression and its inciting factors in Pakistan are unique to the local cultural and social beliefs. Objective: To compare the status of depression and its provoking socio-cultural factors among urban and rural females attending selected hospitals of Peshawar. Materials & Methods: A cross-sectional comparative study was conducted from March to May 2017 on 93 female patients attending two selected urban and rural teaching hospitals of Peshawar. Data were collected on Beck Depression Inventory through convenience sampling, and were analyzed for descriptive statistics by SPSS version 20. Comparisons were done by the Chi Square test and the Student’s T test keeping p≤0.05 as significant. Results: Out of 93 female patients, a final 89 females (53 urban and 36 rural) were included due to incomplete data entries. More urban females were in the normal, mild or borderline clinically depressed categories...
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Environmental Science and Pollution Research, 2021
Potentially toxic elements (PTEs) are a major source of pollution due to their toxicity, persiste... more Potentially toxic elements (PTEs) are a major source of pollution due to their toxicity, persistence, and bio-accumulating nature in riverine bed sediments. The sediment, as the largest storage and source of PTEs, plays an important role in transformation of mercury (Hg), lead (Pb), nickel (Ni), chromium (Cr), copper (Cu), zinc (Zn), and other toxic PTEs. Several important industrial hubs that contain a large population along the banks of different rivers, such as Kabul, Sutlej, Ravi, Jhelum, and Chenab in Pakistan, are acting as major sources of PTEs. In this study, 150 bed sediment samples (n=30 from each river) were collected from different sites. Total (acid extracted) PTE (Hg, Cu, Cr, Ni, Zn, and Pb) concentrations in bed sediments were determined using inductively coupled plasma mass spectrometry (ICP-MS). Sediment pollution indices were calculated in the major rivers of Pakistan. The results demonstrated high levels of Hg and Ni concentrations which exceeded the guideline standards of river authorities in the world. The contamination factor (CF) and contamination degree (CD) indices for Hg, Ni, and Pb showed a moderate to high (CF≥6 and CD≥24) contamination level in all the selected rivers. The values of geo-accumulation index (Igeo) were also high (Igeo≥5) for Hg and Pb and heavily polluted for Ni, while Cr, Cu, and Zn showed low to unpolluted (Igeo) values. Similarly, the enrichment factor (EF) values were moderately severe (5≤EF≤10) for Hg, Pb, and Ni in Sutlej, Ravi, and Jhelum, and severe (10≤EF≤25) in Kabul and Jhelum. Moreover, Hg and Ni showed severe to very severe enrichment in all the sampling sites. The ecological risk index (ERI) values represented considerable, moderate, and low risks, respectively, for Hg (The ERI value should not be bold. Please unbold the ERI in the whole paper. It should be same like RI, CD and EF. 80≥ERI\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}mathtt80gemathttERI\mathtt{80}\ge \mathtt{ERI}mathtt80gemathttERI\end{document}≥160), Pb and Ni (40≤ERI\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}mathttERI\mathtt{ERI}mathttERI\end{document}≤80), and Cr, Cu, and Zn (ERI\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}mathttERI\mathtt{ERI}mathttERI\end{document}≤40). Similarly, potential ecological risk index (PERI) values posed considerable (300≤RI≤600) risk in Ravi and moderate (150≤RI≤300) in Kabul and Jhelum, but low (RI≤150) risk in Ravi and Chenab. On the basis of the abovementioned results, it is concluded that bed sediment pollution can be dangerous for both ecological resources and human beings. Therefore, PTE contamination should be regularly monitored and a cost-effective and environmentally friendly wastewater treatment plant should be installed to ensure removal of PTEs before the discharge of effluents into the freshwater ecosystems.
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Journal of Refractive Surgery, 2006
PURPOSE: To explain the use of the mixed-cylinder approach in treating moderate to high astigmati... more PURPOSE: To explain the use of the mixed-cylinder approach in treating moderate to high astigmatism with the NIDEK EC-5000 excimer laser system. METHODS: Retrospective case series report. RESULTS: Three patients with bilateral moderate to high astigmatism were treated successfully using the mixed cylinder approach. CONCLUSIONS: The use of the mixed-cylinder approach with the NIDEK EC-5000 excimer laser may be a safe and predictable option for treating moderate to high astigmatism. [J Refract Surg. 2006;22:S1073-S1078.]
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Journal of neuroscience research, Jan 19, 2018
Traumatic brain injury (TBI) is the major cause of physical disability and emotional vulnerabilit... more Traumatic brain injury (TBI) is the major cause of physical disability and emotional vulnerability. Treatment of TBI is lacking due to its multimechanistic etiology, including derailed mitochondrial and cellular energy metabolism. Previous studies from our laboratory show that an endogenous nitric oxide (NO) metabolite S-nitrosoglutathione (GSNO) provides neuroprotection and improves neurobehavioral function via anti-inflammatory and anti-neurodegenerative mechanisms. To accelerate the rate and enhance the degree of recovery, we investigated combining GSNO with caffeic acid phenethyl ester (CAPE), a potent antioxidant compound, using a male mouse model of TBI, controlled cortical impact in mice. The combination therapy accelerated improvement of cognitive and depressive-like behavior compared with GSNO or CAPE monotherapy. Separately, both GSNO and CAPE improved mitochondrial integrity/function and decreased oxidative damage; however, the combination therapy had greater effects on D...
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Frogs play important ecological roles as sentinels, insect control and food sources. Several spec... more Frogs play important ecological roles as sentinels, insect control and food sources. Several species are important model organisms for scientific research to study embryogenesis, development, immune function, and endocrine signaling. The globally-distributed Ranidae (true frogs) are the largest frog family, and have substantial evolutionary distance from the model laboratory Xenopus frog species. Consequently, the extensive Xenopus genomic resources are of limited utility for Ranids and related frog species. More widely applicable amphibian genomic data is urgently needed as more than two-thirds of known species are currently threatened or are undergoing population declines.Herein, we report on the first genome sequence of a Ranid species, an adult male North American bullfrog (Rana [Lithobates] catesbeiana). We assembled high-depth Illumina reads (66-fold coverage), into a 5.8 Gbp (NG50 = 57.7 kbp) draft genome using ABySS v1.9.0. The assembly was scaffolded with LINKS and RAILS us...
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Sensors, 2017
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The assembly of DNA sequences de novo is fundamental to genomics research. It is the first of man... more The assembly of DNA sequences de novo is fundamental to genomics research. It is the first of many steps towards elucidating and characterizing whole genomes. Downstream applications, including analysis of genomic variation between species, between or within individuals critically depends on robustly assembled sequences. In the span of a single decade, the sequence throughput of leading DNA sequencing instruments has increased drastically, and coupled with established and planned large-scale, personalized medicine initiatives to sequence genomes in the thousands and even millions, the development of efficient, scalable and accurate bioinformatics tools for producing high-quality reference draft genomes is timely.With ABySS 1.0, we originally showed that assembling the human genome using short 50 bp sequencing reads was possible by aggregating the half terabyte of compute memory needed over several computers using a standardized message-passing system (MPI). We present here its re-de...
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The Breast, 2004
We aimed to assess the effectiveness of a local anaesthetic and steroid combination injection the... more We aimed to assess the effectiveness of a local anaesthetic and steroid combination injection therapy in the management of non-cyclical mastalgia. Patients with non-cyclical mastalgia were assessed for rib tenderness (lateral chest wall tenderness-LCWT). The tenderest spot was injected with a combined preparation of 1 ml 2% lignocaine and 1 ml 40 mg depomedrone. Those who declined injection therapy were advised on topical or oral NSAIDs or reassurance. All patients were reassessed 6 weeks later. A successful outcome was taken as either a complete response (CR) or partial response (PR), i.e. pain although present is tolerated. One hundred and thirty eight women were diagnosed with LCWT. One hundred and four women were injected. Thirty-four women declined and were managed appropriately. At assessment 83 injected cases were successful (83%; CR n = 61, PR n = 22) compared to 13 non-injected cases (44.8%; CR n = 5, PR n = 8, P < 0.0001). No side effects were recorded. Sixteen cases recurred and were successfully re-injected. A steroid and local anaesthetic injection is an effective and safe treatment for LCWT.
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2015 6th International Conference on Automation, Robotics and Applications (ICARA), 2015
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The Breast, 2004
We aimed to confirm suggestions that tamoxifen therapy alone may resolve physiological gynaecomas... more We aimed to confirm suggestions that tamoxifen therapy alone may resolve physiological gynaecomastia. A prospective audit of the outcome of tamoxifen routinely given to men with physiological gynaecomastia was carried out at Nottingham. Men referred with gynaecomastia had clinical signs recorded, e.g., type (diffuse 'fatty' or retro-areolar 'lump'), size and possible aetiology. They were offered oral tamoxifen 20mg once daily for 6-12 weeks. On follow-up patients were assessed for complete resolution (CR), partial resolution where patient is satisfied with outcome (PR) or no resolution (NR). Success was either CR or PR. Thirty-six men accepted tamoxifen for physiological gynaecomastia. Median age was 31 (range 18-64). Tenderness was present in 25 (71%) cases. Sixteen men (45%) had 'fatty' gynaecomastia and 20 had 'lump' gynaecomastia. Tamoxifen resolved the mass in 30 patients (83.3%; CR=22, PR=8) and tenderness in 21 cases (84%; CR=0, PR=0). Lump gynaecomastia was more responsive to tamoxifen than the fatty type (100% vs. 62.5%; P=0.0041). Oral tamoxifen is an effective treatment for physiological gynaecomastia, especially for the lump type.
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Frontiers of Information Technology & Electronic Engineering, 2015
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Biocybernetics and Biomedical Engineering, 2014
ABSTRACT This research presents a novel hand exoskeleton rehabilitation device to facilitate tend... more ABSTRACT This research presents a novel hand exoskeleton rehabilitation device to facilitate tendon therapy exercises. The exoskeleton is designed to assist fingers flexion and extension motions in a natural manner. The proposed multi-Degree Of Freedom (DOF) system consists of a direct-driven, optimized and underactuated serial linkage mechanism having capability to exert extremely high force levels perpendicularly on the finger phalanges. Kinematic and dynamic models of the proposed device have been derived. The device design is based on the results of multi-objective optimization algorithm and series of experiments conducted to study capabilities of the human hand. To permit a user-friendly interaction with the device, the control is based on minimum jerk trajectory generation. Using this control system, the transient response and steady state behavior of the proposed device are analyzed after designing and fabricating a two-fingered prototype. The pilot study shows that the proposed rehabilitation system is capable of flexing and extending the fingers with accurate trajectories.
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International Journal of Mathematics and Mathematical Sciences, 1992
The following theorem is proved: Letr=r(y)>1,s, andtbe non-negative integers. IfRis a lefts-un... more The following theorem is proved: Letr=r(y)>1,s, andtbe non-negative integers. IfRis a lefts-unital ring satisfies the polynomial identity[xy−xsyrxt,x]=0for everyx,y∈R, thenRis commutative. The commutativity of a rights-unital ring satisfying the polynomial identity[xy−yrxt,x]=0for allx,y∈R, is also proved.
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European Journal of Surgical Oncology (EJSO), 2003
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The Annals of The Royal College of Surgeons of England, 2010
Adder bites are common in the UK usually manifesting with localised swelling and gastrointestinal... more Adder bites are common in the UK usually manifesting with localised swelling and gastrointestinal symptoms. We report a rare case of acute pancreatitis secondary to an adder bite in Wales and highlight this serious complication which was managed with standard treatment.
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Brazilian Dental Science
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Scientific Reports
Protein functional effector sncRNAs (pfeRNAs) are approximately 30–60 nucleotides (nt), of which ... more Protein functional effector sncRNAs (pfeRNAs) are approximately 30–60 nucleotides (nt), of which the extraction method from plasma has not yet been reported. Silver staining in a high-resolution polyacrylamide gel suggested that the majority of plasma sncRNAs extracted by some broadly used commercial kits were sncRNAs from 100 nt upwards. Additionally, TRIzol’s protocol is for long RNA but not sncRNA recovery. Here, we report a TRIzol-based frozen precipitation method (TFP method), which shows rigor and reproducibility in high yield and quality for plasma sncRNAs approximately 30–60 nt. In contrast to the yields by the commercial kit, plasma sncRNAs extracted by the TFP method enriched more sncRNAs. We used four different pfeRNAs of 34 nt, 45 nt, 53 nt, and 58 nt to represent typical sizes of sncRNAs from 30 to 60 nt and compared their levels in the recovered sncRNAs by the TFP method and by the commercial kit. The TFP method showed lower cycle threshold (CT) values by 2.01–9.17 cyc...
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Non-Coding RNA, 2021
The ability to differentiate between benign, suspicious, and malignant pulmonary nodules is imper... more The ability to differentiate between benign, suspicious, and malignant pulmonary nodules is imperative for definitive intervention in patients with early stage lung cancers. Here, we report that plasma protein functional effector sncRNAs (pfeRNAs) serve as non-invasive biomarkers for determining both the existence and the nature of pulmonary nodules in a three-stage study that included the healthy group, patients with benign pulmonary nodules, patients with suspicious nodules, and patients with malignant nodules. Following the standards required for a clinical laboratory improvement amendments (CLIA)-compliant laboratory-developed test (LDT), we identified a pfeRNA classifier containing 8 pfeRNAs in 108 biospecimens from 60 patients by sncRNA deep sequencing, deduced prediction rules using a separate training cohort of 198 plasma specimens, and then applied the prediction rules to another 230 plasma specimens in an independent validation cohort. The pfeRNA classifier could (1) diffe...
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Groundwater Law and Management in India, 2021
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Journal of Rehman Medical Institute, 2021
Introduction: Even though frequency of depression is documented globally, the spectrum of depress... more Introduction: Even though frequency of depression is documented globally, the spectrum of depression and its inciting factors in Pakistan are unique to the local cultural and social beliefs. Objective: To compare the status of depression and its provoking socio-cultural factors among urban and rural females attending selected hospitals of Peshawar. Materials & Methods: A cross-sectional comparative study was conducted from March to May 2017 on 93 female patients attending two selected urban and rural teaching hospitals of Peshawar. Data were collected on Beck Depression Inventory through convenience sampling, and were analyzed for descriptive statistics by SPSS version 20. Comparisons were done by the Chi Square test and the Student’s T test keeping p≤0.05 as significant. Results: Out of 93 female patients, a final 89 females (53 urban and 36 rural) were included due to incomplete data entries. More urban females were in the normal, mild or borderline clinically depressed categories...
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Environmental Science and Pollution Research, 2021
Potentially toxic elements (PTEs) are a major source of pollution due to their toxicity, persiste... more Potentially toxic elements (PTEs) are a major source of pollution due to their toxicity, persistence, and bio-accumulating nature in riverine bed sediments. The sediment, as the largest storage and source of PTEs, plays an important role in transformation of mercury (Hg), lead (Pb), nickel (Ni), chromium (Cr), copper (Cu), zinc (Zn), and other toxic PTEs. Several important industrial hubs that contain a large population along the banks of different rivers, such as Kabul, Sutlej, Ravi, Jhelum, and Chenab in Pakistan, are acting as major sources of PTEs. In this study, 150 bed sediment samples (n=30 from each river) were collected from different sites. Total (acid extracted) PTE (Hg, Cu, Cr, Ni, Zn, and Pb) concentrations in bed sediments were determined using inductively coupled plasma mass spectrometry (ICP-MS). Sediment pollution indices were calculated in the major rivers of Pakistan. The results demonstrated high levels of Hg and Ni concentrations which exceeded the guideline standards of river authorities in the world. The contamination factor (CF) and contamination degree (CD) indices for Hg, Ni, and Pb showed a moderate to high (CF≥6 and CD≥24) contamination level in all the selected rivers. The values of geo-accumulation index (Igeo) were also high (Igeo≥5) for Hg and Pb and heavily polluted for Ni, while Cr, Cu, and Zn showed low to unpolluted (Igeo) values. Similarly, the enrichment factor (EF) values were moderately severe (5≤EF≤10) for Hg, Pb, and Ni in Sutlej, Ravi, and Jhelum, and severe (10≤EF≤25) in Kabul and Jhelum. Moreover, Hg and Ni showed severe to very severe enrichment in all the sampling sites. The ecological risk index (ERI) values represented considerable, moderate, and low risks, respectively, for Hg (The ERI value should not be bold. Please unbold the ERI in the whole paper. It should be same like RI, CD and EF. 80≥ERI\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}mathtt80gemathttERI\mathtt{80}\ge \mathtt{ERI}mathtt80gemathttERI\end{document}≥160), Pb and Ni (40≤ERI\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}mathttERI\mathtt{ERI}mathttERI\end{document}≤80), and Cr, Cu, and Zn (ERI\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}mathttERI\mathtt{ERI}mathttERI\end{document}≤40). Similarly, potential ecological risk index (PERI) values posed considerable (300≤RI≤600) risk in Ravi and moderate (150≤RI≤300) in Kabul and Jhelum, but low (RI≤150) risk in Ravi and Chenab. On the basis of the abovementioned results, it is concluded that bed sediment pollution can be dangerous for both ecological resources and human beings. Therefore, PTE contamination should be regularly monitored and a cost-effective and environmentally friendly wastewater treatment plant should be installed to ensure removal of PTEs before the discharge of effluents into the freshwater ecosystems.
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Journal of Refractive Surgery, 2006
PURPOSE: To explain the use of the mixed-cylinder approach in treating moderate to high astigmati... more PURPOSE: To explain the use of the mixed-cylinder approach in treating moderate to high astigmatism with the NIDEK EC-5000 excimer laser system. METHODS: Retrospective case series report. RESULTS: Three patients with bilateral moderate to high astigmatism were treated successfully using the mixed cylinder approach. CONCLUSIONS: The use of the mixed-cylinder approach with the NIDEK EC-5000 excimer laser may be a safe and predictable option for treating moderate to high astigmatism. [J Refract Surg. 2006;22:S1073-S1078.]
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Journal of neuroscience research, Jan 19, 2018
Traumatic brain injury (TBI) is the major cause of physical disability and emotional vulnerabilit... more Traumatic brain injury (TBI) is the major cause of physical disability and emotional vulnerability. Treatment of TBI is lacking due to its multimechanistic etiology, including derailed mitochondrial and cellular energy metabolism. Previous studies from our laboratory show that an endogenous nitric oxide (NO) metabolite S-nitrosoglutathione (GSNO) provides neuroprotection and improves neurobehavioral function via anti-inflammatory and anti-neurodegenerative mechanisms. To accelerate the rate and enhance the degree of recovery, we investigated combining GSNO with caffeic acid phenethyl ester (CAPE), a potent antioxidant compound, using a male mouse model of TBI, controlled cortical impact in mice. The combination therapy accelerated improvement of cognitive and depressive-like behavior compared with GSNO or CAPE monotherapy. Separately, both GSNO and CAPE improved mitochondrial integrity/function and decreased oxidative damage; however, the combination therapy had greater effects on D...
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Frogs play important ecological roles as sentinels, insect control and food sources. Several spec... more Frogs play important ecological roles as sentinels, insect control and food sources. Several species are important model organisms for scientific research to study embryogenesis, development, immune function, and endocrine signaling. The globally-distributed Ranidae (true frogs) are the largest frog family, and have substantial evolutionary distance from the model laboratory Xenopus frog species. Consequently, the extensive Xenopus genomic resources are of limited utility for Ranids and related frog species. More widely applicable amphibian genomic data is urgently needed as more than two-thirds of known species are currently threatened or are undergoing population declines.Herein, we report on the first genome sequence of a Ranid species, an adult male North American bullfrog (Rana [Lithobates] catesbeiana). We assembled high-depth Illumina reads (66-fold coverage), into a 5.8 Gbp (NG50 = 57.7 kbp) draft genome using ABySS v1.9.0. The assembly was scaffolded with LINKS and RAILS us...
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Sensors, 2017
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The assembly of DNA sequences de novo is fundamental to genomics research. It is the first of man... more The assembly of DNA sequences de novo is fundamental to genomics research. It is the first of many steps towards elucidating and characterizing whole genomes. Downstream applications, including analysis of genomic variation between species, between or within individuals critically depends on robustly assembled sequences. In the span of a single decade, the sequence throughput of leading DNA sequencing instruments has increased drastically, and coupled with established and planned large-scale, personalized medicine initiatives to sequence genomes in the thousands and even millions, the development of efficient, scalable and accurate bioinformatics tools for producing high-quality reference draft genomes is timely.With ABySS 1.0, we originally showed that assembling the human genome using short 50 bp sequencing reads was possible by aggregating the half terabyte of compute memory needed over several computers using a standardized message-passing system (MPI). We present here its re-de...
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The Breast, 2004
We aimed to assess the effectiveness of a local anaesthetic and steroid combination injection the... more We aimed to assess the effectiveness of a local anaesthetic and steroid combination injection therapy in the management of non-cyclical mastalgia. Patients with non-cyclical mastalgia were assessed for rib tenderness (lateral chest wall tenderness-LCWT). The tenderest spot was injected with a combined preparation of 1 ml 2% lignocaine and 1 ml 40 mg depomedrone. Those who declined injection therapy were advised on topical or oral NSAIDs or reassurance. All patients were reassessed 6 weeks later. A successful outcome was taken as either a complete response (CR) or partial response (PR), i.e. pain although present is tolerated. One hundred and thirty eight women were diagnosed with LCWT. One hundred and four women were injected. Thirty-four women declined and were managed appropriately. At assessment 83 injected cases were successful (83%; CR n = 61, PR n = 22) compared to 13 non-injected cases (44.8%; CR n = 5, PR n = 8, P < 0.0001). No side effects were recorded. Sixteen cases recurred and were successfully re-injected. A steroid and local anaesthetic injection is an effective and safe treatment for LCWT.
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2015 6th International Conference on Automation, Robotics and Applications (ICARA), 2015
Bookmarks Related papers MentionsView impact
Bookmarks Related papers MentionsView impact
The Breast, 2004
We aimed to confirm suggestions that tamoxifen therapy alone may resolve physiological gynaecomas... more We aimed to confirm suggestions that tamoxifen therapy alone may resolve physiological gynaecomastia. A prospective audit of the outcome of tamoxifen routinely given to men with physiological gynaecomastia was carried out at Nottingham. Men referred with gynaecomastia had clinical signs recorded, e.g., type (diffuse 'fatty' or retro-areolar 'lump'), size and possible aetiology. They were offered oral tamoxifen 20mg once daily for 6-12 weeks. On follow-up patients were assessed for complete resolution (CR), partial resolution where patient is satisfied with outcome (PR) or no resolution (NR). Success was either CR or PR. Thirty-six men accepted tamoxifen for physiological gynaecomastia. Median age was 31 (range 18-64). Tenderness was present in 25 (71%) cases. Sixteen men (45%) had 'fatty' gynaecomastia and 20 had 'lump' gynaecomastia. Tamoxifen resolved the mass in 30 patients (83.3%; CR=22, PR=8) and tenderness in 21 cases (84%; CR=0, PR=0). Lump gynaecomastia was more responsive to tamoxifen than the fatty type (100% vs. 62.5%; P=0.0041). Oral tamoxifen is an effective treatment for physiological gynaecomastia, especially for the lump type.
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Frontiers of Information Technology & Electronic Engineering, 2015
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Biocybernetics and Biomedical Engineering, 2014
ABSTRACT This research presents a novel hand exoskeleton rehabilitation device to facilitate tend... more ABSTRACT This research presents a novel hand exoskeleton rehabilitation device to facilitate tendon therapy exercises. The exoskeleton is designed to assist fingers flexion and extension motions in a natural manner. The proposed multi-Degree Of Freedom (DOF) system consists of a direct-driven, optimized and underactuated serial linkage mechanism having capability to exert extremely high force levels perpendicularly on the finger phalanges. Kinematic and dynamic models of the proposed device have been derived. The device design is based on the results of multi-objective optimization algorithm and series of experiments conducted to study capabilities of the human hand. To permit a user-friendly interaction with the device, the control is based on minimum jerk trajectory generation. Using this control system, the transient response and steady state behavior of the proposed device are analyzed after designing and fabricating a two-fingered prototype. The pilot study shows that the proposed rehabilitation system is capable of flexing and extending the fingers with accurate trajectories.
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International Journal of Mathematics and Mathematical Sciences, 1992
The following theorem is proved: Letr=r(y)>1,s, andtbe non-negative integers. IfRis a lefts-un... more The following theorem is proved: Letr=r(y)>1,s, andtbe non-negative integers. IfRis a lefts-unital ring satisfies the polynomial identity[xy−xsyrxt,x]=0for everyx,y∈R, thenRis commutative. The commutativity of a rights-unital ring satisfying the polynomial identity[xy−yrxt,x]=0for allx,y∈R, is also proved.
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European Journal of Surgical Oncology (EJSO), 2003
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The Annals of The Royal College of Surgeons of England, 2010
Adder bites are common in the UK usually manifesting with localised swelling and gastrointestinal... more Adder bites are common in the UK usually manifesting with localised swelling and gastrointestinal symptoms. We report a rare case of acute pancreatitis secondary to an adder bite in Wales and highlight this serious complication which was managed with standard treatment.
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