Harun Toy - Academia.edu (original) (raw)

Papers by Harun Toy

Research paper thumbnail of Assessment of serum paraoxonase and arylesterase activities in early pregnancy failure

Swiss Medical Weekly Official Journal of the Swiss Society of Infectious Diseases the Swiss Society of Internal Medicine the Swiss Society of Pneumology, Feb 7, 2009

QUESTIONS UNDER STUDY: Paraoxonase-1 (PON1) is an HDL-bound enzyme system which plays a key role ... more QUESTIONS UNDER STUDY: Paraoxonase-1 (PON1) is an HDL-bound enzyme system which plays a key role in the protection of LDL and HDL from oxidation by hydrolysing activated phospholipids and lipid peroxide products. Oxidative stress has been involved in the pathogenesis of many complications of human pregnancy, including early pregnancy failure (EPF), preeclampsia and preterm labour. The purpose of this study was to determine serum paraoxonase/arylesterase activities and lipid hydroperoxide (LOOH) levels as an oxidative stress indicator in women with EPF.METHOD: Paraoxonase/arylesterase activities and LOOH levels were assessed in women with EPF (n = 40) and healthy continuum pregnant women without EPF (n = 38) before 12 weeks' gestation. Serum basal and salt-stimulated paraoxonase/arylesterase activities were measured spectrophotometrically. LOOH levels were measured by ferrous oxidation with a xylenol orange assay. Student's t-test and the Pearson correlation were used for statistical analysis.RESULTS: We found that basal and salt-stimulated paraoxonase/arylesterase activities were significantly lower in women with EPF than in women without EPF (all p <0.05), while LOOH levels were significantly higher (p = 0.009).CONCLUSION: Our study showed that decreased paraoxonase/arylesterase activities and increased LOOH levels may play a role in ethiopathogenesis through increased susceptibility to lipid peroxidation in women with EPF.

Research paper thumbnail of Attention Deficit Hyperactivity Disorder Symptoms in Women with Polycystic Ovary Syndrome

The International Journal of Psychiatry in Medicine

ABSTRACT

Research paper thumbnail of Assessment of serum paraoxonase and arylesterase activity in patients with endometrial cancer

European journal of gynaecological oncology, 2009

Serum paraoxonase (PON 1) is one of the most important enzymatic antioxidants that hydrolyzes lip... more Serum paraoxonase (PON 1) is one of the most important enzymatic antioxidants that hydrolyzes lipid peroxidation, an indicator of carcinogenic activity. The aim of this study was to compare the serum levels of paraoxonase and arylesterase activity in patients with endometrial cancer to those of healthy controls. Serum paraoxonase and arylesterase activities, total free sulphydryl (-SH) groups and lipid hydroperoxide (LOOH) levels were measured in patients with endometrial cancer (n = 20) and controls (n = 23). Serum paraoxonase, arylesterase activities and total -SH group levels were significantly lower in patients compared to controls (p < 0.05, p < 0.05 and p < 0.001; respectively), while LOOH levels were significantly higher (p < 0.001). Among patients, serum paraoxonase and arylesterase activities were inversely correlated with LOOH levels (r = -0.680, p < 0.05; r = -0.708, p < 0.001; respectively), while these were positively correlated with the total -SH grou...

Research paper thumbnail of Polikistik Over Sendromu olan Kadınlarda Psikiyatrik Belirtiler / Psychiatric Symptoms in Women with Polycystic Ovary Syndrome

Dusunen Adam: The Journal of Psychiatry and Neurological Sciences, 2013

Research paper thumbnail of Decreased Paraoxonase and Arylesterase Activities in the Pathogenesis of Future Atherosclerotic Heart Disease in Women with Gestational Diabetes Mellitus

Journal of Women's Health, 2009

The aim of this study was to investigate serum paraoxonase, arlyesterase activities, and lipid hy... more The aim of this study was to investigate serum paraoxonase, arlyesterase activities, and lipid hydroperoxide (LOOH) levels in patients with gestational diabetes mellitus (GDM). Paraoxonase and arylesterase activities, and LOOH levels were assessed for GDM cases (n = 55) and controls (n = 59). Serum basal and salt-stimulated paraoxonase and arylesterase activities were measured spectrophotometrically. LOOH levels were measured by ferrous oxidation with a xylenol orange assay. Basal and salt-stimulated paraoxonase and arylesterase activities were significantly lower (p = 0.002, p = 0.004; and p = 0.013, respectively) in patients with GDM compared to controls, while LOOH levels were significantly higher (p &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt; 0.001). Among gestational diabetes patients, serum paraoxonase and arylesterase activities were inversely correlated with LOOH levels (r = - 0.390, p = 0.003; and r = - 0.287, p = 0.034, respectively). Findings of the present study have shown that serum paraoxonase and arylesterase activities are significantly reduced in women with GDM. Decreased serum paraoxonase and arylesterase activities might play a role in the potential early pathogenesis for atherosclerotic heart disease in GDM beyond their antioxidant properties.

Research paper thumbnail of A Rare Cause of Difficulty with Sexual Intercourse: Large Retroperitoneal Leiomyoma

Journal of Sexual Medicine, 2009

Research paper thumbnail of Serum prolidase activity and oxidative stress markers in pregnancies with intrauterine growth restricted infants

Journal of Obstetrics and Gynaecology Research, 2009

To compare the levels of serum prolidase activity and oxidative stress markers, including total o... more To compare the levels of serum prolidase activity and oxidative stress markers, including total oxidative status (TOS), total antioxidant capacity (TAC), oxidative stress index (OSI), and total free sulfhydryl (-SH) in healthy pregnant women and pregnant women with intrauterine growth restricted infants. Methods: Serum samples were obtained from 18 healthy third trimester pregnancies and 14 pregnancies complicated by fetal growth restriction (FGR). The criteria for FGR were clinical evidence of suboptimal growth, ultrasonographic demonstration of deviation from normal percentiles of growth, and birthweight under the 10th percentile. We spectrophotometrically measured serum prolidase activity, TAC, TOS, and -SH levels. Oxidative stress was determined from total antioxidant capacity and total oxidant status measurement and calculation of the oxidative stress index. Results: Serum TAC and -SH levels were significantly lower in the FGR group than in the healthy control group (P = 0.001, P < 0.001, respectively), whereas TOS level, OSI value, and prolidase activity were significantly higher (P = 0.003, P < 0.001, P < 0.001, respectively). Prolidase activity was positively correlated with TOS and OSI values (rho = 0.552, P = 0.041 and rho = 0.635, P = 0.015, respectively) and negatively correlated with TAC and -SH levels (rho = -0.578, P = 0.030 and rho = -0.622, P = 0.018, respectively).

Research paper thumbnail of Decreased Serum Prolidase Activity and Increased Oxidative Stress in Early Pregnancy Loss

Gynecologic and Obstetric Investigation, 2010

To compare the levels of serum prolidase activity and oxidative stress markers including total ox... more To compare the levels of serum prolidase activity and oxidative stress markers including total oxidative status (TOS), total antioxidant capacity (TAC), lipid hydroperoxide (LOOH) and total free sulfhydryl (-SH) in healthy pregnant women without early pregnancy loss (EPL) and women with EPL. Serum samples were obtained from 45 healthy first-trimester pregnancies and 45 pregnancies complicated with EPL. We have measured serum prolidase activity, TAC, TOS, -SH and LOOH levels spectrophotometrically. Serum prolidase, TAC and -SH levels were significantly lower in the women with EPL than in the women without EPL (p &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt;0.001, p = 0.001, p &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt; 0.001, respectively), whereas TOS and LOOH levels were significantly higher (p &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt; 0.001, p = 0.004, respectively). Prolidase activity was negatively correlated with TOS and LOOH levels (r = -0.299, p = 0.004; r = -0.323, p = 0.002, respectively), while positively correlated with TAC and -SH levels (r = 0.232, p = 0.028, and r = 0.418, p &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt;0.001, respectively) Findings of this study have shown that serum prolidase activity and oxidative stress are significantly associated with the presence of EPL, and the correlation between serum prolidase activity and the markers of oxidative stress was reflected in increased serum TOS and LOOH levels and decreased serum TAC and -SH levels.

Research paper thumbnail of O-19 - Attention deficit hyperactivity disorder in women with polycystic ovary syndrome

European Psychiatry, 2012

ABSTRACT

Research paper thumbnail of Assessment of preoperative serum prolidase activity in epithelial ovarian cancer

European Journal of Obstetrics & Gynecology and Reproductive Biology, 2009

Prolidase is a cytosolic exopeptidase that cleaves iminodipeptides with C-terminal proline and hy... more Prolidase is a cytosolic exopeptidase that cleaves iminodipeptides with C-terminal proline and hydroxyproline and plays a major role in collagen turnover. The aim of this study was to evaluate preoperative serum prolidase activity, total oxidant status (TOS), and total antioxidant capacity (TAC) in patients with newly diagnosed epithelial ovarian cancer (EOC). Serum prolidase activity, TOS, and TAC were measured spectrophotometrically in both EOC cases (n=28) and controls (n=28). Preoperative serum prolidase activity and TOS were significantly higher in patients with EOC compared to controls (p=0.009 and 0.008, respectively), whereas TAC was significantly lower in cases (p&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt;0.001). A significant positive correlation was found between the stage, grade, and CA-125 level of EOC and serum prolidase activity (rho=0.466, p=0.012; rho=0.501, p=0.007; and rho=0.447, p=0.017, respectively) and TOS (rho=0.588, p=0.001; rho=0.412, p=0.029; and rho=0.568, p=0.002, respectively). In contrast, there was a negative correlation between TAC and the stage, grade, and CA-125 level of EOC (rho=-0.555, p=0.002; rho=-0.566, p=0.002; and rho=-0.581, p=0.001, respectively). Findings of the present study demonstrate that serum prolidase activity is significantly associated with the stage, tumor grade, and preoperative CA-125 level of EOC.

Research paper thumbnail of Serum prolidase activity and oxidative status in Helicobacter pylori infection

Clinical Biochemistry, 2007

During the course of Helicobacter pylori infection, increased oxidative stress plays an important... more During the course of Helicobacter pylori infection, increased oxidative stress plays an important role in the pathogenesis of gastroduodenal mucosal inflammation, which can cause gastric mucosal atrophy that characterized by the replacement of the gastric mucosal glands by collagen ...

Research paper thumbnail of Serum paraoxonase and arylesterase activities in patients with lung cancer in a Turkish population

Research paper thumbnail of Attention deficit hyperactivity disorder symptom self-report among medical students in Eldoret, Kenya

African Journal of Psychiatry, 2011

Research paper thumbnail of Autistic traits in women with polycystic ovary syndrome

Research in Autism Spectrum Disorders, 2012

Research paper thumbnail of Assessment of serum paraoxonase and arylesterase activities in early pregnancy failure

Swiss Medical Weekly Official Journal of the Swiss Society of Infectious Diseases the Swiss Society of Internal Medicine the Swiss Society of Pneumology, Feb 7, 2009

QUESTIONS UNDER STUDY: Paraoxonase-1 (PON1) is an HDL-bound enzyme system which plays a key role ... more QUESTIONS UNDER STUDY: Paraoxonase-1 (PON1) is an HDL-bound enzyme system which plays a key role in the protection of LDL and HDL from oxidation by hydrolysing activated phospholipids and lipid peroxide products. Oxidative stress has been involved in the pathogenesis of many complications of human pregnancy, including early pregnancy failure (EPF), preeclampsia and preterm labour. The purpose of this study was to determine serum paraoxonase/arylesterase activities and lipid hydroperoxide (LOOH) levels as an oxidative stress indicator in women with EPF.METHOD: Paraoxonase/arylesterase activities and LOOH levels were assessed in women with EPF (n = 40) and healthy continuum pregnant women without EPF (n = 38) before 12 weeks' gestation. Serum basal and salt-stimulated paraoxonase/arylesterase activities were measured spectrophotometrically. LOOH levels were measured by ferrous oxidation with a xylenol orange assay. Student's t-test and the Pearson correlation were used for statistical analysis.RESULTS: We found that basal and salt-stimulated paraoxonase/arylesterase activities were significantly lower in women with EPF than in women without EPF (all p <0.05), while LOOH levels were significantly higher (p = 0.009).CONCLUSION: Our study showed that decreased paraoxonase/arylesterase activities and increased LOOH levels may play a role in ethiopathogenesis through increased susceptibility to lipid peroxidation in women with EPF.

Research paper thumbnail of Attention Deficit Hyperactivity Disorder Symptoms in Women with Polycystic Ovary Syndrome

The International Journal of Psychiatry in Medicine

ABSTRACT

Research paper thumbnail of Assessment of serum paraoxonase and arylesterase activity in patients with endometrial cancer

European journal of gynaecological oncology, 2009

Serum paraoxonase (PON 1) is one of the most important enzymatic antioxidants that hydrolyzes lip... more Serum paraoxonase (PON 1) is one of the most important enzymatic antioxidants that hydrolyzes lipid peroxidation, an indicator of carcinogenic activity. The aim of this study was to compare the serum levels of paraoxonase and arylesterase activity in patients with endometrial cancer to those of healthy controls. Serum paraoxonase and arylesterase activities, total free sulphydryl (-SH) groups and lipid hydroperoxide (LOOH) levels were measured in patients with endometrial cancer (n = 20) and controls (n = 23). Serum paraoxonase, arylesterase activities and total -SH group levels were significantly lower in patients compared to controls (p < 0.05, p < 0.05 and p < 0.001; respectively), while LOOH levels were significantly higher (p < 0.001). Among patients, serum paraoxonase and arylesterase activities were inversely correlated with LOOH levels (r = -0.680, p < 0.05; r = -0.708, p < 0.001; respectively), while these were positively correlated with the total -SH grou...

Research paper thumbnail of Polikistik Over Sendromu olan Kadınlarda Psikiyatrik Belirtiler / Psychiatric Symptoms in Women with Polycystic Ovary Syndrome

Dusunen Adam: The Journal of Psychiatry and Neurological Sciences, 2013

Research paper thumbnail of Decreased Paraoxonase and Arylesterase Activities in the Pathogenesis of Future Atherosclerotic Heart Disease in Women with Gestational Diabetes Mellitus

Journal of Women's Health, 2009

The aim of this study was to investigate serum paraoxonase, arlyesterase activities, and lipid hy... more The aim of this study was to investigate serum paraoxonase, arlyesterase activities, and lipid hydroperoxide (LOOH) levels in patients with gestational diabetes mellitus (GDM). Paraoxonase and arylesterase activities, and LOOH levels were assessed for GDM cases (n = 55) and controls (n = 59). Serum basal and salt-stimulated paraoxonase and arylesterase activities were measured spectrophotometrically. LOOH levels were measured by ferrous oxidation with a xylenol orange assay. Basal and salt-stimulated paraoxonase and arylesterase activities were significantly lower (p = 0.002, p = 0.004; and p = 0.013, respectively) in patients with GDM compared to controls, while LOOH levels were significantly higher (p &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt; 0.001). Among gestational diabetes patients, serum paraoxonase and arylesterase activities were inversely correlated with LOOH levels (r = - 0.390, p = 0.003; and r = - 0.287, p = 0.034, respectively). Findings of the present study have shown that serum paraoxonase and arylesterase activities are significantly reduced in women with GDM. Decreased serum paraoxonase and arylesterase activities might play a role in the potential early pathogenesis for atherosclerotic heart disease in GDM beyond their antioxidant properties.

Research paper thumbnail of A Rare Cause of Difficulty with Sexual Intercourse: Large Retroperitoneal Leiomyoma

Journal of Sexual Medicine, 2009

Research paper thumbnail of Serum prolidase activity and oxidative stress markers in pregnancies with intrauterine growth restricted infants

Journal of Obstetrics and Gynaecology Research, 2009

To compare the levels of serum prolidase activity and oxidative stress markers, including total o... more To compare the levels of serum prolidase activity and oxidative stress markers, including total oxidative status (TOS), total antioxidant capacity (TAC), oxidative stress index (OSI), and total free sulfhydryl (-SH) in healthy pregnant women and pregnant women with intrauterine growth restricted infants. Methods: Serum samples were obtained from 18 healthy third trimester pregnancies and 14 pregnancies complicated by fetal growth restriction (FGR). The criteria for FGR were clinical evidence of suboptimal growth, ultrasonographic demonstration of deviation from normal percentiles of growth, and birthweight under the 10th percentile. We spectrophotometrically measured serum prolidase activity, TAC, TOS, and -SH levels. Oxidative stress was determined from total antioxidant capacity and total oxidant status measurement and calculation of the oxidative stress index. Results: Serum TAC and -SH levels were significantly lower in the FGR group than in the healthy control group (P = 0.001, P < 0.001, respectively), whereas TOS level, OSI value, and prolidase activity were significantly higher (P = 0.003, P < 0.001, P < 0.001, respectively). Prolidase activity was positively correlated with TOS and OSI values (rho = 0.552, P = 0.041 and rho = 0.635, P = 0.015, respectively) and negatively correlated with TAC and -SH levels (rho = -0.578, P = 0.030 and rho = -0.622, P = 0.018, respectively).

Research paper thumbnail of Decreased Serum Prolidase Activity and Increased Oxidative Stress in Early Pregnancy Loss

Gynecologic and Obstetric Investigation, 2010

To compare the levels of serum prolidase activity and oxidative stress markers including total ox... more To compare the levels of serum prolidase activity and oxidative stress markers including total oxidative status (TOS), total antioxidant capacity (TAC), lipid hydroperoxide (LOOH) and total free sulfhydryl (-SH) in healthy pregnant women without early pregnancy loss (EPL) and women with EPL. Serum samples were obtained from 45 healthy first-trimester pregnancies and 45 pregnancies complicated with EPL. We have measured serum prolidase activity, TAC, TOS, -SH and LOOH levels spectrophotometrically. Serum prolidase, TAC and -SH levels were significantly lower in the women with EPL than in the women without EPL (p &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt;0.001, p = 0.001, p &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt; 0.001, respectively), whereas TOS and LOOH levels were significantly higher (p &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt; 0.001, p = 0.004, respectively). Prolidase activity was negatively correlated with TOS and LOOH levels (r = -0.299, p = 0.004; r = -0.323, p = 0.002, respectively), while positively correlated with TAC and -SH levels (r = 0.232, p = 0.028, and r = 0.418, p &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt;0.001, respectively) Findings of this study have shown that serum prolidase activity and oxidative stress are significantly associated with the presence of EPL, and the correlation between serum prolidase activity and the markers of oxidative stress was reflected in increased serum TOS and LOOH levels and decreased serum TAC and -SH levels.

Research paper thumbnail of O-19 - Attention deficit hyperactivity disorder in women with polycystic ovary syndrome

European Psychiatry, 2012

ABSTRACT

Research paper thumbnail of Assessment of preoperative serum prolidase activity in epithelial ovarian cancer

European Journal of Obstetrics & Gynecology and Reproductive Biology, 2009

Prolidase is a cytosolic exopeptidase that cleaves iminodipeptides with C-terminal proline and hy... more Prolidase is a cytosolic exopeptidase that cleaves iminodipeptides with C-terminal proline and hydroxyproline and plays a major role in collagen turnover. The aim of this study was to evaluate preoperative serum prolidase activity, total oxidant status (TOS), and total antioxidant capacity (TAC) in patients with newly diagnosed epithelial ovarian cancer (EOC). Serum prolidase activity, TOS, and TAC were measured spectrophotometrically in both EOC cases (n=28) and controls (n=28). Preoperative serum prolidase activity and TOS were significantly higher in patients with EOC compared to controls (p=0.009 and 0.008, respectively), whereas TAC was significantly lower in cases (p&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt;0.001). A significant positive correlation was found between the stage, grade, and CA-125 level of EOC and serum prolidase activity (rho=0.466, p=0.012; rho=0.501, p=0.007; and rho=0.447, p=0.017, respectively) and TOS (rho=0.588, p=0.001; rho=0.412, p=0.029; and rho=0.568, p=0.002, respectively). In contrast, there was a negative correlation between TAC and the stage, grade, and CA-125 level of EOC (rho=-0.555, p=0.002; rho=-0.566, p=0.002; and rho=-0.581, p=0.001, respectively). Findings of the present study demonstrate that serum prolidase activity is significantly associated with the stage, tumor grade, and preoperative CA-125 level of EOC.

Research paper thumbnail of Serum prolidase activity and oxidative status in Helicobacter pylori infection

Clinical Biochemistry, 2007

During the course of Helicobacter pylori infection, increased oxidative stress plays an important... more During the course of Helicobacter pylori infection, increased oxidative stress plays an important role in the pathogenesis of gastroduodenal mucosal inflammation, which can cause gastric mucosal atrophy that characterized by the replacement of the gastric mucosal glands by collagen ...

Research paper thumbnail of Serum paraoxonase and arylesterase activities in patients with lung cancer in a Turkish population

Research paper thumbnail of Attention deficit hyperactivity disorder symptom self-report among medical students in Eldoret, Kenya

African Journal of Psychiatry, 2011

Research paper thumbnail of Autistic traits in women with polycystic ovary syndrome

Research in Autism Spectrum Disorders, 2012