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Papers by Hetal Joshi

journal of medical science and clinical research, 2017

Context: Diagnosis of lymphoma constitutes a difficult task in context to subtyping. Accurate dia... more Context: Diagnosis of lymphoma constitutes a difficult task in context to subtyping. Accurate diagnosis is essential because the treatment options, responses to therapy and prognosis vary widely depending on the diagnosis. However to make a definitive diagnosis of a lymphoma based solely on the H & E light microscopy, findings may be exceedingly difficult because of frequent absence of distinguishing features. IHC represents a tool that can provide a clear distinction among the different types of lymphoma. The purpose of IHC is to categorize the patient in order to ensure appropriate and specific treatment, as well as to identify tumours at higher risk of recurrence and fatal outcomes. Aims: To study histomorphology of different lymphomas and correlation of it with immunohistochemical findings. Settings and Design: The present study is a retrospective as well as prospective study of lymphoma cases diagnosed based on routine histopathology as well as correlation of it with immunohistochemistry in surgical pathology section of the Central Diagnostic Laboratory, Shree Krishna Hospital, Karamsad from September 2010 to August 2015. Materials and Methods: A detail clinical history, nature of specimen and other investigations were noted in the proforma. Macroscopic and microscopic findings or any incidental findings were documented in the final report. Results: Total 47 cases of lymphoma were diagnosed in study period among them 42 cases were of B cell lymphoma and 7 cases were of T cell lymphoma. All B cell lymphoma were positive immunihistochemically for CD 20 and LCA. Out of 47 cases 25(53.19%) were of lymphoid origin and 22(46.81%) were of extralymphoid site. Conclusion: From this study it was concluded that:  In all the cases diagnosis of hematoxyllin and eosin stained sections were correlated with immunohistochemical findings  Non Hodgkin's Lymphoma were most common than Hodgkin's lymphoma  Lymphnodes are the most common site of origin.

International Journal of Pharma and Bio Sciences

The metabolic syndrome (MS) is characterized as the clustering of closely associated and interdep... more The metabolic syndrome (MS) is characterized as the clustering of closely associated and interdependent atherosclerotic risk factors.The study was performed to analyse platelet volume indices (PVI) that are useful for identifying large platelets, which are haemostatically more active and produce more thromboxane A2. We measured PVI in 44 subjects with metabolic syndrome (age 51±10 years) and 43 subjects without metabolic syndrome (age 49±15 years). The PVI was significantly higher in patients with metabolic syndrome compared to control group (p <0.0001). PVI is simple, effortless and cost effective tool for predicting the possibility of impending acute events. So, PVI may be used as a better predictor for acute complication in patients with metabolic syndrome.

International Journal of Research in Medical Sciences, 2013

International Journal of Medical Science and Public Health, 2014

Background: The attainment of quality services in a laboratory requires a comprehensive quality a... more Background: The attainment of quality services in a laboratory requires a comprehensive quality assurance program which includes both internal and external quality control material. External Quality Assessment Scheme (EQAS) programs are accepted around the world as an invaluable tool by laboratories to assess the performance of their testing systems. Results are objectively compared to other laboratories, using the same methodologies for every parameter. Aims & Objectives: The goal of this study was to review EQAS results from time to time in an effort to improve the performance of the laboratory.