Heidar Amini - Academia.edu (original) (raw)

Papers by Heidar Amini

Research paper thumbnail of Paper: THE PREVALENCE OF GLAUCOMA IN TEHRAN, IRAN

Research paper thumbnail of Effect of Diode Laser Application with G-Probe on Ocular Hypotony after Trabeculectomy with Mitomycin-C

Photomedicine and Laser Surgery, 2006

The aim of this study was to assess the feasibility of a new technique to treat overfiltering ble... more The aim of this study was to assess the feasibility of a new technique to treat overfiltering blebs leading to hypotony after penetrating glaucoma surgery. There is no previous report on diode laser application with G-probe on ocular hypotony consequent to trabeculectomy with adjunctive mitomycin-C. This clinical trial was conducted on eight eyes of eight patients with hypotony after trabeculectomy with adjunctive mitomycin-C. Ten to 12 diode laser (810 nm) spots were applied by G-probe over the bleb area with 2000-2500 mw power and for 1500-2000 msec duration; if the bleb was thin, the laser was applied on its border. The mean age of patients was 29.1 +/- 12.4 years; two of them were female. Mean preoperative and postoperative intraocular pressure (IOPs) were 4.3 +/- 1.5 and 10.1 +/- 3.4 mm Hg, respectively (p = 0.017). Although the IOP increased in seven eyes (87.5%), the visual acuity increased > or =1 line in four (50%), remained stable in three (37.5%), and decreased 1 line in one (12.5%) after an average follow-up of 4 months. All of the blebs were notably smaller and pigmented. No complications occurred other than the need to start Timolol eye drops in one eye for controlling IOP and peaked pupil in two others. Diode laser application with G-probe appears to be a useful modality of treatment for ocular hypotony and overfiltering blebs resulting from trabeculectomy with mitomycin-C.

Research paper thumbnail of Comparison of Retinal Nerve Fiber Layer Profile in Subjects with Myopia and Emmetropia Using Scanning Laser Polarimetry

Iranian Journal of Ophthalmology, 2013

Purpose: To compare retinal nerve fiber layer (RNFL) profile in subjects with myopia and emmetrop... more Purpose: To compare retinal nerve fiber layer (RNFL) profile in subjects with myopia and emmetropia using GDx variable corneal compensator (VCC)

Research paper thumbnail of Retinal venous pressure in chronic smokers

EPMA Journal, 2015

Background: The overall aim of this study was to determine retinal venous pressure (RVP) in healt... more Background: The overall aim of this study was to determine retinal venous pressure (RVP) in healthy chronic smokers and compare values to those of healthy non-smokers. Methods: Both eyes of 25 healthy chronic smokers and 41 healthy non-smokers were included. Measurements of RVP were performed by means of contact lens ophthalmodynamometry. Ophthalmodynamometry is done by applying increasing force on the eye via a contact lens. If a spontaneous venous pulsation was present, it was noted. If not, the compressive force was increased until the first venous pulsation was detected, and the measurement value was fixed and read. RVP was calculated as the sum of pressure increase induced by the instrument and intraocular pressure. Results: Smokers had a significantly higher frequency of spontaneous venous pulsations than non-smokers (p < 0.001). Mean values of RVP were slightly lower in smokers than in non-smokers: 15.3 and 15.5 (smokers) versus 15.9 and 16.2 (non-smokers) for the right and left eye, respectively; however, the difference in RVP between the two groups did not reach significance. There was no significant difference in blood pressure between the two groups, but heart rate was significantly higher in smokers (p = 0.043). Conclusions: RVP values may differ in healthy smokers than in non-smokers. Therefore, smoking habits should be considered when interpreting RVP results.

Research paper thumbnail of Cataract surgery in eyes with filtered primary angle closure glaucoma

Journal of ophthalmic & vision research, 2013

To evaluate the effect of cataract surgery on intraocular pressure (IOP) in filtered eyes with pr... more To evaluate the effect of cataract surgery on intraocular pressure (IOP) in filtered eyes with primary angle closure glaucoma (PACG). In this prospective interventional case series, 37 previously filtered eyes from 37 PACG patients with mean age of 62.1±10.4 years were consecutively enrolled. All patients had visually significant cataracts and phacoemulsification was performed at least 12 months after trabeculectomy. Visual acuity, IOP and the number of glaucoma medications were recorded preoperatively, and 1, 3, 6 and 12 months after surgery. Anterior chamber (AC) depth was measured preoperatively and 3 months after cataract surgery with A-scan ultrasonography. The main outcome measure was IOP at 12 months. IOP was decreased significantly from 18.16±5.91 mmHg at baseline to 15.37±2.90 mmHg at final follow-up (P<0.01). The mean number of glaucoma medications was significantly decreased from 1.81±0.24 to 0.86±1.00 (P=0.001) at 1 year postoperatively. At final follow up, 36 (97.2%)...

Research paper thumbnail of Topical latanoprost does not cause macular thickening after uncomplicated cataract surgery

Journal of ophthalmic & vision research, 2012

To explore changes in central macular thickness (CMT) after a two-month period of glaucoma therap... more To explore changes in central macular thickness (CMT) after a two-month period of glaucoma therapy with topical latanoprost after uneventful phacoemulsification. Forty-one eyes of 31 patients with primary open angle or pseudoexfoliative glaucoma who required glaucoma medications after cataract surgery were prospectively enrolled. All eyes had undergone uneventful phacoemulsification with intraocular lens implantation at least 4 months before initiation of latanoprost. After a complete ophthalmic examination, spectral-domain optical coherence tomography (SD-OCT) and fluorescein angiography (FA) were performed at baseline before starting latanoprost. All eyes received latanoprost for 2 months, and clinical examinations were repeated one and two months afterwards; OCT and FA were repeated after 2 months. Outcome measures were CMT and loss of more than 2 lines of best corrected visual acuity (BCVA). Mean patient age was 71.6±7.8 years. Intraocular pressure decreased from 21.5±3.4 mmHg t...

Research paper thumbnail of Early-onset Pseudoexfoliation Syndrome following Multiple Intraocular Procedures

Journal of ophthalmic & vision research, 2012

To present early-onset ocular manifestations of pseudoexfoliation syndrome in young patients who ... more To present early-onset ocular manifestations of pseudoexfoliation syndrome in young patients who had undergone multiple intraocular procedures. This is an observational case series, introducing four cases with histories of multiple intraocular procedures for glaucoma. All reported cases demonstrated typical manifestations of pseudoexfoliation unilaterally in the eye that had undergone multiple surgeries. The diagnosis of pseudoexfoliation was made prior to the age of 50 in all subjects and the earliest manifestation was at the age of 18 in a case with primary congenital glaucoma The role of multiple surgical procedures, in addition to genetic predisposition, should be further investigated as a possible inciting factor predisposing to pseudoexfoliation in younger individuals.

Research paper thumbnail of Uveitic glaucoma

Journal of ophthalmic & vision research, 2009

Research paper thumbnail of Prevalence of calibration errors in goldmann applanation tonometers

Journal of ophthalmic & vision research, 2009

To determine the prevalence of calibration errors in Goldmann applanation tonometers at Farabi Ey... more To determine the prevalence of calibration errors in Goldmann applanation tonometers at Farabi Eye Hospital. This cross-sectional study was performed on all tonometers in use at Farabi Eye Hospital. All Haag-Streit Goldmann applanation tonometers were checked according to the manufacturer's method by two independent observers and by a third observer in case of mismatched results. Calibration errors were classified into 6 categories of ±0.5, ±1, ±1.5, ±2, ±2.5 and more than ±2.5 mmHg. Overall, 43 Goldmann tonometers were evaluated. There were 3 (7%), 10 (24.3%), 16 (38.3%), 24 (56.9%), 31 (72.1%) and 12 (27.9%) tonometers within calibration errors of ±0.5, ±1, ±1.5, ±2, ±2.5 and more than ±2.5 mmHg respectively. Goldmann tonometers were not within the manufacturer's recommended range (±0.5 mmHg) in 93%, and not within the acceptable range of ±2.5 mmHg in 28% of checked devices. Further study is needed to demonstrate the correlation between calibration errors and clinical errors.

Research paper thumbnail of Sex Bias in Primary Congenital Glaucoma Patients with and without CYP1B1 Mutations

Journal of ophthalmic & vision research, 2009

To investigate variations in sex ratio among Iranian primary congenital glaucoma (PCG) patients w... more To investigate variations in sex ratio among Iranian primary congenital glaucoma (PCG) patients with and without mutations in the CYP1B1 gene and to evaluate possible clinical variations associated with sex in these two groups. Phenotypical data on 104 unrelated Iranian PCG patients who had previously been screened for CYP1B1 mutations were analyzed. Emphasis was placed on analysis of sex ratios among patients with and without CYP1B1 mutations. In addition to sex, familial and sporadic incidence and clinical features including age at onset, bilateral/unilateral involvement, corneal diameter, intraocular pressure, and cup-disc ratios were compared between these two groups. Information on phenotypical parameters was available for most but not all patients. Among the 93 PCG patients whose sex was recorded, 57 were male (61.3%) and 36 were female (38.7%) (P=0.03). Patients with CYP1B1 mutations included 37 male (66.1%) and 29 female (43.9%) subjects (P=0.30), while patients without the ...

Research paper thumbnail of Glaucoma in a patient with nanophthalmos

Journal of ophthalmic & vision research, 2011

Research paper thumbnail of Central corneal thickness in primary angle closure and open angle glaucoma

Journal of Ophthalmic and Vision Research, 2014

Purpose: To quantitatively analyze central corneal thickness (CCT) in patients with primary angle... more Purpose: To quantitatively analyze central corneal thickness (CCT) in patients with primary angle closure glaucoma (PACG) and primary open-angle glaucoma (POAG), and to evaluate its correlation with severity of glaucoma. Methods: In this retrospective study, records of patients with previously diagnosed POAG or PACG at a tertiary glaucoma service were reviewed. CCT was measured by ultrasound pachymetry. Mean deviation (MD) on visual field (VF) testing was recorded for glaucoma severity determination. CCT and age-and sex-adjusted CCT were compared among the study groups using Student's t-test and analysis of covariance (ANCOVA), respectively. Univariate and multivariate regression models were used for correlation of age, MD and CCT. Results: A total of 115 patients with PACG, 215 with POAG, and 100 normal controls were included with mean age of 64.1 ± 10.4, 59.9 ± 10.5, and 62.04 ± 10.80 years, respectively. CCT was thicker in PACG eyes (545.5 ± 46.1 µm) as compared to POAG eyes (531.7 ± 37.3 µm) and controls (531.0 ± 38.3 µm) even after age and gender adjustment (ANCOVA, P = 0.05). CCT was found to decrease with increasing age only in the POAG group (β =-0.57, P = 0.01). Disease severity (MD of VF) was significantly and inversely correlated with CCT in both POAG and PACG eyes (β = 1.89, P = 0.02; and β = 1.38, P = 0.04, respectively) after age and sex correction. Conclusion: PACG eyes had thicker CCT as compared to POAG and normal healthy eyes in Iranian subjects. Severity of the disease was inversely correlated with CCT in eyes with both POAG and PACG.

Research paper thumbnail of Simultaneous Spontaneous Bilateral Malignant Glaucoma Attack in a Young Patient With Bilateral Posterior Polar Cataract

Annals Of Ophthalmology, 2005

A case of posterior polar cataract developed sudden-onset ocular pain and blurred vision. Because... more A case of posterior polar cataract developed sudden-onset ocular pain and blurred vision. Because of high intraocular pressure and shallow anterior chamber, iridotomy was done and anti-glaucoma medication was started without effect. Subsequently, right-eye vitrectomy was performed after postoperative malignant glaucoma developed. Lefteye intraocular pressure stabilized after accidental use of cycloplegic agent. This therapy was continued.

Research paper thumbnail of CYP1B1 Mutation Profile of Iranian Primary Congenital Glaucoma Patients and Associated Haplotypes

The Journal of Molecular Diagnostics, 2007

The mutation spectrum of CYP1B1 among 104 primary congenital glaucoma patients of the genetically... more The mutation spectrum of CYP1B1 among 104 primary congenital glaucoma patients of the genetically heterogeneous Iranian population was investigated by sequencing. We also determined intragenic single nucleotide polymorphism (SNP) haplotypes associated with the mutations and compared these with haplotypes of other populations. Finally, the frequency distribution of the haplotypes was compared among primary congenital glaucoma patients with and without CYP1B1 mutations and normal controls. Genotype classification of six high-frequency SNPs was performed using the PHASE 2.0 software. CYP1B1 mutations in the Iranian patients were very heterogeneous. Nineteen nonconservative mutations associated with disease, and 10 variations not associated with disease were identified. Ten mutations and three variations not associated with disease were novel. The 13 novel variations make a notable contribution to the ϳ70 known variations in the gene. CYP1B1 mutations were identified in 70% of the patients. The four most common mutations were G61E, R368H, R390H, and R469W, which together constituted 76.2% of the CYP1B1 mutated alleles found. Six unique core SNP haplotypes were identified, four of which were common to the patients with and without CYP1B1 mutations and controls studied. Three SNP blocks determined the haplotypes. Comparison of haplotypes with those of other populations suggests a common origin for many of the mutations.

Research paper thumbnail of Office-based slit-lamp needle revision with adjunctive Mitomycin-C for late failed or encapsulated filtering blebs

Middle East African Journal of Ophthalmology, 2012

Purpose: The purpose of this study was to assess the results of bleb needling in glaucomatous pat... more Purpose: The purpose of this study was to assess the results of bleb needling in glaucomatous patients with late failed filtering blebs. Materials and Methods: A retrospective case series of 27 eyes of 27 patients was considered. All patients underwent needle bleb revision with adjuvant mitomycin-C performed at the slit lamp, during an office visit. Complete success was defined as postneedling intraocular pressure (IOP) ≤ 21 mmHg without any antiglaucoma medications and qualified success was IOP ≤ 21 mmHg with topical antiglaucoma medications. Results: There were 12 eyes with encapsulated blebs and 15 eyes with flat blebs. The mean interval between index filtering surgery and bleb revision was 32.74 ± 15.36 months. Mean IOP was 25.07 ± 4.80 mmHg before surgery and 19.66 ± 4.97 mmHg at last postoperative follow-up. The mean follow-up was 20.31 ± 15.63 months. Complete and qualified successes were 7.4% and 51.9%, respectively. Cumulative rates of success at 1, 2, 3, and 4 years were 76%, 65%, 49%, and 37%, respectively. The mean number of antiglaucoma medications was reduced from 3.15 ± 0.36 preoperatively to 2.33 ± 1.21 postoperatively (P<0.001). Conclusion: Slit-lamp needle revision in office is a simple and effective method for treating late encapsulated or flat filtering blebs without significant complications even for late bleb failure.

Research paper thumbnail of Central corneal thickness in Iranian congenital glaucoma patients

Middle East African Journal of Ophthalmology, 2012

Corneal enlargement and increased axial length in primary congenital glaucoma (PCG) result in a b... more Corneal enlargement and increased axial length in primary congenital glaucoma (PCG) result in a buphthalmic appearance. Some have proposed that corneal stretching could result in increased corneal diameter and reduced central corneal thickness (CCT). 6 Alternatively, corneal edema due to disruption in ABSTRACT Purpose: To compare central corneal thickness (CCT) in subjects with controlled primary congenital glaucoma (PCG) and nonglaucomatous subjects and to investigate the correlation between CCT and intraocular pressure (IOP) in the study population. Materials and Methods: Twenty-three consecutive PCG cases with controlled IOP and no clinical evidence of corneal edema comprised the Study Group. There was an interval of at least 2 months between last intraocular surgery and inclusion in the study. Twenty-one subjects with strabismus or lacrimal drainage insufficiency who did not have glaucoma or any history of intraocular surgery or ocular trauma comprised the control group. The Control Group was age and sex-matched. Data from ultrasonic pachymetry and applanation tonometry were analyzed for differences between groups. Correlation of the study parameters was investigated. A P-value less than 0.05 was statistically significant. Results: Data from both eyes of subjects in the Study Group and Control Group were included in the original analysis. Mean CCT was statistically significantly higher in the Study Group compared to the Control Group (589.42 ± 53.44 µm vs. 556.14 ± 30.51 µm, respectively; P=0.001). There was a significant correlation between CCT and IOP (r=0.63; P<0.0001). Similar statistically significant outcomes were observed when only one eye per subject was used in a reanalysis of the data for the Study and Control Groups. Conclusion: Patients with PCG who had controlled IOP have statistically significantly thicker corneas than nonglaucomatous age and sex-matched subjects The thicker cornea could significantly alter IOP measurement with applanation tonometry. Pachymetry should be considered an essential part of the evaluation for PCG.

Research paper thumbnail of Inhibition of intraocular fibrin formation after infusion of low-molecular-weight heparin during combined phacoemulsification–trabeculectomy surgery

Journal of Cataract and Refractive Surgery, 2006

To evaluate the effect of intraocular infusion of dalteparin, a low-molecular-weight heparin (LMW... more To evaluate the effect of intraocular infusion of dalteparin, a low-molecular-weight heparin (LMWH) administered in the infusion fluid to prevent early postoperative fibrin formation in combined phacoemulsification-trabeculectomy surgery (phacotrabeculectomy). Farabi Eye Hospital, Tehran, Iran. Standard combined phacotrabeculectomy was performed prospectively in a masked fashion in 60 eyes; 35 eyes received 5 IU/mL LMWH in the infusate and 25 eyes served as controls. Masked postoperative examinations assessed visual acuity, intraocular pressure (IOP), anterior chamber cell and flare, and fibrin formation with slitlamp examinations 1, 3, 7, 30, and 90 days after surgery. The rate of intraocular fibrin/membrane formation was significantly lower in the LMWH group than in the control group at each follow-up (P&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt;.001, Student t test) . The amount of IOP was lower in LMWH group at each follow up (P&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt;.01, Student t test). Final visual acuity was better in LMWH group (P = .03, Student t test). The frequency of synechia formation was lower in the LMWH group on day 90 (P = .002, chi-square test). Infusion of dalteparin, a LMWH, may be an effective inhibitor of postoperative fibrin formation in phacotrabeculectomy surgery. It may reduce the frequency of synechia formation and improve visual acuity. It may not be associated with increased risk for intraoperative or postoperative complications at the tested dose. This drug may be a useful adjunct in combined surgery.

Research paper thumbnail of Primary single-plate Molteno tube implantation for management of glaucoma in children with Sturge-Weber syndrome

International Ophthalmology, 2007

Purpose: To evaluate the efficacy and safety of primary single-plate Molteno tube implantation fo... more Purpose: To evaluate the efficacy and safety of primary single-plate Molteno tube implantation for management of glaucoma in children with Sturge-Weber syndrome. Methods: Primary single-plate Molteno tube implantation was performed in eyes of patients with Sturge-Weber syndrome aged <17 years. Success was defined as intraocular pressure (IOP) ≤22 mmHg with (relative success) or without (absolute success) antiglaucoma medications. Intra-and postoperative complications were also evaluated. Results: Overall, nine eyes of seven patients with mean age of 9.6±3.7 (range 5-17) years were operated and followed for 32±4.7 (range 20-36) months. Mean IOP decreased from 34.2±8.3 mmHg preoperatively to 21.2±7.3 mmHg at final follow up (P=0.012). Mean number of antiglaucoma medications decreased from 3.4±0.5 preoperatively to 2.2±1.3 at final follow up (P=0.058). The cumulative probability of relative success was 97.2% (95% confidence interval [CI], 91.8-100%) at 12 months, 78.0% (95%CI, 60.4-95.7%) at 24 months and 43.3% (95%CI, 16.2-70.5%) at final follow up. Two eyes achieved absolute success during the first six months, however, at six months and later no eye achieved absolute success. No intraoperative complication occurred; postoperative complications included choroidal effusion necessitating drainage in three eyes (33.3%), and cataract formation and retinal detachment, each in one eye (11%). At final follow up, visual acuity remained unchanged in five eyes and deteriorated in four eyes. Conclusion: The outcomes of this small series revealed that primary single-plate Molteno tube implantation appears to be associated with limited success and a relatively high complication rate in pediatric glaucoma associated with Sturge-Weber syndrome.

Research paper thumbnail of The results of trabeculectomy using a sutureless scleral tunnel technique

International Ophthalmology, 2008

To evaluate the surgical outcome in terms of intraocular pressure (IOP) control and safety of pro... more To evaluate the surgical outcome in terms of intraocular pressure (IOP) control and safety of procedure using a sutureless scleral tunnel technique in patients with uncontrolled glaucoma. This was a prospective, consecutive, noncomparative interventional case series of patients undergoing trabeculectomy. The study was conducted on 19 eyes of 19 patients with medically uncontrolled glaucoma. All of the patients underwent sutureless scleral tunnel trabeculectomy and were followed for 6 months. Patient data such as sex, age, IOP, LogMAR visual acuity (LogMAR VA), antiglaucoma medications, intraoperative and postoperative complications, bleb morphology, and success rate were collected and statistically analyzed. Two patients were excluded because of defaulted follow-up. Mean age was 60.58 (+/-15.14) years, and 65% of the patients were male. Before intervention mean IOP was 29.29 (+/-8.22) mmHg, and mean number of antiglaucoma medications was 2.05 (+/-0.89). Six months after intervention, mean IOP was 15.00 (+/-3.82) mmHg (P &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt; 0.001), mean number of antiglaucoma medications was 0.52 (+/-1.06) (P &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt; 0.001), complete success rate was 65%, and qualified success rate was 23%. Five patients (29.4%) needed adjunctive needling bleb revision. No major intraoperative complications were encountered. Only four patients (23.5%) had microscopic hyphema and three patients (18%) had flat anterior chamber (grade I) in the immediate postoperative period that managed medically. All but four had shallow and diffuse blebs at last follow-up. It appears that sutureless scleral tunnel trabeculectomy is a safe and effective drainage procedure for treating uncontrolled glaucoma. Larger-scale study is recommended.

Research paper thumbnail of Relationship between GDx VCC and Stratus OCT in juvenile glaucoma

Eye, 2009

Purpose To compare the ability of scanning laser polarimetry (GDx VCC) and optical coherence tomo... more Purpose To compare the ability of scanning laser polarimetry (GDx VCC) and optical coherence tomography (OCT) to discriminate eyes with juvenile glaucoma from normal eyes and to assess the relationship between their parameters. Methods A total of 24 glaucomatous eyes of 24 patients and 24 normal eyes were enrolled. The age range of the patient was 11-40 years with a mean age of 25.1 ± 8.2 years. Contol groups consisted 24 eyes of 24 individuals without glaucoma with a mean age of 33.2 ± 8.2 years. All subjects underwent a full ophthalmic examination, automated perimetry, GDx VCC, and OCT. Correlation coefficients between the parameters of OCT and GDx VCC were calculated. We calculated the area under the receiver operating characteristic curve (AROC) for the main parameters of GDx VCC and OCT. Results Statistically significant correlations were observed between GDx VCC and OCT parameters. Pearson coefficients ranged from 0.75 for inferior average to 0.86 for nerve fibre indicator (NFI)/average thickness OCT. The greatest AROC parameter in OCT (inferior average: 0.92) had a lower area than that in GDx VCC (NFI: 0.99). There was a significant statistical significance in all visual field, GDx VCC, and OCT variables between two groups (Po0.05). Conclusions Many GDx VCC parameters were significantly correlated with those of the OCT in patients with juvenile glaucoma. Inferior average and NFI had the greatest AROC parameter in OCT and GDx VCC, respectively. NFI had high sensitivity and specificity for the diagnosis of JOAG.

Research paper thumbnail of Paper: THE PREVALENCE OF GLAUCOMA IN TEHRAN, IRAN

Research paper thumbnail of Effect of Diode Laser Application with G-Probe on Ocular Hypotony after Trabeculectomy with Mitomycin-C

Photomedicine and Laser Surgery, 2006

The aim of this study was to assess the feasibility of a new technique to treat overfiltering ble... more The aim of this study was to assess the feasibility of a new technique to treat overfiltering blebs leading to hypotony after penetrating glaucoma surgery. There is no previous report on diode laser application with G-probe on ocular hypotony consequent to trabeculectomy with adjunctive mitomycin-C. This clinical trial was conducted on eight eyes of eight patients with hypotony after trabeculectomy with adjunctive mitomycin-C. Ten to 12 diode laser (810 nm) spots were applied by G-probe over the bleb area with 2000-2500 mw power and for 1500-2000 msec duration; if the bleb was thin, the laser was applied on its border. The mean age of patients was 29.1 +/- 12.4 years; two of them were female. Mean preoperative and postoperative intraocular pressure (IOPs) were 4.3 +/- 1.5 and 10.1 +/- 3.4 mm Hg, respectively (p = 0.017). Although the IOP increased in seven eyes (87.5%), the visual acuity increased &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;gt; or =1 line in four (50%), remained stable in three (37.5%), and decreased 1 line in one (12.5%) after an average follow-up of 4 months. All of the blebs were notably smaller and pigmented. No complications occurred other than the need to start Timolol eye drops in one eye for controlling IOP and peaked pupil in two others. Diode laser application with G-probe appears to be a useful modality of treatment for ocular hypotony and overfiltering blebs resulting from trabeculectomy with mitomycin-C.

Research paper thumbnail of Comparison of Retinal Nerve Fiber Layer Profile in Subjects with Myopia and Emmetropia Using Scanning Laser Polarimetry

Iranian Journal of Ophthalmology, 2013

Purpose: To compare retinal nerve fiber layer (RNFL) profile in subjects with myopia and emmetrop... more Purpose: To compare retinal nerve fiber layer (RNFL) profile in subjects with myopia and emmetropia using GDx variable corneal compensator (VCC)

Research paper thumbnail of Retinal venous pressure in chronic smokers

EPMA Journal, 2015

Background: The overall aim of this study was to determine retinal venous pressure (RVP) in healt... more Background: The overall aim of this study was to determine retinal venous pressure (RVP) in healthy chronic smokers and compare values to those of healthy non-smokers. Methods: Both eyes of 25 healthy chronic smokers and 41 healthy non-smokers were included. Measurements of RVP were performed by means of contact lens ophthalmodynamometry. Ophthalmodynamometry is done by applying increasing force on the eye via a contact lens. If a spontaneous venous pulsation was present, it was noted. If not, the compressive force was increased until the first venous pulsation was detected, and the measurement value was fixed and read. RVP was calculated as the sum of pressure increase induced by the instrument and intraocular pressure. Results: Smokers had a significantly higher frequency of spontaneous venous pulsations than non-smokers (p < 0.001). Mean values of RVP were slightly lower in smokers than in non-smokers: 15.3 and 15.5 (smokers) versus 15.9 and 16.2 (non-smokers) for the right and left eye, respectively; however, the difference in RVP between the two groups did not reach significance. There was no significant difference in blood pressure between the two groups, but heart rate was significantly higher in smokers (p = 0.043). Conclusions: RVP values may differ in healthy smokers than in non-smokers. Therefore, smoking habits should be considered when interpreting RVP results.

Research paper thumbnail of Cataract surgery in eyes with filtered primary angle closure glaucoma

Journal of ophthalmic & vision research, 2013

To evaluate the effect of cataract surgery on intraocular pressure (IOP) in filtered eyes with pr... more To evaluate the effect of cataract surgery on intraocular pressure (IOP) in filtered eyes with primary angle closure glaucoma (PACG). In this prospective interventional case series, 37 previously filtered eyes from 37 PACG patients with mean age of 62.1±10.4 years were consecutively enrolled. All patients had visually significant cataracts and phacoemulsification was performed at least 12 months after trabeculectomy. Visual acuity, IOP and the number of glaucoma medications were recorded preoperatively, and 1, 3, 6 and 12 months after surgery. Anterior chamber (AC) depth was measured preoperatively and 3 months after cataract surgery with A-scan ultrasonography. The main outcome measure was IOP at 12 months. IOP was decreased significantly from 18.16±5.91 mmHg at baseline to 15.37±2.90 mmHg at final follow-up (P<0.01). The mean number of glaucoma medications was significantly decreased from 1.81±0.24 to 0.86±1.00 (P=0.001) at 1 year postoperatively. At final follow up, 36 (97.2%)...

Research paper thumbnail of Topical latanoprost does not cause macular thickening after uncomplicated cataract surgery

Journal of ophthalmic & vision research, 2012

To explore changes in central macular thickness (CMT) after a two-month period of glaucoma therap... more To explore changes in central macular thickness (CMT) after a two-month period of glaucoma therapy with topical latanoprost after uneventful phacoemulsification. Forty-one eyes of 31 patients with primary open angle or pseudoexfoliative glaucoma who required glaucoma medications after cataract surgery were prospectively enrolled. All eyes had undergone uneventful phacoemulsification with intraocular lens implantation at least 4 months before initiation of latanoprost. After a complete ophthalmic examination, spectral-domain optical coherence tomography (SD-OCT) and fluorescein angiography (FA) were performed at baseline before starting latanoprost. All eyes received latanoprost for 2 months, and clinical examinations were repeated one and two months afterwards; OCT and FA were repeated after 2 months. Outcome measures were CMT and loss of more than 2 lines of best corrected visual acuity (BCVA). Mean patient age was 71.6±7.8 years. Intraocular pressure decreased from 21.5±3.4 mmHg t...

Research paper thumbnail of Early-onset Pseudoexfoliation Syndrome following Multiple Intraocular Procedures

Journal of ophthalmic & vision research, 2012

To present early-onset ocular manifestations of pseudoexfoliation syndrome in young patients who ... more To present early-onset ocular manifestations of pseudoexfoliation syndrome in young patients who had undergone multiple intraocular procedures. This is an observational case series, introducing four cases with histories of multiple intraocular procedures for glaucoma. All reported cases demonstrated typical manifestations of pseudoexfoliation unilaterally in the eye that had undergone multiple surgeries. The diagnosis of pseudoexfoliation was made prior to the age of 50 in all subjects and the earliest manifestation was at the age of 18 in a case with primary congenital glaucoma The role of multiple surgical procedures, in addition to genetic predisposition, should be further investigated as a possible inciting factor predisposing to pseudoexfoliation in younger individuals.

Research paper thumbnail of Uveitic glaucoma

Journal of ophthalmic & vision research, 2009

Research paper thumbnail of Prevalence of calibration errors in goldmann applanation tonometers

Journal of ophthalmic & vision research, 2009

To determine the prevalence of calibration errors in Goldmann applanation tonometers at Farabi Ey... more To determine the prevalence of calibration errors in Goldmann applanation tonometers at Farabi Eye Hospital. This cross-sectional study was performed on all tonometers in use at Farabi Eye Hospital. All Haag-Streit Goldmann applanation tonometers were checked according to the manufacturer's method by two independent observers and by a third observer in case of mismatched results. Calibration errors were classified into 6 categories of ±0.5, ±1, ±1.5, ±2, ±2.5 and more than ±2.5 mmHg. Overall, 43 Goldmann tonometers were evaluated. There were 3 (7%), 10 (24.3%), 16 (38.3%), 24 (56.9%), 31 (72.1%) and 12 (27.9%) tonometers within calibration errors of ±0.5, ±1, ±1.5, ±2, ±2.5 and more than ±2.5 mmHg respectively. Goldmann tonometers were not within the manufacturer's recommended range (±0.5 mmHg) in 93%, and not within the acceptable range of ±2.5 mmHg in 28% of checked devices. Further study is needed to demonstrate the correlation between calibration errors and clinical errors.

Research paper thumbnail of Sex Bias in Primary Congenital Glaucoma Patients with and without CYP1B1 Mutations

Journal of ophthalmic & vision research, 2009

To investigate variations in sex ratio among Iranian primary congenital glaucoma (PCG) patients w... more To investigate variations in sex ratio among Iranian primary congenital glaucoma (PCG) patients with and without mutations in the CYP1B1 gene and to evaluate possible clinical variations associated with sex in these two groups. Phenotypical data on 104 unrelated Iranian PCG patients who had previously been screened for CYP1B1 mutations were analyzed. Emphasis was placed on analysis of sex ratios among patients with and without CYP1B1 mutations. In addition to sex, familial and sporadic incidence and clinical features including age at onset, bilateral/unilateral involvement, corneal diameter, intraocular pressure, and cup-disc ratios were compared between these two groups. Information on phenotypical parameters was available for most but not all patients. Among the 93 PCG patients whose sex was recorded, 57 were male (61.3%) and 36 were female (38.7%) (P=0.03). Patients with CYP1B1 mutations included 37 male (66.1%) and 29 female (43.9%) subjects (P=0.30), while patients without the ...

Research paper thumbnail of Glaucoma in a patient with nanophthalmos

Journal of ophthalmic & vision research, 2011

Research paper thumbnail of Central corneal thickness in primary angle closure and open angle glaucoma

Journal of Ophthalmic and Vision Research, 2014

Purpose: To quantitatively analyze central corneal thickness (CCT) in patients with primary angle... more Purpose: To quantitatively analyze central corneal thickness (CCT) in patients with primary angle closure glaucoma (PACG) and primary open-angle glaucoma (POAG), and to evaluate its correlation with severity of glaucoma. Methods: In this retrospective study, records of patients with previously diagnosed POAG or PACG at a tertiary glaucoma service were reviewed. CCT was measured by ultrasound pachymetry. Mean deviation (MD) on visual field (VF) testing was recorded for glaucoma severity determination. CCT and age-and sex-adjusted CCT were compared among the study groups using Student's t-test and analysis of covariance (ANCOVA), respectively. Univariate and multivariate regression models were used for correlation of age, MD and CCT. Results: A total of 115 patients with PACG, 215 with POAG, and 100 normal controls were included with mean age of 64.1 ± 10.4, 59.9 ± 10.5, and 62.04 ± 10.80 years, respectively. CCT was thicker in PACG eyes (545.5 ± 46.1 µm) as compared to POAG eyes (531.7 ± 37.3 µm) and controls (531.0 ± 38.3 µm) even after age and gender adjustment (ANCOVA, P = 0.05). CCT was found to decrease with increasing age only in the POAG group (β =-0.57, P = 0.01). Disease severity (MD of VF) was significantly and inversely correlated with CCT in both POAG and PACG eyes (β = 1.89, P = 0.02; and β = 1.38, P = 0.04, respectively) after age and sex correction. Conclusion: PACG eyes had thicker CCT as compared to POAG and normal healthy eyes in Iranian subjects. Severity of the disease was inversely correlated with CCT in eyes with both POAG and PACG.

Research paper thumbnail of Simultaneous Spontaneous Bilateral Malignant Glaucoma Attack in a Young Patient With Bilateral Posterior Polar Cataract

Annals Of Ophthalmology, 2005

A case of posterior polar cataract developed sudden-onset ocular pain and blurred vision. Because... more A case of posterior polar cataract developed sudden-onset ocular pain and blurred vision. Because of high intraocular pressure and shallow anterior chamber, iridotomy was done and anti-glaucoma medication was started without effect. Subsequently, right-eye vitrectomy was performed after postoperative malignant glaucoma developed. Lefteye intraocular pressure stabilized after accidental use of cycloplegic agent. This therapy was continued.

Research paper thumbnail of CYP1B1 Mutation Profile of Iranian Primary Congenital Glaucoma Patients and Associated Haplotypes

The Journal of Molecular Diagnostics, 2007

The mutation spectrum of CYP1B1 among 104 primary congenital glaucoma patients of the genetically... more The mutation spectrum of CYP1B1 among 104 primary congenital glaucoma patients of the genetically heterogeneous Iranian population was investigated by sequencing. We also determined intragenic single nucleotide polymorphism (SNP) haplotypes associated with the mutations and compared these with haplotypes of other populations. Finally, the frequency distribution of the haplotypes was compared among primary congenital glaucoma patients with and without CYP1B1 mutations and normal controls. Genotype classification of six high-frequency SNPs was performed using the PHASE 2.0 software. CYP1B1 mutations in the Iranian patients were very heterogeneous. Nineteen nonconservative mutations associated with disease, and 10 variations not associated with disease were identified. Ten mutations and three variations not associated with disease were novel. The 13 novel variations make a notable contribution to the ϳ70 known variations in the gene. CYP1B1 mutations were identified in 70% of the patients. The four most common mutations were G61E, R368H, R390H, and R469W, which together constituted 76.2% of the CYP1B1 mutated alleles found. Six unique core SNP haplotypes were identified, four of which were common to the patients with and without CYP1B1 mutations and controls studied. Three SNP blocks determined the haplotypes. Comparison of haplotypes with those of other populations suggests a common origin for many of the mutations.

Research paper thumbnail of Office-based slit-lamp needle revision with adjunctive Mitomycin-C for late failed or encapsulated filtering blebs

Middle East African Journal of Ophthalmology, 2012

Purpose: The purpose of this study was to assess the results of bleb needling in glaucomatous pat... more Purpose: The purpose of this study was to assess the results of bleb needling in glaucomatous patients with late failed filtering blebs. Materials and Methods: A retrospective case series of 27 eyes of 27 patients was considered. All patients underwent needle bleb revision with adjuvant mitomycin-C performed at the slit lamp, during an office visit. Complete success was defined as postneedling intraocular pressure (IOP) ≤ 21 mmHg without any antiglaucoma medications and qualified success was IOP ≤ 21 mmHg with topical antiglaucoma medications. Results: There were 12 eyes with encapsulated blebs and 15 eyes with flat blebs. The mean interval between index filtering surgery and bleb revision was 32.74 ± 15.36 months. Mean IOP was 25.07 ± 4.80 mmHg before surgery and 19.66 ± 4.97 mmHg at last postoperative follow-up. The mean follow-up was 20.31 ± 15.63 months. Complete and qualified successes were 7.4% and 51.9%, respectively. Cumulative rates of success at 1, 2, 3, and 4 years were 76%, 65%, 49%, and 37%, respectively. The mean number of antiglaucoma medications was reduced from 3.15 ± 0.36 preoperatively to 2.33 ± 1.21 postoperatively (P<0.001). Conclusion: Slit-lamp needle revision in office is a simple and effective method for treating late encapsulated or flat filtering blebs without significant complications even for late bleb failure.

Research paper thumbnail of Central corneal thickness in Iranian congenital glaucoma patients

Middle East African Journal of Ophthalmology, 2012

Corneal enlargement and increased axial length in primary congenital glaucoma (PCG) result in a b... more Corneal enlargement and increased axial length in primary congenital glaucoma (PCG) result in a buphthalmic appearance. Some have proposed that corneal stretching could result in increased corneal diameter and reduced central corneal thickness (CCT). 6 Alternatively, corneal edema due to disruption in ABSTRACT Purpose: To compare central corneal thickness (CCT) in subjects with controlled primary congenital glaucoma (PCG) and nonglaucomatous subjects and to investigate the correlation between CCT and intraocular pressure (IOP) in the study population. Materials and Methods: Twenty-three consecutive PCG cases with controlled IOP and no clinical evidence of corneal edema comprised the Study Group. There was an interval of at least 2 months between last intraocular surgery and inclusion in the study. Twenty-one subjects with strabismus or lacrimal drainage insufficiency who did not have glaucoma or any history of intraocular surgery or ocular trauma comprised the control group. The Control Group was age and sex-matched. Data from ultrasonic pachymetry and applanation tonometry were analyzed for differences between groups. Correlation of the study parameters was investigated. A P-value less than 0.05 was statistically significant. Results: Data from both eyes of subjects in the Study Group and Control Group were included in the original analysis. Mean CCT was statistically significantly higher in the Study Group compared to the Control Group (589.42 ± 53.44 µm vs. 556.14 ± 30.51 µm, respectively; P=0.001). There was a significant correlation between CCT and IOP (r=0.63; P<0.0001). Similar statistically significant outcomes were observed when only one eye per subject was used in a reanalysis of the data for the Study and Control Groups. Conclusion: Patients with PCG who had controlled IOP have statistically significantly thicker corneas than nonglaucomatous age and sex-matched subjects The thicker cornea could significantly alter IOP measurement with applanation tonometry. Pachymetry should be considered an essential part of the evaluation for PCG.

Research paper thumbnail of Inhibition of intraocular fibrin formation after infusion of low-molecular-weight heparin during combined phacoemulsification–trabeculectomy surgery

Journal of Cataract and Refractive Surgery, 2006

To evaluate the effect of intraocular infusion of dalteparin, a low-molecular-weight heparin (LMW... more To evaluate the effect of intraocular infusion of dalteparin, a low-molecular-weight heparin (LMWH) administered in the infusion fluid to prevent early postoperative fibrin formation in combined phacoemulsification-trabeculectomy surgery (phacotrabeculectomy). Farabi Eye Hospital, Tehran, Iran. Standard combined phacotrabeculectomy was performed prospectively in a masked fashion in 60 eyes; 35 eyes received 5 IU/mL LMWH in the infusate and 25 eyes served as controls. Masked postoperative examinations assessed visual acuity, intraocular pressure (IOP), anterior chamber cell and flare, and fibrin formation with slitlamp examinations 1, 3, 7, 30, and 90 days after surgery. The rate of intraocular fibrin/membrane formation was significantly lower in the LMWH group than in the control group at each follow-up (P&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt;.001, Student t test) . The amount of IOP was lower in LMWH group at each follow up (P&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt;.01, Student t test). Final visual acuity was better in LMWH group (P = .03, Student t test). The frequency of synechia formation was lower in the LMWH group on day 90 (P = .002, chi-square test). Infusion of dalteparin, a LMWH, may be an effective inhibitor of postoperative fibrin formation in phacotrabeculectomy surgery. It may reduce the frequency of synechia formation and improve visual acuity. It may not be associated with increased risk for intraoperative or postoperative complications at the tested dose. This drug may be a useful adjunct in combined surgery.

Research paper thumbnail of Primary single-plate Molteno tube implantation for management of glaucoma in children with Sturge-Weber syndrome

International Ophthalmology, 2007

Purpose: To evaluate the efficacy and safety of primary single-plate Molteno tube implantation fo... more Purpose: To evaluate the efficacy and safety of primary single-plate Molteno tube implantation for management of glaucoma in children with Sturge-Weber syndrome. Methods: Primary single-plate Molteno tube implantation was performed in eyes of patients with Sturge-Weber syndrome aged <17 years. Success was defined as intraocular pressure (IOP) ≤22 mmHg with (relative success) or without (absolute success) antiglaucoma medications. Intra-and postoperative complications were also evaluated. Results: Overall, nine eyes of seven patients with mean age of 9.6±3.7 (range 5-17) years were operated and followed for 32±4.7 (range 20-36) months. Mean IOP decreased from 34.2±8.3 mmHg preoperatively to 21.2±7.3 mmHg at final follow up (P=0.012). Mean number of antiglaucoma medications decreased from 3.4±0.5 preoperatively to 2.2±1.3 at final follow up (P=0.058). The cumulative probability of relative success was 97.2% (95% confidence interval [CI], 91.8-100%) at 12 months, 78.0% (95%CI, 60.4-95.7%) at 24 months and 43.3% (95%CI, 16.2-70.5%) at final follow up. Two eyes achieved absolute success during the first six months, however, at six months and later no eye achieved absolute success. No intraoperative complication occurred; postoperative complications included choroidal effusion necessitating drainage in three eyes (33.3%), and cataract formation and retinal detachment, each in one eye (11%). At final follow up, visual acuity remained unchanged in five eyes and deteriorated in four eyes. Conclusion: The outcomes of this small series revealed that primary single-plate Molteno tube implantation appears to be associated with limited success and a relatively high complication rate in pediatric glaucoma associated with Sturge-Weber syndrome.

Research paper thumbnail of The results of trabeculectomy using a sutureless scleral tunnel technique

International Ophthalmology, 2008

To evaluate the surgical outcome in terms of intraocular pressure (IOP) control and safety of pro... more To evaluate the surgical outcome in terms of intraocular pressure (IOP) control and safety of procedure using a sutureless scleral tunnel technique in patients with uncontrolled glaucoma. This was a prospective, consecutive, noncomparative interventional case series of patients undergoing trabeculectomy. The study was conducted on 19 eyes of 19 patients with medically uncontrolled glaucoma. All of the patients underwent sutureless scleral tunnel trabeculectomy and were followed for 6 months. Patient data such as sex, age, IOP, LogMAR visual acuity (LogMAR VA), antiglaucoma medications, intraoperative and postoperative complications, bleb morphology, and success rate were collected and statistically analyzed. Two patients were excluded because of defaulted follow-up. Mean age was 60.58 (+/-15.14) years, and 65% of the patients were male. Before intervention mean IOP was 29.29 (+/-8.22) mmHg, and mean number of antiglaucoma medications was 2.05 (+/-0.89). Six months after intervention, mean IOP was 15.00 (+/-3.82) mmHg (P &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt; 0.001), mean number of antiglaucoma medications was 0.52 (+/-1.06) (P &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt; 0.001), complete success rate was 65%, and qualified success rate was 23%. Five patients (29.4%) needed adjunctive needling bleb revision. No major intraoperative complications were encountered. Only four patients (23.5%) had microscopic hyphema and three patients (18%) had flat anterior chamber (grade I) in the immediate postoperative period that managed medically. All but four had shallow and diffuse blebs at last follow-up. It appears that sutureless scleral tunnel trabeculectomy is a safe and effective drainage procedure for treating uncontrolled glaucoma. Larger-scale study is recommended.

Research paper thumbnail of Relationship between GDx VCC and Stratus OCT in juvenile glaucoma

Eye, 2009

Purpose To compare the ability of scanning laser polarimetry (GDx VCC) and optical coherence tomo... more Purpose To compare the ability of scanning laser polarimetry (GDx VCC) and optical coherence tomography (OCT) to discriminate eyes with juvenile glaucoma from normal eyes and to assess the relationship between their parameters. Methods A total of 24 glaucomatous eyes of 24 patients and 24 normal eyes were enrolled. The age range of the patient was 11-40 years with a mean age of 25.1 ± 8.2 years. Contol groups consisted 24 eyes of 24 individuals without glaucoma with a mean age of 33.2 ± 8.2 years. All subjects underwent a full ophthalmic examination, automated perimetry, GDx VCC, and OCT. Correlation coefficients between the parameters of OCT and GDx VCC were calculated. We calculated the area under the receiver operating characteristic curve (AROC) for the main parameters of GDx VCC and OCT. Results Statistically significant correlations were observed between GDx VCC and OCT parameters. Pearson coefficients ranged from 0.75 for inferior average to 0.86 for nerve fibre indicator (NFI)/average thickness OCT. The greatest AROC parameter in OCT (inferior average: 0.92) had a lower area than that in GDx VCC (NFI: 0.99). There was a significant statistical significance in all visual field, GDx VCC, and OCT variables between two groups (Po0.05). Conclusions Many GDx VCC parameters were significantly correlated with those of the OCT in patients with juvenile glaucoma. Inferior average and NFI had the greatest AROC parameter in OCT and GDx VCC, respectively. NFI had high sensitivity and specificity for the diagnosis of JOAG.