Katharina Heydon - Academia.edu (original) (raw)

Katharina Heydon

Address: Bavilliers, Franche-Comté, France

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Papers by Katharina Heydon

The International Journal of Developmental Biology, 2005

The question of how neurons and glial cells are generated during the development of the CNS has o... more The question of how neurons and glial cells are generated during the development of the CNS has over time led to two alternative models: either neuroepithelial cells are capable of giving rise to neurons first and to glial cells at a later stage (switching model), or they are intrinsically committed to generate one or the other (segregating model). Using the developing diencephalon as a model and by selecting a subpopulation of ventricular cells, we analyzed both in vitro, using clonal analysis, and in vivo, using inducible Cre/loxP fate mapping, the fate of neuroepithelial and radial glial cells generated at different time points during embryonic development. We found that, during neurogenic periods [embryonic day 9.5 (E9.5) to 12.5], proteolipid protein ( plp)-expressing cells were lineage-restricted neuronal precursors, but later in embryogenesis, during gliogenic periods (E13.5 to early postnatal), plp-expressing cells were lineage-restricted glial precursors. In addition, we sh...

International Journal of Developmental Neuroscience, 1996

Development, Dec 15, 2001

Development (Cambridge, England), 2001

Most studies on the origin of oligodendrocyte lineage have been performed in the spinal cord. By ... more Most studies on the origin of oligodendrocyte lineage have been performed in the spinal cord. By contrast, molecular mechanisms that regulate the appearance of the oligodendroglial lineage in the brain have not yet attracted much attention. We provide evidence for three distinct sources of oligodendrocytes in the mouse telencephalon. In addition to two subpallial ventricular foci, the anterior entopeduncular area and the medial ganglionic eminence, the rostral telencephalon also gives rise to oligodendrocytes. We show that oligodendrocytes in the olfactory bulb are generated within the rostral pallium from ventricular progenitors characterized by the expression of PLP: We provide evidence that these Plp oligodendrocyte progenitors do not depend on signal transduction mediated by platelet-derived growth factor receptors (PDGFRs), and therefore propose that they belong to a different lineage than the PDGFRalpha-expressing progenitors. Moreover, induction of oligodendrocytes in the tel...

Immunology and Cell Biology, 2000

Brain Research, 2000

Our laboratory has generated a mouse deficient in the alpha (α) subunit of the G protein, Gz, (Gz... more Our laboratory has generated a mouse deficient in the alpha (α) subunit of the G protein, Gz, (Gzα) gene and we have examined the involvement of Gzα in spinal and supraspinal analgesia and tolerance mechanisms. Spinal analgesia was tested by the response times to heat or cold tail flick times in a water bath at 50°C or −5°C and supraspinal