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Recent fossil shell mining for a new rail line in the Orlando area of Orange County, Florida has ... more Recent fossil shell mining for a new rail line in the Orlando area of Orange County, Florida has uncovered two species of the ellobioid genus Carychium O. F. Müller, 1773 in a bed of freshwater marl from the Lower Pleistocene Nashua Formation. To taxonomically interpret these finds, the well-preserved shells were imaged via high-resolution X-ray tomography (micro-CT) to view significant internal diagnostic characters such as the columellar configuration and the degree of lamellar sinuosity and their relationship in context to the entire shell. The image data are compared to that of type material and extant and fossil Carychium species inhabiting the SE USA, Mexico, Central America, and Jamaica. Based on these results, the species Carychium floridanum G. H. Clapp, 1918 and Carychium nashuaensesp. nov. are identified from fossil shells dating from the Early Pleistocene. This work documents the first fossil members of C. floridanum and the first fossil Carychium from the SE USA.
Bulletin of Zoological Nomenclature, 2007
Bulletin of the World Health Organization, 1971
The effectiveness of chemotherapy in human schistosomiasis varies from one area to another, and l... more The effectiveness of chemotherapy in human schistosomiasis varies from one area to another, and limited data from experimentally infected animals suggest inherent differences in the susceptibility of certain parasites to drugs. In the present study, groups of mice infected with each of several geographic strains of Schistosoma mansoni were treated with one of four selected drugs and parasiticidal effects were compared.Responses to treatment were generally similar among strains except in two trials involving a Puerto Rican strain that was unusually sensitive to hycanthone and relatively resistant to stibophen.Selective killing of male worms occurred consistently with lucanthone and hycanthone treatment. The use of portal perfusion rather than dissection to recover surviving worms appears to have been instrumental in allowing the relatively resistant female worms to be found, namely in the liver.The results of this study indicate that strain differences in susceptibility to drugs do o...
ZooKeys
Recent fossil shell mining for a new rail line in the Orlando area of Orange County, Florida has ... more Recent fossil shell mining for a new rail line in the Orlando area of Orange County, Florida has uncovered two species of the ellobioid genus Carychium O. F. Müller, 1773 in a bed of freshwater marl from the Lower Pleistocene Nashua Formation. To taxonomically interpret these finds, the well-preserved shells were imaged via high-resolution X-ray tomography (micro-CT) to view significant internal diagnostic characters such as the columellar configuration and the degree of lamellar sinuosity and their relationship in context to the entire shell. The image data are compared to that of type material and extant and fossil Carychium species inhabiting the SE USA, Mexico, Central America, and Jamaica. Based on these results, the species Carychium floridanum G. H. Clapp, 1918 and Carychium nashuaensesp. nov. are identified from fossil shells dating from the Early Pleistocene. This work documents the first fossil members of C. floridanum and the first fossil Carychium from the SE USA.
Bulletin of Zoological Nomenclature, 2007
Bulletin of the World Health Organization, 1971
The effectiveness of chemotherapy in human schistosomiasis varies from one area to another, and l... more The effectiveness of chemotherapy in human schistosomiasis varies from one area to another, and limited data from experimentally infected animals suggest inherent differences in the susceptibility of certain parasites to drugs. In the present study, groups of mice infected with each of several geographic strains of Schistosoma mansoni were treated with one of four selected drugs and parasiticidal effects were compared.Responses to treatment were generally similar among strains except in two trials involving a Puerto Rican strain that was unusually sensitive to hycanthone and relatively resistant to stibophen.Selective killing of male worms occurred consistently with lucanthone and hycanthone treatment. The use of portal perfusion rather than dissection to recover surviving worms appears to have been instrumental in allowing the relatively resistant female worms to be found, namely in the liver.The results of this study indicate that strain differences in susceptibility to drugs do o...