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Papers by Hedwig Roggendorf

Journal of personalized medicine, Mar 29, 2024

This article is an open access article distributed under the terms and conditions of the Creative... more This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY

Journal of Clinical Virology, Jan 31, 2024

Microbiology Spectrum

The continuous genetic evolution of SARS-CoV-2 resulting in the immune escape variant of concern ... more The continuous genetic evolution of SARS-CoV-2 resulting in the immune escape variant of concern (VoC) Omicron poses a challenge to rapid and accurate diagnosis of infection, especially in high-risk groups such as healthcare workers. We performed a clinical study to determine the diagnostic accuracy and robustness of a second-generation rapid antigen test compared to a first-generation rapid antigen test with an RT-qPCR-based assay as gold standard, for early detection of infections with SARS-CoV-2 Omicron VoC. A total of 428 healthcare workers with COVID-19-associated symptoms or during routine testing participated in the study and completed a questionnaire on infection-associated symptoms, previous SARS-CoV-2 infections, and vaccination status. All participants performed a second- and first-generation rapid antigen test on the day of presentation and repeated the test 2 days later, and a diagnostic SARS-CoV-2 RT-qPCR assay was performed. qPCR-confirmed SARS-CoV-2 infections ( n = ...

Gesundheitswesen, Mar 25, 2015

Zusammenfassung Ziel der Studie: Medizinisches Personal hat ein erhöhtes Infektionsrisiko und kan... more Zusammenfassung Ziel der Studie: Medizinisches Personal hat ein erhöhtes Infektionsrisiko und kann Infektionskrankheiten auf Patienten übertragen. Auch Medizinstudierende haben regelmäßigen Kontakt mit Patienten und sollten deswegen über den gleichen Immunschutz gegenüber impfpräventablen Infektionen wie medizinisches Personal verfügen. Ziel unserer Studie war das Wissen und die Einstellung zu arbeitsmedizinisch indizierten Impfungen sowie den Impfstaus der Medizinstudierenden zu erheben. Methodik: Anonyme Fragebogenerhebung bei Medizinstudierenden des 4. vorklinischen Semesters der Goethe-Universität Frankfurt. Ergebnisse und Schlussfolgerungen: Wenngleich eine hohe Akzeptanz der Medizinstudierenden hinsichtlich Impfungen festgestellt wurde, so ist das Wissen und der Impfstatus der Studierenden verbesserungswürdig. Bspw. wussten nur 46,4% der Medizinstudierenden, dass es eine generelle Influenzaimpfempfehlung für medizinisches Personal gibt und lediglich 76,8% der Studierenden gaben an, dass sie 2 Masernimpfungen erhalten hatten. Insgesamt 2/3 der Studierenden waren „sehr für Impfen“ bzw. „vollkommenen für Impfen“ und bewerteten die Wahrscheinlichkeit für ungeimpftes medizinisches Personal an einer arbeitsbedingten Infektion zu erkranken als „ziemlich groß“ bis „sehr groß“. Vor dem Hintergrund der positiven Grundeinstellung der Studierenden können – durch die Vermittlung von weiterem Wissen hinsichtlich impfpräventabler Infektionen und arbeitsbedingter Infektionsrisiken – mit einen konsequenten Impfangebot voraussichtlich hohe Impfquoten bei den Studierenden erreicht werden.

CNE.fortbildung, Aug 1, 2016

Life Sciences, Jun 1, 1987

The effect of ethanol on the cardiovascular system (ECG, heart rate, blood pressure) was studied ... more The effect of ethanol on the cardiovascular system (ECG, heart rate, blood pressure) was studied in anesthetized, nonstressed or stressed rats. In anesthetized rats, ethanol showed no effect on heart rate or ECG. In nonstressed rats, ethanol sedated the animals but increased heart rate significantly. This ethanol induced tachycardia seemed the result of a direct stimulation of the sympathetic nerves to the heart. Blood pressure was not significantly affected by ethanol in these nonstressed rats. In stressed rats, marked behavioral excitation and significant increases in heart rate and blood pressure were noted. Ethanol pretreatment calmed the animals considerably during restraint. Ethanol did reduce slightly the stress-induced tachycardia but markedly reduced or antagonized stress-induced blood pressure increases. No major changes in the ECG were noted during these studies with the exception of a few individual animals which showed pathologic ECG responses to ethanol. These data show that ethanol affects cardiovascular functions differently in anesthetized, nonstressed or stressed rats, and that ethanol can significantly reduce or antagonize stress-induced behavioral excitation, tachycardia and hypertension.

medRxiv (Cold Spring Harbor Laboratory), Dec 9, 2022

CNE.fortbildung, Aug 1, 2016

CNE.fortbildung, Aug 1, 2016

CNE.fortbildung, Aug 1, 2016

Monatsschrift Kinderheilkunde, May 2, 2009

IMPORTANCEThe rapid genetic evolution of SARS-CoV-2 and in particular the highly contagious Omicr... more IMPORTANCEThe rapid genetic evolution of SARS-CoV-2 and in particular the highly contagious Omicron variant of concern (VoC) may pose problems for rapid and accurate diagnosis of infection.OBJECTIVEDetermine the diagnostic accuracy and robustness of a second generation rapid antigen tests compared to gold-standard, PCR-based diagnostics, for detection of infection with different SARS-CoV-2 Omicron VoC sub lineages in health care workers.DESIGN, SETTING, AND PARTICIPANTSThe study included 428 health care workers from the University Hospital Munich Rechts der Isar of the Technical University of Munich who either reported recent onset of COVID-19 associated symptoms or completed routine diagnostic testing between 24thof May and 22ndof September 2022. All participants gave written informed consent to participate in this study and completed a questionnaire on infection-associated symptoms, prior SARS-CoV-2 infections and vaccination status.INTERVENTIONSDuring the first visit, two nasal s...

Deutsches Ärzteblatt international

Emerging Infectious Diseases, 2022

H ealthcare workers (HCWs) are exposed to severe acute respiratory syndrome coronavirus 2 (SARS-C... more H ealthcare workers (HCWs) are exposed to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in the private context, as well as professionally with varying exposure risk depending on their workplace. Prevalence rates have been measured as high as 13.7% in the New York, NY, USA, area, 10.2% in a nationwide study in Spain, 7.5% for 580 HCWs in a hospital in Spain, 6.4% for >3,000 HCWs in a tertiary hospital in Belgium, 4.0% for >2,8790 HCWs in Denmark, and 0.4%-3.8% for hospitals in China (1-6). Working in coronavirus disease (COVID-19)-designated units has been reported to carry an increased risk for infection (4,7). The greater Munich area in Germany became the epicenter of a SARS-CoV-2 outbreak after a confi rmed case was reported on January 27, 2020. A rapid and massive increase in SARS-CoV-2 infections occurred during March 2020, when infected persons returned from skiing resorts, such as Ischgl, Austria, where the spread of infection was dramatic (8). The University Hospital Munich rechts der Isar faced the challenge of rapidly increasing numbers of COVID-19 patients, combined with an increasing number of staff in quarantine. To reduce the spread of infections, guidelines for the use of personal protective equipment (PPE) for staff and patients were introduced, including the obligation to wear face masks in all areas of the hospital (Figure 1). In addition, a telephone hotline was established to provide staff with guidance for reverse transcription PCR (RT-PCR) testing and quarantine policies. Infection Control Measures and Prevalence of SARS-CoV-2 IgG among 4,

Monatsschrift Kinderheilkunde, 2009

Journal of personalized medicine, Mar 29, 2024

This article is an open access article distributed under the terms and conditions of the Creative... more This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY

Journal of Clinical Virology, Jan 31, 2024

Microbiology Spectrum

The continuous genetic evolution of SARS-CoV-2 resulting in the immune escape variant of concern ... more The continuous genetic evolution of SARS-CoV-2 resulting in the immune escape variant of concern (VoC) Omicron poses a challenge to rapid and accurate diagnosis of infection, especially in high-risk groups such as healthcare workers. We performed a clinical study to determine the diagnostic accuracy and robustness of a second-generation rapid antigen test compared to a first-generation rapid antigen test with an RT-qPCR-based assay as gold standard, for early detection of infections with SARS-CoV-2 Omicron VoC. A total of 428 healthcare workers with COVID-19-associated symptoms or during routine testing participated in the study and completed a questionnaire on infection-associated symptoms, previous SARS-CoV-2 infections, and vaccination status. All participants performed a second- and first-generation rapid antigen test on the day of presentation and repeated the test 2 days later, and a diagnostic SARS-CoV-2 RT-qPCR assay was performed. qPCR-confirmed SARS-CoV-2 infections ( n = ...

Gesundheitswesen, Mar 25, 2015

Zusammenfassung Ziel der Studie: Medizinisches Personal hat ein erhöhtes Infektionsrisiko und kan... more Zusammenfassung Ziel der Studie: Medizinisches Personal hat ein erhöhtes Infektionsrisiko und kann Infektionskrankheiten auf Patienten übertragen. Auch Medizinstudierende haben regelmäßigen Kontakt mit Patienten und sollten deswegen über den gleichen Immunschutz gegenüber impfpräventablen Infektionen wie medizinisches Personal verfügen. Ziel unserer Studie war das Wissen und die Einstellung zu arbeitsmedizinisch indizierten Impfungen sowie den Impfstaus der Medizinstudierenden zu erheben. Methodik: Anonyme Fragebogenerhebung bei Medizinstudierenden des 4. vorklinischen Semesters der Goethe-Universität Frankfurt. Ergebnisse und Schlussfolgerungen: Wenngleich eine hohe Akzeptanz der Medizinstudierenden hinsichtlich Impfungen festgestellt wurde, so ist das Wissen und der Impfstatus der Studierenden verbesserungswürdig. Bspw. wussten nur 46,4% der Medizinstudierenden, dass es eine generelle Influenzaimpfempfehlung für medizinisches Personal gibt und lediglich 76,8% der Studierenden gaben an, dass sie 2 Masernimpfungen erhalten hatten. Insgesamt 2/3 der Studierenden waren „sehr für Impfen“ bzw. „vollkommenen für Impfen“ und bewerteten die Wahrscheinlichkeit für ungeimpftes medizinisches Personal an einer arbeitsbedingten Infektion zu erkranken als „ziemlich groß“ bis „sehr groß“. Vor dem Hintergrund der positiven Grundeinstellung der Studierenden können – durch die Vermittlung von weiterem Wissen hinsichtlich impfpräventabler Infektionen und arbeitsbedingter Infektionsrisiken – mit einen konsequenten Impfangebot voraussichtlich hohe Impfquoten bei den Studierenden erreicht werden.

CNE.fortbildung, Aug 1, 2016

Life Sciences, Jun 1, 1987

The effect of ethanol on the cardiovascular system (ECG, heart rate, blood pressure) was studied ... more The effect of ethanol on the cardiovascular system (ECG, heart rate, blood pressure) was studied in anesthetized, nonstressed or stressed rats. In anesthetized rats, ethanol showed no effect on heart rate or ECG. In nonstressed rats, ethanol sedated the animals but increased heart rate significantly. This ethanol induced tachycardia seemed the result of a direct stimulation of the sympathetic nerves to the heart. Blood pressure was not significantly affected by ethanol in these nonstressed rats. In stressed rats, marked behavioral excitation and significant increases in heart rate and blood pressure were noted. Ethanol pretreatment calmed the animals considerably during restraint. Ethanol did reduce slightly the stress-induced tachycardia but markedly reduced or antagonized stress-induced blood pressure increases. No major changes in the ECG were noted during these studies with the exception of a few individual animals which showed pathologic ECG responses to ethanol. These data show that ethanol affects cardiovascular functions differently in anesthetized, nonstressed or stressed rats, and that ethanol can significantly reduce or antagonize stress-induced behavioral excitation, tachycardia and hypertension.

medRxiv (Cold Spring Harbor Laboratory), Dec 9, 2022

CNE.fortbildung, Aug 1, 2016

CNE.fortbildung, Aug 1, 2016

CNE.fortbildung, Aug 1, 2016

Monatsschrift Kinderheilkunde, May 2, 2009

IMPORTANCEThe rapid genetic evolution of SARS-CoV-2 and in particular the highly contagious Omicr... more IMPORTANCEThe rapid genetic evolution of SARS-CoV-2 and in particular the highly contagious Omicron variant of concern (VoC) may pose problems for rapid and accurate diagnosis of infection.OBJECTIVEDetermine the diagnostic accuracy and robustness of a second generation rapid antigen tests compared to gold-standard, PCR-based diagnostics, for detection of infection with different SARS-CoV-2 Omicron VoC sub lineages in health care workers.DESIGN, SETTING, AND PARTICIPANTSThe study included 428 health care workers from the University Hospital Munich Rechts der Isar of the Technical University of Munich who either reported recent onset of COVID-19 associated symptoms or completed routine diagnostic testing between 24thof May and 22ndof September 2022. All participants gave written informed consent to participate in this study and completed a questionnaire on infection-associated symptoms, prior SARS-CoV-2 infections and vaccination status.INTERVENTIONSDuring the first visit, two nasal s...

Deutsches Ärzteblatt international

Emerging Infectious Diseases, 2022

H ealthcare workers (HCWs) are exposed to severe acute respiratory syndrome coronavirus 2 (SARS-C... more H ealthcare workers (HCWs) are exposed to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in the private context, as well as professionally with varying exposure risk depending on their workplace. Prevalence rates have been measured as high as 13.7% in the New York, NY, USA, area, 10.2% in a nationwide study in Spain, 7.5% for 580 HCWs in a hospital in Spain, 6.4% for >3,000 HCWs in a tertiary hospital in Belgium, 4.0% for >2,8790 HCWs in Denmark, and 0.4%-3.8% for hospitals in China (1-6). Working in coronavirus disease (COVID-19)-designated units has been reported to carry an increased risk for infection (4,7). The greater Munich area in Germany became the epicenter of a SARS-CoV-2 outbreak after a confi rmed case was reported on January 27, 2020. A rapid and massive increase in SARS-CoV-2 infections occurred during March 2020, when infected persons returned from skiing resorts, such as Ischgl, Austria, where the spread of infection was dramatic (8). The University Hospital Munich rechts der Isar faced the challenge of rapidly increasing numbers of COVID-19 patients, combined with an increasing number of staff in quarantine. To reduce the spread of infections, guidelines for the use of personal protective equipment (PPE) for staff and patients were introduced, including the obligation to wear face masks in all areas of the hospital (Figure 1). In addition, a telephone hotline was established to provide staff with guidance for reverse transcription PCR (RT-PCR) testing and quarantine policies. Infection Control Measures and Prevalence of SARS-CoV-2 IgG among 4,

Monatsschrift Kinderheilkunde, 2009