Mary Hardin - Academia.edu (original) (raw)

Papers by Mary Hardin

Balancing Computer Use and Design Content in Studio Projects

Proceedings of the 18th Annual Conference of the Association for Computer Aided Design in Architecture (ACADIA)

Journal of Clinical and Translational Science

OBJECTIVES/GOALS: Heart failure (HF) is a clinical condition that notably affects the lives of pa... more OBJECTIVES/GOALS: Heart failure (HF) is a clinical condition that notably affects the lives of patients in rural areas. The partnering of a rural satellite hospital with an urban academic medical center may provide geographically underrepresented populations with HF an opportunity to access controlled clinical trials (CCTs). METHODS/STUDY POPULATION: We report our experience in screening, consenting and enrolling subjects at the VCU Health Community Memorial Hospital (VCU-CMH) in rural South Hill, Virginia, that is part of the larger VCU Health network, with the lead institution being VCU Health Medical College of Virginia Hospitals (VCU-MCV), Richmond, VA. Subjects were enrolled in a clinical trial sponsored by the National Institutes of Health (ClinicalTrials.gov: NCT03797001) and assigned to treatment with an anti-inflammatory drug for HF or placebo. We used the electronic health record and remote guidance and oversight from the VCU-MCV resources using a closed-loop communication...

The University of Arizona's architectural education program utilizes the dual learning vehicles o... more The University of Arizona's architectural education program utilizes the dual learning vehicles of design-build pedagogy and affordable housing projects to investigate the cost effectiveness of regional vernacular construction methods paired with contemporary energy and water conservation strategies to control initial construction costs and long-term operational costs of single-family dwellings. Earth, clay and stone, indigenous building materials with long histories in the arid deserts of the southwestern U.S., have diminished in use as labor prices have risen in the construction industry. Over the course of six design-build projects, Building Technology faculty and students experimented with and improved wall forming systems for rammed earth and pumice-crete, in order to reduce labor costs and bring these vernacular materials into use for affordable housing. The focus of the applied field research was the design of the wall forms and the sequence of building multiple walls with bond beams. Students built full scale wall mock-ups, created budget and energy models, tackled critical path construction scheduling, and interacted with subcontractors, inspectors, and building permit officials during design and construction of the housing units. Our methods of earthen wall construction were refined over three main iterations and six projects, resulting in streamlined procedures, reduced construction time, and costs that were much lower than similar commercially built systems. The value of the design-build and research processes for students goes beyond exposure to the entire spectrum of housing design; the iterative investigations of wall forming systems across multiple projects teaches the value of Building Technology research and discovery through architectural practice.

Interview with Mary Hardin and Nancy Thomas

IN PROCESSIN

Fall 2014 Orientation and Testing

Journal of Clinical and Translational Science, 2021

Introduction: Controlled clinical trials (CCTs) have traditionally been limited to urban academic... more Introduction: Controlled clinical trials (CCTs) have traditionally been limited to urban academic clinical centers. Implementation of CCTs in rural setting is challenged by lack of resources, the inexperience of patient care team members in CCT conductance and workflow interruption, and global inexperience with remote data monitoring. Methods: We report our experience during the coronavirus disease 2019 (COVID-19) pandemic in activating through remote monitoring a multicenter clinical trial (the Study of Efficacy and Safety of Canakinumab Treatment for cytokine release syndrome (CRS) in Participants with COVID-19-induced Pneumonia [CAN-COVID] trial, ClinicalTrials.gov Identifier: NCT04362813) at a rural satellite hospital, the VCU Health Community Memorial Hospital (VCU-CMH) in South Hill, VA, that is part of the larger VCU Health network, with the lead institution being VCU Health Medical College of Virginia Hospital (VCU-MCV), Richmond, VA. We used the local resources at the facil...

JAMA, 2021

IMPORTANCE Effective treatments for patients with severe COVID-19 are needed. OBJECTIVE To evalua... more IMPORTANCE Effective treatments for patients with severe COVID-19 are needed. OBJECTIVE To evaluate the efficacy of canakinumab, an anti-interleukin-1β antibody, in patients hospitalized with severe COVID-19. DESIGN, SETTING, AND PARTICIPANTS This randomized, double-blind, placebo-controlled phase 3 trial was conducted at 39 hospitals in Europe and the United States. A total of 454 hospitalized patients with COVID-19 pneumonia, hypoxia (not requiring invasive mechanical ventilation [IMV]), and systemic hyperinflammation defined by increased blood concentrations of C-reactive protein or ferritin were enrolled between April 30 and August 17, 2020, with the last assessment of the primary end point on September 22, 2020. INTERVENTION Patients were randomly assigned 1:1 to receive a single intravenous infusion of canakinumab (450 mg for body weight of 40-<60 kg, 600 mg for 60-80 kg, and 750 mg for >80 kg; n = 227) or placebo (n = 227). MAIN OUTCOMES AND MEASURES The primary outcome was survival without IMV from day 3 to day 29. Secondary outcomes were COVID-19-related mortality, measurements of biomarkers of systemic hyperinflammation, and safety evaluations. RESULTS Among 454 patients who were randomized (median age, 59 years; 187 women [41.2%]), 417 (91.9%) completed day 29 of the trial. Between days 3 and 29, 198 of 223 patients (88.8%) survived without requiring IMV in the canakinumab group and 191 of 223 (85.7%) in the placebo group, with a rate difference of 3.1% (95% CI, −3.1% to 9.3%) and an odds ratio of 1.39 (95% CI, 0.76 to 2.54; P = .29). COVID-19-related mortality occurred in 11 of 223 patients (4.9%) in the canakinumab group vs 16 of 222 (7.2%) in the placebo group, with a rate difference of −2.3% (95% CI, −6.7% to 2.2%) and an odds ratio of 0.67 (95% CI, 0.30 to 1.50). Serious adverse events were observed in 36 of 225 patients (16%) treated with canakinumab vs 46 of 223 (20.6%) who received placebo. CONCLUSIONS AND RELEVANCE Among patients hospitalized with severe COVID-19, treatment with canakinumab, compared with placebo, did not significantly increase the likelihood of survival without IMV at day 29.

Technology|Architecture + Design, 2018

Nicotine staining of the hair and nails

Journal of the American Academy of Dermatology, 2015

CLINICAL CHALLENGE Patients are not always forthcoming about their tobacco use. Smoking and other... more CLINICAL CHALLENGE Patients are not always forthcoming about their tobacco use. Smoking and other forms of tobacco use have serious health consequences, and many dermatologic diseases and treatments are negatively affected by tobacco exposure. When a patient does not disclose their full tobacco history, the dermatologist can miss a valuable opportunity to counsel the patient on tobacco cessation. In addition, tobacco use assessment and tobacco cessation intervention are clinical quality measures for physicians to report for stage-1 meaningful use according to Medicare and Medicaid; therefore an accurate tobacco use history is needed for documentation in the electronic medical record.

ACM SIGGRAPH Computer Graphics, 1996

Beginning design students often find that it is difficult to master the varied and complex issues... more Beginning design students often find that it is difficult to master the varied and complex issues of architectural daylighting within a short timescale. Daylight is very dynamic and difficult to capture, and students struggle to document and understand daylighting phenomena through the traditional approaches of physical modeling, graphic techniques and computations. However, computer graphics and multimedia technologies are becoming widely used in educational applications and can facilitate non-linear, interactive learning environments particularly suited to complex concepts.An interactive multimedia courseware prototype, Daylight Visual Effects (DVE), has been designed to provide a demonstration database and easy-to-use interface for beginning design students. Users gain or enhance knowledge about the visual effects of daylighting by reviewing relevant daylighting images, written information animations and 3D computer models in the DVE's database. A live demonstration of the DV...

DDBC Residence one: Tucson, Arizona/2004: Casa de adobe y acero

Pasajes construcción, 2007

Información del artículo DDBC Residence one: Tucson, Arizona / 2004: Casa de adobe y acero.

JNCI Journal of the National Cancer Institute, 2009

Auto-Graphics Impact/ILL: A Tutorial

Journal of Interlibrary Loan, Document Delivery & Information Supply, 1999

BACKGROUND Oklahoma libraries have been thrust onto the highway to the Twenty-first century fast!... more BACKGROUND Oklahoma libraries have been thrust onto the highway to the Twenty-first century fast! In a year's time many of the libraries in Oklahoma went from having the Fax machine hidden unused in a storage closet to the next day moving around on the Internet ...

Journal of Green Building, 2006

The metropolitan area of Tucson, Arizona is a repository of traditions for dwelling in extreme co... more The metropolitan area of Tucson, Arizona is a repository of traditions for dwelling in extreme conditions, as well as an incubator for new ideas about desert architecture. It is also a place with a long history of poverty and struggle for existence against harsh natural elements. With these conditions in mind, the City of Tucson partnered with five non-profit housing providers to build on one avenue an array of affordable housing prototypes that demonstrate to the public a variety of building systems that work to stabilize interiors from the diurnal temperature swings through insulation or thermal mass. Beginning in 1997, local non-profit housing providers designed and constructed sixteen residences representing five different methods of building low cost housing that comfortably mitigates the summer heat and winter chill. The last of the residences was completed in 2003; all are currently inhabited and in constant use. This article proposes a comparison of the environmental control...

Journal of Communication Disorders, 1989

This study examined the relationship between receipt of adaptive seating devices (ASD) and sophis... more This study examined the relationship between receipt of adaptive seating devices (ASD) and sophistication of early vocalizations/verbalizations. Eight nonverbal children with cerebral palsy were studied prior to and following receipt of an ASD. Total speech tokens increased for 7 of the 8 subjects and diversity of speech sounds increased for 6 subjects. A concomitant improvement in feeding independence was observed for those subjects who demonstrated the greatest increase in speech sound diversity.

A New Breed of Online Specialty: The Remote Profiler

Online, 1978

Abstract: Authors share their experiences in training Oklahoma Teletype Interlibrary System/Oklah... more Abstract: Authors share their experiences in training Oklahoma Teletype Interlibrary System/Oklahoma Information Line (OTIS/OIL) personnel in the techniques of" profiling" searches during a one day workshop. Components of the workshop described are straight ...

Analysis of African American college students' perceptions of obesity and health risk behaviors

Abstract: Increases in overweight and obesity suggest that the transition between adolescence and... more Abstract: Increases in overweight and obesity suggest that the transition between adolescence and adulthood is frequently accompanied by dramatic and inappropriate weight gain. Research has shown that high obesity rates among college students will ...

The Cleft Palate-Craniofacial Journal, 1992

The Cleft Palate-Craniofacial Journal, 1991