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Papers by Henry Paul Goodell
Journal of Chromatography A, Aug 1, 2000
Linear solvation energy relationships and free energy of transfer data were used to evaluate the ... more Linear solvation energy relationships and free energy of transfer data were used to evaluate the influence of the surfactant counter-ion on selectivity in micellar electrokinetic chromatography. It was determined that selectivity differences are dependent on the valency of the counter-ion but not the type of counter-ion. Monovalent surfactants, sodium dodecyl sulfate (SDS) and lithium dodecyl sulfate, have nearly identical selectivity
Scientific Reports, Aug 7, 2017
IEEE Journal of Biomedical and Health Informatics, Sep 1, 2016
Journal of Chromatography A, Oct 1, 1978
Wearable self-powered medical devices have long been a goal of the medical community. The ability... more Wearable self-powered medical devices have long been a goal of the medical community. The ability to constantly monitor the patient's vital signs for abnormalities, in addition to alerting first responders to immediate problems, would allow for more rapid medical treatment. As the population of the United States ages, low-cost and ubiquitous medical devices will improve the ability of medical personnel to diagnose potential health issues early, thus increasing the survival rate and decreasing the potential complications. Electrocardiograms are a major focus of the medical community due to the prevalence of heart issues among elderly Americans, and as the cost of sensors and wireless communication decreases, new devices are possible. This paper describes a Bluetooth-based, dry electrode electrocardiogram monitoring system seamlessly integrated into a T-shirt. The shirt used three dry silver-based electrodes to collect the ECG signal and streamed the resulting signal to an Android smartphone for analysis.
Within the bra industry there exists a need to quantify fit and performance of test bra designs. ... more Within the bra industry there exists a need to quantify fit and performance of test bra designs. While finite element simulation of breast dynamics has been undertaken for imaging and surgical planning, for this real-world application a physical breast simulator with motion control was designed, built, evaluated, and refined through a second iteration. This simulator is based on 3D scans from a professional bra-testing model which were converted into composites of molded-silicone-simulated skin and breast tissue integrated around a SLS 3D printed nylon lattice torso. An initial evaluation of the simulator breast motion was undertaken using standard position and acceleration metrics as well as damped oscillation and rheological studies of various breast formulations. A clinical study of breast firmness and tissue dynamics was completed to validate the simulator formulation and motion as well as to provide a knowledgebase for further improvements and future research inquiries.
Science Advances, 2022
Cystic fibrosis (CF) is characterized by abnormal transepithelial ion transport. However, a descr... more Cystic fibrosis (CF) is characterized by abnormal transepithelial ion transport. However, a description of CF lung disease pathophysiology unifying superficial epithelial and submucosal gland (SMG) dysfunctions has remained elusive. We hypothesized that biophysical abnormalities associated with CF mucus hyperconcentration provide a unifying mechanism. Studies of the anion secretion–inhibited pig airway model of CF revealed elevated SMG mucus concentrations, osmotic pressures, and SMG mucus accumulation. Human airway studies revealed hyperconcentrated CF SMG mucus with raised osmotic pressures and cohesive forces predicted to limit SMG mucus secretion/release. Using proline-rich protein 4 (PRR4) as a biomarker of SMG secretion, CF sputum proteomics analyses revealed markedly lower PRR4 levels compared to healthy and bronchiectasis controls, consistent with a failure of CF SMGs to secrete mucus onto airway surfaces. Raised mucus osmotic/cohesive forces, reflecting mucus hyperconcentra...
Cystic fibrosis (CF) is characterized by abnormal transepithelial ion transport. However, a descr... more Cystic fibrosis (CF) is characterized by abnormal transepithelial ion transport. However, a description of CF lung disease pathophysiology unifying superficial epithelial and submucosal gland (SMG) dysfunctions has remained elusive. We hypothesized that biophysical abnormalities associated with CF mucus hyperconcentration provide a unifying mechanism. Studies of the anion secretion-inhibited pig airway CF model revealed elevated SMG mucus concentrations, osmotic pressures, and SMG mucus accumulation. Human airway studies revealed hyperconcentrated CF SMG mucus with raised osmotic pressures and cohesive forces predicted to limit SMG mucus secretion/release. Utilizing proline-rich protein 4 (PRR4) as a biomarker of SMG secretion, proteomics analyses of CF sputum revealed markedly lower PRR4 levels compared to healthy and bronchiectasis controls, consistent with a failure of CF SMGs to secrete mucus onto airway surfaces. Raised mucus osmotic/cohesive forces, reflecting mucus hyperconce...
2015 IEEE 12th International Conference on Wearable and Implantable Body Sensor Networks (BSN), 2015
ABSTRACT We present a wearable sensor system consisting of a wristband and chest patch to enable ... more ABSTRACT We present a wearable sensor system consisting of a wristband and chest patch to enable the correlation of individual environmental exposure to health response for understanding impacts of ozone on chronic asthma conditions. The wrist worn device measures ambient ozone concentration, heart rate via plethysmography (PPG), three-axis acceleration, ambient temperature, and ambient relative humidity. The chest patch measures heart rate via electrocardiography (ECG) and PPG, respiratory rate via PPG, wheezing via a microphone, and three-axis acceleration. The data from each sensor is continually streamed to a peripheral data aggregation device, and is subsequently transferred to a dedicated server for cloud storage. The current generation of the system uses only commercially-off-the-shelf (COTS) components where the entire electronic structure of the wristband has dimensions of 3.1x4.1x1.2 cm3 while the chest patch electronics has a dimensions of 3.3x4.4x1.2 cm3. The power consumptions of the wristband and chest patch are 78 mW and 33 mW respectively where using a 400 mAh lithium polymer battery would operate the wristband for around 15 hours and the chest patch for around 36 hours.
The American Surgeon, 2017
Proceedings of the National Academy of Sciences
Clearance of intrapulmonary mucus by the high-velocity airflow generated by cough is the major re... more Clearance of intrapulmonary mucus by the high-velocity airflow generated by cough is the major rescue clearance mechanism in subjects with mucoobstructive diseases and failed cilial-dependent mucus clearance, e.g., subjects with cystic fibrosis (CF) or chronic obstructive pulmonary disease (COPD). Previous studies have investigated the mechanical forces generated at airway surfaces by cough but have not considered the effects of mucus biophysical properties on cough efficacy. Theoretically, mucus can be cleared by cough from the lung by an adhesive failure, i.e., breaking mucus-cell surface adhesive bonds and/or by cohesive failure, i.e., directly fracturing mucus. Utilizing peel-testing technologies, mucus-epithelial surface adhesive and mucus cohesive strengths were measured. Because both mucus concentration and pH have been reported to alter mucus biophysical properties in disease, the effects of mucus concentration and pH on adhesion and cohesion were compared. Both adhesive and...
Scientific reports, Jan 7, 2017
In the past 5 years, e-cigarette use has been increasing rapidly, particularly in youth and young... more In the past 5 years, e-cigarette use has been increasing rapidly, particularly in youth and young adults. Due to the novelty of e-cigarettes (e-cigs) and e-cigarette liquids (e-liquids), research on their chemo-physical properties is still in its infancy. Here, we describe a previously unknown and potentially useful property of e-liquids, namely their autofluorescence. We performed an emission scan at 9 excitation wavelengths common to fluorescent microscopy and found (i) that autofluorescence differs widely between e-liquids, (ii) that e-liquids are most fluorescent in the UV range (between 350 and 405 nm) and (iii) fluorescence intensity wanes as the emission wavelength increases. Furthermore, we used the autofluorescence of e-liquids as a marker for tracking e-cig aerosol deposition in the laboratory. Using linear regression analysis, we were able to quantify the deposition of a "vaped" e-liquid onto hard surfaces. Using this technique, we found that every 70 mL puff of...
Journal of Chromatography A, 2000
Linear solvation energy relationships and free energy of transfer data were used to evaluate the ... more Linear solvation energy relationships and free energy of transfer data were used to evaluate the influence of the surfactant counter-ion on selectivity in micellar electrokinetic chromatography. It was determined that selectivity differences are dependent on the valency of the counter-ion but not the type of counter-ion. Monovalent surfactants, sodium dodecyl sulfate (SDS) and lithium dodecyl sulfate, have nearly identical selectivity
Journal of Chromatography A, Aug 1, 2000
Linear solvation energy relationships and free energy of transfer data were used to evaluate the ... more Linear solvation energy relationships and free energy of transfer data were used to evaluate the influence of the surfactant counter-ion on selectivity in micellar electrokinetic chromatography. It was determined that selectivity differences are dependent on the valency of the counter-ion but not the type of counter-ion. Monovalent surfactants, sodium dodecyl sulfate (SDS) and lithium dodecyl sulfate, have nearly identical selectivity
Scientific Reports, Aug 7, 2017
IEEE Journal of Biomedical and Health Informatics, Sep 1, 2016
Journal of Chromatography A, Oct 1, 1978
Wearable self-powered medical devices have long been a goal of the medical community. The ability... more Wearable self-powered medical devices have long been a goal of the medical community. The ability to constantly monitor the patient's vital signs for abnormalities, in addition to alerting first responders to immediate problems, would allow for more rapid medical treatment. As the population of the United States ages, low-cost and ubiquitous medical devices will improve the ability of medical personnel to diagnose potential health issues early, thus increasing the survival rate and decreasing the potential complications. Electrocardiograms are a major focus of the medical community due to the prevalence of heart issues among elderly Americans, and as the cost of sensors and wireless communication decreases, new devices are possible. This paper describes a Bluetooth-based, dry electrode electrocardiogram monitoring system seamlessly integrated into a T-shirt. The shirt used three dry silver-based electrodes to collect the ECG signal and streamed the resulting signal to an Android smartphone for analysis.
Within the bra industry there exists a need to quantify fit and performance of test bra designs. ... more Within the bra industry there exists a need to quantify fit and performance of test bra designs. While finite element simulation of breast dynamics has been undertaken for imaging and surgical planning, for this real-world application a physical breast simulator with motion control was designed, built, evaluated, and refined through a second iteration. This simulator is based on 3D scans from a professional bra-testing model which were converted into composites of molded-silicone-simulated skin and breast tissue integrated around a SLS 3D printed nylon lattice torso. An initial evaluation of the simulator breast motion was undertaken using standard position and acceleration metrics as well as damped oscillation and rheological studies of various breast formulations. A clinical study of breast firmness and tissue dynamics was completed to validate the simulator formulation and motion as well as to provide a knowledgebase for further improvements and future research inquiries.
Science Advances, 2022
Cystic fibrosis (CF) is characterized by abnormal transepithelial ion transport. However, a descr... more Cystic fibrosis (CF) is characterized by abnormal transepithelial ion transport. However, a description of CF lung disease pathophysiology unifying superficial epithelial and submucosal gland (SMG) dysfunctions has remained elusive. We hypothesized that biophysical abnormalities associated with CF mucus hyperconcentration provide a unifying mechanism. Studies of the anion secretion–inhibited pig airway model of CF revealed elevated SMG mucus concentrations, osmotic pressures, and SMG mucus accumulation. Human airway studies revealed hyperconcentrated CF SMG mucus with raised osmotic pressures and cohesive forces predicted to limit SMG mucus secretion/release. Using proline-rich protein 4 (PRR4) as a biomarker of SMG secretion, CF sputum proteomics analyses revealed markedly lower PRR4 levels compared to healthy and bronchiectasis controls, consistent with a failure of CF SMGs to secrete mucus onto airway surfaces. Raised mucus osmotic/cohesive forces, reflecting mucus hyperconcentra...
Cystic fibrosis (CF) is characterized by abnormal transepithelial ion transport. However, a descr... more Cystic fibrosis (CF) is characterized by abnormal transepithelial ion transport. However, a description of CF lung disease pathophysiology unifying superficial epithelial and submucosal gland (SMG) dysfunctions has remained elusive. We hypothesized that biophysical abnormalities associated with CF mucus hyperconcentration provide a unifying mechanism. Studies of the anion secretion-inhibited pig airway CF model revealed elevated SMG mucus concentrations, osmotic pressures, and SMG mucus accumulation. Human airway studies revealed hyperconcentrated CF SMG mucus with raised osmotic pressures and cohesive forces predicted to limit SMG mucus secretion/release. Utilizing proline-rich protein 4 (PRR4) as a biomarker of SMG secretion, proteomics analyses of CF sputum revealed markedly lower PRR4 levels compared to healthy and bronchiectasis controls, consistent with a failure of CF SMGs to secrete mucus onto airway surfaces. Raised mucus osmotic/cohesive forces, reflecting mucus hyperconce...
2015 IEEE 12th International Conference on Wearable and Implantable Body Sensor Networks (BSN), 2015
ABSTRACT We present a wearable sensor system consisting of a wristband and chest patch to enable ... more ABSTRACT We present a wearable sensor system consisting of a wristband and chest patch to enable the correlation of individual environmental exposure to health response for understanding impacts of ozone on chronic asthma conditions. The wrist worn device measures ambient ozone concentration, heart rate via plethysmography (PPG), three-axis acceleration, ambient temperature, and ambient relative humidity. The chest patch measures heart rate via electrocardiography (ECG) and PPG, respiratory rate via PPG, wheezing via a microphone, and three-axis acceleration. The data from each sensor is continually streamed to a peripheral data aggregation device, and is subsequently transferred to a dedicated server for cloud storage. The current generation of the system uses only commercially-off-the-shelf (COTS) components where the entire electronic structure of the wristband has dimensions of 3.1x4.1x1.2 cm3 while the chest patch electronics has a dimensions of 3.3x4.4x1.2 cm3. The power consumptions of the wristband and chest patch are 78 mW and 33 mW respectively where using a 400 mAh lithium polymer battery would operate the wristband for around 15 hours and the chest patch for around 36 hours.
The American Surgeon, 2017
Proceedings of the National Academy of Sciences
Clearance of intrapulmonary mucus by the high-velocity airflow generated by cough is the major re... more Clearance of intrapulmonary mucus by the high-velocity airflow generated by cough is the major rescue clearance mechanism in subjects with mucoobstructive diseases and failed cilial-dependent mucus clearance, e.g., subjects with cystic fibrosis (CF) or chronic obstructive pulmonary disease (COPD). Previous studies have investigated the mechanical forces generated at airway surfaces by cough but have not considered the effects of mucus biophysical properties on cough efficacy. Theoretically, mucus can be cleared by cough from the lung by an adhesive failure, i.e., breaking mucus-cell surface adhesive bonds and/or by cohesive failure, i.e., directly fracturing mucus. Utilizing peel-testing technologies, mucus-epithelial surface adhesive and mucus cohesive strengths were measured. Because both mucus concentration and pH have been reported to alter mucus biophysical properties in disease, the effects of mucus concentration and pH on adhesion and cohesion were compared. Both adhesive and...
Scientific reports, Jan 7, 2017
In the past 5 years, e-cigarette use has been increasing rapidly, particularly in youth and young... more In the past 5 years, e-cigarette use has been increasing rapidly, particularly in youth and young adults. Due to the novelty of e-cigarettes (e-cigs) and e-cigarette liquids (e-liquids), research on their chemo-physical properties is still in its infancy. Here, we describe a previously unknown and potentially useful property of e-liquids, namely their autofluorescence. We performed an emission scan at 9 excitation wavelengths common to fluorescent microscopy and found (i) that autofluorescence differs widely between e-liquids, (ii) that e-liquids are most fluorescent in the UV range (between 350 and 405 nm) and (iii) fluorescence intensity wanes as the emission wavelength increases. Furthermore, we used the autofluorescence of e-liquids as a marker for tracking e-cig aerosol deposition in the laboratory. Using linear regression analysis, we were able to quantify the deposition of a "vaped" e-liquid onto hard surfaces. Using this technique, we found that every 70 mL puff of...
Journal of Chromatography A, 2000
Linear solvation energy relationships and free energy of transfer data were used to evaluate the ... more Linear solvation energy relationships and free energy of transfer data were used to evaluate the influence of the surfactant counter-ion on selectivity in micellar electrokinetic chromatography. It was determined that selectivity differences are dependent on the valency of the counter-ion but not the type of counter-ion. Monovalent surfactants, sodium dodecyl sulfate (SDS) and lithium dodecyl sulfate, have nearly identical selectivity