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Papers by Heritiana Randrianatoandro

Research paper thumbnail of Primate Conservation Genomics and Paleogenomics

American Anthropologist, Nov 10, 2015

Over the past few decades, anthropologists have increasingly used genetic approaches in their eff... more Over the past few decades, anthropologists have increasingly used genetic approaches in their efforts to understand humans and their primate relatives. Technological and theoretical developments in recent years have enabled anthropological geneticists to expand their field of inquiry far beyond what was thought possible even a few years ago (Crawford 2000). Most importantly, the cost of collecting large genetic data sets has dropped dramatically, aiding researchers to better investigate complex questions such as the organization of our genome and the diversity of microbes living in our guts. Spectacular recent genetic discoveries, moreover, have altered understandings of our relationships to other hominin lineages. For example, genetic data have shown that both Neandertals (Green et al. 2010) and a newly discovered Denisovan population (Krause et al. 2010; Meyer et al. 2012) interbred with modern humans. Anthropological geneticists have long examined biological relationships among populations and described genetic variants such as disease-causing mutations that can be linked to specific human phenotypes (Crawford 2000). Great advances have been made on both fronts. The general patterns of human dispersal across the globe have been established (e.g., Henn et al. 2012). Genetic data continue to reveal the complex demographic histories of regional populations. In particular, studies have revealed how both geography and culture have stratified genetic diversity in contemporary populations. This can happen over short periods of time, as with the genetic stratification by religion of populations in the Levant (Haber et al. 2013). Our emerging understanding of diverse complex interactions between genetics and culture has both increased our understanding of these

Research paper thumbnail of Data from: Evolutionary and phylogenetic insights from a nuclear genome sequence of the extinct, giant 'subfossil' koala lemur Megaladapis edwardsi

No endemic Madagascar animal with body mass >10 kg survived a relatively recent wave of extinc... more No endemic Madagascar animal with body mass >10 kg survived a relatively recent wave of extinction on the island. From morphological and isotopic analyses of skeletal 'subfossil' remains we can reconstruct some of the biology and behavioral ecology of giant lemurs (primates; up to ~160 kg), elephant birds (up to ~860 kg), and other extraordinary Malagasy megafauna that survived well into the past millennium. Yet much about the evolutionary biology of these now extinct species remains unknown, along with persistent phylogenetic uncertainty in some cases. Thankfully, despite the challenges of DNA preservation in tropical and sub-tropical environments, technical advances have enabled the recovery of ancient DNA from some Malagasy subfossil specimens. Here we present a nuclear genome sequence (~2X coverage) for one of the largest extinct lemurs, the koala lemur Megaladapis edwardsi (~85kg). To support the testing of key phylogenetic and evolutionary hypotheses we also generat...

Research paper thumbnail of Potential evolutionary body size reduction in a Malagasy primate ( Propithecus verreauxi ) in response to human size‐selective hunting pressure

American Journal of Biological Anthropology, 2022

Research paper thumbnail of Primate Conservation Genomics and Paleogenomics

American Anthropologist, 2015

Over the past few decades, anthropologists have increasingly used genetic approaches in their eff... more Over the past few decades, anthropologists have increasingly used genetic approaches in their efforts to understand humans and their primate relatives. Technological and theoretical developments in recent years have enabled anthropological geneticists to expand their field of inquiry far beyond what was thought possible even a few years ago (Crawford 2000). Most importantly, the cost of collecting large genetic data sets has dropped dramatically, aiding researchers to better investigate complex questions such as the organization of our genome and the diversity of microbes living in our guts. Spectacular recent genetic discoveries, moreover, have altered understandings of our relationships to other hominin lineages. For example, genetic data have shown that both Neandertals (Green et al. 2010) and a newly discovered Denisovan population (Krause et al. 2010; Meyer et al. 2012) interbred with modern humans. Anthropological geneticists have long examined biological relationships among populations and described genetic variants such as disease-causing mutations that can be linked to specific human phenotypes (Crawford 2000). Great advances have been made on both fronts. The general patterns of human dispersal across the globe have been established (e.g., Henn et al. 2012). Genetic data continue to reveal the complex demographic histories of regional populations. In particular, studies have revealed how both geography and culture have stratified genetic diversity in contemporary populations. This can happen over short periods of time, as with the genetic stratification by religion of populations in the Levant (Haber et al. 2013). Our emerging understanding of diverse complex interactions between genetics and culture has both increased our understanding of these

Research paper thumbnail of Anthropological Genetics

American Anthropologist, 2015

Research paper thumbnail of Evolutionary and phylogenetic insights from a nuclear genome sequence of the extinct, giant ‘subfossil’ koala lemur Megaladapis edwardsi

No endemic Madagascar animal with body mass >10 kg survived a relatively recent wave of extinc... more No endemic Madagascar animal with body mass >10 kg survived a relatively recent wave of extinction on the island. From morphological and isotopic analyses of skeletal ‘subfossil’ remains we can reconstruct some of the biology and behavioral ecology of giant lemurs (primates; up to ~160 kg), elephant birds (up to ~860 kg), and other extraordinary Malagasy megafauna that survived well into the past millennium. Yet much about the evolutionary biology of these now extinct species remains unknown, along with persistent phylogenetic uncertainty in some cases. Thankfully, despite the challenges of DNA preservation in tropical and sub-tropical environments, technical advances have enabled the recovery of ancient DNA from some Malagasy subfossil specimens. Here we present a nuclear genome sequence (~2X coverage) for one of the largest extinct lemurs, the koala lemur Megaladapis edwardsi (~85kg). To support the testing of key phylogenetic and evolutionary hypotheses we also generated new h...

Research paper thumbnail of Primate Conservation Genomics and Paleogenomics

American Anthropologist, Nov 10, 2015

Over the past few decades, anthropologists have increasingly used genetic approaches in their eff... more Over the past few decades, anthropologists have increasingly used genetic approaches in their efforts to understand humans and their primate relatives. Technological and theoretical developments in recent years have enabled anthropological geneticists to expand their field of inquiry far beyond what was thought possible even a few years ago (Crawford 2000). Most importantly, the cost of collecting large genetic data sets has dropped dramatically, aiding researchers to better investigate complex questions such as the organization of our genome and the diversity of microbes living in our guts. Spectacular recent genetic discoveries, moreover, have altered understandings of our relationships to other hominin lineages. For example, genetic data have shown that both Neandertals (Green et al. 2010) and a newly discovered Denisovan population (Krause et al. 2010; Meyer et al. 2012) interbred with modern humans. Anthropological geneticists have long examined biological relationships among populations and described genetic variants such as disease-causing mutations that can be linked to specific human phenotypes (Crawford 2000). Great advances have been made on both fronts. The general patterns of human dispersal across the globe have been established (e.g., Henn et al. 2012). Genetic data continue to reveal the complex demographic histories of regional populations. In particular, studies have revealed how both geography and culture have stratified genetic diversity in contemporary populations. This can happen over short periods of time, as with the genetic stratification by religion of populations in the Levant (Haber et al. 2013). Our emerging understanding of diverse complex interactions between genetics and culture has both increased our understanding of these

Research paper thumbnail of Data from: Evolutionary and phylogenetic insights from a nuclear genome sequence of the extinct, giant 'subfossil' koala lemur Megaladapis edwardsi

No endemic Madagascar animal with body mass >10 kg survived a relatively recent wave of extinc... more No endemic Madagascar animal with body mass >10 kg survived a relatively recent wave of extinction on the island. From morphological and isotopic analyses of skeletal 'subfossil' remains we can reconstruct some of the biology and behavioral ecology of giant lemurs (primates; up to ~160 kg), elephant birds (up to ~860 kg), and other extraordinary Malagasy megafauna that survived well into the past millennium. Yet much about the evolutionary biology of these now extinct species remains unknown, along with persistent phylogenetic uncertainty in some cases. Thankfully, despite the challenges of DNA preservation in tropical and sub-tropical environments, technical advances have enabled the recovery of ancient DNA from some Malagasy subfossil specimens. Here we present a nuclear genome sequence (~2X coverage) for one of the largest extinct lemurs, the koala lemur Megaladapis edwardsi (~85kg). To support the testing of key phylogenetic and evolutionary hypotheses we also generat...

Research paper thumbnail of Potential evolutionary body size reduction in a Malagasy primate ( Propithecus verreauxi ) in response to human size‐selective hunting pressure

American Journal of Biological Anthropology, 2022

Research paper thumbnail of Primate Conservation Genomics and Paleogenomics

American Anthropologist, 2015

Over the past few decades, anthropologists have increasingly used genetic approaches in their eff... more Over the past few decades, anthropologists have increasingly used genetic approaches in their efforts to understand humans and their primate relatives. Technological and theoretical developments in recent years have enabled anthropological geneticists to expand their field of inquiry far beyond what was thought possible even a few years ago (Crawford 2000). Most importantly, the cost of collecting large genetic data sets has dropped dramatically, aiding researchers to better investigate complex questions such as the organization of our genome and the diversity of microbes living in our guts. Spectacular recent genetic discoveries, moreover, have altered understandings of our relationships to other hominin lineages. For example, genetic data have shown that both Neandertals (Green et al. 2010) and a newly discovered Denisovan population (Krause et al. 2010; Meyer et al. 2012) interbred with modern humans. Anthropological geneticists have long examined biological relationships among populations and described genetic variants such as disease-causing mutations that can be linked to specific human phenotypes (Crawford 2000). Great advances have been made on both fronts. The general patterns of human dispersal across the globe have been established (e.g., Henn et al. 2012). Genetic data continue to reveal the complex demographic histories of regional populations. In particular, studies have revealed how both geography and culture have stratified genetic diversity in contemporary populations. This can happen over short periods of time, as with the genetic stratification by religion of populations in the Levant (Haber et al. 2013). Our emerging understanding of diverse complex interactions between genetics and culture has both increased our understanding of these

Research paper thumbnail of Anthropological Genetics

American Anthropologist, 2015

Research paper thumbnail of Evolutionary and phylogenetic insights from a nuclear genome sequence of the extinct, giant ‘subfossil’ koala lemur Megaladapis edwardsi

No endemic Madagascar animal with body mass >10 kg survived a relatively recent wave of extinc... more No endemic Madagascar animal with body mass >10 kg survived a relatively recent wave of extinction on the island. From morphological and isotopic analyses of skeletal ‘subfossil’ remains we can reconstruct some of the biology and behavioral ecology of giant lemurs (primates; up to ~160 kg), elephant birds (up to ~860 kg), and other extraordinary Malagasy megafauna that survived well into the past millennium. Yet much about the evolutionary biology of these now extinct species remains unknown, along with persistent phylogenetic uncertainty in some cases. Thankfully, despite the challenges of DNA preservation in tropical and sub-tropical environments, technical advances have enabled the recovery of ancient DNA from some Malagasy subfossil specimens. Here we present a nuclear genome sequence (~2X coverage) for one of the largest extinct lemurs, the koala lemur Megaladapis edwardsi (~85kg). To support the testing of key phylogenetic and evolutionary hypotheses we also generated new h...