Hayat M Mukhtar - Academia.edu (original) (raw)

Papers by Hayat M Mukhtar

Toxicology Letters, Aug 1, 1983

Nigerian Journal of Medicine, 2010

Background: Abdominal tuberculosis is a common complication of pulmonary tuberculosis. With the r... more Background: Abdominal tuberculosis is a common complication of pulmonary tuberculosis. With the rising incidence of HIV, tuberculosis has become a major public health problem particularly in developing countries. Methods: This is a retrospective study involving patients whose surgical specimens were processed at the central histopathology laboratory of the Ahmadu Bello University Teaching Hospital (ABUTH) Zaria-Nigeria, between January1975 to December 2006. Results: There were 68 males and 49 females, aged 12-70 years (mean 28.6yrs 11yrs). While paroxysmal dry cough was present in about 20 patients, abdominal pain and distension were very common. Concomitant pulmonary tuberculosis was confirmed in 15 patients (14%). The findings at Surgery in 66 patients are presented in fig.2. Multiple deposits on the peritoneum and omentum were the commonest findings (48.7% and 26.2%) respectively. Conclusion: Abdominal tuberculosis is not uncommon and there is need to establish an early less invasive diagnostic protocol.

Journal of emerging technologies and innovative research, May 1, 2020

International Research Journal of Pure and Applied Chemistry, Jul 20, 2019

Schiff base derived from salicylaldehyde and 2,4-dinitrophenylhydrazine was synthesized. Its Mn(I... more Schiff base derived from salicylaldehyde and 2,4-dinitrophenylhydrazine was synthesized. Its Mn(II) and Fe(II) complexes (MnL 2 and FeL 2) were synthesized by refluxing the metal (II) chlorides with the Schiff base. All the compounds were characterized by melting point/decomposition temperature, solubility, molar conductance, magnetic susceptibility infrared analysis and UV-visible spectrophotometry. The composition of the complexes has been found to be 1:2 (Metal-Ligand) ratio. The complexes have low molar conductance values 6.39-6.59 ohm-1 cm 2 mol-1 indicating nonelectrolytes. The Schiff base and its metal (II) complexes were screened for antibacterial Original Research Article

PubMed, Oct 1, 1981

The formation of p-nitrophenylglucuronide from p-nitrophenol and [14C]uridine disphosphoglucuroni... more The formation of p-nitrophenylglucuronide from p-nitrophenol and [14C]uridine disphosphoglucuronic acid was demonstrated in intact rat liver nuclei and nuclear membranes. Most of the enzymatic activity in nuclei (80%) was localized in the nuclear envelope. Several in vitro activators of microsomal glucuronyltransferase had no effect on enzyme activity in whole nuclei, but were effective in stimulating the activity in nuclear membranes; however, the magnitude of activation (45%) was much less than with microsomes (500%). UDP-N-acetylglucosamine had no effect on nuclear UDP-glucuronyltransferase activity in whole nuclei or in nuclear membrane preparations. The nuclear membrane enzyme(s) did not obey simple Michaelis-Menten kinetics in native or detergent-activated enzyme preparations. The kinetic behavior did not change upon activation and the apparent Km values remained constant, 1.0 and 0.7 mM for UDP-glucuronic acid and nitrophenol, respectively. Nuclear membrane UDP-glucuronyltransferase activity was increased 3-fold by pretreatment with 3-methylcholanthrene. Phenobarbital or trans-stilbene oxide pretreatment had no effect on nuclear enzyme activity. In contrast, microsomal UDP-glucuronyltransferase activity was increased upon pretreatment with all of these inducers. The results suggest that rat hepatic nuclear glycuronyltransferase activity is localized in the nuclear envelope and that the activity is possibly under a different control mechanism than tha for the microsomes. The properties and physiological significance of the nuclear enzyme are discussed.

Pakistan journal of science, Jan 4, 2023

Highland Medical Research Journal, Apr 16, 2008

Background: Anaemia in HIV-infected individuals has been known to be a common complication that c... more Background: Anaemia in HIV-infected individuals has been known to be a common complication that correlates well with disease progression, patient survival and final outcome. Objective: To determine the prevalence of anaemia in HAART naive patients at the Ahmadu Bello University Teaching Hospital (ABUTH), a designated national antiretroviral treatment center Methods: This is cross sectional descriptive study of HIV- patients receiving treatment at ABUTH treatment center from March 2002 to September 2005. Study process included documenting patients' bio-data, standardized medical history, hematocrit, reticulocyte counts, bone marrow aspirations and biopsy and CD4+T cell counts. Anaemia in this study was defined as hematocrit of less than 0.36L/L. Results were analysed using SPSS version 11 soft ware. Results: Out of 856 patients, 119 (13.9%) had anaemia. Median age of the patients was 34 yrs. Eighty (67.2%) were females while 39(32.8%) were males. Hematocrit levels ranged from 0.13-0.35L/L with a mean of 0.29L/L and SD of 0.48L/L in the anaemic patients and 0.37-0.44L/lLmean 39l/l +/-5 SD in the non-anaemic patients. Reticulocyte counts ranged from 2.8-12.3% (median 6.2%). CD4+ cell counts in all patients ranged from 40-1060 cells/ul, 49 (89.1%) of the anaemic patients had CD4 cell counts 350. Twenty one (15.9%) were in stages 1, 36 (26%) were in stage 2, 67 (48.5%) were in stage 3 and 13 (9.4%) were in stage 4 respectively. Type of anaemia based on morphology found 15.2% with dimorphic blood picture 33.4% with macrocytic picture while 51.4% had normocytic normpchromic blood picture. Conclusions: Anaemia is common in our patients and was more severe in advanced stages of the disease in patients with low CD4+T cell counts. Keywords : Haart, Hiv/Aids, Arv, Aneamia Highland Medical Research Journal Vol. 4 (2) 2006 pp. 27-31

International Journal of Nursing and Health Care Research, 2020

International Journal of Research -GRANTHAALAYAH, 2019

Background: The profession of Nursing has been at the forefront of patient safety taking special ... more Background: The profession of Nursing has been at the forefront of patient safety taking special attention to the training and education of its workforce. Internationally, the International Council of Nurses (ICN) has been tackling this issue with force since it established that Patient safety is fundamental to quality health and nursing care Aim: To study the impact of a design propose program for nurses about patient safety and evaluate the impact of it on nurses knowledge. Methodology: This was quiz experimental study, one hundred eight nurses were included as all the entire population meeting the inclusion criteria taken as a sample, using census to achieve a desirable level of precision, the data was collected in four phases using a self-administered questionnaire, phase one include an orientation about the training program. Phase two (pretest data), in which the questionnaire was distributed for nurses and each one was allowed sufficient time to fill it. After collection of ...

AIP Conference Proceedings, Dec 31, 2022

Research Journal of Pharmacognosy and Phytochemistry, 2012

Research Journal of Pharmacognosy and Phytochemistry, Aug 6, 2012

Grewia asiatica is a small deciduous tree consisting of ripe fruits, seeds, flowers, bark and lea... more Grewia asiatica is a small deciduous tree consisting of ripe fruits, seeds, flowers, bark and leaves of the plant belonging to family Tiliaceae. In present study, various standardization parameters of fruits like macroscopical, microscopical characters, physicochemical parameters like total ash (5.16%), water soluble ash (2.5%), acid insoluble ash (1%), sulphated ash (0.66%), loss on drying (8.3%), swelling index (0.1), foaming index (less than 100), successive extractive values in various solvents like petroleum ether (1.6%), benzene (2.1%), chloroform (2.6%), ethyl acetate (3.7%), methanol (30.9%). Cold Maceration values, petroleum ether (3%), benzene (3.3%), chloroform (4%), ethyl acetate (4.3%), methanol (45.6%). Behaviour on treatment with different chemical reagents of the dried fruits, fluorescence characters under visible and ultralviolet light were studied to fix some pharmacognostic parameters that vary from region to region. Preliminary phytochemical studies on different extracts were reported.

Research Journal of Pharmacy and Technology, Apr 28, 2012

This specification covers the standardization and preliminary phytochemical investigation of the ... more This specification covers the standardization and preliminary phytochemical investigation of the plant Benincasa hispida (Cucurbitaceae). It is widely used as antiulcer, anti-angiogenic, bronchodilator, in opioid withdrawal benefit, anti-diabetic and in mental disability. The plant material was subjected to pharmacognostical studies like macroscopic and microscopic studies (powder microscopy, micrometry, histochemical tests and transverse section). The microscopic characters revealed the presence of: Seeds [lignified trichomes found in groups (17.28μ,1.62μ), transparent fibers (70.20μ, 1.35μ), round shaped oil cells (9.45μ) found in thin walled parenchyma cells, parenchyma cells with wrinkled walls and lignified spiral vessels (52.38μ, 1.48μ)] mesocarp [lignified covering trichomes (27.43μ, 1.73μ) fibers (34.10μ, 2.22μ), lignified parenchyma cells (14.58) and vascular bundles]. Dried plant material was subjected to various physiochemical parameters like Hot extraction-seeds [water (15%) alcohol (7%)] mesocarp [water (60%) alcohol (25%)], ash values {seeds [total ash value (4%), water soluble ash (1%), acid insoluble ash (0.5%) sulphated ash value (3%)] mesocarp [total ash value (10%), water soluble ash (8%), acid insoluble ash (0.5%) sulphated ash value (7%)]}, cold maceration-{[petroleum ether [seeds (29%) mesocarp (1%)], benzene [seeds (28%) mesocarp (2%)], ethyl acetate [seeds (28%) mesocarp (2%)], chloroform [seeds (28%) mesocarp (2%)], acetone [seeds (30%) mesocarp (4%)], methanol [seeds (12%) mesocarp (31%)], water [seeds (11%) mesocarp (44%)]}, TLC with different solvents and at different wavelengths, fluorescent analysis, loss on drying, foaming index, swelling index, microscopic studies (powder microscopy, micrometry, transverse section, histo-chemical tests), successive extraction {[petroleum ether [seeds (18%) mesocarp (1.2%)], benzene [seeds (1.2%) mesocarp (1.2%)], ethyl acetate [seeds (1.8%) mesocarp (3.6%)], chloroform [seeds (1.6%) mesocarp (5.6%)], acetone [seeds (2.4%) mesocarp (8.8%)], methanol[seeds (4%) mesocarp (15.2%)]. The preliminary phytochemical investigation revealed the presence of amino acids, triterpenoids, tannins, carbohydrates. These parameters can be utilized for quick identification of the Benincasa hispida and are particularly useful in powdered form.

Asian journal of pharmacy and pharmacology, May 1, 2019

Nepeta cataria L. (Catnip) is a member of the mint family and belongs to the botanical family cal... more Nepeta cataria L. (Catnip) is a member of the mint family and belongs to the botanical family called Lamiaceae (Labiatae), a perennial herb native of southeast Europe, southwest Asia, and western temperate Himalaya from Dalhousie to Kashmir up to an altitude of 1500 m (Sarkar et al., 1995). This plant can obtain a height of one meter, has pubescent leaves and spikelike inflorescent with purple-spotted flower (Edewor et al., 2011). In folk medicine, this plant has been used for antispasmodic, carminative, stimulant and tonic properties. Moreover, traditionally, the tea made of its leaves is known as a sedative and also is used to relieve gastrointestinal and respiratory disorders such as colic, diarrhea, cough, asthma, and bronchitis (Zomorodian et al., 2012). This plant is reported various biological activities include antibacterial (Edewor et al., 2011), behavioral effect (Polosomboon et al., 2008), anti-diabetic effects (Aly et al., 2010), spasmolytic and bronchodilatory effect (Gilani et al., 2009), antinociceptive and anti-inflammatory effects (Ricci et al., 2010). Various compounds have been identified in the

Journal of complementary and alternative medical research, Jan 10, 2017

The study is aimed at evaluating some medicinal plants used traditionally to treat tuberculosis a... more The study is aimed at evaluating some medicinal plants used traditionally to treat tuberculosis and related symptoms. The stem-barks from 10 plants species were prepared using methanol by Soxhlet and was partitioned with n-butanol and water. The extracts were evaluated for the presence of phytochemicals and antimicrobial activity against six microorganisms using agar well and micro dilution assay. The qualitative phytochemical screening revealed the presence of some of phytochemicals such as tannins, phenols, saponins, glycocide, alkaloids, flavonoids and steriods The quantitative estimation revealed that Anogeissus leiocarpus has the highest percentage of alkaloids (10.50%), tannins (4.97%), saponins (11.32%) and flavonoids (15.8%). Ficus trichopoda recorded the lowest percentage of alkaloids (0.45%), tannins (0.43%). Saponins and flavonoids are the lowest in Bombax constantum. Echinaceae angustifolia has the highest percentage of steroids (0.29%) and lowest is for Anogeissus leiocarpus (0.13%). The antimicrobial activity of the methanol extract showed good activity against the microbial strains. The zones of inhibition ranged from 17

Asian Journal of Pharmaceutical and Clinical Research, Aug 1, 2017

This study provides the detailed summary of pharmacognostical characters of rhizomes to give clea... more This study provides the detailed summary of pharmacognostical characters of rhizomes to give clear standards for the identification of drug. Methods: Important details such as macroscopy, microscopy (transverse section [TS] and powder microscopy) along with physico-chemical parameters (such as loss on drying, ash values, and extractive values), and quantitative studies (i.e foreign matter, length and width of xylem vessels and calcium oxalate crystals, and diameter of starch grains) were performed by standard procedure. Results: The findings of macroscopic studies revealed that the rhizomes were internally creamish to light brown and dark brown externally with longitudinal wrinkles. TS and powder microscopy of rhizomes showed the presence of fragments of cork, cellulosic parenchyma; scalariform type xylem vessels, fragments of ligneous parenchyma, lignified astrosclereids, and small ovoid, and rounded starch grains. The mean length and mean width of xylem vessels and calcium oxalate crystals were found to be 406 µm (micrometer) and 60.2 µm and 63.36 µm and 48.96 µm. Whereas mean diameter of starch grains was 34.56 µ. Physicochemical standards quantified were foreign organic matter (0.2%), total ash (12.3%), acid insoluble ash (6.3%), water soluble ash (3%), loss on drying (12.5%), alcohol-soluble extractive value (32.6%), and water soluble extractive value (27.6%). Conclusion: As various pharmacognostical and physico-chemical parameters have pivotal roles in authentication, identification and establishments of quality parameters of the plant. This study was conducted for this purpose.

Research Journal of Pharmacy and Technology, 2018

Plant-based medication disclosure has drawn the consideration of researchers, particularly the on... more Plant-based medication disclosure has drawn the consideration of researchers, particularly the ones utilized as conventional solutions. Because of its rich biodiversity, India has the richest plant based medicinal traditional system Ayurveda. Zanthoxylum armatum DC. from family Rutaceae, also known as Indian prickly ash finds an important place in Indian medicinal system. It has been used as stomachic, carminative, anthelmintic. The fruits have been used in dental problems and their lotion for scabies. The plant has been screened for various biological activities like antibacterial, antifungal, antiviral, anthelmintic, cytotoxic, anti-inflammatory, mosquito larvicidal, hepatoprotective, antinociceptive, immunomodulatory, antioxidant activity and cardiovascular problems. It has also been subjected to allelopathic studies. Various studies have indicated the presence of a variety of medicinally important chemical constituents in the plant. It contains alkaloids, essential oil, resins, sterols, triterpenes, glycosides, saponins, tannins and flavonoids. Significant medicinal properties and excessive increase in demand has put this plant in the category of endangered plants. In this review, the authors have done an effort to compile up the literature available on the medicinal properties of this amazing traditional healer.

Asian journal of pharmacy and pharmacology, Apr 1, 2018

Jasmine mesnyi Hance is well known traditional medicinal plant for the treatment of CNS disorders... more Jasmine mesnyi Hance is well known traditional medicinal plant for the treatment of CNS disorders. It belongs to family oleaceae and found in China, Napal and India and commonly known as Primrose Jasmine or Japanese Jasmine. The Plant has been found to possess some pharmacological activities such as antibacterial, antioxidant, antiulcer, antihelminitic, antiulcer etc. But still require exploring its pharmacological activities. It is research oriented plant and may provide new aspect to treat the various disorders. Authors hope that researcher will utilize this current knowledge to explore and establish the potential role of in their investigation and validation of its traditional Jasminum mesnyi claims.