Hassan Mahmoud - Academia.edu (original) (raw)

Papers by Hassan Mahmoud

Clinical Cancer Research, 2020

Background: Machine learning models that rely on single omics data for drug sensitivity predictio... more Background: Machine learning models that rely on single omics data for drug sensitivity prediction are challenging and frequently fail within precision medicine scenarios. Proteomics, for example, reflects the system biology and the regulatory network better than genomics. However, it is less likely available for many preclinical and in vivo data, mainly due to the cost of data generation. Currently, there are massive amounts of genomics data available, such as CNV, mutation, and RNA-seq signatures. However, these data do not characterize the post-translational modifications in proteins, limiting their utility for biomarker discovery. Objective: The main objective of this study is to overcome the lack of proteomics data gap. Herein, we propose a novel modeling approach to improve the prediction accuracy of drug sensitivity, that is, combining genomics and proteomics signatures. In addition to genomics and transcriptomics data, the model infers proteomic activity from gene expression...

Egyptian Journal of Food Science, 2021

Economic Modelling, 2019

Using a comprehensive dataset covering 42 countries spanning 2002-2013, this paper empirically ex... more Using a comprehensive dataset covering 42 countries spanning 2002-2013, this paper empirically examines the effect of environmentally sustainable practices (ESP) on R&D intensity in firms. We use three separate firm-level ESP scores that distinguish between the mandatory and voluntary compliance of environmental regulations mandated within an industry and a country. Our main finding is that an increase in ESP increases R&D intensity. Therefore, ESP encourages a higher number of innovations and there is a negligible trade-off between these two factors of firm performance. Further, the positive effect of ESP is stronger in countries where institutional quality and R&D infrastructure supports are superior. Our results have important policy implications for firms, investors and national governments.

World s Veterinary Journal, 2015

For isolation and identification of the antibiotic resistance profile of Staphylococcal infection... more For isolation and identification of the antibiotic resistance profile of Staphylococcal infection derived from buffalo (Bubalus bubalis) milk, a total of 100 milk samples have been collected from different villages in Qena governorate, Egypt, these animals were owned by small scale breeding farmers. S. aureus formed 23%, 58% other Staphylococci and other pathogens contained19% of the total number of samples. The S. aureus isolates have been tested for antibiotic susceptibility against 14 different widely used antibiotics, all S. aureus strains were resistant to Nalidixic acid by 100% and the lower percentage of resistance was to Ampicillin by 4.8%. The Multiple antibiotic resistances have been calculated for all S. aureus strains, the highest value was 1 and the least one was 0.143. The Buffaloe is considered one of the most important dairy animals in Egypt especially in the small scale breeding and the presence of S. aureus and other Staphylococci causing a great risk on the productive level of these animals due to mastitis as well as for the human beings, from here comes the importance of the detection of the antibiotic resistance profile.

Computational Intelligence Methods for Bioinformatics and Biostatistics, 2015

In this work we propose a novel hybrid technique for overlapping community detection in biologica... more In this work we propose a novel hybrid technique for overlapping community detection in biological networks able to exploit both the available quantitative and the semantic information, that we call Semantically Enriched Fuzzy C-Means Spectral Modularity (SE-FSM) community detection method. We applied SE-FSM in analyzing Protein-protein interactions (PPIs) networks of HIV-1 infection and Leukemia in Homo sapiens. SE-FSM found significant overlapping biological communities. In particular, it found a strong relationship between HIV-1 and Leukemia as their communities share several significant pathways, and biological functions.

Advances in Neural Networks: Computational and Theoretical Issues, 2015

In this study we aim at identifying companies influencing the performance of the stock market sec... more In this study we aim at identifying companies influencing the performance of the stock market sector. We propose an approach for constructing the similarity between stock company profiles based on the estimates of the log return similarity of stock prices and on Fuzzy Spectral Modularity community detection method to infer the network hubs and significant communities and we applied it to the Italian stock market store. Experimental results show that companies in the same sector highly affect the price change of each other. Moreover, We notice a robust temporal stability of detected communities, and the short time correlation computed with the fuzzy rand index is strong.

Lecture Notes in Computer Science, 2013

We present an overview of association criteria that build upon the relative position of a set of ... more We present an overview of association criteria that build upon the relative position of a set of reference data items with respect to given query data items, and propose fuzzy generalizations that allows to use these criteria as real-valued similarity measures. Some experimental consistency tests are also presented.

Journal of the Society of Dyers and Colourists, 2008

Azo and phthalocyanine dyes carrying the chlorohydrin group, as the precursor of the reactive epo... more Azo and phthalocyanine dyes carrying the chlorohydrin group, as the precursor of the reactive epoxy group, were prepared using new catalyzed reactions. The reactive group is attached to the coupling component in some cases and to the diazonium component in other cases. A phthalocyanine dye carrying two reactive groups was also synthesized. studied, under different dyeing conditions. Various techniques of dyeing and printing were used. Exhaustion and padding methods were investigated for dyeing, and direct, reserve and discharge methods for printing. Onestage and two-stage procedures were employed for both printing and dyeing. it was found that the chlorohydrin reactive dyes prepared in the present work could be applied by nearly all known methods of dyeing and printing on cotton, wool, viscose rayon, nylon and acrylic fibres. The dyeings obtained had satisfactory fastness properties and showed fairly good dye fixation on the substrate. The dyeing of cotton, wool and multifibre fabrics was

BMJ Open, 2021

IntroductionPressure ulcers are serious and potentially life-threatening problems across all age ... more IntroductionPressure ulcers are serious and potentially life-threatening problems across all age groups and across all medical specialties and care settings. The hospitalised elderly population is the most common group to develop pressure ulcers. This study aims to systematically review studies implementing pressure ulcer prevention strategies recommended in the Pressure Ulcer Prevention Practice Guidelines for the prevention of pressure ulcers among hospitalised elderly patients globally.Methods and analysisA systematic review of all studies that have assessed the use of pressure ulcer prevention strategies in hospital settings among hospitalised elderly patients shall be conducted. A comprehensive search of all published articles in Medline Ovid, Cumulative Index to Nursing and Allied Health Literature, PubMed, Embase, Cochrane library, Scopus and Web of Science will be done using terms such as pressure ulcers, prevention strategies, elderly patients and hospital. Studies will be ...

Applied Sciences, 2021

Additive manufacturing (AM) has drawn tremendous interest in engineering applications because it ... more Additive manufacturing (AM) has drawn tremendous interest in engineering applications because it offers almost unlimited possibilities of innovative structural design to save weight and optimize performance. However, fatigue properties are one of the limiting factors for structural applications of AM materials. The recently developed Tanaka–Mura–Wu (TMW) model is modified to include the microstructure and surface roughness factors, in addition to the material’s elastic modulus, surface energy and Burgers vector, to predict the fatigue curves as functions of stress or plastic strain for several typical AM materials as well as their conventional (wrought) counterpart. Furthermore, with statistical characterization of the microstructural effect, the model can be established to evaluate fatigue design allowables.

Plant physiology and biochemistry : PPB, 2017

Exploration of new and promising anticancer compounds continues to be one of the main tasks of ca... more Exploration of new and promising anticancer compounds continues to be one of the main tasks of cancer research because of the drug resistance, high cytotoxicity and limitations of tumor selectivity. Natural products represent a better choice for cancer treatment in comparison with synthetic compounds because of their pharmacokinetic properties and lower side effects. In the current study, we isolated a steroidal saponin, named Cepa2, from the dry roots of shallot (Allium cepa L. Aggregatum group), and determined its structure by using two-dimensional nuclear manganic resonance (2D NMR). The (1)H NMR and (13)C NMR data revealed that the newly isolated Cepa2 compound is identical to alliospiroside A (C38H60O12) [(25S)-3β-hydroxyspirost-5-en-1β-yl-2-O-(6-deoxy-α-L-mannopyranosyl)-α-L-arabinopyranoside], whose anticancer activity remains elusive. Our in vitro examination of the cytotoxic activity of the identified Cepa2 against P3U1 myeloma cancer cell line showed its high efficiency as...

Virus research, Jan 2, 2015

Equine herpesvirus type 1 (EHV-1) has haemagglutination (HA) activity toward equine red blood cel... more Equine herpesvirus type 1 (EHV-1) has haemagglutination (HA) activity toward equine red blood cells (RBCs), but the identity of its haemagglutinin is unknown. To identify the haemagglutinin of EHV-1, the major glycoproteins of EHV-1 were expressed in 293T cells, and the cells or cell lysates were mixed with equine RBCs. The results showed that only EHV-1 glycoprotein C (gC)-producing cells adsorbed equine RBCs, and that the lysate of EHV-1 gC-expressing cells agglutinated equine RBCs. EHV-1 lacking gC did not show HA activity. HA activity was inhibited by monoclonal antibodies (MAbs) specific for gC, but not by antibodies directed against other glycoproteins. In addition, HA activity was not inhibited by the addition of heparin. These results indicate that EHV-1 gC can bind equine RBCs irrespective of heparin, in contrast to other herpesvirus gC proteins.

Journal of Veterinary Medical Science, 2011

In Japan, most pig populations are now free from pseudorabies virus (PRV) due to the recent succe... more In Japan, most pig populations are now free from pseudorabies virus (PRV) due to the recent success of an extensive eradication program. However, PRV infection persists in Japanese wild boars (Sus scrofa leucomystax), representing another potential reservoir for the virus in Japan. In this study, the seroprevalence of PRV in wild boars captured in three different prefectures was ascertained. A virus neutralization (VN) test showed that 6 of 173 serum samples (3%) were positive for VN antibody; glycoprotein E-ELISA revealed infection with the wild-type, but not the available vaccine strain, PRV. These results indicate that PRV has continued to spread among wild boars in Japan.