Henrik Bluhme - Academia.edu (original) (raw)
Papers by Henrik Bluhme
![Research paper thumbnail of Extravasation of [177Lu]Lu-DOTATOC: case report and discussion](https://attachments.academia-assets.com/73187250/thumbnails/1.jpg)
](EJNMMI Research
Background In the case of extravasation of radioactive drugs used in peptide-receptor radionuclid... more Background In the case of extravasation of radioactive drugs used in peptide-receptor radionuclide therapy of neuroendocrine tumors, or in radionuclide therapy in general, rapid action is important to reduce or avoid complications. The literature on extravasation of drugs for radionuclide therapy is sparse. Based on the present case, we discuss handling and consequences of extravasation. Further, we demonstrate that dosimetry can aid in judging if the treatment of neuroendocrine tumors is satisfactory even after extravasation. Case presentation A case of extravasation of [177Lu]Lu-DOTATOC with a treatment strategy involving exercise and elevation of the affected arm and application of a compression bandage and heating is reported. Redistribution of the drug is verified and quantified by whole-body imaging and quantitative SPECT/CT and measurements of the dose rate at contact with the injection site. [177Lu]Lu-DOTATOC was redistributed to tumors and organs within 1 day. The patient d...
Time and dose-related changes in lung perfusion after definitive radiotherapy for NSCLC
Radiotherapy and Oncology
[Monitoring renal function in patients treated with cytostatics]
Ugeskrift For Laeger, Dec 1, 2008
Some cytostatics, used in the treatment of cancer, are excreted by the kidneys and may be nephrot... more Some cytostatics, used in the treatment of cancer, are excreted by the kidneys and may be nephrotoxic. The glomerular filtration rate (GFR) represents a method for reliable assessement of the 51Cr-EDTA plasma clearance before and during treatment with nephrotoxic drugs. The aim of this retrospective study was to evaluate whether this method could be replaced by a more simplified GFR estimate calculated from the creatinine plasma concentration. We included all patients who had had at least four GFR measurements in 2005 as part of their nephrotoxic cytostatic treatment. The estimated GFR (eGFR) was calculated from sex, age and weight, according to the Cockcroft formula. Forty-eight patients with a mean age of 47 years were included. 51Cr-EDTA plasma clearance and eGFR showed a poor correlation (r(2) = 0,678). On average, GFR decreased from 95 ml/min to 80 ml/min from the first to the fourth measurement, whereas plasma concentration of creatinine and eGFR remained unchanged. In 13 patients (27%), the treatment dose was reduced due to a fall in GFR. Seven of these 13 patients would have continued their treatment unchanged, if the clinical decision had been based on eGFR. Neither creatinine plasma concentration nor estimated GFR ad modum Cockcroft can be recommended for measurement of GFR in patients treated with nephrotoxic cytostatics.
Back to the line of stability Chasing mass accuracies below 10- 9 using a Penning trap and highly charged ions
European Physical Journal a, 2002
COMMENT: Comment on `e+-H- four-particle threshold break-up
J Phys B at Mol Opt Phys, 2000
Inclusion of functional information from perfusion SPECT improves predictive value of dose–volume parameters in lung toxicity outcome after radiotherapy for non-small cell lung cancer: A prospective study
Radiotherapy and Oncology, 2015
To compare functional and standard dose-volume parameters as predictors of postradiation pulmonar... more To compare functional and standard dose-volume parameters as predictors of postradiation pulmonary toxicity in lung cancer patients undergoing curative chemo-radiotherapy (RT) studied prospectively. A total of 58 patients treated with Intensity Modulated RT (60-66Gy) were analysed. Standard dose-volume parameters were extracted from treatment planning computed tomography (CT) scans. Corresponding functional dose-volume parameters were calculated from perfusion single-photon emission computed tomography (SPECT). Primary end-point was radiation pneumonitis (RP) grade 2-5. Functional mean lung dose (MLD) and lung volumes receiving 5, 10, 20 and 30Gy (V5-V30, respectively) revealed high correlation with corresponding standard parameters (r>0.8). Standard MLD, V20 and V30 were significantly higher in patients with RP (p=0.01). All functional parameters were significantly higher in the RP patients (p<0.03). In multivariate analysis functional parameters produced superior risk estimates, while all standard parameters, except V30, were not related to the risk of RP. Area under the curve (AUC) for functional metrics generally exceeded the AUC for corresponding standard parameters, but they were not significantly different from each other. SPECT-based functional parameters were better to predict the risk of RP compared to standard CT-based dose-volume parameters. Functional parameters may be useful to guide radiotherapy planning in order to reduce the risk of radiation-induced toxicity.
[Monitoring renal function in patients treated with cytostatics]
Ugeskrift for laeger, Jan 3, 2008
Some cytostatics, used in the treatment of cancer, are excreted by the kidneys and may be nephrot... more Some cytostatics, used in the treatment of cancer, are excreted by the kidneys and may be nephrotoxic. The glomerular filtration rate (GFR) represents a method for reliable assessement of the 51Cr-EDTA plasma clearance before and during treatment with nephrotoxic drugs. The aim of this retrospective study was to evaluate whether this method could be replaced by a more simplified GFR estimate calculated from the creatinine plasma concentration. We included all patients who had had at least four GFR measurements in 2005 as part of their nephrotoxic cytostatic treatment. The estimated GFR (eGFR) was calculated from sex, age and weight, according to the Cockcroft formula. Forty-eight patients with a mean age of 47 years were included. 51Cr-EDTA plasma clearance and eGFR showed a poor correlation (r(2) = 0,678). On average, GFR decreased from 95 ml/min to 80 ml/min from the first to the fourth measurement, whereas plasma concentration of creatinine and eGFR remained unchanged. In 13 pati...
Gastric emptying: a comparison of three methods
Scandinavian Journal of Gastroenterology, 2007
A better understanding of the clinical relevance of delayed gastric emptying (e.g. in diabetes) r... more A better understanding of the clinical relevance of delayed gastric emptying (e.g. in diabetes) requires a simple, easily accessible and inexpensive method for measuring it. Two "new" methods for measuring gastric emptying of liquids (the paracetamol absorption test and the 13C-acetate breath test) are compared with the gold standard (gastric emptying scintigraphy (GES)). The three techniques were used simultaneously in 10 healthy subjects. A gastric emptying time-retention curve was drawn for each technique and the results were compared at the 75%, 50% and 25% retention quartiles. Agreement was found between the paracetamol absorption test and GES (p=0.95; Hotelling's T 2 test). Using the Wagner-Nelson one compartment correction produced a retention curve for the 13C-acetate breath test statistically significantly below GES (p<0.01). In healthy subjects, the paracetamol absorption test produced results comparable to those of liquid GES, but not to the results of the 13C-acetate breath test.
Biodistribution of 99m Tc-HYNIC-lactadherin in mice – a potential tracer for visualizing apoptosis in vivo
Scandinavian Journal of Clinical & Laboratory Investigation, 2010
The aim of this study was to establish a radio synthesis of (99m)Tc-HYNIC-lactadherin for in vivo... more The aim of this study was to establish a radio synthesis of (99m)Tc-HYNIC-lactadherin for in vivo studies and to perform biodistribution analysis studies in mice, comparing (99m)Tc-HYNIC-lactadherin to (99m)Tc-HYNIC-annexin V. The radiochemical purity of (99m)Tc-HYNIC-lactadherin was optimized by varying the amount of SnCl(2) in the synthesis. Furthermore, the need for bovine serum albumin (BSA) as a stabilizing agent was evaluated by following the stability by radiochemical purity measurement with and without the addition of BSA. A total of 24 mice were assigned to groups of 15 and nine mice, respectively. The animals were sacrificed at different time points; 10 min, 60 min, and 180 min. The synthesis of (99m)Tc-HYNIC-lactadherin for in vivo studies has been optimized to give a stable product without addition of BSA and with a radiochemical purity of more than 95%. Approximately 60% of the injected dose of (99m)Tc-HYNIC-lactadherin was found in the liver and 4-5% could be assigned to kidneys. In contrast, (99m)Tc-HYNIC-annexin V distributes with around 13% and 45% of the injected dose in liver and kidneys, respectively. Over the experimental period (10-180 min) only small distributional changes were observed for both probes. In conclusion, the biodistribution of (99m)Tc-HYNIC-lactadherin, a potential new tracer for in vivo quantification of apoptosis, was evaluated. The small renal uptake of (99m)Tc-HYNIC-lactadherin makes it possible to image apoptosis in the kidneys, but the high liver clearance may be a disadvantage during myocardial perfusion.
Electron Scattering on Centrosymmetric Molecular Dianions Pt(CN)42- and Pt(CN)62
Physical Review Letters, 2004
Electron scattering on stored Pt(CN)2-4 and Pt(CN)2-6 centrosymmetric molecular dianions has been... more Electron scattering on stored Pt(CN)2-4 and Pt(CN)2-6 centrosymmetric molecular dianions has been performed at the electrostatic storage ring ELISA. The thresholds for production of neutral particles by electron bombardment were found to be 17.2 and 18.7 eV, respectively. The relatively high thresholds reflect the strong Coulomb repulsion in the incoming channel as well as a high energetic stability of the target electrons. A trianion resonance was identified with a positive energy of 17.0 eV for the Pt(CN)2-4 square-planar complex, while three trianion resonances were identified for the Pt(CN)2-6 octahedral complex with positive energies of 15.3, 18.1, and 20.1 eV.
Strong Suppression of the Positronium Channel in Double Ionization of Noble Gases by Positron Impact
Physical Review Letters, 1998
... Another argument is that previous positron measurements on heavy noble gases (Ar, Kr, and Xe)... more ... Another argument is that previous positron measurements on heavy noble gases (Ar, Kr, and Xe) have claimed to show that positronium formation accompanied by ionization of an additional electron ... 1 1 (b) Single ionization of Ne by e1 impact: stot , Laricchia [8]; sI , Kara et al. ...
Dissociative recombination of small carbon cluster cations
Physical Review A, 2006
The dissociative recombination of small cluster cations with free, zero-energy electrons was stud... more The dissociative recombination of small cluster cations with free, zero-energy electrons was studied at the ASTRID storage ring. It was found that only two-body fragmentation channels contribute: C+ C 2 for C 3+, C 2+ C 2 and C+ C 3 for C 4+. For C 5+ and C 6+ the final ...
Shedding light on the mercury mass discrepancy by weighing Hg52+ ions in a Penning trap
Nuclear Physics A, 2003
ABSTRACT In their nuclear tables Audi and Wapstra have pointed out a serious mass discrepancy bet... more ABSTRACT In their nuclear tables Audi and Wapstra have pointed out a serious mass discrepancy between their extrapolated values for the mercury isotopes and those from a direct measurement by the Manitoba group. The values deviate by as much as 85 ppb from each other with claimed uncertainties of about 16 and 7 ppb, respectively. In order to decide which values are correct the masses of the 198Hg and 204Hg isotopes have been measured in the Stockholm Penning trap mass spectrometer SMILETRAP using 52+ ions. This charge state corresponds to a filled Ni electron configuration for which the electron binding energy can be accurately calculated. The mass values obtained are 197.966 768 44(43) u for 198Hg and 203.973 494 10(39) u for 204Hg. These values agree with those measured by the Manitoba group, with a 3 times lower uncertainty. This measurement was made possible through the implementation of a cooling technique of the highly charged mercury ions during charge breeding in the electron beam ion source used for producing the Hg52+ ions.
Ionization of helium, neon and xenon by positron impact
Journal of Physics B: Atomic, Molecular and Optical Physics, 1999
Single ionization of xenon and double ionization of helium, neon and xenon by positron impact hav... more Single ionization of xenon and double ionization of helium, neon and xenon by positron impact have been studied at energies from threshold to~ 1 keV. The total single ionization cross section of xenon is seen to behave as expected. In particular, single ionization with ...
Ionization of argon and krypton by positron impact
Journal of Physics B: Atomic, Molecular and Optical Physics, 1999
Total single and double ionization cross sections for argon and krypton by positron impact have b... more Total single and double ionization cross sections for argon and krypton by positron impact have been measured for projectile energies ranging from threshold to~ 1 keV. The single ionization cross sections are seen to behave as expected, showing large contributions ...
The European Physical Journal A - Hadrons and Nuclei, 2002
The Stockholm Penning trap has been connected to an electron beam ion source named CRYSIS located... more The Stockholm Penning trap has been connected to an electron beam ion source named CRYSIS located at the Manne Siegbahn Laboratory. It is combined to a high-resolution isotope separator that can provide singly charged mass selected ions of practically any element. These ions are fed into CRYSIS where it is subject to a very intense electron beam with an energy of 10-20 keV. The mass of the neutral atom is obtained by adding the masses of the missing electrons and subtracting their binding energies. The results on some 16 mass determinations made at an uncertainty from 3 to 0.3 ppb are commented on. In these measurements the mass number varies from 1 to 204 and the ion charges from 1+ to 52+. New mass values are obtained for the 3 H, 3 He and 4 He masses. We have confirmed the Manitoba measurements of the Q-value of the double beta-decay of 76 Ge and their mass measurements of the masses of 198 Hg and 204 Hg reaching the higher accuracy that traps offer. At present the mass uncertainty limit is about 3 × 10 −10 which is demonstrated by comparing our results with the most accurately measured masses by other groups.
Monitoring renal function during chemotherapy
European Journal of Nuclear Medicine and Molecular Imaging, 2012
Renal function is monitored during chemotherapy because chemotherapeutic drugs are excreted by th... more Renal function is monitored during chemotherapy because chemotherapeutic drugs are excreted by the kidneys and are potentially nephrotoxic. Doses are adjusted according to the glomerular filtration rate (GFR), i.e. the more reduced the GFR, the lower the treatment dose. Plasma clearance of (51)Cr-EDTA is a reliable indicator of GFR before and during treatment with potentially nephrotoxic drugs, but its measurement is costly. GFR can also be estimated using an algorithm that converts plasma creatinine concentration to GFR, e.g. the MDRD equation. The aim of this investigation was to evaluate the reliability of estimated GFR (eGFR) in detecting changes in GFR as assessed by the MDRD equation in cancer patients treated with nephrotoxic chemotherapeutic drugs. We included all patients from the Department of Oncology undergoing chemotherapy who were referred to the Department of Nuclear Medicine for measurement of GFR by the (51)Cr-EDTA plasma clearance technique at least four times during the study period of 12 months. The eGFR was calculated from plasma creatinine concentration and the MDRD formula. GFR was determined by the (51)Cr-EDTA plasma clearance method. In 48 patients with a mean age of 47 years, GFR decreased from 86 to 73 ml/min/1.73 m(2) (mean values, p < 0.002) from the first to the last measurement, whereas plasma creatinine concentration and eGFR remained unchanged. In 13 patients (27 %) the finding of a decreased GFR led to adjustment of the dose of the chemotherapy drug. Eight of the 13 patients with decreased GFR also had a reduced eGFR but five patients had a normal eGFR. These five patients would have been treated with the nephrotoxic drug at a dose that was too high. Neither creatinine plasma concentration nor eGFR (MDRD) can be recommended as a replacement for measurement of GFR with the (51)Cr-EDTA plasma clearance method in patients treated with nephrotoxic cytostatic drugs.
Electron scattering on p-benzoquinone anions
Chemical Physics Letters, 2005
... The combination of an electrospray ion source with an electrostatic ion storage ring (ELISA) ... more ... The combination of an electrospray ion source with an electrostatic ion storage ring (ELISA) that contains an electron target for crossed-beam experiments has opened up large possibilities for studies of interactions between biomolecular ions and electrons [14], [15], [16] and [17 ...
AJP: Regulatory, Integrative and Comparative Physiology, 2010
Acute hyponatremia is a serious condition, which poses major challenges. Of particular importance... more Acute hyponatremia is a serious condition, which poses major challenges. Of particular importance is what determines plasma sodium concentration ([Na+]). Edelman introduced an explicit model to describe plasma [Na+] in a population as [Na+] = α·(exchangeable Na+ + exchangeable K+)/(total body water) − β. Evidence for the clinical utility of the model in the individual and in acute hyponatremia is sparse. We, therefore, investigated how the measured plasma [Na+] could be predicted in a porcine model of hyponatremia. Plasma [Na+] was estimated from in vivo-determined balances of water, Na+, and K+, according to Edelman's equation. Acute hyponatremia was induced with desmopressin acetate and infusion of a 2.5% glucose solution in anesthetized pigs. During 480 min, plasma [Na+] and osmolality were reduced from 136 (SD 2) to 120 mmol/l (SD 3) and from 284 (SD 4) to 252 mosmol/kgH2O (SD 5), respectively. The following interpretations were made. First, Edelman's model, which, besid...
Hyperfine Interactions, 2000
The positron induced absolute single and double ionisation cross sections for the noble gases Ar,... more The positron induced absolute single and double ionisation cross sections for the noble gases Ar, Kr and Xe have been determined in the energy region from below threshold to ∼1000 eV. With the use of an admixture of He to the target gas normalisation was performed by comparison to known single ionisation cross sections for He. Special interest has been taken in the energy gap of 6.8 eV below the direct double ionisation threshold energy, where only double ionisation with positronium formation is possible. This has been done to study the significance of double ionisation with Ps formation for the heavy noble gases.
EJNMMI Research
Background In the case of extravasation of radioactive drugs used in peptide-receptor radionuclid... more Background In the case of extravasation of radioactive drugs used in peptide-receptor radionuclide therapy of neuroendocrine tumors, or in radionuclide therapy in general, rapid action is important to reduce or avoid complications. The literature on extravasation of drugs for radionuclide therapy is sparse. Based on the present case, we discuss handling and consequences of extravasation. Further, we demonstrate that dosimetry can aid in judging if the treatment of neuroendocrine tumors is satisfactory even after extravasation. Case presentation A case of extravasation of [177Lu]Lu-DOTATOC with a treatment strategy involving exercise and elevation of the affected arm and application of a compression bandage and heating is reported. Redistribution of the drug is verified and quantified by whole-body imaging and quantitative SPECT/CT and measurements of the dose rate at contact with the injection site. [177Lu]Lu-DOTATOC was redistributed to tumors and organs within 1 day. The patient d...
Time and dose-related changes in lung perfusion after definitive radiotherapy for NSCLC
Radiotherapy and Oncology
[Monitoring renal function in patients treated with cytostatics]
Ugeskrift For Laeger, Dec 1, 2008
Some cytostatics, used in the treatment of cancer, are excreted by the kidneys and may be nephrot... more Some cytostatics, used in the treatment of cancer, are excreted by the kidneys and may be nephrotoxic. The glomerular filtration rate (GFR) represents a method for reliable assessement of the 51Cr-EDTA plasma clearance before and during treatment with nephrotoxic drugs. The aim of this retrospective study was to evaluate whether this method could be replaced by a more simplified GFR estimate calculated from the creatinine plasma concentration. We included all patients who had had at least four GFR measurements in 2005 as part of their nephrotoxic cytostatic treatment. The estimated GFR (eGFR) was calculated from sex, age and weight, according to the Cockcroft formula. Forty-eight patients with a mean age of 47 years were included. 51Cr-EDTA plasma clearance and eGFR showed a poor correlation (r(2) = 0,678). On average, GFR decreased from 95 ml/min to 80 ml/min from the first to the fourth measurement, whereas plasma concentration of creatinine and eGFR remained unchanged. In 13 patients (27%), the treatment dose was reduced due to a fall in GFR. Seven of these 13 patients would have continued their treatment unchanged, if the clinical decision had been based on eGFR. Neither creatinine plasma concentration nor estimated GFR ad modum Cockcroft can be recommended for measurement of GFR in patients treated with nephrotoxic cytostatics.
Back to the line of stability Chasing mass accuracies below 10- 9 using a Penning trap and highly charged ions
European Physical Journal a, 2002
COMMENT: Comment on `e+-H- four-particle threshold break-up
J Phys B at Mol Opt Phys, 2000
Inclusion of functional information from perfusion SPECT improves predictive value of dose–volume parameters in lung toxicity outcome after radiotherapy for non-small cell lung cancer: A prospective study
Radiotherapy and Oncology, 2015
To compare functional and standard dose-volume parameters as predictors of postradiation pulmonar... more To compare functional and standard dose-volume parameters as predictors of postradiation pulmonary toxicity in lung cancer patients undergoing curative chemo-radiotherapy (RT) studied prospectively. A total of 58 patients treated with Intensity Modulated RT (60-66Gy) were analysed. Standard dose-volume parameters were extracted from treatment planning computed tomography (CT) scans. Corresponding functional dose-volume parameters were calculated from perfusion single-photon emission computed tomography (SPECT). Primary end-point was radiation pneumonitis (RP) grade 2-5. Functional mean lung dose (MLD) and lung volumes receiving 5, 10, 20 and 30Gy (V5-V30, respectively) revealed high correlation with corresponding standard parameters (r>0.8). Standard MLD, V20 and V30 were significantly higher in patients with RP (p=0.01). All functional parameters were significantly higher in the RP patients (p<0.03). In multivariate analysis functional parameters produced superior risk estimates, while all standard parameters, except V30, were not related to the risk of RP. Area under the curve (AUC) for functional metrics generally exceeded the AUC for corresponding standard parameters, but they were not significantly different from each other. SPECT-based functional parameters were better to predict the risk of RP compared to standard CT-based dose-volume parameters. Functional parameters may be useful to guide radiotherapy planning in order to reduce the risk of radiation-induced toxicity.
[Monitoring renal function in patients treated with cytostatics]
Ugeskrift for laeger, Jan 3, 2008
Some cytostatics, used in the treatment of cancer, are excreted by the kidneys and may be nephrot... more Some cytostatics, used in the treatment of cancer, are excreted by the kidneys and may be nephrotoxic. The glomerular filtration rate (GFR) represents a method for reliable assessement of the 51Cr-EDTA plasma clearance before and during treatment with nephrotoxic drugs. The aim of this retrospective study was to evaluate whether this method could be replaced by a more simplified GFR estimate calculated from the creatinine plasma concentration. We included all patients who had had at least four GFR measurements in 2005 as part of their nephrotoxic cytostatic treatment. The estimated GFR (eGFR) was calculated from sex, age and weight, according to the Cockcroft formula. Forty-eight patients with a mean age of 47 years were included. 51Cr-EDTA plasma clearance and eGFR showed a poor correlation (r(2) = 0,678). On average, GFR decreased from 95 ml/min to 80 ml/min from the first to the fourth measurement, whereas plasma concentration of creatinine and eGFR remained unchanged. In 13 pati...
Gastric emptying: a comparison of three methods
Scandinavian Journal of Gastroenterology, 2007
A better understanding of the clinical relevance of delayed gastric emptying (e.g. in diabetes) r... more A better understanding of the clinical relevance of delayed gastric emptying (e.g. in diabetes) requires a simple, easily accessible and inexpensive method for measuring it. Two "new" methods for measuring gastric emptying of liquids (the paracetamol absorption test and the 13C-acetate breath test) are compared with the gold standard (gastric emptying scintigraphy (GES)). The three techniques were used simultaneously in 10 healthy subjects. A gastric emptying time-retention curve was drawn for each technique and the results were compared at the 75%, 50% and 25% retention quartiles. Agreement was found between the paracetamol absorption test and GES (p=0.95; Hotelling's T 2 test). Using the Wagner-Nelson one compartment correction produced a retention curve for the 13C-acetate breath test statistically significantly below GES (p<0.01). In healthy subjects, the paracetamol absorption test produced results comparable to those of liquid GES, but not to the results of the 13C-acetate breath test.
Biodistribution of 99m Tc-HYNIC-lactadherin in mice – a potential tracer for visualizing apoptosis in vivo
Scandinavian Journal of Clinical & Laboratory Investigation, 2010
The aim of this study was to establish a radio synthesis of (99m)Tc-HYNIC-lactadherin for in vivo... more The aim of this study was to establish a radio synthesis of (99m)Tc-HYNIC-lactadherin for in vivo studies and to perform biodistribution analysis studies in mice, comparing (99m)Tc-HYNIC-lactadherin to (99m)Tc-HYNIC-annexin V. The radiochemical purity of (99m)Tc-HYNIC-lactadherin was optimized by varying the amount of SnCl(2) in the synthesis. Furthermore, the need for bovine serum albumin (BSA) as a stabilizing agent was evaluated by following the stability by radiochemical purity measurement with and without the addition of BSA. A total of 24 mice were assigned to groups of 15 and nine mice, respectively. The animals were sacrificed at different time points; 10 min, 60 min, and 180 min. The synthesis of (99m)Tc-HYNIC-lactadherin for in vivo studies has been optimized to give a stable product without addition of BSA and with a radiochemical purity of more than 95%. Approximately 60% of the injected dose of (99m)Tc-HYNIC-lactadherin was found in the liver and 4-5% could be assigned to kidneys. In contrast, (99m)Tc-HYNIC-annexin V distributes with around 13% and 45% of the injected dose in liver and kidneys, respectively. Over the experimental period (10-180 min) only small distributional changes were observed for both probes. In conclusion, the biodistribution of (99m)Tc-HYNIC-lactadherin, a potential new tracer for in vivo quantification of apoptosis, was evaluated. The small renal uptake of (99m)Tc-HYNIC-lactadherin makes it possible to image apoptosis in the kidneys, but the high liver clearance may be a disadvantage during myocardial perfusion.
Electron Scattering on Centrosymmetric Molecular Dianions Pt(CN)42- and Pt(CN)62
Physical Review Letters, 2004
Electron scattering on stored Pt(CN)2-4 and Pt(CN)2-6 centrosymmetric molecular dianions has been... more Electron scattering on stored Pt(CN)2-4 and Pt(CN)2-6 centrosymmetric molecular dianions has been performed at the electrostatic storage ring ELISA. The thresholds for production of neutral particles by electron bombardment were found to be 17.2 and 18.7 eV, respectively. The relatively high thresholds reflect the strong Coulomb repulsion in the incoming channel as well as a high energetic stability of the target electrons. A trianion resonance was identified with a positive energy of 17.0 eV for the Pt(CN)2-4 square-planar complex, while three trianion resonances were identified for the Pt(CN)2-6 octahedral complex with positive energies of 15.3, 18.1, and 20.1 eV.
Strong Suppression of the Positronium Channel in Double Ionization of Noble Gases by Positron Impact
Physical Review Letters, 1998
... Another argument is that previous positron measurements on heavy noble gases (Ar, Kr, and Xe)... more ... Another argument is that previous positron measurements on heavy noble gases (Ar, Kr, and Xe) have claimed to show that positronium formation accompanied by ionization of an additional electron ... 1 1 (b) Single ionization of Ne by e1 impact: stot , Laricchia [8]; sI , Kara et al. ...
Dissociative recombination of small carbon cluster cations
Physical Review A, 2006
The dissociative recombination of small cluster cations with free, zero-energy electrons was stud... more The dissociative recombination of small cluster cations with free, zero-energy electrons was studied at the ASTRID storage ring. It was found that only two-body fragmentation channels contribute: C+ C 2 for C 3+, C 2+ C 2 and C+ C 3 for C 4+. For C 5+ and C 6+ the final ...
Shedding light on the mercury mass discrepancy by weighing Hg52+ ions in a Penning trap
Nuclear Physics A, 2003
ABSTRACT In their nuclear tables Audi and Wapstra have pointed out a serious mass discrepancy bet... more ABSTRACT In their nuclear tables Audi and Wapstra have pointed out a serious mass discrepancy between their extrapolated values for the mercury isotopes and those from a direct measurement by the Manitoba group. The values deviate by as much as 85 ppb from each other with claimed uncertainties of about 16 and 7 ppb, respectively. In order to decide which values are correct the masses of the 198Hg and 204Hg isotopes have been measured in the Stockholm Penning trap mass spectrometer SMILETRAP using 52+ ions. This charge state corresponds to a filled Ni electron configuration for which the electron binding energy can be accurately calculated. The mass values obtained are 197.966 768 44(43) u for 198Hg and 203.973 494 10(39) u for 204Hg. These values agree with those measured by the Manitoba group, with a 3 times lower uncertainty. This measurement was made possible through the implementation of a cooling technique of the highly charged mercury ions during charge breeding in the electron beam ion source used for producing the Hg52+ ions.
Ionization of helium, neon and xenon by positron impact
Journal of Physics B: Atomic, Molecular and Optical Physics, 1999
Single ionization of xenon and double ionization of helium, neon and xenon by positron impact hav... more Single ionization of xenon and double ionization of helium, neon and xenon by positron impact have been studied at energies from threshold to~ 1 keV. The total single ionization cross section of xenon is seen to behave as expected. In particular, single ionization with ...
Ionization of argon and krypton by positron impact
Journal of Physics B: Atomic, Molecular and Optical Physics, 1999
Total single and double ionization cross sections for argon and krypton by positron impact have b... more Total single and double ionization cross sections for argon and krypton by positron impact have been measured for projectile energies ranging from threshold to~ 1 keV. The single ionization cross sections are seen to behave as expected, showing large contributions ...
The European Physical Journal A - Hadrons and Nuclei, 2002
The Stockholm Penning trap has been connected to an electron beam ion source named CRYSIS located... more The Stockholm Penning trap has been connected to an electron beam ion source named CRYSIS located at the Manne Siegbahn Laboratory. It is combined to a high-resolution isotope separator that can provide singly charged mass selected ions of practically any element. These ions are fed into CRYSIS where it is subject to a very intense electron beam with an energy of 10-20 keV. The mass of the neutral atom is obtained by adding the masses of the missing electrons and subtracting their binding energies. The results on some 16 mass determinations made at an uncertainty from 3 to 0.3 ppb are commented on. In these measurements the mass number varies from 1 to 204 and the ion charges from 1+ to 52+. New mass values are obtained for the 3 H, 3 He and 4 He masses. We have confirmed the Manitoba measurements of the Q-value of the double beta-decay of 76 Ge and their mass measurements of the masses of 198 Hg and 204 Hg reaching the higher accuracy that traps offer. At present the mass uncertainty limit is about 3 × 10 −10 which is demonstrated by comparing our results with the most accurately measured masses by other groups.
Monitoring renal function during chemotherapy
European Journal of Nuclear Medicine and Molecular Imaging, 2012
Renal function is monitored during chemotherapy because chemotherapeutic drugs are excreted by th... more Renal function is monitored during chemotherapy because chemotherapeutic drugs are excreted by the kidneys and are potentially nephrotoxic. Doses are adjusted according to the glomerular filtration rate (GFR), i.e. the more reduced the GFR, the lower the treatment dose. Plasma clearance of (51)Cr-EDTA is a reliable indicator of GFR before and during treatment with potentially nephrotoxic drugs, but its measurement is costly. GFR can also be estimated using an algorithm that converts plasma creatinine concentration to GFR, e.g. the MDRD equation. The aim of this investigation was to evaluate the reliability of estimated GFR (eGFR) in detecting changes in GFR as assessed by the MDRD equation in cancer patients treated with nephrotoxic chemotherapeutic drugs. We included all patients from the Department of Oncology undergoing chemotherapy who were referred to the Department of Nuclear Medicine for measurement of GFR by the (51)Cr-EDTA plasma clearance technique at least four times during the study period of 12 months. The eGFR was calculated from plasma creatinine concentration and the MDRD formula. GFR was determined by the (51)Cr-EDTA plasma clearance method. In 48 patients with a mean age of 47 years, GFR decreased from 86 to 73 ml/min/1.73 m(2) (mean values, p < 0.002) from the first to the last measurement, whereas plasma creatinine concentration and eGFR remained unchanged. In 13 patients (27 %) the finding of a decreased GFR led to adjustment of the dose of the chemotherapy drug. Eight of the 13 patients with decreased GFR also had a reduced eGFR but five patients had a normal eGFR. These five patients would have been treated with the nephrotoxic drug at a dose that was too high. Neither creatinine plasma concentration nor eGFR (MDRD) can be recommended as a replacement for measurement of GFR with the (51)Cr-EDTA plasma clearance method in patients treated with nephrotoxic cytostatic drugs.
Electron scattering on p-benzoquinone anions
Chemical Physics Letters, 2005
... The combination of an electrospray ion source with an electrostatic ion storage ring (ELISA) ... more ... The combination of an electrospray ion source with an electrostatic ion storage ring (ELISA) that contains an electron target for crossed-beam experiments has opened up large possibilities for studies of interactions between biomolecular ions and electrons [14], [15], [16] and [17 ...
AJP: Regulatory, Integrative and Comparative Physiology, 2010
Acute hyponatremia is a serious condition, which poses major challenges. Of particular importance... more Acute hyponatremia is a serious condition, which poses major challenges. Of particular importance is what determines plasma sodium concentration ([Na+]). Edelman introduced an explicit model to describe plasma [Na+] in a population as [Na+] = α·(exchangeable Na+ + exchangeable K+)/(total body water) − β. Evidence for the clinical utility of the model in the individual and in acute hyponatremia is sparse. We, therefore, investigated how the measured plasma [Na+] could be predicted in a porcine model of hyponatremia. Plasma [Na+] was estimated from in vivo-determined balances of water, Na+, and K+, according to Edelman's equation. Acute hyponatremia was induced with desmopressin acetate and infusion of a 2.5% glucose solution in anesthetized pigs. During 480 min, plasma [Na+] and osmolality were reduced from 136 (SD 2) to 120 mmol/l (SD 3) and from 284 (SD 4) to 252 mosmol/kgH2O (SD 5), respectively. The following interpretations were made. First, Edelman's model, which, besid...
Hyperfine Interactions, 2000
The positron induced absolute single and double ionisation cross sections for the noble gases Ar,... more The positron induced absolute single and double ionisation cross sections for the noble gases Ar, Kr and Xe have been determined in the energy region from below threshold to ∼1000 eV. With the use of an admixture of He to the target gas normalisation was performed by comparison to known single ionisation cross sections for He. Special interest has been taken in the energy gap of 6.8 eV below the direct double ionisation threshold energy, where only double ionisation with positronium formation is possible. This has been done to study the significance of double ionisation with Ps formation for the heavy noble gases.