Hanh Tran - Academia.edu (original) (raw)

Papers by Hanh Tran

Journal of Science and Technology Issue on Information and Communications Technology

In this paper, we propose a novel method for video anomaly detection motivated by an existing arc... more In this paper, we propose a novel method for video anomaly detection motivated by an existing architecture for sequence-to-sequence prediction and reconstruction using a spatio-temporal convolutional Long Short-Term Memory (convLSTM). As in previous work on anomaly detection, anomalies arise as spatially localised failures in reconstruction or prediction. In experiments with five benchmark datasets, we show that using prediction gives superior performance to using reconstruction. We also compare performance with different length input/output sequences. Overall, our results using prediction are comparable with the state of the art on the benchmark datasets.

Infectious Diseases of Poverty

BackgroundThe risk factors for scrub typhus in Vietnam remain unknown. Scrub typhus caused byOrie... more BackgroundThe risk factors for scrub typhus in Vietnam remain unknown. Scrub typhus caused byOrientia tsutsugamushioften presents as an undifferentiated febrile illness and remains under appreciated due to the limited availability of diagnostic tests. This tropical rickettsial illness is increasingly recognized as an important cause of non-malaria acute undifferentiated fever in Asia. This study aimed to investigate behavioural and ecological related risk factors of scrub typhus to prevent this potentially life-threatening disease in Vietnam.MethodsWe conducted a clinical hospital-based active surveillance study, and a retrospective residence-enrolment date-age-matched case–control study in Khanh Hoa province, Vietnam, from August 2018 to March 2020. Clinical examinations, polymerase chain reaction and enzyme-linked immunosorbent assay IgM tests were applied to define cases and controls. All enrolled participants filled out a questionnaire including demographic socio-economic status...

Hypertension, 2014

The dopamine-1 receptor (D 1 R) is responsible for regulating up to 60% of natriuresis in the kid... more The dopamine-1 receptor (D 1 R) is responsible for regulating up to 60% of natriuresis in the kidney under sodium loaded conditions. G protein coupled receptor kinase type 4 (GRK4) phosphorylates the D 1 R and reduces its membrane expression, but little is known about regulation of GRK4. We hypothesized that GRK4 is targeted for elimination through ubiquitylation. Using D 1 R and GRK4γ stably transfected human embryonic kidney cells (HEK293), we demonstrated GRK4 and ubiquitin coimmunoprecipitation. Addition of clasto-lactacystin beta-lactone (CLBL, an inhibitor of the 26S proteasome) increased GRK4 expression levels (western blot) using two different GRK4 fusion protein constructs. The addition of CLBL (10 μmol/L, 24 hrs) increased the expression of both a tandem affinity tagged (tap-tag) GRK4 fusion construct (2.65±0.19 fold over vehicle (VEH): VEH 4,010±404 RFU; CLBL 10,626±744 RFU, P<0.05, N=3) as well as a mCherry GRK4 fusion construct (6.98±0.50 fold increase over VEH: VEH ...

To date, genomic analyses in amoebozoans have been mostly limited to model organisms or medically... more To date, genomic analyses in amoebozoans have been mostly limited to model organisms or medically important lineages. Consequently, the vast diversity of Amoebozoa genomes remain unexplored. A draft genome of Cochliopodium minus, an amoeba characterized by extensive cellular and nuclear fusions, is presented. C. minus has been a subject of recent investigation for its unusual sexual behavior. Cochliopodium’s sexual activity occurs during vegetative stage making it an ideal model for studying sexual development, which is sorely lacking in the group. Here we generate a C. minus draft genome assembly. From this genome, we detect a substantial number of lateral gene transfer (LGT) instances from bacteria (15%), archaea (0.9%) and viruses (0.7%) the majority of which are detected in our transcriptome data. We identify the complete meiosis toolkit genes in the C. minus genome, as well as the absence of several key genes involved in plasmogamy and karyogamy. Comparative genomics of amoeboz...

Asia Pacific journal of clinical nutrition, 2007

OBJECTIVE To assess the nutritional status of adolescents in Ho Chi Minh City, and in particular ... more OBJECTIVE To assess the nutritional status of adolescents in Ho Chi Minh City, and in particular determine the prevalence of overweight and obesity in adolescents across different sub groups, based on gender, household economic status and geographic location. DESIGN A cross-sectional survey based on a two-stage cluster sampling design. SETTING Secondary high schools in Ho Chi Minh City. SUBJECTS There were 1504 adolescents involved in the study, of which 50% were girls and the mean age of participants was 13.1 years. RESULTS Overall, 4.9% of the students were overweight and 0.6% were obese, while 13.1% of the students were underweight. The prevalence of underweight was significantly higher in boys than girls (p=0.001) and overweight and obesity were also higher in boys although these differences were not statistically significant (p=0.074). There was a much higher prevalence of overweight and obesity in students from schools in wealthy urban districts (8.2% and 0.6%, respectively) i...

Annals of medicine and surgery (2012), 2018

Immunosuppression in transplant patients increases the risk of wound complications. However, an o... more Immunosuppression in transplant patients increases the risk of wound complications. However, an optimal surgical approach to kidney and pancreas transplantation can minimise this risk. We performed a systematic review and meta-analysis to examine factors contributing to incisional hernia formation in kidney and pancreas transplant recipients. Bias appraisal of studies was conducted via the Newcastle-Ottawa scale. We considered recipient factors, surgical methods, and complications of repair. The rate of incisional hernia formation in recipients of kidney and pancreas transplants was 4.4% (CI 95% 2.6-7.3, p < 0.001). Age above or below 50 years did not predict hernia formation ( (1) = 0.09, = 0.77). Body mass index (BMI) above 25 (10.8%, CI 95% 3.2-30.9, p < 0.001) increased the risk of an incisional hernia. Mycophenolate mofetil (MMF) use significantly reduced the risk of incisional hernia from 11.9% (CI 95% 4.3-28.7, p < 0.001) to 3.8% (CI 95% 2.5-5.7, p < 0.001), (1) ...

PloS one, 2018

Salt sensitivity of blood pressure affects >30% of the hypertensive and >15% of the normote... more Salt sensitivity of blood pressure affects >30% of the hypertensive and >15% of the normotensive population. Variants of the electrogenic sodium bicarbonate cotransporter NBCe2 gene, SLC4A5, are associated with increased blood pressure in several ethnic groups. SLC4A5 variants are also highly associated with salt sensitivity, independent of hypertension. However, little is known about how NBCe2 contributes to salt sensitivity, although NBCe2 regulates renal tubular sodium bicarbonate transport. We hypothesized that SLC4A5 rs10177833 and rs7571842 increase NBCe2 expression and human renal proximal tubule cell (hRPTC) sodium transport and may be a cause of salt sensitivity of blood pressure. To characterize the hRPTC ion transport of wild-type (WT) and homozygous variants (HV) of SLC4A5. The expressions of NBCe2 mRNA and protein were not different between hRPTCs carrying WT or HV SLC4A5 before or after dopaminergic or angiotensin (II and III) stimulation. However, luminal to bas...

BMC infectious diseases, Mar 7, 2018

Hand hygiene compliance is the basis of infection control programs. In developing countries model... more Hand hygiene compliance is the basis of infection control programs. In developing countries models to improve hand hygiene compliance to reduce healthcare acquired infections are required. The aim of this study was to determine hand hygiene compliance following an educational program in an obstetric and gynecological hospital in Vietnam. Health care workers from neonatal intensive care, delivery suite and a surgical ward from Hung Vuong Hospital, Ho Chi Minh City, Vietnam undertook a 4-h educational program targeting hand hygiene. Compliance was monitored monthly for six months following the intervention. Hand hygiene knowledge was assessed at baseline and after six months of the study. There were 7124 opportunities over 370 hand hygiene recording sessions with 1531 opportunities at baseline and 1620 at 6 months following the intervention. Hand hygiene compliance increased significantly from baseline across all sites (43.6% [95% Confidence interval CI: 41.1-46.1] to 63% [95% CI: 60....

CRSLS: MIS Case Reports from SLS, 2014

Introduction: Evidence-based treatment of abdominal hernias involves the use of prosthetic mesh. ... more Introduction: Evidence-based treatment of abdominal hernias involves the use of prosthetic mesh. However, the most commonly used method of treatment of diastasis of the recti involves plication with non-absorbable sutures as part of an abdominoplasty procedure. This case report describes single-port laparoscopic repair of diastasis of recti and umbilical hernia with prosthetic mesh after plication with slowly absorbable sutures combined with abdominoplasty. Technique Description: Our patient is a 36-year-old woman with severe diastasis of the recti, umbilical hernia and an excessive amount of redundant skin after two previous pregnancies and caesarean sections. After raising the upper abdominal flap, a single-port was placed in the left upper quadrant and the ligamenturn teres was divided. The diastasis of the recti and umbilical hernia were plicated under direct vision with continuous and interrupted slowly absorbable sutures before an antiadhesive mesh was placed behind the repair with 6 cm overlap, transfixed in 4 quadrants and tacked in place with non-absorbable tacks in a double-crown technique. The left upper quadrant wound was closed with slowly absorbable sutures. The excess skin was removed and fibrin sealant was sprayed in the subcutaneous space to minimize the risk of serorna formation without using drains. Discussion: Combining single-port laparoscopic repair of diastasis of recti and umbilical hemia repair minimizes inadvertent suturing of abdominal contents during plication, the risks of port site hernias associated with conventional multipart repair and permanently reinforced the midline weakness while achieving "scarless" surgery.

JSLS : Journal of the Society of Laparoendoscopic Surgeons / Society of Laparoendoscopic Surgeons

Despite the exponential increase in the use of laparoscopic inguinal herniorrhaphy, overall recur... more Despite the exponential increase in the use of laparoscopic inguinal herniorrhaphy, overall recurrence rates have remained unchanged. Therefore, a growing number of patients are presenting with recurrent hernias after conventional anterior and laparoscopic repairs have failed. This study reports our experience with single-incision laparoscopic (SIL) intraperitoneal onlay mesh (IPOM) repair of these hernias. Patients referred with two or more recurrences of inguinal hernia underwent SIL-IPOM from November 1, 2009, to June 24, 2014. A 2.5-cm infraumbilical incision was made, and an SIL port was placed intraperitoneally. Modified dissection techniques were used: chopstick and inline dissection, 5.5-mm/52-cm/30° angled laparoscope, and conventional straight dissecting instruments. The peritoneum was incised above the pubic symphysis, and dissection was continued laterally and proximally, raising the inferior flap below the previous extraperitoneal mesh while reducing any direct, indirec...

2008 5th IEEE Annual Communications Society Conference on Sensor, Mesh and Ad Hoc Communications and Networks Workshops, 2008

Page 1. Design and Implementation of Cognitive Wireless Network based on IEEE P1900.4 Kentaro Ish... more Page 1. Design and Implementation of Cognitive Wireless Network based on IEEE P1900.4 Kentaro Ishizu 1), Homare Murakami 1), Goh Miyamoto 1), Ha Nguyen Tran 1), Stanislav Filin 1), Mikio Hasegawa 2)1), Yoshitoshi Murata 3)1), Hiroshi Harada 1), Shuzo Kato 4)1) ...

Hernia, 2014

Background Multiple prospective studies have confirmed safety and efficacy of laparoscopic inguin... more Background Multiple prospective studies have confirmed safety and efficacy of laparoscopic inguinal herniorraphy with single-port compared to multiport surgery. This prospective randomized controlled trial aimed to assess safety, efficacy and potential benefits of singleport total extraperitoneal inguinal herniorraphy beyond the learning curve. Methods All referred patients with inguinal/femoral hernias were enrolled from December 2011 to February 2013. Exclusion criteria included workers compensation cases. Identical balloon dissector, lightweight mesh and non-absorbable tacks were used in all cases. For single-port cases Triport TM was used while structural balloon trocar/inflation bulb for multiport cases. Results were analyzed with IBM Ò SPSS Ò version 22 for Windows. Results Participation rate was 100 % with 157 inguinal/femoral hernias in 100 patients: 51 randomized to single-port and 49 to multiport group. There was no conversion to open surgery/need for additional ports. There were no statistical differences between single-port and multiport groups with respect to age, sex, body mass index, American Society of Anesthesiologists scores, preoperative pain, hernia defect sizes and length of hospital stay. Operation times were equivalent for single-port and multiport 60.0 vs 61.0 min, P = 0.23, respectively. Significantly, single-port patients ingested fewer pain killers: 6 tablets vs 14 Dextropropoxyphene tablets, P \ 0.001, experienced less pain (visual analog scores) on day 1 and 7 post-op op: 2.5 and 0, P \ 0.001 compared to 4.5 and 2.5, P \ 0.001, respectively, returned to work/normal physical activities 7 days quicker: 7.0 vs 14.0, P \ 0.001 and had higher cosmetic scar scores at 6-week follow-up: 24 vs 21, P \ 0.001, compared to multiport patients. There were no mortalities, morbidities or recurrences after followup of 6-21 months. Conclusions Compared to multiport, single-port laparoscopic total extraperitoneal inguinal herniorraphy, when performed by a high-volume and highly dedicated hernia surgeon, resulted in significantly reduced postoperative pain, analgesic requirements, quicker return to work/normal activities, improved cosmesis, and equivalent safety and efficacy.

Xenotransplantation, 1997

Xenotransplantation, 1999

Physics Letters B, 1999

The reaction g p ™ K 0 S q has been measured with the SAPHIR detector at the electron stretcher r... more The reaction g p ™ K 0 S q has been measured with the SAPHIR detector at the electron stretcher ring ELSA. The total cross section rises up to a peak value of 1.1mb at a photon energy of 1.4 GeV. The differential cross sections dsrdV are consistent with being flat throughout the measured energy range. The first measurement of the S q polarization in photon induced reactions was obtained.

Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms, 2011

This paper presents stopping power and ranges of electrons, protons, and alpha particles in liqui... more This paper presents stopping power and ranges of electrons, protons, and alpha particles in liquid water, calculated using the latest Geant4-DNA processes implemented in the Geant4 Monte Carlo simulation toolkit. Inelastic cross sections are obtained using the first Born approximation and semi-empirical formulas like Rudd’s model for ionisation and the Miller and Green formula for excitation. Elastic collisions and vibrational

Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms, 2012

The Geant4 Monte Carlo simulation toolkit provides a set of electromagnetic physics processes ada... more The Geant4 Monte Carlo simulation toolkit provides a set of electromagnetic physics processes adapted to the detailed simulation of particle interactions in liquid water for microdosimetry applications, such as single-cell irradiation with light ion beams. These processes, developed within the framework of the Geant4-DNA project, adopt a software design allowing their combination with other electromagnetic physics processes available in the

Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms, 2012

In the present work, we report theoretical differential and integrated cross sections of the elas... more In the present work, we report theoretical differential and integrated cross sections of the elastic scattering process for sub-thermalization electrons (Einc≅10meV–10keV) and 1keV–1MeV protons in water vapour. The calculations are performed within the quantum mechanical framework for electrons whereas classical calculations are provided for protons. The results obtained in this free-parameter theoretical treatment are compared to available data and quantitative differences are reported.

JSLS, Journal of the Society of Laparoendoscopic Surgeons, 2012

Introduction: Adhesions to mesh/tacks in laparoscopic ventral hernia repair are often cited as re... more Introduction: Adhesions to mesh/tacks in laparoscopic ventral hernia repair are often cited as reasons not to adopt its evidence-based superiority over conventional open methods. This pilot study assessed the occurrence of adhesions to full-sized Polypropylene and Gore-tex Du-alMesh Plus meshes and the possibility for adhesion prevention using fibrin sealant. Methods: Two 10-cm to 15-cm pieces of mesh were placed and fixed laparoscopically in pigs (25kg to 55kg). Group I: 2 animals with Polypropylene mesh on one side and DualMesh on other side. Group II: 2 animals with DualMesh on each side with fibrin sealant applied to the periphery of mesh and staples to one side. Group III: 1 animal with 2 pieces of Polypropylene mesh with fibrin sealant applied to the entire mesh. All animals underwent laparoscopy 3 months later to assess the extent of adhesions, and full-thickness specimens were removed for histological evaluation. Results: More Polypropylene mesh was involved in adhesions than DualMesh. However, with the DualMesh involved in adhesions, more of the surface area was involved in forming adhesions than with Polypropylene mesh. None of the implanted DualMesh had visceral adhesions, while 2 out of 3 Polypropylene meshes had adhesions to both the liver and spleen but none to the bowel. Implanted Polypropylene mesh with fibrin sealant had no adhesions. DualMesh had shrunk more significantly than Polypropylene mesh. Histological evaluation showed absence of acute inflammatory response, significantly more chronic inflammatory response to DualMesh compared to Polypropylene and complete mesothelializa-tion with both meshes. There was extensive collagen deposition between Polypropylene mesh fibers, while fibrosis occurred on both sides of DualMesh with synovial metaplasia over its peritoneal surface akin to encapsulation. Conclusions: DualMesh caused fewer omental and visceral adhesions than Polypropylene mesh did. Fibrin sealant eliminated adhesions to DualMesh and prevented adhesions to Polypropylene mesh when applied over the entire surface. These results support our current use of DualMesh and fibrin sealant in LVHR.

Hypertension, 2012

Little is known regarding how the kidney shifts from a sodium and water reclaiming state (antinat... more Little is known regarding how the kidney shifts from a sodium and water reclaiming state (antinatriuresis) to a state where sodium and water are eliminated (natriuresis). In human renal proximal tubule cells, sodium reabsorption is decreased by the dopamine D 1 -like receptors (D 1 R/D 5 R) and the angiotensin type 2 receptor (AT 2 R), whereas the angiotensin type 1 receptor increases sodium reabsorption. Aberrant control of these opposing systems is thought to lead to sodium retention and, subsequently, hypertension. We show that D 1 R/D 5 R stimulation increased plasma membrane AT 2 R 4-fold via a D 1 R-mediated, cAMP-coupled, and protein phosphatase 2A–dependent specific signaling pathway. D 1 R/D 5 R stimulation also reduced the ability of angiotensin II to stimulate phospho-extracellular signal–regulated kinase, an effect that was partially reversed by an AT 2 R antagonist. Fenoldopam did not increase AT 2 R recruitment in renal proximal tubule cells with D 1 Rs uncoupled from ...

Journal of Science and Technology Issue on Information and Communications Technology

In this paper, we propose a novel method for video anomaly detection motivated by an existing arc... more In this paper, we propose a novel method for video anomaly detection motivated by an existing architecture for sequence-to-sequence prediction and reconstruction using a spatio-temporal convolutional Long Short-Term Memory (convLSTM). As in previous work on anomaly detection, anomalies arise as spatially localised failures in reconstruction or prediction. In experiments with five benchmark datasets, we show that using prediction gives superior performance to using reconstruction. We also compare performance with different length input/output sequences. Overall, our results using prediction are comparable with the state of the art on the benchmark datasets.

Infectious Diseases of Poverty

BackgroundThe risk factors for scrub typhus in Vietnam remain unknown. Scrub typhus caused byOrie... more BackgroundThe risk factors for scrub typhus in Vietnam remain unknown. Scrub typhus caused byOrientia tsutsugamushioften presents as an undifferentiated febrile illness and remains under appreciated due to the limited availability of diagnostic tests. This tropical rickettsial illness is increasingly recognized as an important cause of non-malaria acute undifferentiated fever in Asia. This study aimed to investigate behavioural and ecological related risk factors of scrub typhus to prevent this potentially life-threatening disease in Vietnam.MethodsWe conducted a clinical hospital-based active surveillance study, and a retrospective residence-enrolment date-age-matched case–control study in Khanh Hoa province, Vietnam, from August 2018 to March 2020. Clinical examinations, polymerase chain reaction and enzyme-linked immunosorbent assay IgM tests were applied to define cases and controls. All enrolled participants filled out a questionnaire including demographic socio-economic status...

Hypertension, 2014

The dopamine-1 receptor (D 1 R) is responsible for regulating up to 60% of natriuresis in the kid... more The dopamine-1 receptor (D 1 R) is responsible for regulating up to 60% of natriuresis in the kidney under sodium loaded conditions. G protein coupled receptor kinase type 4 (GRK4) phosphorylates the D 1 R and reduces its membrane expression, but little is known about regulation of GRK4. We hypothesized that GRK4 is targeted for elimination through ubiquitylation. Using D 1 R and GRK4γ stably transfected human embryonic kidney cells (HEK293), we demonstrated GRK4 and ubiquitin coimmunoprecipitation. Addition of clasto-lactacystin beta-lactone (CLBL, an inhibitor of the 26S proteasome) increased GRK4 expression levels (western blot) using two different GRK4 fusion protein constructs. The addition of CLBL (10 μmol/L, 24 hrs) increased the expression of both a tandem affinity tagged (tap-tag) GRK4 fusion construct (2.65±0.19 fold over vehicle (VEH): VEH 4,010±404 RFU; CLBL 10,626±744 RFU, P<0.05, N=3) as well as a mCherry GRK4 fusion construct (6.98±0.50 fold increase over VEH: VEH ...

To date, genomic analyses in amoebozoans have been mostly limited to model organisms or medically... more To date, genomic analyses in amoebozoans have been mostly limited to model organisms or medically important lineages. Consequently, the vast diversity of Amoebozoa genomes remain unexplored. A draft genome of Cochliopodium minus, an amoeba characterized by extensive cellular and nuclear fusions, is presented. C. minus has been a subject of recent investigation for its unusual sexual behavior. Cochliopodium’s sexual activity occurs during vegetative stage making it an ideal model for studying sexual development, which is sorely lacking in the group. Here we generate a C. minus draft genome assembly. From this genome, we detect a substantial number of lateral gene transfer (LGT) instances from bacteria (15%), archaea (0.9%) and viruses (0.7%) the majority of which are detected in our transcriptome data. We identify the complete meiosis toolkit genes in the C. minus genome, as well as the absence of several key genes involved in plasmogamy and karyogamy. Comparative genomics of amoeboz...

Asia Pacific journal of clinical nutrition, 2007

OBJECTIVE To assess the nutritional status of adolescents in Ho Chi Minh City, and in particular ... more OBJECTIVE To assess the nutritional status of adolescents in Ho Chi Minh City, and in particular determine the prevalence of overweight and obesity in adolescents across different sub groups, based on gender, household economic status and geographic location. DESIGN A cross-sectional survey based on a two-stage cluster sampling design. SETTING Secondary high schools in Ho Chi Minh City. SUBJECTS There were 1504 adolescents involved in the study, of which 50% were girls and the mean age of participants was 13.1 years. RESULTS Overall, 4.9% of the students were overweight and 0.6% were obese, while 13.1% of the students were underweight. The prevalence of underweight was significantly higher in boys than girls (p=0.001) and overweight and obesity were also higher in boys although these differences were not statistically significant (p=0.074). There was a much higher prevalence of overweight and obesity in students from schools in wealthy urban districts (8.2% and 0.6%, respectively) i...

Annals of medicine and surgery (2012), 2018

Immunosuppression in transplant patients increases the risk of wound complications. However, an o... more Immunosuppression in transplant patients increases the risk of wound complications. However, an optimal surgical approach to kidney and pancreas transplantation can minimise this risk. We performed a systematic review and meta-analysis to examine factors contributing to incisional hernia formation in kidney and pancreas transplant recipients. Bias appraisal of studies was conducted via the Newcastle-Ottawa scale. We considered recipient factors, surgical methods, and complications of repair. The rate of incisional hernia formation in recipients of kidney and pancreas transplants was 4.4% (CI 95% 2.6-7.3, p < 0.001). Age above or below 50 years did not predict hernia formation ( (1) = 0.09, = 0.77). Body mass index (BMI) above 25 (10.8%, CI 95% 3.2-30.9, p < 0.001) increased the risk of an incisional hernia. Mycophenolate mofetil (MMF) use significantly reduced the risk of incisional hernia from 11.9% (CI 95% 4.3-28.7, p < 0.001) to 3.8% (CI 95% 2.5-5.7, p < 0.001), (1) ...

PloS one, 2018

Salt sensitivity of blood pressure affects >30% of the hypertensive and >15% of the normote... more Salt sensitivity of blood pressure affects >30% of the hypertensive and >15% of the normotensive population. Variants of the electrogenic sodium bicarbonate cotransporter NBCe2 gene, SLC4A5, are associated with increased blood pressure in several ethnic groups. SLC4A5 variants are also highly associated with salt sensitivity, independent of hypertension. However, little is known about how NBCe2 contributes to salt sensitivity, although NBCe2 regulates renal tubular sodium bicarbonate transport. We hypothesized that SLC4A5 rs10177833 and rs7571842 increase NBCe2 expression and human renal proximal tubule cell (hRPTC) sodium transport and may be a cause of salt sensitivity of blood pressure. To characterize the hRPTC ion transport of wild-type (WT) and homozygous variants (HV) of SLC4A5. The expressions of NBCe2 mRNA and protein were not different between hRPTCs carrying WT or HV SLC4A5 before or after dopaminergic or angiotensin (II and III) stimulation. However, luminal to bas...

BMC infectious diseases, Mar 7, 2018

Hand hygiene compliance is the basis of infection control programs. In developing countries model... more Hand hygiene compliance is the basis of infection control programs. In developing countries models to improve hand hygiene compliance to reduce healthcare acquired infections are required. The aim of this study was to determine hand hygiene compliance following an educational program in an obstetric and gynecological hospital in Vietnam. Health care workers from neonatal intensive care, delivery suite and a surgical ward from Hung Vuong Hospital, Ho Chi Minh City, Vietnam undertook a 4-h educational program targeting hand hygiene. Compliance was monitored monthly for six months following the intervention. Hand hygiene knowledge was assessed at baseline and after six months of the study. There were 7124 opportunities over 370 hand hygiene recording sessions with 1531 opportunities at baseline and 1620 at 6 months following the intervention. Hand hygiene compliance increased significantly from baseline across all sites (43.6% [95% Confidence interval CI: 41.1-46.1] to 63% [95% CI: 60....

CRSLS: MIS Case Reports from SLS, 2014

Introduction: Evidence-based treatment of abdominal hernias involves the use of prosthetic mesh. ... more Introduction: Evidence-based treatment of abdominal hernias involves the use of prosthetic mesh. However, the most commonly used method of treatment of diastasis of the recti involves plication with non-absorbable sutures as part of an abdominoplasty procedure. This case report describes single-port laparoscopic repair of diastasis of recti and umbilical hernia with prosthetic mesh after plication with slowly absorbable sutures combined with abdominoplasty. Technique Description: Our patient is a 36-year-old woman with severe diastasis of the recti, umbilical hernia and an excessive amount of redundant skin after two previous pregnancies and caesarean sections. After raising the upper abdominal flap, a single-port was placed in the left upper quadrant and the ligamenturn teres was divided. The diastasis of the recti and umbilical hernia were plicated under direct vision with continuous and interrupted slowly absorbable sutures before an antiadhesive mesh was placed behind the repair with 6 cm overlap, transfixed in 4 quadrants and tacked in place with non-absorbable tacks in a double-crown technique. The left upper quadrant wound was closed with slowly absorbable sutures. The excess skin was removed and fibrin sealant was sprayed in the subcutaneous space to minimize the risk of serorna formation without using drains. Discussion: Combining single-port laparoscopic repair of diastasis of recti and umbilical hemia repair minimizes inadvertent suturing of abdominal contents during plication, the risks of port site hernias associated with conventional multipart repair and permanently reinforced the midline weakness while achieving "scarless" surgery.

JSLS : Journal of the Society of Laparoendoscopic Surgeons / Society of Laparoendoscopic Surgeons

Despite the exponential increase in the use of laparoscopic inguinal herniorrhaphy, overall recur... more Despite the exponential increase in the use of laparoscopic inguinal herniorrhaphy, overall recurrence rates have remained unchanged. Therefore, a growing number of patients are presenting with recurrent hernias after conventional anterior and laparoscopic repairs have failed. This study reports our experience with single-incision laparoscopic (SIL) intraperitoneal onlay mesh (IPOM) repair of these hernias. Patients referred with two or more recurrences of inguinal hernia underwent SIL-IPOM from November 1, 2009, to June 24, 2014. A 2.5-cm infraumbilical incision was made, and an SIL port was placed intraperitoneally. Modified dissection techniques were used: chopstick and inline dissection, 5.5-mm/52-cm/30° angled laparoscope, and conventional straight dissecting instruments. The peritoneum was incised above the pubic symphysis, and dissection was continued laterally and proximally, raising the inferior flap below the previous extraperitoneal mesh while reducing any direct, indirec...

2008 5th IEEE Annual Communications Society Conference on Sensor, Mesh and Ad Hoc Communications and Networks Workshops, 2008

Page 1. Design and Implementation of Cognitive Wireless Network based on IEEE P1900.4 Kentaro Ish... more Page 1. Design and Implementation of Cognitive Wireless Network based on IEEE P1900.4 Kentaro Ishizu 1), Homare Murakami 1), Goh Miyamoto 1), Ha Nguyen Tran 1), Stanislav Filin 1), Mikio Hasegawa 2)1), Yoshitoshi Murata 3)1), Hiroshi Harada 1), Shuzo Kato 4)1) ...

Hernia, 2014

Background Multiple prospective studies have confirmed safety and efficacy of laparoscopic inguin... more Background Multiple prospective studies have confirmed safety and efficacy of laparoscopic inguinal herniorraphy with single-port compared to multiport surgery. This prospective randomized controlled trial aimed to assess safety, efficacy and potential benefits of singleport total extraperitoneal inguinal herniorraphy beyond the learning curve. Methods All referred patients with inguinal/femoral hernias were enrolled from December 2011 to February 2013. Exclusion criteria included workers compensation cases. Identical balloon dissector, lightweight mesh and non-absorbable tacks were used in all cases. For single-port cases Triport TM was used while structural balloon trocar/inflation bulb for multiport cases. Results were analyzed with IBM Ò SPSS Ò version 22 for Windows. Results Participation rate was 100 % with 157 inguinal/femoral hernias in 100 patients: 51 randomized to single-port and 49 to multiport group. There was no conversion to open surgery/need for additional ports. There were no statistical differences between single-port and multiport groups with respect to age, sex, body mass index, American Society of Anesthesiologists scores, preoperative pain, hernia defect sizes and length of hospital stay. Operation times were equivalent for single-port and multiport 60.0 vs 61.0 min, P = 0.23, respectively. Significantly, single-port patients ingested fewer pain killers: 6 tablets vs 14 Dextropropoxyphene tablets, P \ 0.001, experienced less pain (visual analog scores) on day 1 and 7 post-op op: 2.5 and 0, P \ 0.001 compared to 4.5 and 2.5, P \ 0.001, respectively, returned to work/normal physical activities 7 days quicker: 7.0 vs 14.0, P \ 0.001 and had higher cosmetic scar scores at 6-week follow-up: 24 vs 21, P \ 0.001, compared to multiport patients. There were no mortalities, morbidities or recurrences after followup of 6-21 months. Conclusions Compared to multiport, single-port laparoscopic total extraperitoneal inguinal herniorraphy, when performed by a high-volume and highly dedicated hernia surgeon, resulted in significantly reduced postoperative pain, analgesic requirements, quicker return to work/normal activities, improved cosmesis, and equivalent safety and efficacy.

Xenotransplantation, 1997

Xenotransplantation, 1999

Physics Letters B, 1999

The reaction g p ™ K 0 S q has been measured with the SAPHIR detector at the electron stretcher r... more The reaction g p ™ K 0 S q has been measured with the SAPHIR detector at the electron stretcher ring ELSA. The total cross section rises up to a peak value of 1.1mb at a photon energy of 1.4 GeV. The differential cross sections dsrdV are consistent with being flat throughout the measured energy range. The first measurement of the S q polarization in photon induced reactions was obtained.

Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms, 2011

This paper presents stopping power and ranges of electrons, protons, and alpha particles in liqui... more This paper presents stopping power and ranges of electrons, protons, and alpha particles in liquid water, calculated using the latest Geant4-DNA processes implemented in the Geant4 Monte Carlo simulation toolkit. Inelastic cross sections are obtained using the first Born approximation and semi-empirical formulas like Rudd’s model for ionisation and the Miller and Green formula for excitation. Elastic collisions and vibrational

Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms, 2012

The Geant4 Monte Carlo simulation toolkit provides a set of electromagnetic physics processes ada... more The Geant4 Monte Carlo simulation toolkit provides a set of electromagnetic physics processes adapted to the detailed simulation of particle interactions in liquid water for microdosimetry applications, such as single-cell irradiation with light ion beams. These processes, developed within the framework of the Geant4-DNA project, adopt a software design allowing their combination with other electromagnetic physics processes available in the

Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms, 2012

In the present work, we report theoretical differential and integrated cross sections of the elas... more In the present work, we report theoretical differential and integrated cross sections of the elastic scattering process for sub-thermalization electrons (Einc≅10meV–10keV) and 1keV–1MeV protons in water vapour. The calculations are performed within the quantum mechanical framework for electrons whereas classical calculations are provided for protons. The results obtained in this free-parameter theoretical treatment are compared to available data and quantitative differences are reported.

JSLS, Journal of the Society of Laparoendoscopic Surgeons, 2012

Introduction: Adhesions to mesh/tacks in laparoscopic ventral hernia repair are often cited as re... more Introduction: Adhesions to mesh/tacks in laparoscopic ventral hernia repair are often cited as reasons not to adopt its evidence-based superiority over conventional open methods. This pilot study assessed the occurrence of adhesions to full-sized Polypropylene and Gore-tex Du-alMesh Plus meshes and the possibility for adhesion prevention using fibrin sealant. Methods: Two 10-cm to 15-cm pieces of mesh were placed and fixed laparoscopically in pigs (25kg to 55kg). Group I: 2 animals with Polypropylene mesh on one side and DualMesh on other side. Group II: 2 animals with DualMesh on each side with fibrin sealant applied to the periphery of mesh and staples to one side. Group III: 1 animal with 2 pieces of Polypropylene mesh with fibrin sealant applied to the entire mesh. All animals underwent laparoscopy 3 months later to assess the extent of adhesions, and full-thickness specimens were removed for histological evaluation. Results: More Polypropylene mesh was involved in adhesions than DualMesh. However, with the DualMesh involved in adhesions, more of the surface area was involved in forming adhesions than with Polypropylene mesh. None of the implanted DualMesh had visceral adhesions, while 2 out of 3 Polypropylene meshes had adhesions to both the liver and spleen but none to the bowel. Implanted Polypropylene mesh with fibrin sealant had no adhesions. DualMesh had shrunk more significantly than Polypropylene mesh. Histological evaluation showed absence of acute inflammatory response, significantly more chronic inflammatory response to DualMesh compared to Polypropylene and complete mesothelializa-tion with both meshes. There was extensive collagen deposition between Polypropylene mesh fibers, while fibrosis occurred on both sides of DualMesh with synovial metaplasia over its peritoneal surface akin to encapsulation. Conclusions: DualMesh caused fewer omental and visceral adhesions than Polypropylene mesh did. Fibrin sealant eliminated adhesions to DualMesh and prevented adhesions to Polypropylene mesh when applied over the entire surface. These results support our current use of DualMesh and fibrin sealant in LVHR.

Hypertension, 2012

Little is known regarding how the kidney shifts from a sodium and water reclaiming state (antinat... more Little is known regarding how the kidney shifts from a sodium and water reclaiming state (antinatriuresis) to a state where sodium and water are eliminated (natriuresis). In human renal proximal tubule cells, sodium reabsorption is decreased by the dopamine D 1 -like receptors (D 1 R/D 5 R) and the angiotensin type 2 receptor (AT 2 R), whereas the angiotensin type 1 receptor increases sodium reabsorption. Aberrant control of these opposing systems is thought to lead to sodium retention and, subsequently, hypertension. We show that D 1 R/D 5 R stimulation increased plasma membrane AT 2 R 4-fold via a D 1 R-mediated, cAMP-coupled, and protein phosphatase 2A–dependent specific signaling pathway. D 1 R/D 5 R stimulation also reduced the ability of angiotensin II to stimulate phospho-extracellular signal–regulated kinase, an effect that was partially reversed by an AT 2 R antagonist. Fenoldopam did not increase AT 2 R recruitment in renal proximal tubule cells with D 1 Rs uncoupled from ...