Mohamed Hassan Mahmoud - Academia.edu (original) (raw)

Papers by Mohamed Hassan Mahmoud

2013 10th IEEE International Conference and Workshops on Automatic Face and Gesture Recognition (FG), 2013

We investigate the capabilities of automatic nonverbal behavior descriptors to identify indicator... more We investigate the capabilities of automatic nonverbal behavior descriptors to identify indicators of psychological disorders such as depression, anxiety, and post-traumatic stress disorder. We seek to confirm and enrich present state of the art, predominantly based on qualitative manual annotations, with automatic quantitative behavior descriptors. In this paper, we propose four nonverbal behavior descriptors that can be automatically estimated from visual signals. We introduce a new dataset called the Distress Assessment Interview Corpus (DAIC) which includes 167 dyadic interactions between a confederate interviewer and a paid participant. Our evaluation on this dataset shows correlation of our automatic behavior descriptors with specific psychological disorders as well as a generic distress measure. Our analysis also includes a deeper study of selfadaptor and fidgeting behaviors based on detailed annotations of where these behaviors occur.

Indian Journal of Chemistry -Section B

The current project deals with designing and synthesizing of colourimetric chemosensors to detect... more The current project deals with designing and synthesizing of colourimetric chemosensors to detect the cations in the aqueous medium and biological sample. To achieve this goal a new series of quinazolinone derivatives have been synthesized via reaction of the novel 6-nitro-2-propyl-4H-benzo[d][1,3]oxazin-4-one 3 with selected nitrogen nucleophiles, namely, formamide, hydrazine hydrate, hydroxylamine hydrochloride, o-phenylendiamine, o-aminophenol and oaminothiophenol, urea and/or thiourea. Structures of the new compounds have been investigated depending on their spectral data (IR, 1 H and 13 C NMR and MS) and elemental analyses. Some of the newly synthesized products exhibit significant response as chemosensors for a few cations detection.

International journal of health sciences

Background: Bicuspid aortic valve (BAV) is the most frequent congenital heart disease affecting 1... more Background: Bicuspid aortic valve (BAV) is the most frequent congenital heart disease affecting 1% to 2% of the population, with thoracic aortic aneurysm (TAA) formation being its second most frequent complication after aortic valve dysfunction (stenosis or insufficiency). Aortic valve replacement (AVR) with mechanical or biologic prostheses has long been the procedure of choice. Although prosthetic AVR is effective in correcting the hemodynamic problem, there are important long-term drawbacks. These are particularly present in a younger patient population, such as the majority of individuals with a BAV. Patient and methods: 40 patients underwent aortic valve repair for bicuspid aortic valve disease with ascending aortic aneurysm in the period between June 2020 and February 2022 in Kasr Alainy hospitals. Results: All our patients showed significant improvement regarding left ventricular dimensions and contractility. Two patients had mild to moderate regurge and thirty eight patients...

Egyptian Spine Journal, 2021

Background Data: Degenerative lumbar spine, including spondylolisthesis, is a common clinical con... more Background Data: Degenerative lumbar spine, including spondylolisthesis, is a common clinical condition that affects humans in the most productive period of their life. There are many surgical options for the management of such conditions after the failure of conservative therapy. Recently, there has been a great debate regarding the use of minimally invasive (MI) versus open transforaminal lumbar interbody fusion (O-TLIF) in the treatment of single-level low-grade lumbar spondylolisthesis, so there was a need to reach a consensus over this issue. Purpose: To compare the clinical efficacy and safety of MI-TLIF versus O-TLIF in the treatment of single-level low-grade degenerative lumbar spondylolisthesis. Study Design: A systematic review for recent studies in the context and meta-analysis. Patients and Methods: We searched online databases of PubMed, Google Scholar, Cochrane Library, and DOAJ (2016–2020), and the search yielded 1352 articles. Based on our inclusion and exclusion cri...

The cascaded reservoirs hydropower plant is a complex nonlinear system that involves interacting ... more The cascaded reservoirs hydropower plant is a complex nonlinear system that involves interacting input and output nonlinear parameters, nonlinear flow rates, and nonlinear dynamical hydraulic heads. This thesis aims to enhance the existing cascaded reservoirs hydropower systems and future ones by new designs of control and optimization systems based on fuzzy logic. In this thesis, a new nonlinear mathematical model of a cascaded reservoirs hydropower plant is developed. The developed model was accurate enough to represent and simulate the plant nonlinear dynamics and to design and test three new fuzzy control systems addressing three major cascaded reservoirs hydropower plant problems. The first one is a fuzzy turbine governor replacing the classical PID controller, the second is a fuzzy controller for three hydraulically coupled turbines under nonlinear and interacting process conditions, and the third is a fuzzy supervisory control and optimization system for geographically-separa...

Cervical kyphotic deformity (CKD) associated with cervical spondylotic myelopathy (CSM) is contro... more Cervical kyphotic deformity (CKD) associated with cervical spondylotic myelopathy (CSM) is controversy issue in degenerative spine disease. In addition to cord compression, it carries a risk of fusion failure due to progression of the angle and sagittal imbalance. We illustrated a young male patient diagnosed as progressive myelopathy from kyphotic angle. He had posterior decompression with lateral mass fixation that failed after 5 years and mandated 360° fusion. Circumferential fusion should be surgical preferential in patient with angle progression.

IEEE Transactions on Intelligent Transportation Systems, 2021

A smart vehicle should be able to monitor the actions and behaviors of the human driver to provid... more A smart vehicle should be able to monitor the actions and behaviors of the human driver to provide critical warnings or intervene when necessary. Recent advancements in deep learning and computer vision have shown great promise in monitoring human behavior and activities. While these algorithms work well in a controlled environment, naturalistic driving conditions add new challenges such as illumination variations, occlusions, and extreme head poses. A vast amount of in-domain data is required to train models that provide high performance in predicting driving related tasks to effectively monitor driver actions and behaviors. Toward building the required infrastructure, this paper presents the multimodal driver monitoring (MDM) dataset, which was collected with 59 subjects that were recorded performing various tasks. We use the Fi-Cap device that continuously tracks the head movement of the driver using fiducial markers, providing frame-based annotations to train head pose algorithms in naturalistic driving conditions. We ask the driver to look at predetermined gaze locations to obtain accurate correlation between the driver's facial image and visual attention. We also collect data when the driver performs common secondary activities such as navigation using a smart phone and operating the in-car infotainment system. All of the driver's activities are recorded with high definition RGB cameras and a time-of-flight depth camera. We also record the controller area network-bus (CAN-Bus), extracting important information. These high quality recordings serve as the ideal resource to train various efficient algorithms for monitoring the driver, providing further advancements in the field of in-vehicle safety systems.

Integrative Journal of Medical Sciences, 2020

Background : Schwannomas originating from the sciatic nerve are extremely rare and usually presen... more Background : Schwannomas originating from the sciatic nerve are extremely rare and usually present as a pathological mass in palpable examination or pain located in the thigh. Motor and sensory deficits are observed more often when the size of the tumor is more than 40 mm.Case Description : A 19-years- old female patient was referred to Suez Canal University Hospital after 6 years of pain and 2 years of improper management. Neurological examination and MRI of the right thigh was done and revealed huge mass attached to the right sciatic nerve. Surgical excision was undertaken, carefully dissecting the lesion from the sciatic nerve. Histopathological examination revealed the tumor to be a schwannoma. The patient had marked postoperative recovery with marked pain reduction and improved neurological deficits.Conclusions : Schwannomas of the sciatic nerve are rare tumors eccentrically located on the nerve. Although rare, schwannoma of the sciatic nerve should be systematically suspected ...

Iranian journal of basic medical sciences, 2018

Heat stress (HS) is a catastrophic stressor that dampens immunity. The current study investigates... more Heat stress (HS) is a catastrophic stressor that dampens immunity. The current study investigates the effect of dietary administration with camel whey protein (CWP) on apoptotic pathway caused by HS. Forty-five male mice were divided into three groups: a control group; HS group; and HS mice that were orally supplemented with CWP (CWP-HS group). We found that reactive oxygen species (ROS), pro-inflammatory cytokines (IL-6), and C reactive protein (CRP) were elevated in the HS group along with a significant increase of caspase-9 and -3 and decrease of total antioxidant capacity (TAC). HS mice revealed impaired phosphorylation of Bcl-2 and Survivin, as well as increased expression of Bax, Bim and cytochrome C. Additionally, we observed an aberrant distribution of HSP-70 expressing lymphocytes in the spleen and thymus of HS mice. Moreover, histopathological examination showed alterations on the architectures of immune organs. In comparison with CWP-HS group, we found that CWP restored t...

Molecular reproduction and development, Jan 23, 2018

Elevation of scrotal temperature is one of the most important causes of impaired spermatogenesis ... more Elevation of scrotal temperature is one of the most important causes of impaired spermatogenesis and male infertility, but the exact mechanism remains controversial. The present study investigated the impact of camel whey protein (CWP) on the mechanisms of heat stress (HS)-mediated testicular damage in male mice. Exposure to HS was associated with significant increase in the testicular tissues' oxidative stress. Mechanistically, exposure to HS resulted in upregulation of P53 and Nrf2 expressions; downregulation of Bcl2 and PPAR-γ expressions; and induction of testicular Leydig cell hyperplasia. Because Leydig cells produce testosterone up on stimulation with Luteinizing hormone (LH), HS mice also exhibited significant reduction in the serum testosterone levels followed by significant reduction in the percentages of progressively motile sperm and higher percentages of immotile sperm, when compared with those of control mice. Interestingly, treatment of HS mice with CWP significan...

Child abuse & neglect, Jan 3, 2018

This paper explores child disciplinary methods used by parents in Qatar and Palestine. In this st... more This paper explores child disciplinary methods used by parents in Qatar and Palestine. In this study ICAST-P, an internationally recognized tool, was used with mothers reporting on one of their children up to their 12th birthday. It questions about disciplinary methods: nonviolent; physical: moderate and severe; and psychological methods that had been used in the previous year on the index child in the family. A comparative national cross-sectional household survey of mothers aged 25-50 years old was conducted in both Qatar and Palestine, both Arabic Muslim states, but with very different socio-economic and political contexts that place Qataris in a much more advantageous position. Our results show that the 1299 Palestinian mothers interviewed were younger, had more children and less education compared to the 1018 Qatari mothers. Fewer mothers from Palestine were working. The index child in Palestine tended to be younger with 60% being under 5 years, while 73.7% of Qatari children w...

Biochemistry and cell biology = Biochimie et biologie cellulaire, Aug 22, 2017

Heat stress (HS) is an environmental factor that depresses the immune systems mediating dysfuncti... more Heat stress (HS) is an environmental factor that depresses the immune systems mediating dysfunctional immune cells. Camel whey protein (CWP) can scavenge free radicals and enhance immunity. The present study investigated the impact of dietary supplementation with CWP on immune dysfunction induced by exposure to HS. Male mice (n = 45) were divided into three groups: control group; HS group; and HS mice that were orally administered CWP (HS+CWP group). The HS group exhibited elevated levels of reactive oxygen species (ROS) and pro-inflammatory cytokines (IL-1β, IL-6, TNF-α) as well as a significant reduction in the IL-2 and IL-4 levels. Exposure to HS resulted in impaired AKT and IκB-α phosphorylation; increased ATF-3 and HSP70 expression; and aberrant distribution of CD3+ T cells and CD20+ B cells in the thymus and spleen. Interestingly, HS mice treated with CWP presented significantly restored levels of ROS and pro-inflammatory cytokines near the levels observed in control mice. Fur...

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, Jan 24, 2017

Type I diabetes (T1D) is a characterized by the inflammation of pancreatic islets and destruction... more Type I diabetes (T1D) is a characterized by the inflammation of pancreatic islets and destruction of β cells. Long and persistent uncontrolled diabetes tends to degenerate the immune system and increase the incidence of infections in diabetic individuals. Most serious diabetic complications are mediated by the free radicals, which damage multiple cellular components through direct effects of the cell cycle regulatory proteins. Camel whey protein (CWP) has antioxidant activity and decreases the effects of free radicals. However, the effects of CWP on lymphoid organs have not been studied in the context of diabetes. Therefore, the present study was designed to investigate the dietary influence of CWP supplementation on the lymphoid organs in streptozotocin (STZ)-induced type 1 diabetic mouse model. Three experimental groups were used: non diabetic control mice, diabetic mice, and diabetic mice treated with CWP. Induction of diabetes was associated with a marked reduction in glutathion...

Food & Nutrition Research, 2016

Background and objective: To our knowledge, no previous studies have focused on the immunomodulat... more Background and objective: To our knowledge, no previous studies have focused on the immunomodulatory effects of fresh royal jelly (RJ) administration on systemic lupus erythematosus (SLE) in humans. Our aim was to study the effect of fresh RJ administration on the disease course in children with SLE with some immunological markers (CD4 ' and CD8 ' regulatory T cells and T lymphocytes apoptosis). Methods: This was an open-label study in which 20 SLE children received 2 g of freshly prepared RJ daily, for 12 weeks. Results: The percentages of CD4 ' CD25 ' high FOXP3 ' cells (CD4 ' regulatory T cells) and CD8 ' CD25 ' high FOXP3 ' cells (CD8 ' regulatory T cells) were significantly increased after RJ treatment when compared with baseline values. Apoptotic CD4 T lymphocytes were significantly decreased after RJ therapy when compared with baseline values and the control group. Conclusion: This is the first human study on the effect of RJ supplementation in children with SLE. Our results showed improvements with 3-month RJ treatment with regard to the clinical severity score and laboratory markers for the disease. At this stage, it is a single study with a small number of patients, and a great deal of additional wide-scale randomized controlled studies are needed to critically validate the efficacy of RJ in SLE.

Lipids in Health and Disease, 2015

Background: Non-alcoholic fatty liver disease (NAFLD) is a multifactorial disease with a complex ... more Background: Non-alcoholic fatty liver disease (NAFLD) is a multifactorial disease with a complex pathophysiology. The clinical features of NAFLD include obesity, insulin resistance (IR) and dyslipidemia. Consumption of a diet high in saturated fats and sucrose is an important factor in the increasing occurrence of these metabolic disorders, primarily NAFLD and IR. We sought to assess the role of a high-fat, high-sucrose (HFS) diet in the promotion of NAFLD and to evaluate the effects of quercetin (Q), berberine (BB) and o-coumaric acid (CA) on modulation of these disorders. Methods: Fifty male rats were divided into 2 main groups as follows: group 1 comprised 10 rats fed a standard diet (SD), and group 2 comprised 40 rats fed an HFS diet for 6 weeks and then subdivided equally into 4 groups; one of these groups served as the HFS diet and each of the other three groups received daily supplementation with either Q, CA or BB for 6 weeks. Results: In the present study, several metabolic disorders were induced in our laboratory animal model, as evidenced by histological and biochemical changes. These alterations included serum and hepatic dyslipidemia (i.e., increased triglyceride, total cholesterol and low-density lipoprotein levels and decreased high-density lipoprotein levels), alterations in metabolic enzyme activities (lipase, glycerol-3-phosphate dehydrogenase, and glucose-6-phosphate dehydrogenase), histological changes in the liver (micro-and macrovesicular steatosis) and the downregulation of peroxisome proliferator-activated receptor γ (PPARγ) in adipose tissue and the liver. Daily oral supplementation with Q, CA or BB for 6 weeks after NAFLD induction had a hypolipidemic action and modulated metabolic markers. Conclusion: We showed that an HFS diet is able to promote NAFLD, and our results suggest that CA and BB are promising complementary supplements that can ameliorate the metabolic disorders associated with an HFS diet; however, Q requires further investigation.

Cellular Signalling, 2015

Type 1 diabetes mellitus (T1D) is associated with increased type 1 interferon (IFN) levels and su... more Type 1 diabetes mellitus (T1D) is associated with increased type 1 interferon (IFN) levels and subsequent severe defects in lymphocyte function, which increase susceptibility to infections. The blockade of type 1 IFN receptor 1 (IFNAR1) in non-obese diabetic mice has been shown to delay T1D onset and decrease T1D incidence by enhancing spleen CD4+ T cells and restoring B cell function. However, the effect of type 1 IFN blockade during T1D on splenic CD8+ T cells has not previously been studied. Therefore, we investigated, for the first time, the effect of IFNAR1 blockade on the survival and architecture of spleen-homing CD8+ T cells in a streptozotocin-induced T1D mouse model. Three groups of mice were examined: a non-diabetic control group; a diabetic group; and a diabetic group treated with an anti-IFNAR1 blocking antibody. We observed that T1D induction was accompanied by a marked destruction of β cells followed by a marked reduction in insulin levels and increased IFN-α and IFN-β levels in the diabetic group. The diabetic mice also exhibited many abnormal changes including an elevation in blood and spleen free radical (reactive oxygen species and nitric oxide) and pro-inflammatory cytokine (IL-6 and TNF-α) levels, a significant decrease in IL-7 levels, and subsequently, a significant decrease in the numbers of spleen-homing CD8+ T cells. This decrease in spleen-homing CD8+ T cells resulted from a marked reduction in the CCL21-mediated entry of CD8+ T cells into the spleen and from increased apoptosis due to a marked reduction in IL-7-mediated STAT5 and AKT phosphorylation. Interestingly, type 1 IFN signaling blockade in diabetic mice significantly restored the numbers of splenic CD8+ T cells by restoring free radical, pro-inflammatory cytokine and IL-7 levels. These effects subsequently rescued splenic CD8+ T cells from apoptosis through a mechanism that was dependent upon CCL21- and IL-7-mediated signaling. Our data suggest that type 1 IFN is an essential mediator of pathogenesis in T1D and that this role results from the negative effect of IFN signaling on the survival of splenic CD8+ T cells.

All Days, 2011

Different fluids have been introduced in the oil industry to be used as alternatives to HCl. Chel... more Different fluids have been introduced in the oil industry to be used as alternatives to HCl. Chelating agents such as EDTA (ethylenediaminetetraaceticacid), HEDTA (hydroxyethylenediaminetriaceticacid), and GLDA (L-glutamic acid-N, N-diacetic acid) have been introduced to be used as stand-alone stimulation fluids. These fluids can be used to stimulate water injectors, oil, or gas producers, therefore, the effect of the type of reservoir fluid on the stimulation process should be investigated. In this study, 0.6M concentration of GLDA, EDTA, and HEDTA were used in the coreflood experiments on carbonate rocks at 300°F. The cores were saturated with water, oil, or gas to determine the effect of reservoir fluid type on the performance of the chelating agents with the carbonate cores. The different chelants were injected into the calcite cores saturated by oil and gas after flooding the water into the cores until the residual saturations were reached. The effect of using 10 vol% mutual so...

All Days, 2011

The objective of stimulation of sandstone reservoirs is to remove the damage caused to the produc... more The objective of stimulation of sandstone reservoirs is to remove the damage caused to the production zone during drilling or completion operations. Many problems may occur during sandstone acidizing with HCl/HF mud acid. Among these problems: decomposition of clays in HCl acids, precipitation of fluosilicates, the presence of carbonates can cause the precipitation of calcium fluorides, silica-gel filming, colloidal silica-gel precipitation. In this study, a recently introduced chelating agent, glutami-N, N-diacetic acid(GLDA), was used to stimulate sandstone cores. Berea sandstone cores with 8 wt% clays content were used in this study. Different GLDA solution pH values (1.7 - 13) were used in the coreflood experiments. The sandstone cores were scanned before and after the treatment to investigate the effect of GLDA on the core. The effluent samples were analyzed for calcium, magnesium, aluminum, and iron using the ICP to assess the ability of GLDA on the complexation of these ions....

All Days, 2011

Chelating agents such as GLDA, EDTA, and HEDTA have been used to stimulate calcite reservoirs as ... more Chelating agents such as GLDA, EDTA, and HEDTA have been used to stimulate calcite reservoirs as alternatives to HCl. HCl based stimulation fluids are very corrosive at high temperatures and should be loaded with many additives to reduce corrosion problems. In addition, the application of HCl can lead to face dissolution at low flow rates. GLDA chelating agent was used to stimulate calcium carbonate cores up to temperature of 300°F and at low rates without any face dissolution problems. The dissolution of dolomite by chelating agents has not been thoroughly investigated. Preliminary experiments with EDTA at ambient temperature revealed no significant dolomite dissolution. The dissolution mechanism is probably inhibited by the low stability of the magnesium chelate at that temperature. In this study, we will investigate the ability of GLDA (glutamic -N,N- diacetic acid) to stimulate dolomite cores as well as calcite cores. GLDA with different pH (1.7, 3 and 13) was used for this stud...

International Journal of Biological Macromolecules, 2015

In this study we have investigated the heat induced denaturation of HSA byutilizing spectroscopic... more In this study we have investigated the heat induced denaturation of HSA byutilizing spectroscopic approaches including fluorescence and circular dichroism. Thermal denaturation of N isomer (domain I-III remains intact), B isomer (loss of helical structure of interdomain contacts) and I state (domain II intact) was found to be cooperative processes while for F isomer domains unfold non-cooperatively. These finding pointed out that during N-F transition, HSA suffers more structural alterationswhich are not localized only to domain III. Loss of secondary structure in the temperature range 20-60 0C without effecting tertiary structure of N isomer of HSA is mainly due to loss in helical extensions connecting domain I to II and domain II to III. All the four thermally denatured states (60-96 0C) of HSA retained approximately 50% residual alpha helical structures. Near-UV CD used as a probe for tertiary structure indicated that heat denatured states lost almost all of the tertiary contacts,thereby forming molten globule like states. Furthermore, our results provide evidence that residual helical structuresare mainly located in domain II.

2013 10th IEEE International Conference and Workshops on Automatic Face and Gesture Recognition (FG), 2013

We investigate the capabilities of automatic nonverbal behavior descriptors to identify indicator... more We investigate the capabilities of automatic nonverbal behavior descriptors to identify indicators of psychological disorders such as depression, anxiety, and post-traumatic stress disorder. We seek to confirm and enrich present state of the art, predominantly based on qualitative manual annotations, with automatic quantitative behavior descriptors. In this paper, we propose four nonverbal behavior descriptors that can be automatically estimated from visual signals. We introduce a new dataset called the Distress Assessment Interview Corpus (DAIC) which includes 167 dyadic interactions between a confederate interviewer and a paid participant. Our evaluation on this dataset shows correlation of our automatic behavior descriptors with specific psychological disorders as well as a generic distress measure. Our analysis also includes a deeper study of selfadaptor and fidgeting behaviors based on detailed annotations of where these behaviors occur.

Indian Journal of Chemistry -Section B

The current project deals with designing and synthesizing of colourimetric chemosensors to detect... more The current project deals with designing and synthesizing of colourimetric chemosensors to detect the cations in the aqueous medium and biological sample. To achieve this goal a new series of quinazolinone derivatives have been synthesized via reaction of the novel 6-nitro-2-propyl-4H-benzo[d][1,3]oxazin-4-one 3 with selected nitrogen nucleophiles, namely, formamide, hydrazine hydrate, hydroxylamine hydrochloride, o-phenylendiamine, o-aminophenol and oaminothiophenol, urea and/or thiourea. Structures of the new compounds have been investigated depending on their spectral data (IR, 1 H and 13 C NMR and MS) and elemental analyses. Some of the newly synthesized products exhibit significant response as chemosensors for a few cations detection.

International journal of health sciences

Background: Bicuspid aortic valve (BAV) is the most frequent congenital heart disease affecting 1... more Background: Bicuspid aortic valve (BAV) is the most frequent congenital heart disease affecting 1% to 2% of the population, with thoracic aortic aneurysm (TAA) formation being its second most frequent complication after aortic valve dysfunction (stenosis or insufficiency). Aortic valve replacement (AVR) with mechanical or biologic prostheses has long been the procedure of choice. Although prosthetic AVR is effective in correcting the hemodynamic problem, there are important long-term drawbacks. These are particularly present in a younger patient population, such as the majority of individuals with a BAV. Patient and methods: 40 patients underwent aortic valve repair for bicuspid aortic valve disease with ascending aortic aneurysm in the period between June 2020 and February 2022 in Kasr Alainy hospitals. Results: All our patients showed significant improvement regarding left ventricular dimensions and contractility. Two patients had mild to moderate regurge and thirty eight patients...

Egyptian Spine Journal, 2021

Background Data: Degenerative lumbar spine, including spondylolisthesis, is a common clinical con... more Background Data: Degenerative lumbar spine, including spondylolisthesis, is a common clinical condition that affects humans in the most productive period of their life. There are many surgical options for the management of such conditions after the failure of conservative therapy. Recently, there has been a great debate regarding the use of minimally invasive (MI) versus open transforaminal lumbar interbody fusion (O-TLIF) in the treatment of single-level low-grade lumbar spondylolisthesis, so there was a need to reach a consensus over this issue. Purpose: To compare the clinical efficacy and safety of MI-TLIF versus O-TLIF in the treatment of single-level low-grade degenerative lumbar spondylolisthesis. Study Design: A systematic review for recent studies in the context and meta-analysis. Patients and Methods: We searched online databases of PubMed, Google Scholar, Cochrane Library, and DOAJ (2016–2020), and the search yielded 1352 articles. Based on our inclusion and exclusion cri...

The cascaded reservoirs hydropower plant is a complex nonlinear system that involves interacting ... more The cascaded reservoirs hydropower plant is a complex nonlinear system that involves interacting input and output nonlinear parameters, nonlinear flow rates, and nonlinear dynamical hydraulic heads. This thesis aims to enhance the existing cascaded reservoirs hydropower systems and future ones by new designs of control and optimization systems based on fuzzy logic. In this thesis, a new nonlinear mathematical model of a cascaded reservoirs hydropower plant is developed. The developed model was accurate enough to represent and simulate the plant nonlinear dynamics and to design and test three new fuzzy control systems addressing three major cascaded reservoirs hydropower plant problems. The first one is a fuzzy turbine governor replacing the classical PID controller, the second is a fuzzy controller for three hydraulically coupled turbines under nonlinear and interacting process conditions, and the third is a fuzzy supervisory control and optimization system for geographically-separa...

Cervical kyphotic deformity (CKD) associated with cervical spondylotic myelopathy (CSM) is contro... more Cervical kyphotic deformity (CKD) associated with cervical spondylotic myelopathy (CSM) is controversy issue in degenerative spine disease. In addition to cord compression, it carries a risk of fusion failure due to progression of the angle and sagittal imbalance. We illustrated a young male patient diagnosed as progressive myelopathy from kyphotic angle. He had posterior decompression with lateral mass fixation that failed after 5 years and mandated 360° fusion. Circumferential fusion should be surgical preferential in patient with angle progression.

IEEE Transactions on Intelligent Transportation Systems, 2021

A smart vehicle should be able to monitor the actions and behaviors of the human driver to provid... more A smart vehicle should be able to monitor the actions and behaviors of the human driver to provide critical warnings or intervene when necessary. Recent advancements in deep learning and computer vision have shown great promise in monitoring human behavior and activities. While these algorithms work well in a controlled environment, naturalistic driving conditions add new challenges such as illumination variations, occlusions, and extreme head poses. A vast amount of in-domain data is required to train models that provide high performance in predicting driving related tasks to effectively monitor driver actions and behaviors. Toward building the required infrastructure, this paper presents the multimodal driver monitoring (MDM) dataset, which was collected with 59 subjects that were recorded performing various tasks. We use the Fi-Cap device that continuously tracks the head movement of the driver using fiducial markers, providing frame-based annotations to train head pose algorithms in naturalistic driving conditions. We ask the driver to look at predetermined gaze locations to obtain accurate correlation between the driver's facial image and visual attention. We also collect data when the driver performs common secondary activities such as navigation using a smart phone and operating the in-car infotainment system. All of the driver's activities are recorded with high definition RGB cameras and a time-of-flight depth camera. We also record the controller area network-bus (CAN-Bus), extracting important information. These high quality recordings serve as the ideal resource to train various efficient algorithms for monitoring the driver, providing further advancements in the field of in-vehicle safety systems.

Integrative Journal of Medical Sciences, 2020

Background : Schwannomas originating from the sciatic nerve are extremely rare and usually presen... more Background : Schwannomas originating from the sciatic nerve are extremely rare and usually present as a pathological mass in palpable examination or pain located in the thigh. Motor and sensory deficits are observed more often when the size of the tumor is more than 40 mm.Case Description : A 19-years- old female patient was referred to Suez Canal University Hospital after 6 years of pain and 2 years of improper management. Neurological examination and MRI of the right thigh was done and revealed huge mass attached to the right sciatic nerve. Surgical excision was undertaken, carefully dissecting the lesion from the sciatic nerve. Histopathological examination revealed the tumor to be a schwannoma. The patient had marked postoperative recovery with marked pain reduction and improved neurological deficits.Conclusions : Schwannomas of the sciatic nerve are rare tumors eccentrically located on the nerve. Although rare, schwannoma of the sciatic nerve should be systematically suspected ...

Iranian journal of basic medical sciences, 2018

Heat stress (HS) is a catastrophic stressor that dampens immunity. The current study investigates... more Heat stress (HS) is a catastrophic stressor that dampens immunity. The current study investigates the effect of dietary administration with camel whey protein (CWP) on apoptotic pathway caused by HS. Forty-five male mice were divided into three groups: a control group; HS group; and HS mice that were orally supplemented with CWP (CWP-HS group). We found that reactive oxygen species (ROS), pro-inflammatory cytokines (IL-6), and C reactive protein (CRP) were elevated in the HS group along with a significant increase of caspase-9 and -3 and decrease of total antioxidant capacity (TAC). HS mice revealed impaired phosphorylation of Bcl-2 and Survivin, as well as increased expression of Bax, Bim and cytochrome C. Additionally, we observed an aberrant distribution of HSP-70 expressing lymphocytes in the spleen and thymus of HS mice. Moreover, histopathological examination showed alterations on the architectures of immune organs. In comparison with CWP-HS group, we found that CWP restored t...

Molecular reproduction and development, Jan 23, 2018

Elevation of scrotal temperature is one of the most important causes of impaired spermatogenesis ... more Elevation of scrotal temperature is one of the most important causes of impaired spermatogenesis and male infertility, but the exact mechanism remains controversial. The present study investigated the impact of camel whey protein (CWP) on the mechanisms of heat stress (HS)-mediated testicular damage in male mice. Exposure to HS was associated with significant increase in the testicular tissues' oxidative stress. Mechanistically, exposure to HS resulted in upregulation of P53 and Nrf2 expressions; downregulation of Bcl2 and PPAR-γ expressions; and induction of testicular Leydig cell hyperplasia. Because Leydig cells produce testosterone up on stimulation with Luteinizing hormone (LH), HS mice also exhibited significant reduction in the serum testosterone levels followed by significant reduction in the percentages of progressively motile sperm and higher percentages of immotile sperm, when compared with those of control mice. Interestingly, treatment of HS mice with CWP significan...

Child abuse & neglect, Jan 3, 2018

This paper explores child disciplinary methods used by parents in Qatar and Palestine. In this st... more This paper explores child disciplinary methods used by parents in Qatar and Palestine. In this study ICAST-P, an internationally recognized tool, was used with mothers reporting on one of their children up to their 12th birthday. It questions about disciplinary methods: nonviolent; physical: moderate and severe; and psychological methods that had been used in the previous year on the index child in the family. A comparative national cross-sectional household survey of mothers aged 25-50 years old was conducted in both Qatar and Palestine, both Arabic Muslim states, but with very different socio-economic and political contexts that place Qataris in a much more advantageous position. Our results show that the 1299 Palestinian mothers interviewed were younger, had more children and less education compared to the 1018 Qatari mothers. Fewer mothers from Palestine were working. The index child in Palestine tended to be younger with 60% being under 5 years, while 73.7% of Qatari children w...

Biochemistry and cell biology = Biochimie et biologie cellulaire, Aug 22, 2017

Heat stress (HS) is an environmental factor that depresses the immune systems mediating dysfuncti... more Heat stress (HS) is an environmental factor that depresses the immune systems mediating dysfunctional immune cells. Camel whey protein (CWP) can scavenge free radicals and enhance immunity. The present study investigated the impact of dietary supplementation with CWP on immune dysfunction induced by exposure to HS. Male mice (n = 45) were divided into three groups: control group; HS group; and HS mice that were orally administered CWP (HS+CWP group). The HS group exhibited elevated levels of reactive oxygen species (ROS) and pro-inflammatory cytokines (IL-1β, IL-6, TNF-α) as well as a significant reduction in the IL-2 and IL-4 levels. Exposure to HS resulted in impaired AKT and IκB-α phosphorylation; increased ATF-3 and HSP70 expression; and aberrant distribution of CD3+ T cells and CD20+ B cells in the thymus and spleen. Interestingly, HS mice treated with CWP presented significantly restored levels of ROS and pro-inflammatory cytokines near the levels observed in control mice. Fur...

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, Jan 24, 2017

Type I diabetes (T1D) is a characterized by the inflammation of pancreatic islets and destruction... more Type I diabetes (T1D) is a characterized by the inflammation of pancreatic islets and destruction of β cells. Long and persistent uncontrolled diabetes tends to degenerate the immune system and increase the incidence of infections in diabetic individuals. Most serious diabetic complications are mediated by the free radicals, which damage multiple cellular components through direct effects of the cell cycle regulatory proteins. Camel whey protein (CWP) has antioxidant activity and decreases the effects of free radicals. However, the effects of CWP on lymphoid organs have not been studied in the context of diabetes. Therefore, the present study was designed to investigate the dietary influence of CWP supplementation on the lymphoid organs in streptozotocin (STZ)-induced type 1 diabetic mouse model. Three experimental groups were used: non diabetic control mice, diabetic mice, and diabetic mice treated with CWP. Induction of diabetes was associated with a marked reduction in glutathion...

Food & Nutrition Research, 2016

Background and objective: To our knowledge, no previous studies have focused on the immunomodulat... more Background and objective: To our knowledge, no previous studies have focused on the immunomodulatory effects of fresh royal jelly (RJ) administration on systemic lupus erythematosus (SLE) in humans. Our aim was to study the effect of fresh RJ administration on the disease course in children with SLE with some immunological markers (CD4 ' and CD8 ' regulatory T cells and T lymphocytes apoptosis). Methods: This was an open-label study in which 20 SLE children received 2 g of freshly prepared RJ daily, for 12 weeks. Results: The percentages of CD4 ' CD25 ' high FOXP3 ' cells (CD4 ' regulatory T cells) and CD8 ' CD25 ' high FOXP3 ' cells (CD8 ' regulatory T cells) were significantly increased after RJ treatment when compared with baseline values. Apoptotic CD4 T lymphocytes were significantly decreased after RJ therapy when compared with baseline values and the control group. Conclusion: This is the first human study on the effect of RJ supplementation in children with SLE. Our results showed improvements with 3-month RJ treatment with regard to the clinical severity score and laboratory markers for the disease. At this stage, it is a single study with a small number of patients, and a great deal of additional wide-scale randomized controlled studies are needed to critically validate the efficacy of RJ in SLE.

Lipids in Health and Disease, 2015

Background: Non-alcoholic fatty liver disease (NAFLD) is a multifactorial disease with a complex ... more Background: Non-alcoholic fatty liver disease (NAFLD) is a multifactorial disease with a complex pathophysiology. The clinical features of NAFLD include obesity, insulin resistance (IR) and dyslipidemia. Consumption of a diet high in saturated fats and sucrose is an important factor in the increasing occurrence of these metabolic disorders, primarily NAFLD and IR. We sought to assess the role of a high-fat, high-sucrose (HFS) diet in the promotion of NAFLD and to evaluate the effects of quercetin (Q), berberine (BB) and o-coumaric acid (CA) on modulation of these disorders. Methods: Fifty male rats were divided into 2 main groups as follows: group 1 comprised 10 rats fed a standard diet (SD), and group 2 comprised 40 rats fed an HFS diet for 6 weeks and then subdivided equally into 4 groups; one of these groups served as the HFS diet and each of the other three groups received daily supplementation with either Q, CA or BB for 6 weeks. Results: In the present study, several metabolic disorders were induced in our laboratory animal model, as evidenced by histological and biochemical changes. These alterations included serum and hepatic dyslipidemia (i.e., increased triglyceride, total cholesterol and low-density lipoprotein levels and decreased high-density lipoprotein levels), alterations in metabolic enzyme activities (lipase, glycerol-3-phosphate dehydrogenase, and glucose-6-phosphate dehydrogenase), histological changes in the liver (micro-and macrovesicular steatosis) and the downregulation of peroxisome proliferator-activated receptor γ (PPARγ) in adipose tissue and the liver. Daily oral supplementation with Q, CA or BB for 6 weeks after NAFLD induction had a hypolipidemic action and modulated metabolic markers. Conclusion: We showed that an HFS diet is able to promote NAFLD, and our results suggest that CA and BB are promising complementary supplements that can ameliorate the metabolic disorders associated with an HFS diet; however, Q requires further investigation.

Cellular Signalling, 2015

Type 1 diabetes mellitus (T1D) is associated with increased type 1 interferon (IFN) levels and su... more Type 1 diabetes mellitus (T1D) is associated with increased type 1 interferon (IFN) levels and subsequent severe defects in lymphocyte function, which increase susceptibility to infections. The blockade of type 1 IFN receptor 1 (IFNAR1) in non-obese diabetic mice has been shown to delay T1D onset and decrease T1D incidence by enhancing spleen CD4+ T cells and restoring B cell function. However, the effect of type 1 IFN blockade during T1D on splenic CD8+ T cells has not previously been studied. Therefore, we investigated, for the first time, the effect of IFNAR1 blockade on the survival and architecture of spleen-homing CD8+ T cells in a streptozotocin-induced T1D mouse model. Three groups of mice were examined: a non-diabetic control group; a diabetic group; and a diabetic group treated with an anti-IFNAR1 blocking antibody. We observed that T1D induction was accompanied by a marked destruction of β cells followed by a marked reduction in insulin levels and increased IFN-α and IFN-β levels in the diabetic group. The diabetic mice also exhibited many abnormal changes including an elevation in blood and spleen free radical (reactive oxygen species and nitric oxide) and pro-inflammatory cytokine (IL-6 and TNF-α) levels, a significant decrease in IL-7 levels, and subsequently, a significant decrease in the numbers of spleen-homing CD8+ T cells. This decrease in spleen-homing CD8+ T cells resulted from a marked reduction in the CCL21-mediated entry of CD8+ T cells into the spleen and from increased apoptosis due to a marked reduction in IL-7-mediated STAT5 and AKT phosphorylation. Interestingly, type 1 IFN signaling blockade in diabetic mice significantly restored the numbers of splenic CD8+ T cells by restoring free radical, pro-inflammatory cytokine and IL-7 levels. These effects subsequently rescued splenic CD8+ T cells from apoptosis through a mechanism that was dependent upon CCL21- and IL-7-mediated signaling. Our data suggest that type 1 IFN is an essential mediator of pathogenesis in T1D and that this role results from the negative effect of IFN signaling on the survival of splenic CD8+ T cells.

All Days, 2011

Different fluids have been introduced in the oil industry to be used as alternatives to HCl. Chel... more Different fluids have been introduced in the oil industry to be used as alternatives to HCl. Chelating agents such as EDTA (ethylenediaminetetraaceticacid), HEDTA (hydroxyethylenediaminetriaceticacid), and GLDA (L-glutamic acid-N, N-diacetic acid) have been introduced to be used as stand-alone stimulation fluids. These fluids can be used to stimulate water injectors, oil, or gas producers, therefore, the effect of the type of reservoir fluid on the stimulation process should be investigated. In this study, 0.6M concentration of GLDA, EDTA, and HEDTA were used in the coreflood experiments on carbonate rocks at 300°F. The cores were saturated with water, oil, or gas to determine the effect of reservoir fluid type on the performance of the chelating agents with the carbonate cores. The different chelants were injected into the calcite cores saturated by oil and gas after flooding the water into the cores until the residual saturations were reached. The effect of using 10 vol% mutual so...

All Days, 2011

The objective of stimulation of sandstone reservoirs is to remove the damage caused to the produc... more The objective of stimulation of sandstone reservoirs is to remove the damage caused to the production zone during drilling or completion operations. Many problems may occur during sandstone acidizing with HCl/HF mud acid. Among these problems: decomposition of clays in HCl acids, precipitation of fluosilicates, the presence of carbonates can cause the precipitation of calcium fluorides, silica-gel filming, colloidal silica-gel precipitation. In this study, a recently introduced chelating agent, glutami-N, N-diacetic acid(GLDA), was used to stimulate sandstone cores. Berea sandstone cores with 8 wt% clays content were used in this study. Different GLDA solution pH values (1.7 - 13) were used in the coreflood experiments. The sandstone cores were scanned before and after the treatment to investigate the effect of GLDA on the core. The effluent samples were analyzed for calcium, magnesium, aluminum, and iron using the ICP to assess the ability of GLDA on the complexation of these ions....

All Days, 2011

Chelating agents such as GLDA, EDTA, and HEDTA have been used to stimulate calcite reservoirs as ... more Chelating agents such as GLDA, EDTA, and HEDTA have been used to stimulate calcite reservoirs as alternatives to HCl. HCl based stimulation fluids are very corrosive at high temperatures and should be loaded with many additives to reduce corrosion problems. In addition, the application of HCl can lead to face dissolution at low flow rates. GLDA chelating agent was used to stimulate calcium carbonate cores up to temperature of 300°F and at low rates without any face dissolution problems. The dissolution of dolomite by chelating agents has not been thoroughly investigated. Preliminary experiments with EDTA at ambient temperature revealed no significant dolomite dissolution. The dissolution mechanism is probably inhibited by the low stability of the magnesium chelate at that temperature. In this study, we will investigate the ability of GLDA (glutamic -N,N- diacetic acid) to stimulate dolomite cores as well as calcite cores. GLDA with different pH (1.7, 3 and 13) was used for this stud...

International Journal of Biological Macromolecules, 2015

In this study we have investigated the heat induced denaturation of HSA byutilizing spectroscopic... more In this study we have investigated the heat induced denaturation of HSA byutilizing spectroscopic approaches including fluorescence and circular dichroism. Thermal denaturation of N isomer (domain I-III remains intact), B isomer (loss of helical structure of interdomain contacts) and I state (domain II intact) was found to be cooperative processes while for F isomer domains unfold non-cooperatively. These finding pointed out that during N-F transition, HSA suffers more structural alterationswhich are not localized only to domain III. Loss of secondary structure in the temperature range 20-60 0C without effecting tertiary structure of N isomer of HSA is mainly due to loss in helical extensions connecting domain I to II and domain II to III. All the four thermally denatured states (60-96 0C) of HSA retained approximately 50% residual alpha helical structures. Near-UV CD used as a probe for tertiary structure indicated that heat denatured states lost almost all of the tertiary contacts,thereby forming molten globule like states. Furthermore, our results provide evidence that residual helical structuresare mainly located in domain II.