Harish Reddy - Academia.edu (original) (raw)
Papers by Harish Reddy
Cureus
Artificial intelligence (AI) techniques have the potential to revolutionize drug release modeling... more Artificial intelligence (AI) techniques have the potential to revolutionize drug release modeling, optimize therapy for personalized medicine, and minimize side effects. By applying AI algorithms, researchers can predict drug release profiles, incorporate patient-specific factors, and optimize dosage regimens to achieve tailored and effective therapies. This AI-based approach has the potential to improve treatment outcomes, enhance patient satisfaction, and advance the field of pharmaceutical sciences. International collaborations and professional organizations play vital roles in establishing guidelines and best practices for data collection and sharing. Open data initiatives can enhance transparency and scientific progress, facilitating algorithm validation.
Body Mass Index - Overweight, Normal Weight, Underweight [Working Title]
Leptin, a hormone produced by fat cells, regulates energy balance and body weight by suppressing ... more Leptin, a hormone produced by fat cells, regulates energy balance and body weight by suppressing appetite and increasing energy expenditure. In obesity, there is often leptin resistance, reducing the hormone’s effects due to factors such as inflammation and changes in leptin receptors. This resistance leads to an increased risk of weight gain and obesity. Leptin therapy shows promise in treating obesity and related metabolic disorders, such as dyslipidemia and type 2 diabetes mellitus. It can lower body weight, improve insulin sensitivity, and reduce blood glucose and lipid levels. However, its effectiveness may be limited by the development of leptin resistance. Leptin also exhibits anti-inflammatory and cardiovascular protective effects, with potential therapeutic value for obesity-related conditions. Nevertheless, further research is necessary to comprehend leptin’s mechanisms and develop safe and effective therapies for these conditions, including those targeting dyslipidemia.
JOURNAL OF CLINICAL AND BIOMEDICAL SCIENCES
Harmonization of laboratory testing refers to ability to achieve the same result, within clinical... more Harmonization of laboratory testing refers to ability to achieve the same result, within clinically acceptable limits and the same interpretation irrespective of the measurement procedure used, the unit or reference interval applied, and when and/or where a measurement made is in agreement. 1 The purpose of harmonizing laboratory data is to enhance patient care quality, leading to better patient outcomes and safety. Initiatives for harmonization and standardization have primarily concentrated on analytical processes carried out within the laboratories, particularly clinical chemistry testing. 2
JOURNAL OF CLINICAL AND BIOMEDICAL SCIENCES
JOURNAL OF CLINICAL AND DIAGNOSTIC RESEARCH
International Journal of Biomedicine
The emergence of oxidized low-density lipoprotein (OxLDL) is crucial for the progression of cardi... more The emergence of oxidized low-density lipoprotein (OxLDL) is crucial for the progression of cardiovascular diseases (CVD) linked to atherosclerosis. OxLDL stimulates endothelial activation and smooth muscle proliferation and has an atherosclerotic-promoting effect. The measurement of OxLDL correlates with the presence of CVD and may be a prognostic marker for future health outcomes. Circulating OxLDLs can be used as biomarkers since their levels rise in patients with advanced atherosclerosis. Immunological methods have proven to be very useful methodologies. Anti-OxLDL monoclonal antibodies have been developed that bind strongly to OxLDL and are used in ELISA for OxLDL measurements. Routine inclusion of OxLDL estimation in an at-risk population can help the clinicians understand the disease initiation and progression and improve early intervention and management.
JOURNAL OF CLINICAL AND DIAGNOSTIC RESEARCH, 2021
Introduction: Variability in the levels of these trace elements may reflect altered insulin metab... more Introduction: Variability in the levels of these trace elements may reflect altered insulin metabolism and poor glycaemic control in the background of elevated oxidative stress. Mineral metabolism is another entity that may be disrupted by diabetes mellitus. Conversely, there are studies implicating early imbalances of trace elements in upsetting glucose homeostasis and insulin metabolism. Aim: To estimate and compare serum zinc, copper and magnesium in Type 2 Diabetes Mellitus (DM) patients with non diabetic controls and to correlate the serum zinc, copper and magnesium with Glycated Haemoglobin levels in Type 2 DM. Materials and Methods: This cross-sectional study was conducted at the Sapthagiri Institute of Medical Sciences and Research Center, Bengaluru, Karnataka, India. The study included 30 Type 2 DM patients and 30 healthy, age and gender matched controls without Type 2 DM. Their serum levels of zinc, copper and magnesium were measured and compared. Statistical Package for t...
Journal of Biomedical and Pharmaceutical Research, 2020
Background and aim: Hyperuricemia is common in individuals with obesity, metabolic syndrome and t... more Background and aim: Hyperuricemia is common in individuals with obesity, metabolic syndrome and type 2 diabetes mellitus. This has been attributed to the hyperinsulinemia due to insulin resistance in T2DM and it’s effect on the renal excretion of uric acid. There have been recent studies depicting that hyperuricemia may independently predict the development of diabetes. However, there are conflicting studies of hypouricemia in T2DM as well which may be due to increased glomerular filtration rate with increased renal clearance of uric acid. In order to add further evidence to the existing database of knowledge about uric acid metabolism in T2DM this study was carried out. Material and Methods: This cross sectional study and the subjects were selected according to inclusion and exclusion criteria. Data recorded included serum uric acid, HbA1c, fasting and post prandial plasma glucose, serum creatinine, fasting lipid profile and waist hip ratio. Results: The mean value of serum uric ac...
Medical education in India is challenging and can impose a significant quantum of psychological s... more Medical education in India is challenging and can impose a significant quantum of psychological stress on undergraduates. The various contributors of perceived stress among medical students like the excessive workload and educational content, combined with high level of educational demands, a lack of time for leisure, family & friends, studying for residency, choice of specialty, and delayed income have been studied. However, the health effects of commuting have been surprisingly not elaborated upon at all in case of Indian medical students. There should be efforts to understand the complex interactions of medical education and commuting of students during pandemic with a planning to increase awareness of physical distancing, use of sanitizer and face mask among the general population as well as
Background and Aim: Glycated hemoglobin is a form of hemoglobin used primarily to identify the av... more Background and Aim: Glycated hemoglobin is a form of hemoglobin used primarily to identify the average plasma glucose concentration over prolonged periods of time. In a developing country like India there are quite a few resource poor settings where HbA1c is not available. In such circumstances, a mathematical tool like calculated HbA1c would have some advantages over true estimation of HbA1c. This study was carried out to explore the feasibility of using such a formula to calculate HbA1c and compare with the plasma fasting and post prandial glucose levels, measured HbA1c; also to correlate with estimated average blood glucose (eAG) assessed from estimated HbA1c. Materials and Methods: This is a cross sectional study where 50 type 2 diabetes mellitus patients and 50 healthy controls were enrolled. Blood work up done for fasting plasma glucose (FBS), postprandial glucose (PPBS) and HbA1c. Results: The mean±SD levels of estimated HbA1c are 7.574±1.52% and calculated HbA1c 7.540± 2.29%...
International Journal of Reproduction, Contraception, Obstetrics and Gynecology, 2021
Preeclampsia is one of the common complications of pregnancy and associated with elevated leptin ... more Preeclampsia is one of the common complications of pregnancy and associated with elevated leptin concentrations. In this review the potential sources of leptin are explored and the factors that contribute to maternal increased concentrations of leptin include obesity, insulin resistance and hypoxia. Further research is warranted to understand the role of leptin in pathogenesis of preeclampsia.
Journal of Cancer Research and Therapeutics, 2014
To estimate serum lipid profile in oral squamous cell carcinoma and correlate the risk factors an... more To estimate serum lipid profile in oral squamous cell carcinoma and correlate the risk factors and lipid profile with oral squamous cell carcinoma. Lipid profile was done in agriculturists/laborers in the age group of 30-70 years; 56 subjects (cases = 28, control = 28) were included. Study was carried out for a duration of four months; statistical analyses applied were mean, standard deviation, and independent 't' test. P < 0.05 was considered statistically significant. Eleven cases had buccal mucosa cancer, nine had tongue carcinoma, and eight had gingivobuccal sulcus carcinoma. Lipid profile such as total cholesterol, triglycerides, LDL cholesterol, non-high-density lipoprotein (non-HDL) cholesterol, and very-low-density lipoprotein (VLDL) were marginally and slightly elevated in cases compared to controls. HDL was grossly decreased in cases compared to controls. There was a significant association between HDL and squamous cell carcinoma; maximum number of SCC had a history of smoking in the range of 10-19 years, irrespective of other lipid parameters, constrained to the fact that lipids are genetically determined, have geographical variation, and are highly skewed.
Introduction: Snake bite is a significant cause of mortality and morbidity in tropical and sub-tr... more Introduction: Snake bite is a significant cause of mortality and morbidity in tropical and sub-tropical countries. Snake venom is a complex mixture containing peptides, polypeptides, enzymes, glycoproteins and other substances which have pharmacological properties. It mainly affects the vital organ systems such as the cardiovascular, nervous, renal and respiratory systems. Studies have shown that following the bite krait snake, patients suffer from hypokalemia and sink into coma. However, no clear conclusive result has been arrived at in studies conducted in rural Kolar district. Objective: To explore the biochemical changes with respect to renal disturbances in snake bites. Methodology: This is a hospital based observational study since these parameters were studied after the snake bite and at the time of admission; data was collected from our hospital records and includes the measured values of blood urea, serum creatinine, serum sodium and potassium levels, bleeding time and clot...
Cureus
Artificial intelligence (AI) techniques have the potential to revolutionize drug release modeling... more Artificial intelligence (AI) techniques have the potential to revolutionize drug release modeling, optimize therapy for personalized medicine, and minimize side effects. By applying AI algorithms, researchers can predict drug release profiles, incorporate patient-specific factors, and optimize dosage regimens to achieve tailored and effective therapies. This AI-based approach has the potential to improve treatment outcomes, enhance patient satisfaction, and advance the field of pharmaceutical sciences. International collaborations and professional organizations play vital roles in establishing guidelines and best practices for data collection and sharing. Open data initiatives can enhance transparency and scientific progress, facilitating algorithm validation.
Body Mass Index - Overweight, Normal Weight, Underweight [Working Title]
Leptin, a hormone produced by fat cells, regulates energy balance and body weight by suppressing ... more Leptin, a hormone produced by fat cells, regulates energy balance and body weight by suppressing appetite and increasing energy expenditure. In obesity, there is often leptin resistance, reducing the hormone’s effects due to factors such as inflammation and changes in leptin receptors. This resistance leads to an increased risk of weight gain and obesity. Leptin therapy shows promise in treating obesity and related metabolic disorders, such as dyslipidemia and type 2 diabetes mellitus. It can lower body weight, improve insulin sensitivity, and reduce blood glucose and lipid levels. However, its effectiveness may be limited by the development of leptin resistance. Leptin also exhibits anti-inflammatory and cardiovascular protective effects, with potential therapeutic value for obesity-related conditions. Nevertheless, further research is necessary to comprehend leptin’s mechanisms and develop safe and effective therapies for these conditions, including those targeting dyslipidemia.
JOURNAL OF CLINICAL AND BIOMEDICAL SCIENCES
Harmonization of laboratory testing refers to ability to achieve the same result, within clinical... more Harmonization of laboratory testing refers to ability to achieve the same result, within clinically acceptable limits and the same interpretation irrespective of the measurement procedure used, the unit or reference interval applied, and when and/or where a measurement made is in agreement. 1 The purpose of harmonizing laboratory data is to enhance patient care quality, leading to better patient outcomes and safety. Initiatives for harmonization and standardization have primarily concentrated on analytical processes carried out within the laboratories, particularly clinical chemistry testing. 2
JOURNAL OF CLINICAL AND BIOMEDICAL SCIENCES
JOURNAL OF CLINICAL AND DIAGNOSTIC RESEARCH
International Journal of Biomedicine
The emergence of oxidized low-density lipoprotein (OxLDL) is crucial for the progression of cardi... more The emergence of oxidized low-density lipoprotein (OxLDL) is crucial for the progression of cardiovascular diseases (CVD) linked to atherosclerosis. OxLDL stimulates endothelial activation and smooth muscle proliferation and has an atherosclerotic-promoting effect. The measurement of OxLDL correlates with the presence of CVD and may be a prognostic marker for future health outcomes. Circulating OxLDLs can be used as biomarkers since their levels rise in patients with advanced atherosclerosis. Immunological methods have proven to be very useful methodologies. Anti-OxLDL monoclonal antibodies have been developed that bind strongly to OxLDL and are used in ELISA for OxLDL measurements. Routine inclusion of OxLDL estimation in an at-risk population can help the clinicians understand the disease initiation and progression and improve early intervention and management.
JOURNAL OF CLINICAL AND DIAGNOSTIC RESEARCH, 2021
Introduction: Variability in the levels of these trace elements may reflect altered insulin metab... more Introduction: Variability in the levels of these trace elements may reflect altered insulin metabolism and poor glycaemic control in the background of elevated oxidative stress. Mineral metabolism is another entity that may be disrupted by diabetes mellitus. Conversely, there are studies implicating early imbalances of trace elements in upsetting glucose homeostasis and insulin metabolism. Aim: To estimate and compare serum zinc, copper and magnesium in Type 2 Diabetes Mellitus (DM) patients with non diabetic controls and to correlate the serum zinc, copper and magnesium with Glycated Haemoglobin levels in Type 2 DM. Materials and Methods: This cross-sectional study was conducted at the Sapthagiri Institute of Medical Sciences and Research Center, Bengaluru, Karnataka, India. The study included 30 Type 2 DM patients and 30 healthy, age and gender matched controls without Type 2 DM. Their serum levels of zinc, copper and magnesium were measured and compared. Statistical Package for t...
Journal of Biomedical and Pharmaceutical Research, 2020
Background and aim: Hyperuricemia is common in individuals with obesity, metabolic syndrome and t... more Background and aim: Hyperuricemia is common in individuals with obesity, metabolic syndrome and type 2 diabetes mellitus. This has been attributed to the hyperinsulinemia due to insulin resistance in T2DM and it’s effect on the renal excretion of uric acid. There have been recent studies depicting that hyperuricemia may independently predict the development of diabetes. However, there are conflicting studies of hypouricemia in T2DM as well which may be due to increased glomerular filtration rate with increased renal clearance of uric acid. In order to add further evidence to the existing database of knowledge about uric acid metabolism in T2DM this study was carried out. Material and Methods: This cross sectional study and the subjects were selected according to inclusion and exclusion criteria. Data recorded included serum uric acid, HbA1c, fasting and post prandial plasma glucose, serum creatinine, fasting lipid profile and waist hip ratio. Results: The mean value of serum uric ac...
Medical education in India is challenging and can impose a significant quantum of psychological s... more Medical education in India is challenging and can impose a significant quantum of psychological stress on undergraduates. The various contributors of perceived stress among medical students like the excessive workload and educational content, combined with high level of educational demands, a lack of time for leisure, family & friends, studying for residency, choice of specialty, and delayed income have been studied. However, the health effects of commuting have been surprisingly not elaborated upon at all in case of Indian medical students. There should be efforts to understand the complex interactions of medical education and commuting of students during pandemic with a planning to increase awareness of physical distancing, use of sanitizer and face mask among the general population as well as
Background and Aim: Glycated hemoglobin is a form of hemoglobin used primarily to identify the av... more Background and Aim: Glycated hemoglobin is a form of hemoglobin used primarily to identify the average plasma glucose concentration over prolonged periods of time. In a developing country like India there are quite a few resource poor settings where HbA1c is not available. In such circumstances, a mathematical tool like calculated HbA1c would have some advantages over true estimation of HbA1c. This study was carried out to explore the feasibility of using such a formula to calculate HbA1c and compare with the plasma fasting and post prandial glucose levels, measured HbA1c; also to correlate with estimated average blood glucose (eAG) assessed from estimated HbA1c. Materials and Methods: This is a cross sectional study where 50 type 2 diabetes mellitus patients and 50 healthy controls were enrolled. Blood work up done for fasting plasma glucose (FBS), postprandial glucose (PPBS) and HbA1c. Results: The mean±SD levels of estimated HbA1c are 7.574±1.52% and calculated HbA1c 7.540± 2.29%...
International Journal of Reproduction, Contraception, Obstetrics and Gynecology, 2021
Preeclampsia is one of the common complications of pregnancy and associated with elevated leptin ... more Preeclampsia is one of the common complications of pregnancy and associated with elevated leptin concentrations. In this review the potential sources of leptin are explored and the factors that contribute to maternal increased concentrations of leptin include obesity, insulin resistance and hypoxia. Further research is warranted to understand the role of leptin in pathogenesis of preeclampsia.
Journal of Cancer Research and Therapeutics, 2014
To estimate serum lipid profile in oral squamous cell carcinoma and correlate the risk factors an... more To estimate serum lipid profile in oral squamous cell carcinoma and correlate the risk factors and lipid profile with oral squamous cell carcinoma. Lipid profile was done in agriculturists/laborers in the age group of 30-70 years; 56 subjects (cases = 28, control = 28) were included. Study was carried out for a duration of four months; statistical analyses applied were mean, standard deviation, and independent 't' test. P < 0.05 was considered statistically significant. Eleven cases had buccal mucosa cancer, nine had tongue carcinoma, and eight had gingivobuccal sulcus carcinoma. Lipid profile such as total cholesterol, triglycerides, LDL cholesterol, non-high-density lipoprotein (non-HDL) cholesterol, and very-low-density lipoprotein (VLDL) were marginally and slightly elevated in cases compared to controls. HDL was grossly decreased in cases compared to controls. There was a significant association between HDL and squamous cell carcinoma; maximum number of SCC had a history of smoking in the range of 10-19 years, irrespective of other lipid parameters, constrained to the fact that lipids are genetically determined, have geographical variation, and are highly skewed.
Introduction: Snake bite is a significant cause of mortality and morbidity in tropical and sub-tr... more Introduction: Snake bite is a significant cause of mortality and morbidity in tropical and sub-tropical countries. Snake venom is a complex mixture containing peptides, polypeptides, enzymes, glycoproteins and other substances which have pharmacological properties. It mainly affects the vital organ systems such as the cardiovascular, nervous, renal and respiratory systems. Studies have shown that following the bite krait snake, patients suffer from hypokalemia and sink into coma. However, no clear conclusive result has been arrived at in studies conducted in rural Kolar district. Objective: To explore the biochemical changes with respect to renal disturbances in snake bites. Methodology: This is a hospital based observational study since these parameters were studied after the snake bite and at the time of admission; data was collected from our hospital records and includes the measured values of blood urea, serum creatinine, serum sodium and potassium levels, bleeding time and clot...