Javier Haya - Academia.edu (original) (raw)
Papers by Javier Haya
Menopause, 2009
Objective: There is increasing evidence to suggest that ossein-hydroxyapatite complex (OHC) is mo... more Objective: There is increasing evidence to suggest that ossein-hydroxyapatite complex (OHC) is more effective than calcium supplements in maintaining bone mass. The aim of this meta-analysis was to determine whether OHC has a different clinical effect on bone mineral density (BMD) compared with calcium carbonate (CC).
Clinical Drug Investigation, 2007
The long-term effects of ossein-hydroxyapatite compound (OHC), Abstract a drug used for osteoporo... more The long-term effects of ossein-hydroxyapatite compound (OHC), Abstract a drug used for osteoporosis prevention, have not been previously reported. The aim of this study was to assess the long-term efficacy of OHC in postmenopausal women with bone mineral density (BMD) in the osteopenia range. Methods: We performed a retrospective 4-year follow-up study in a primary-care setting to assess changes in BMD in a cohort of 112 postmenopausal women included in an osteoporosis programme that included health and dietary advice and who were treated with OHC 1660mg every 12 hours. BMD was measured annually in the distal part of the forearm, with T-and Z-score values being calculated for trabecular and total bone. Results: A progressive and statistically significant increase in BMD was observed in trabecular and total T-and Z-score mean values. At baseline, mean ± SD trabecular T-and Z-scores were -1.27 ± 0.7 and -1.03 ± 0.7, respectively, and -0.86 ± 0.7 and -0.62 ± 0.7, respectively, at the end of the 4-year follow-up period (both p < 0.0001). Mild constipation was observed in 3.2% of patients during the follow-up period. Conclusion: Ossein-hydroxyapatite compound could be an effective and safe agent for the prevention of bone loss in postmenopausal osteopenic women, with significant increases in BMD being observed in this group of patients.
ABSTRACT Incluye bibliografía e índice
El fruto del sauzgatillo o agnocasto (Vitex agnus castus L.) mejora la sintomatología del síndrom... more El fruto del sauzgatillo o agnocasto (Vitex agnus castus L.) mejora la sintomatología del síndrome premenstrual, especialmente la mastodinia, debido a un efecto dopaminérgico sobre receptores D2. Esta actividad es atribuida a los diterpenos, principalmente al rotundifurano ( diterpeno labdánico) y a otros compuestos aislados recientemnete, que presental mayor actividad dopaminérgica. Entre estos últimos destacan los diterpenos clerodanos que son, también, potentes inhibidores de la liberación de prolactina, hecho relacionado con la reducción de los elevados niveles de esta hormona que produce el furto del sauzgatillo en la fase final del ciclo menstrual. In vitro, se ha demostrado la interacción selectiva sobre el receptor estrogénico b (ERB), y en este sentido la apigenina se ha identificado como el componente más activo. Además, la actividad farmacológica se relaciona con la capacidad de unirse a receptores opiáceos. Adicionalmente, la utilización fitoterapeútica de preparados del...
![Research paper thumbnail of [Combined epidural-spinal analgesia during labor: a quantitative systematic review of the literature (meta-analysis)]](https://attachments.academia-assets.com/43181719/thumbnails/1.jpg)
](Revista española de anestesiología y reanimación, 2013
To perform a meta-analysis on the use of combined epidural-intrathecal analgesia during labor, in... more To perform a meta-analysis on the use of combined epidural-intrathecal analgesia during labor, including intrathecal fentanyl and/or morphine compared to usual epidural techniques. A literature search was made looking for randomized clinical trials in MEDLINE, EMBASE and Cochrane Library. The size of the effect for quantitative variables was analyzed by weighted mean difference; for qualitative variables, by odds ratio. Variables analyzed were: labor duration, type of delivery (spontaneous, instrumental and caesarean section), motor blockade, pain, and satisfaction. The analysis used in most cases was a random effects model. A total of 21 trials, which included 3.646 patients, were selected out of the 38 initially found. The type of delivery variable with its 3 subgroups was the only one to show uniformity (p>Q 0.1; I(2)<50%). There were no differences in the variables analyzed except pain, which was advantageous for the group with intrathecal fentanyl or morphine by 0.55 poin...
Tesis doctoral inédita leída en la Universidad Autónoma de Madrid, Facultad de Medicina. Departam... more Tesis doctoral inédita leída en la Universidad Autónoma de Madrid, Facultad de Medicina. Departamento de Obstetricia y Ginecología. Fecha de lectura: 28 de Mayo de 2010 Bibliografía: p. pp.271-292
Plant Foods for Human Nutrition, 2010
Recently, polyphenols have been found to affect blood lipids in animals in a similar manner as so... more Recently, polyphenols have been found to affect blood lipids in animals in a similar manner as soluble dietary fibre. The aim was to assess whether an insoluble dietary fiber very rich in polyphenols has a beneficial effect on serum lipids in humans. In a double-blind randomized placebo-controlled clinical study with parallel arms, 88 volunteers with hypercholesterolemia were randomly assigned to consume daily either, fiber with insoluble 84% polyphenols 4 g twice a day (n=43) or placebo (n= 45). Serum total, LDL and HDL cholesterol and triglycerides were assessed at baseline and after 4 weeks. The insoluble polyphenols consumption reduced the total cholesterol by 17.8±6.1% (p<0.05), LDL cholesterol by 22.5±8.9% (p<0.001), LDL: HDL cholesterol ratio by 26.2±14.3% (p<0.001) and triglycerides by 16.3±23.4% (p<0.05) at the end of the study compared with baseline. No significant differences were found during the study time in the placebo group for the lipid profile. The consumption of fiber very rich in insoluble polyphenols shows beneficial effects on human blood lipid profile and may be effective in prevention and treatment of hyperlipemia.
Toko-ginecología práctica
Radiology, 2003
To evaluate the effectiveness of uterine artery embolization (UAE) in the management of bleeding ... more To evaluate the effectiveness of uterine artery embolization (UAE) in the management of bleeding in patients with uterine fibroids and to compare UAE with hysterectomy, particularly with regard to length of hospital stay and associated complications (ie, safety). A prospective clinical trial was performed with patients who were randomly assigned to one of two groups: patients who were offered the option of undergoing either UAE or hysterectomy (group 1) and patients who were not informed of the alternative treatment-that is, UAE (group 2). The primary variables that were considered for evaluation of the effectiveness, efficiency, and safety of the two procedures were, respectively, bleeding cessation, total length of hospital stay, and resulting complications. The lengths of hospital stay in the two study arms were compared on an intent-to-treat basis. Owing to crossover between the treatment arms, however, effectiveness and safety were evaluated on the basis of the actual treatment received. The clinical success rate for the patients who underwent UAE, which was based on the cessation of bleeding, was 86% (31 of 36 patients). The mean hospital stay for group 1 was 4.14 days shorter than that for group 2 (P &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt;.001). Ten (25%) of the 40 patients who underwent UAE experienced minor complications, in contrast to four (20%) of the 20 who underwent hysterectomy and experienced major complications. Compared with hysterectomy, UAE is safe and effective for treatment of bleeding fibroids, necessitates a shorter hospital stay, and results in fewer major complications.
Los gestágenos clásicamente han sido relacionado con el cáncer mamario. Por esto, cuando se requi... more Los gestágenos clásicamente han sido relacionado con el cáncer mamario. Por esto, cuando se requiere indicar un anticonceptivos hormonal en una paciente tratada por cáncer de mama, surge la opción del uso de anticonceptivos con gestágenos solos (POP). Algunos ...
Progresos de Obstetricia y Ginecología, 2006
ABSTRACT Objective To evaluate the tolerability of the contraceptive vaginal ring in a representa... more ABSTRACT Objective To evaluate the tolerability of the contraceptive vaginal ring in a representative simple of the Spanish women willing hormonal contraception.
SEMERGEN - Medicina de Familia, 2008
SEMERGEN - Medicina de Familia, 2000
Reproductive Sciences, 2009
Objective: The aim of the study was to focus on the association of vitamin D and breast cancer. M... more Objective: The aim of the study was to focus on the association of vitamin D and breast cancer. Methods: The study of evidence concerning vitamin D's influence on the origin and development of breast cancer from a PubMed and individual searches. Results: Body sunlight exposure may reduce the prevalence of breast cancer. However, these studies correspond to global populations of different countries and regions without considering other geographic factors and individual, ethnic, and cultural factors that may affect sunlight exposure. Epidemiological analyses show that low vitamin D ingestion is associated with increased risk of breast cancer. Studies measuring serum vitamin D metabolites in women who were followed many years suggest that low circulating 25-hydroxyvitamin D 3 levels are associated with increased breast cancer risk. Conclusions: Although there are controversial results, it seems plausible that sufficient endogenous vitamin D levels may have a protective function on mammary cells, reducing breast cancer risk.
Radiotherapy and Oncology, 1992
From 1971 to 1988 72 cases of carcinoma of the anal canal were treated by external beam radiother... more From 1971 to 1988 72 cases of carcinoma of the anal canal were treated by external beam radiotherapy, most commonly by 5000 cGy in 20 fractions given over 4 weeks. The actuarial survival at 5 years was 66~o and the disease specific survival 78~o. Nine patients had inguinal node metastases at diagnosis; their 5-year disease specific survival was 75 ~o. 63 patients were inguinal node negative at presentation; their 5-year disease specific survival was 78 ~o, by UICC 1987 staging: T 1 71 ~o, T2 88 ~o, T3 41 ~o, T 4 42~o. 17 patients developed local recurrence; 10 were suitable for abdominoperineal (AP) resection which was successful in 7. The probability of local control was related to T stage. 13 patients were left with a colostomy because of recurrence, 2 had a colostomy for radiation damage and 4 had their local recurrence managed palliatively, without a colostomy. As a result, 53 of the 72 patients (74~o) were left with a functional anus. Severe late complications occurred in 6 (8~o).
Menopause, 2003
To assess the incidence of endometrial polyps during postmenopausal replacement therapy with tibo... more To assess the incidence of endometrial polyps during postmenopausal replacement therapy with tibolone, using an appropriate control group. A total of 485 postmenopausal women were included in this open, prospective, comparative study for a duration of 36 months. Of this group, 249 women received 2.5 mg/day of tibolone and 244 women served as controls, receiving continuous-combined estrogen-progestogen therapy (HT). Transvaginal ultrasound, hysteroscopy, and directed biopsies were performed before treatment was initiated and at the end of the study. Two hundred twenty-one of the women receiving tibolone and 203 receiving continuous-combined HT completed the study. Endometrial polyps were detected in 74 women (33.4%) from the tibolone group and in 22 women (10.8%) from the HT group (P &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt; 0.01). The vaginal bleeding rate did not differ between the groups. The frequency of atrophic polyps was significantly higher in the tibolone group (P &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt; 0.01). No difference was found in the size of the polyps. Tibolone increases by threefold the risk for endometrial polyps.
Menopause, 2008
Objective: To compare the efficacy and safety of adding ossein-hydroxyapatite compound (OHC) or c... more Objective: To compare the efficacy and safety of adding ossein-hydroxyapatite compound (OHC) or calcium carbonate (CC) to raloxifene (RLX) therapy for controlling bone loss in postmenopausal women.
Menopause, 2003
To assess the beliefs of climacteric women regarding their health, menopause, and hormone replace... more To assess the beliefs of climacteric women regarding their health, menopause, and hormone replacement therapy (HRT). Medical students asked to interview 526 healthy women, ranging from 40 to 64 years of age, between January and February of 2002. Of that number, 26 (4.9%) declined to participate in the interview. Thus, 500 women were interviewed about their beliefs and perceptions regarding their quality of life and health risks, as well as their opinions on menopause and HRT. The mean age of the sample was 53.3 +/- 6.2 years; 83.4% were postmenopausal, and 18.8% were HRT users. Of the women interviewed, 38.6% believed that their health was good. Although 78.8% thought that cancer is the main cause of death, 64% of them considered themselves to be at high risk for cardiovascular disease and osteoporosis. Most (64%) believed that menopause deteriorates the quality of life and that it increases cardiovascular risk (52.4%) and osteoporosis (72.0%). The HRT users perceived that they had better health status (48.9% v 36.2%, P &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt; 0.02) and smaller cardiovascular risk (54.3% v 66.3%, P &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt; 0.04) than did the nonusers; however, they ignored the preventive effect of estrogens in osteoporosis. Women believe that menopause deteriorates their health. The HRT users perceived themselves to be healthier and to have a smaller risk for cardiovascular disease.
Menopause, 2009
Objective: There is increasing evidence to suggest that ossein-hydroxyapatite complex (OHC) is mo... more Objective: There is increasing evidence to suggest that ossein-hydroxyapatite complex (OHC) is more effective than calcium supplements in maintaining bone mass. The aim of this meta-analysis was to determine whether OHC has a different clinical effect on bone mineral density (BMD) compared with calcium carbonate (CC).
Clinical Drug Investigation, 2007
The long-term effects of ossein-hydroxyapatite compound (OHC), Abstract a drug used for osteoporo... more The long-term effects of ossein-hydroxyapatite compound (OHC), Abstract a drug used for osteoporosis prevention, have not been previously reported. The aim of this study was to assess the long-term efficacy of OHC in postmenopausal women with bone mineral density (BMD) in the osteopenia range. Methods: We performed a retrospective 4-year follow-up study in a primary-care setting to assess changes in BMD in a cohort of 112 postmenopausal women included in an osteoporosis programme that included health and dietary advice and who were treated with OHC 1660mg every 12 hours. BMD was measured annually in the distal part of the forearm, with T-and Z-score values being calculated for trabecular and total bone. Results: A progressive and statistically significant increase in BMD was observed in trabecular and total T-and Z-score mean values. At baseline, mean ± SD trabecular T-and Z-scores were -1.27 ± 0.7 and -1.03 ± 0.7, respectively, and -0.86 ± 0.7 and -0.62 ± 0.7, respectively, at the end of the 4-year follow-up period (both p < 0.0001). Mild constipation was observed in 3.2% of patients during the follow-up period. Conclusion: Ossein-hydroxyapatite compound could be an effective and safe agent for the prevention of bone loss in postmenopausal osteopenic women, with significant increases in BMD being observed in this group of patients.
ABSTRACT Incluye bibliografía e índice
El fruto del sauzgatillo o agnocasto (Vitex agnus castus L.) mejora la sintomatología del síndrom... more El fruto del sauzgatillo o agnocasto (Vitex agnus castus L.) mejora la sintomatología del síndrome premenstrual, especialmente la mastodinia, debido a un efecto dopaminérgico sobre receptores D2. Esta actividad es atribuida a los diterpenos, principalmente al rotundifurano ( diterpeno labdánico) y a otros compuestos aislados recientemnete, que presental mayor actividad dopaminérgica. Entre estos últimos destacan los diterpenos clerodanos que son, también, potentes inhibidores de la liberación de prolactina, hecho relacionado con la reducción de los elevados niveles de esta hormona que produce el furto del sauzgatillo en la fase final del ciclo menstrual. In vitro, se ha demostrado la interacción selectiva sobre el receptor estrogénico b (ERB), y en este sentido la apigenina se ha identificado como el componente más activo. Además, la actividad farmacológica se relaciona con la capacidad de unirse a receptores opiáceos. Adicionalmente, la utilización fitoterapeútica de preparados del...
Revista española de anestesiología y reanimación, 2013
To perform a meta-analysis on the use of combined epidural-intrathecal analgesia during labor, in... more To perform a meta-analysis on the use of combined epidural-intrathecal analgesia during labor, including intrathecal fentanyl and/or morphine compared to usual epidural techniques. A literature search was made looking for randomized clinical trials in MEDLINE, EMBASE and Cochrane Library. The size of the effect for quantitative variables was analyzed by weighted mean difference; for qualitative variables, by odds ratio. Variables analyzed were: labor duration, type of delivery (spontaneous, instrumental and caesarean section), motor blockade, pain, and satisfaction. The analysis used in most cases was a random effects model. A total of 21 trials, which included 3.646 patients, were selected out of the 38 initially found. The type of delivery variable with its 3 subgroups was the only one to show uniformity (p>Q 0.1; I(2)<50%). There were no differences in the variables analyzed except pain, which was advantageous for the group with intrathecal fentanyl or morphine by 0.55 poin...
Tesis doctoral inédita leída en la Universidad Autónoma de Madrid, Facultad de Medicina. Departam... more Tesis doctoral inédita leída en la Universidad Autónoma de Madrid, Facultad de Medicina. Departamento de Obstetricia y Ginecología. Fecha de lectura: 28 de Mayo de 2010 Bibliografía: p. pp.271-292
Plant Foods for Human Nutrition, 2010
Recently, polyphenols have been found to affect blood lipids in animals in a similar manner as so... more Recently, polyphenols have been found to affect blood lipids in animals in a similar manner as soluble dietary fibre. The aim was to assess whether an insoluble dietary fiber very rich in polyphenols has a beneficial effect on serum lipids in humans. In a double-blind randomized placebo-controlled clinical study with parallel arms, 88 volunteers with hypercholesterolemia were randomly assigned to consume daily either, fiber with insoluble 84% polyphenols 4 g twice a day (n=43) or placebo (n= 45). Serum total, LDL and HDL cholesterol and triglycerides were assessed at baseline and after 4 weeks. The insoluble polyphenols consumption reduced the total cholesterol by 17.8±6.1% (p<0.05), LDL cholesterol by 22.5±8.9% (p<0.001), LDL: HDL cholesterol ratio by 26.2±14.3% (p<0.001) and triglycerides by 16.3±23.4% (p<0.05) at the end of the study compared with baseline. No significant differences were found during the study time in the placebo group for the lipid profile. The consumption of fiber very rich in insoluble polyphenols shows beneficial effects on human blood lipid profile and may be effective in prevention and treatment of hyperlipemia.
Toko-ginecología práctica
Radiology, 2003
To evaluate the effectiveness of uterine artery embolization (UAE) in the management of bleeding ... more To evaluate the effectiveness of uterine artery embolization (UAE) in the management of bleeding in patients with uterine fibroids and to compare UAE with hysterectomy, particularly with regard to length of hospital stay and associated complications (ie, safety). A prospective clinical trial was performed with patients who were randomly assigned to one of two groups: patients who were offered the option of undergoing either UAE or hysterectomy (group 1) and patients who were not informed of the alternative treatment-that is, UAE (group 2). The primary variables that were considered for evaluation of the effectiveness, efficiency, and safety of the two procedures were, respectively, bleeding cessation, total length of hospital stay, and resulting complications. The lengths of hospital stay in the two study arms were compared on an intent-to-treat basis. Owing to crossover between the treatment arms, however, effectiveness and safety were evaluated on the basis of the actual treatment received. The clinical success rate for the patients who underwent UAE, which was based on the cessation of bleeding, was 86% (31 of 36 patients). The mean hospital stay for group 1 was 4.14 days shorter than that for group 2 (P &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt;.001). Ten (25%) of the 40 patients who underwent UAE experienced minor complications, in contrast to four (20%) of the 20 who underwent hysterectomy and experienced major complications. Compared with hysterectomy, UAE is safe and effective for treatment of bleeding fibroids, necessitates a shorter hospital stay, and results in fewer major complications.
Los gestágenos clásicamente han sido relacionado con el cáncer mamario. Por esto, cuando se requi... more Los gestágenos clásicamente han sido relacionado con el cáncer mamario. Por esto, cuando se requiere indicar un anticonceptivos hormonal en una paciente tratada por cáncer de mama, surge la opción del uso de anticonceptivos con gestágenos solos (POP). Algunos ...
Progresos de Obstetricia y Ginecología, 2006
ABSTRACT Objective To evaluate the tolerability of the contraceptive vaginal ring in a representa... more ABSTRACT Objective To evaluate the tolerability of the contraceptive vaginal ring in a representative simple of the Spanish women willing hormonal contraception.
SEMERGEN - Medicina de Familia, 2008
SEMERGEN - Medicina de Familia, 2000
Reproductive Sciences, 2009
Objective: The aim of the study was to focus on the association of vitamin D and breast cancer. M... more Objective: The aim of the study was to focus on the association of vitamin D and breast cancer. Methods: The study of evidence concerning vitamin D's influence on the origin and development of breast cancer from a PubMed and individual searches. Results: Body sunlight exposure may reduce the prevalence of breast cancer. However, these studies correspond to global populations of different countries and regions without considering other geographic factors and individual, ethnic, and cultural factors that may affect sunlight exposure. Epidemiological analyses show that low vitamin D ingestion is associated with increased risk of breast cancer. Studies measuring serum vitamin D metabolites in women who were followed many years suggest that low circulating 25-hydroxyvitamin D 3 levels are associated with increased breast cancer risk. Conclusions: Although there are controversial results, it seems plausible that sufficient endogenous vitamin D levels may have a protective function on mammary cells, reducing breast cancer risk.
Radiotherapy and Oncology, 1992
From 1971 to 1988 72 cases of carcinoma of the anal canal were treated by external beam radiother... more From 1971 to 1988 72 cases of carcinoma of the anal canal were treated by external beam radiotherapy, most commonly by 5000 cGy in 20 fractions given over 4 weeks. The actuarial survival at 5 years was 66~o and the disease specific survival 78~o. Nine patients had inguinal node metastases at diagnosis; their 5-year disease specific survival was 75 ~o. 63 patients were inguinal node negative at presentation; their 5-year disease specific survival was 78 ~o, by UICC 1987 staging: T 1 71 ~o, T2 88 ~o, T3 41 ~o, T 4 42~o. 17 patients developed local recurrence; 10 were suitable for abdominoperineal (AP) resection which was successful in 7. The probability of local control was related to T stage. 13 patients were left with a colostomy because of recurrence, 2 had a colostomy for radiation damage and 4 had their local recurrence managed palliatively, without a colostomy. As a result, 53 of the 72 patients (74~o) were left with a functional anus. Severe late complications occurred in 6 (8~o).
Menopause, 2003
To assess the incidence of endometrial polyps during postmenopausal replacement therapy with tibo... more To assess the incidence of endometrial polyps during postmenopausal replacement therapy with tibolone, using an appropriate control group. A total of 485 postmenopausal women were included in this open, prospective, comparative study for a duration of 36 months. Of this group, 249 women received 2.5 mg/day of tibolone and 244 women served as controls, receiving continuous-combined estrogen-progestogen therapy (HT). Transvaginal ultrasound, hysteroscopy, and directed biopsies were performed before treatment was initiated and at the end of the study. Two hundred twenty-one of the women receiving tibolone and 203 receiving continuous-combined HT completed the study. Endometrial polyps were detected in 74 women (33.4%) from the tibolone group and in 22 women (10.8%) from the HT group (P &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt; 0.01). The vaginal bleeding rate did not differ between the groups. The frequency of atrophic polyps was significantly higher in the tibolone group (P &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt; 0.01). No difference was found in the size of the polyps. Tibolone increases by threefold the risk for endometrial polyps.
Menopause, 2008
Objective: To compare the efficacy and safety of adding ossein-hydroxyapatite compound (OHC) or c... more Objective: To compare the efficacy and safety of adding ossein-hydroxyapatite compound (OHC) or calcium carbonate (CC) to raloxifene (RLX) therapy for controlling bone loss in postmenopausal women.
Menopause, 2003
To assess the beliefs of climacteric women regarding their health, menopause, and hormone replace... more To assess the beliefs of climacteric women regarding their health, menopause, and hormone replacement therapy (HRT). Medical students asked to interview 526 healthy women, ranging from 40 to 64 years of age, between January and February of 2002. Of that number, 26 (4.9%) declined to participate in the interview. Thus, 500 women were interviewed about their beliefs and perceptions regarding their quality of life and health risks, as well as their opinions on menopause and HRT. The mean age of the sample was 53.3 +/- 6.2 years; 83.4% were postmenopausal, and 18.8% were HRT users. Of the women interviewed, 38.6% believed that their health was good. Although 78.8% thought that cancer is the main cause of death, 64% of them considered themselves to be at high risk for cardiovascular disease and osteoporosis. Most (64%) believed that menopause deteriorates the quality of life and that it increases cardiovascular risk (52.4%) and osteoporosis (72.0%). The HRT users perceived that they had better health status (48.9% v 36.2%, P &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt; 0.02) and smaller cardiovascular risk (54.3% v 66.3%, P &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt; 0.04) than did the nonusers; however, they ignored the preventive effect of estrogens in osteoporosis. Women believe that menopause deteriorates their health. The HRT users perceived themselves to be healthier and to have a smaller risk for cardiovascular disease.