Hasan Bayram - Academia.edu (original) (raw)

Papers by Hasan Bayram

Cell Communication and Signaling

Infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been growing swif... more Infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been growing swiftly worldwide. Patients with background chronic pulmonary inflammations such as asthma or chronic obstructive pulmonary diseases (COPD) are likely to be infected with this virus. Of note, there is an argument that COVID-19 can remain with serious complications like fibrosis or other pathological changes in the pulmonary tissue of patients with chronic diseases. Along with conventional medications, regenerative medicine, and cell-based therapy could be alternative approaches to compensate for organ loss or restore injured sites using different stem cell types. Owing to unique differentiation capacity and paracrine activity, these cells can accelerate the healing procedure. In this review article, we have tried to scrutinize different reports related to the harmful effects of SARS-CoV-2 on patients with asthma and COPD, as well as the possible therapeutic effects of stem cells in the allev...

This article has been accepted for publication and undergone full peer review but has not been th... more This article has been accepted for publication and undergone full peer review but has not been through the copyediting, typesetting, pagination and proofreading process which may lead to differences between this version and the Version of Record. Please cite this article as

Journal of the Chinese Chemical Society, 2017

A new series of thiourea derivatives were obtained by the reaction of 4-(4-fluorophenoxy) aniline... more A new series of thiourea derivatives were obtained by the reaction of 4-(4-fluorophenoxy) aniline with different isothiocyanates. Their chemical structures were confirmed by ultraviolet (UV), infrared (IR), nuclear magnetic resonance (NMR), and mass spectral data and elemental analysis. All the synthesized thiourea derivatives were evaluated for their in vitro cancer activity against the human breast cancer cell lines MCF-7 (human breast adenocarcinoma) and SKBr-3 (human epithelial breast adenocarcinoma). Most of the derivatives exhibited significant anticancer activity. Especially, compound 3 showed the most potent activity (IC 50 20.1 μM) against SKBr-3 when compared with the drugs 5-fluorouracil and cisplatin, and, most importantly, it did not affect normal breast epithelial cells (4010).

EMBO Molecular Medicine, 2021

HAL is a multidisciplinary open access archive for the deposit and dissemination of scientific re... more HAL is a multidisciplinary open access archive for the deposit and dissemination of scientific research documents, whether they are published or not. The documents may come from teaching and research institutions in France or abroad, or from public or private research centers. L'archive ouverte pluridisciplinaire HAL, est destinée au dépôt et à la diffusion de documents scientifiques de niveau recherche, publiés ou non, émanant des établissements d'enseignement et de recherche français ou étrangers, des laboratoires publics ou privés.

Frontiers in Pharmacology

Take Home Message: Capsaicin modified inflammatory response and caused toxicity in bronchial epit... more Take Home Message: Capsaicin modified inflammatory response and caused toxicity in bronchial epithelial cultures from patients with COPD. More importantly, capsaicin decreased ciliary beat frequency and induced epithelial permeability and these effects were partially prevented by formoterol and roflumilast.Tear gas is widely used to halt mass demonstrations. Studies have reported its adverse effects on multiple organ systems; however, its effect on individuals with chronic respiratory diseases and the underlying mechanisms of these effects are unclear. For the first time in the literature, we investigated the effects of capsaicin, the active ingredient of tear gas, on bronchial epithelial cell (BEC) cultures obtained from well-characterized groups of nonsmokers, smokers, and patients with chronic obstructive pulmonary disease (COPD). BEC cultures were incubated with 50-500 μM capsaicin in the absence and presence of formoterol (1μM) and roflumilast (0.1 μM) for 24 h. Ciliary beat fr...

Occupational and environmental health, 2021

World Academy of Science, Engineering and Technology, International Journal of Medical and Health Sciences, 2014

Emergency Medicine International, 2018

Objective. This study was designed to investigate the effects of Desert Dust Storms and Climatolo... more Objective. This study was designed to investigate the effects of Desert Dust Storms and Climatological Factors on Mortality and Morbidity of Cardiovascular Diseases admitted to emergency department in Gaziantep. Method. Hospital records, obtained between September 01, 2009 and January 31, 2014, from four state hospitals in Gaziantep, Turkey, were compared to meteorological and climatological data. Statistical analysis was performed by Statistical Package for the Social Science (SPSS) for windows version 24.0. Results. 168,467 patients were included in this study. 83% of the patients had chest pain and 17% of patients had cardiac failure (CF). An increase in inpatient hospitalization due to CF was observed and corresponded to the duration of dust storms measured by number of days. However, there was no significant increase in emergency department (ED) presentations. There was no significant association of cardiac related mortality and coinciding presence of a dust storm or higher rec...

American Journal of Physiology-Lung Cellular and Molecular Physiology, 2019

Chronic obstructive pulmonary disease (COPD) is a life-threatening lung disease. Although cigaret... more Chronic obstructive pulmonary disease (COPD) is a life-threatening lung disease. Although cigarette smoke was considered the main cause of development, the heterogeneous nature of the disease leaves it unclear whether other factors contribute to the predisposition or impaired regeneration response observed. Recently, epigenetic modification has emerged to be a key player in the pathogenesis of COPD. The addition of methyl groups to arginine residues in both histone and nonhistone proteins by protein arginine methyltransferases (PRMTs) is an important posttranslational epigenetic modification event regulating cellular proliferation, differentiation, apoptosis, and senescence. Here, we hypothesize that coactivator-associated arginine methyltransferase-1 (CARM1) regulates airway epithelial cell injury in COPD pathogenesis by controlling cellular senescence. Using the naphthalene (NA)-induced mouse model of airway epithelial damage, we demonstrate that loss of CC10-positive club cells i...

Journal of Asthma, 2018

Objective: This study aimed to evaluate the factors that affect asthma control and adherence to t... more Objective: This study aimed to evaluate the factors that affect asthma control and adherence to treatment in newly diagnosed elderly asthmatics in Turkey compared with younger patients. Methods: This real-life prospective observational cohort study was conducted at 136 centers. A web-based questionnaire was administered to the patients who were followed up for 12 months. Results: Analysis included 1037 young adult asthma patients (age <65 years) and 79 elderly asthma patients (age ≥65 years). The percentage of patients with total control in the elderly and young groups were 33.9% and 37.1% at visit 1, 20.0% and 42.1% (p=0.012) at visit 2, and 50.0% and 49.8% at visit 3. Adherence to treatment was similar for both groups. Visit compliance was better in the elderly group than in the young group at visit 1 (72.2% vs. 60.8%, p=0.045), visit 2 (51.9% vs. 34.9%, p=0.002) and visit 3 (32.9% vs. 19.4%, p=0.004). Adherence to treatment increased with asthma control in both groups (both p<0.001) but decreased with the presence of gastritis/ulcer, gastroesophageal reflux and coronary artery disease in the elderly. Conclusions: Asthma control and adherence to treatment were similar for the elderly and young asthma patients, though the follow-up rate was lower in young patients. The presence of gastritis/ulcer, gastroesophageal reflux and coronary artery disease had negative impacts on the adherence to treatment in both groups.

Allergologia et Immunopathologia, 2014

Objective: Exhaled breath condensate (EBC) is a completely non-invasive method for the collection... more Objective: Exhaled breath condensate (EBC) is a completely non-invasive method for the collection of airway secretions to measure intense inflammation in the airways of asthmatics. It has been shown that the childhood asthma control test (c-ACT) is a good tool for use in the evaluation of asthmatics. Whether the c-ACT score and asthma control level correlate with the airway inflammation is not well known. We aimed to evaluate the relationship between exhaled cysteinyl leukotrienes (Cys-LTs) and 8-isoprostane levels and asthma severity, asthma control level and c-ACT score in asthmatic children. Methods: Thirty asthmatic children were evaluated with c-ACT score and pulmonary function tests. Asthma severity and asthma control level were assessed according to GINA. EBC was collected and Cys-LTs and 8-isoprostane concentrations were determined using a specific immunoassay kit. Results: Exhaled 8-isoprostane level in patients with moderate persistent asthma [114 (55-146) pg/ml] was higher than in the mild persistent group [52 (21-91) pg/ml] (p = 0.05, Mann-Whitney U [MWU]). EBC 8-isoprostane in children with 1-4 asthma exacerbations/year [52 (16-80) pg/ml] was significantly lower than in children with >4 asthma exacerbations/year [114 (57-129) pg/ml] (p < 0.05, MWU). No significant relation was determined between exhaled 8isoprostane and Cys-LTs levels and c-ACT score and asthma control level. Exhaled 8-isoprostane correlated negatively with bronchodilator response (p = 0.015, r = −0.45). Abbreviations: c-ACT, childhood asthma control test; Cys-LTs, cysteinyl leukotrienes; EBC, exhaled breath condensate; FEV 1 , forced expiratory volume in first second; ELISA, enzyme linked immunoassay; GINA, Global Initiative for Asthma.

Allergy, 1997

Several studies have investigated the effects of ozone, sulphur dioxide (SO2), and nitrogen dioxi... more Several studies have investigated the effects of ozone, sulphur dioxide (SO2), and nitrogen dioxide (NO2) on lung function in normal and asthmatic subjects. Decreased lung function has been observed with ozone levels as low as 0.15 ppm-this effect is concentration dependent and is exacerbated by exercise. A number of lines of evidence suggest that the effect on lung function is mediated, at least in part, by neural mechanisms. In both normals and asthmatics, ozone has been shown to induce neutrophilic inflammation, with increased levels of several inflammatory mediators, including prostaglandin E2. However, in normal subjects, none of the markers of inflammation correlate with changes in lung function. The lung function changes in asthmatics may be associated with inflammatory effects; alternatively, ozone may prime the airways for an increased response to subsequently inhaled allergen. Indeed, an influx of both polymorphonucleocytes and eosinophils has been observed in asthmatic patients after ozone exposure. It has been suggested that the effect of ozone on classic allergen-induced bronchoconstriction may be more significant than any direct effect of this pollutant in asthmatics. SO2 does not appear to affect lung function in normal subjects, but may induce bronchoconstriction in asthmatics. Nasal breathing, which is often impaired in asthmatics, reduces the pulmonary effects of SO2, since this water-soluble gas is absorbed by the nasal mucosa. NO2 may also influence lung function in asthmatics, but further research is warranted. SO2 and NO2 alone do not seem to have a priming effect in asthmatics, but a combination of these two gases has resulted in a heightened sensitivity to subsequently inhaled allergen.

Stem Cell Research & Therapy

Chronic obstructive pulmonary disease (COPD) is known as the third leading cause of human death g... more Chronic obstructive pulmonary disease (COPD) is known as the third leading cause of human death globally. Enhanced chronic inflammation and pathological remodeling are the main consequences of COPD, leading to decreased life span. Histological and molecular investigations revealed that prominent immune cell infiltration and release of several cytokines contribute to progressive chronic remodeling. Recent investigations have revealed that exosomes belonging to extracellular vesicles are involved in the pathogenesis of COPD. It has been elucidated that exosomes secreted from immune cells are eligible to carry numerous pro-inflammatory factors exacerbating the pathological conditions. Here, in this review article, we have summarized various and reliable information about the negative role of immune cell-derived exosomes in the remodeling of pulmonary tissue and airways destruction in COPD patients.

Turkish Thoracic Journal, 2019

Biomedical and Biotechnology Research Journal (BBRJ), 2017

Chronic obstructive pulmonary disease (COPD) and asthma are the two of the most common chronic in... more Chronic obstructive pulmonary disease (COPD) and asthma are the two of the most common chronic inflammatory lung diseases (CILDs) and affect > 500 million people worldwide. [1] Conventional treatments mainly focus on easing the symptoms by mitigating inflammation with corticosteroids (CSs) or by bronchodilators (BDs). [2,3] However, these are proven to be ineffective preventing the progression of CILD and particularly of COPD. [4] Furthermore, the CS, which is used in routine, has adverse health effects when systematically applied in high doses. [5] Therefore, there is an urgent need for new, effective therapeutics that can treat, and ultimately cure, patients who suffer from CILD. This review will evaluate the hallmarks of CILD and the therapeutics that are currently used for treatment. Then elucidate the area of liposome-based theranostics as an improvement to these therapies and exemplify the research that has done in the area. Hallmarks of cHronIc Inflammatory lung dIsease and conventIonal treatments COPD is the fourth largest cause of death worldwide, and it is expected to be the third by 2020. [6] COPD is an inclusive term for a group of conditions, such as emphysema and chronic bronchitis, which causes the persistent difficulty in exhaling air from the lungs. [7] Cigarette smoking is the major cause of COPD, and it induces chronic inflammation that leads to irreversible destruction of lung alveoli and the promotion of mucus secretion, which further blocks the airway and causes cilia damage in the respiratory track and makes lungs vulnerable to chronic infections. [7] Asthma is a common type of CILD that occurs in airways in the lung and affects >300 million people worldwide. [8] Inflammation leads to swelling and narrowing of the airways, therefore obstructing breathing. In contrast to COPD, airflow obstruction in mild to moderate asthma is usually reversible naturally or with treatment. [9] Even though inflammation in the respiratory track is common to both of them, the nature of inflammation usually differs particularly in terms of anatomical

Frontiers in Medicine

Background and objectivesAlthough several repurposed antiviral drugs have been used for the treat... more Background and objectivesAlthough several repurposed antiviral drugs have been used for the treatment of COVID-19, only a few such as remdesivir and molnupiravir have shown promising effects. The objectives of our study were to investigate the association of repurposed antiviral drugs with COVID-19 morbidity.MethodsPatients admitted to 26 different hospitals located in 16 different provinces between March 11–July 18, 2020, were enrolled. Case definition was based on WHO criteria. Patients were managed according to the guidelines by Scientific Board of Ministry of Health of Turkey. Primary outcomes were length of hospitalization, intensive care unit (ICU) requirement, and intubation.ResultsWe retrospectively evaluated 1,472 COVID-19 adult patients; 57.1% were men (mean age = 51.9 ± 17.7years). A total of 210 (14.3%) had severe pneumonia, 115 (7.8%) were admitted to ICUs, and 69 (4.7%) were intubated during hospitalization. The median (interquartile range) of duration of hospitalizati...

New Journal of Chemistry, 2022

Hypoxia-inducible factors (HIF), one of the targeted treatment strategies with a rising promise i... more Hypoxia-inducible factors (HIF), one of the targeted treatment strategies with a rising promise in lung cancer, are known to play a role in tumor growth and other oncogenic properties in...

Turkish Thoracic Journal, 2020

It has been more than 3 months now since the first case of COVID-19 was reported in Turkey. Globa... more It has been more than 3 months now since the first case of COVID-19 was reported in Turkey. Globally, the number of confirmed cases and deaths reached 9,653,048 and 491,128 respectively, as reported by 216 countries by June 27, 2020. Turkey had 1,396 new cases, 194,511 total cases, and 5,065 deaths by the same date. From the first case until today, the Turkish Thoracic Society (TTS) has been very proactive in educating doctors, increasing public awareness, undertaking academic studies, and assisting with public health policies. In the present report, social, academic, and management perspectives of the pandemic are presented under appropriate subtitles. During this critical public health crisis, TTS has once again demonstrated its readiness and constructive stance by supporting public health, healthcare workers, and the environment. This review summarizes the perspective of TTS on each aspect of the COVID-19 pandemic and casts light on its contributions.