Hank Lin - Academia.edu (original) (raw)

Papers by Hank Lin

Scientific Reports

Type 2 diabetes (T2D) and its complications can have debilitating, sometimes fatal consequences f... more Type 2 diabetes (T2D) and its complications can have debilitating, sometimes fatal consequences for afflicted individuals. The disease can be difficult to control, and therapeutic strategies to prevent T2D-induced tissue and organ damage are needed. Here we describe the results of administering a potent and selective inhibitor of Protein Kinase C (PKC) family members PKCα and PKCβ, Cmpd 1, in the ZSF1 obese rat model of hyperphagia-induced, obesity-driven T2D. Although our initial intent was to evaluate the effect of PKCα/β inhibition on renal damage in this model setting, Cmpd 1 unexpectedly caused a marked reduction in the hyperphagic response of ZSF1 obese animals. This halted renal function decline but did so indirectly and indistinguishably from a pair feeding comparator group. However, above and beyond this food intake effect, Cmpd 1 lowered overall animal body weights, reduced liver vacuolation, and reduced inguinal adipose tissue (iWAT) mass, inflammation, and adipocyte size...

2019 IEEE International Symposium on Electromagnetic Compatibility, Signal & Power Integrity (EMC+SIPI)

Nowadays, demand for slimmer and better performance consumer electronics increases dramatically. ... more Nowadays, demand for slimmer and better performance consumer electronics increases dramatically. As PCB size keeps shrinking, power integrity issues such as high voltage drop and power loss arise due to lack of power and ground planes and broken power and ground shapes caused by densely-populated signal vias. In this paper, a novel design of power and ground bridging trace, placed between anti-pads of through-hole vias, the voltage drop issue can be greatly improved.

2019 IEEE International Symposium on Electromagnetic Compatibility, Signal & Power Integrity (EMC+SIPI), 2019

Selection of decoupling capacitors (decaps) is important for power distribution network (PDN) des... more Selection of decoupling capacitors (decaps) is important for power distribution network (PDN) design in terms of lowering impedance and saving cost. Good PDN designs typically mean satisfying a target impedance with as less decaps as possible. In this paper, an inductance-based method is utilized to calculate the port priority fist, and afterwards deep reinforcement learning (DRL) with deep neural network (DNN) is applied to optimize the assignment of decaps on the prioritized locations. The DRL algorithm can explore by itself without any prior physical knowledge, and the DNN is trained with the exploration experience and eventually converges to an optimum state. The proposed hybrid method was tested on a printed-circuit-board (PCB) example. After some iterations of training the DNN successfully reached to an optimum design, which turned out to be the minimum number of decaps that can satisfy the target impedance. The usage of DRL with DNN makes the algorithm promising to include more variables as input and handle more complicated cases in the future.

2016 IEEE International Symposium on Electromagnetic Compatibility (EMC), 2016

The power switching noise caused by rapid charging and discharging has always been an issue in PD... more The power switching noise caused by rapid charging and discharging has always been an issue in PDN (Power Delivery Network) design. This noise would not only deteriorate the stability of the power profile, it would also couple to signal transition via if the power via is placed nearby, resulting in deterioration of the overall system signal integrity. Therefore, the relative placement between power via and signal transition via is very important in board design. The relationship between effects of power-signal coupling and distance will be addressed in this paper and will be validated with both simulation results and measurement results from a real-case board design.

Journal of Environmental Chemical Engineering, 2021

2018 IEEE Symposium on Electromagnetic Compatibility, Signal Integrity and Power Integrity (EMC, SI & PI), 2018

As technology advances rapidly, the demand for smaller form factor and higher performance consume... more As technology advances rapidly, the demand for smaller form factor and higher performance consumer electronics also increases drastically. Dual-stripline design is becoming more and more popular on account of the fact that it reduces the number of layers and cost of PCB which ultimately helps achieving smaller form factor. However, due to the fact that dual-stripline design does not have an extra metal reference layer in between two signal layers, far-end crosstalk becomes a critical issue that limits the performance of the whole system. Conventional methods of mitigating far-end crosstalk in dual-stripline are to increase the vertical distance and the horizontal offset between the two adjacent signal layers. In this paper, the effectiveness of vertical and horizontal distance offsets between single-ended dual-stripline is analyzed and improved estimation equations of FEXT are presented. Finally, a set of suggested optimized parameters of dual-stripline offsets is also proposed.

In this paper, an optimized FPC structure design method is proposed to maintain good signal integ... more In this paper, an optimized FPC structure design method is proposed to maintain good signal integrity with EMI film. The proposed FPC design could achieve better insertion loss, return loss, and impedance control compared to common FPC designs with no extra cost.

2017 IEEE International Symposium on Electromagnetic Compatibility & Signal/Power Integrity (EMCSI), 2017

As technology advances, the demand for slim size and higher performance consumer electronics also... more As technology advances, the demand for slim size and higher performance consumer electronics also increases drastically. Stripline is one of the layout designs that is becoming more and more popular on account of the fact that its homogenous characteristics could effectively decrease the interference from both the environmental and material factors. However, far-end crosstalk (FEXT) still exists due to inhomogeneous dielectric environment in realistic board designs. In this paper, a novel layout design for single-ended stripline that could achieve minimized FEXT is proposed. The design aims at cancelling out the FEXT term by having two opposite polarities applied voltages that have the same magnitude. This method is achieved by placing the victim single-ended stripline in between two pairs of differential striplines. In particular, the closest two traces to the victim single-ended stripline are one of positive trace from one differential pair and one of negative trace from the other...

2021 Asia-Pacific International Symposium on Electromagnetic Compatibility (APEMC), 2021

The mounting pads of surface mount device introduce transmission line discontinuities and cause s... more The mounting pads of surface mount device introduce transmission line discontinuities and cause signal integrity degradation. To compensate for the excess parasitic capacitance, ground void may be utilized on the ground plane underneath the pads. In this paper, conventional patterns of plane cutout are presented and analyzed using a 3-D full wave solver. In addition, new void patterns with circular outline are proposed and investigated. From the simulation results, for a pair of 85-Ohm differential traces with 0201 package-sized components in series, suitable design of ground void can be determined, and can effectively control the trace impedance.

2021 IEEE International Joint EMC/SI/PI and EMC Europe Symposium, 2021

In this paper, a behavior modeling method of a buck converter with adaptive voltage positioning (... more In this paper, a behavior modeling method of a buck converter with adaptive voltage positioning (AVP) and PCB parasitics for power distribution network design (PDN) is introduced. The behavior model of voltage regulator module (VRM) is previously proposed for the power integrity modeling and analysis. The proposed behavior model is applied to the buck VRM in a practical high-speed digital board. For the completeness of the behavior model, an AVP design and PCB parasitics are applied to reproduce the power supply rail noise in the practical design. To validate the behavior model, the design parameters of voltage and current controllers of buck VRM in the board are extracted based on the measurement. The proposed model shows a good correlation with the measurement under various loading conditions.

Chemosphere, 2021

Algae is able to accelerate the photodegradation rate of contaminants under sunlight irradiation,... more Algae is able to accelerate the photodegradation rate of contaminants under sunlight irradiation, and this process can be attributed to algal substances, namely, intracellular organic matter (IOM) and extracellular organic matter (EOM). This study aimed to investigate the efficiencies and mechanisms of the photodegradation of three pharmaceuticals - acetaminophen (ACE), codeine (COD) and cephradine (CFD) - in the presence of Chlorella vulgaris and its algal substances. The result shows that a much higher photodegradation rate of acetaminophen was obtained in the presence of IOM (kobs = 0.250 hr-1) than in the presence of EOM (kobs = 0.060 hr-1). The photodegradation mechanisms of acetaminophen were demonstrated and verified by scavenger experiments and probe tests. The major reactive species for acetaminophen photodegradation was triplet-state IOM (3IOM∗), which contributed 93.52% of the photodegradation, while ⋅OH was the secondary contributor (5.60%), with 1O2 contributing the least (0.88%). Chlorella vulgaris also effectively enhanced the photodegradation of codeine and cephradine. However, the photodegradation behaviors of codeine and cephradine in the presence of algal substances were different from those of acetaminophen, indicating that the photodegradation mechanisms might depend on the type of compound. This study not only demonstrates the effectiveness of algal substances in the photodegradation of acetaminophen, codeine and cephradine under sunlight irradiation but also provides a comprehensive study on the photodegradation mechanisms of acetaminophen in the presence of algal substances.

Type 2 diabetes (T2D) and its complications can have debilitating, sometimes fatal consequences. ... more Type 2 diabetes (T2D) and its complications can have debilitating, sometimes fatal consequences. Despite advances that address some of the metabolic aspects of T2D, for many patients these approaches do not sufficiently control the disease. As a result, an emerging therapeutic strategy is to target the pathobiological mechanisms downstream of T2D metabolic derangement that can result in organ damage, morbidity, and mortality in afflicted individuals. One such proposed mechanism involves the Protein Kinase C (PKC) family members PKCα and PKCβ, which have been linked to diabetes-induced tissue damage to organs including the kidneys. To evaluate the therapeutic potential of dual inhibition of PKCα and PKCβ in the context of T2D, we have evaluated a potent and orally bioavailable inhibitor, herein referred to as Cmpd 1, in the ZSF1 rat model of leptin-receptor deficiency, obesity-driven T2D. Therapeutic dosing of Cmpd 1 virtually halted renal function decline but did so indirectly by bl...

IEEE Transactions on Electromagnetic Compatibility, 2018

A system such as a human-assisting robot consists of many subsystems such as sensors, display, mo... more A system such as a human-assisting robot consists of many subsystems such as sensors, display, motors, and control. When an electrostatic discharge (ESD) occurs, it can disrupt the normal operation of any subsystem. This paper analyzes such events beginning at the tribo-charging down to the sensor disruption. The rolling wheels charge the robot, and a discharge occurs when it reaches the charging station. Based on the charge voltage, the discharge current is simulated using a simple switch model along with the loop impedance which limits the current. In multiple steps, the discharge current couples to the sensor. This coupling is represented as S-parameters obtaining the noise voltage at the sensor. This noise voltage is compared to the sensor's noise sensitivity threshold to reproduce the disruptive event. The model is validated with measurements. The simulation model can help system designers assess ESD risks without damaging hardware as well as efficiently design filtering components and effective on-board ESD protection.

IEEE Transactions on Electromagnetic Compatibility, 2019

Clinical nuclear medicine, 2015

A 73-year-old man presented with a rising prostate-specific antigen (PSA) level 5 years following... more A 73-year-old man presented with a rising prostate-specific antigen (PSA) level 5 years following brachytherapy for prostate cancer. In-111 capromab pendetide (ProstaScint) whole-body planar imaging revealed abnormal uptake in the right knee, localizing to a mass in the popliteal fossa on SPECT/CT. MRI showed a mass encasing the popliteal artery and vein, subsequently found to be non-Hodgkin lymphoma on biopsy. Response of the mass to chemotherapy was documented on F-FDG PET/CT. Elevated In-111 capromab pendetide uptake in soft tissue can be important but unrelated to prostate cancer, as demonstrated in this case.

Journal of Chemical Technology & Biotechnology, 2014

BACKGROUND: 5-Fluorouracil is one of the most commonly used cytostatic drugs worldwide. However, ... more BACKGROUND: 5-Fluorouracil is one of the most commonly used cytostatic drugs worldwide. However, the toxicity and persistence of 5-fluorouracil in the environment have recently received considerable attention. In this study, 5-fluorouracil removal was performed by photocatalytic oxidation with microwave-treated N-doped TiO 2 under visible light. RESULTS: The microwave-treated N-doped TiO 2 removed 5-fluorouracil with a higher degradation efficiency than N-doped TiO 2 synthesized with the traditional thermal treatments. The most efficient N-doped TiO 2 (N6) was synthesized using 1 M NH 4 OH pre-immersion and a 3 h 180 ∘ C microwave treatment, followed by 55 ∘ C calcination for 6 h. The photocatalytic degradation of 5-fluorouracil achieved 88.8% removal within 20 h of treatment by N6 under visible light, which is higher than that obtained by Degussa P25 TiO 2 (61.5%). Higher concentrations of NH 4 OH and longer calcination times resulted in decreased 5-fluorouracil degradation; the particle size of the synthesized N-doped TiO 2 increased after calcination. The surface area decreased while the pore volume and pore size increased after synthesis. Furthermore, the basicity of the sites on the synthesized N-doped TiO 2 decreased after calcination. CONCLUSION: This study, for the first time, reported that microwave-assisted treatment for N-doped TiO 2 synthesis effectively removed 5-fluorouracil and cyclophosphamide compared with traditional thermal treatment.